scholarly journals Effect of Surfactant Dynamics on Flow Patterns Inside Drops Moving in Rectangular Microfluidic Channels

2021 ◽  
Vol 5 (3) ◽  
pp. 40
Author(s):  
Nina M. Kovalchuk ◽  
Mark J. H. Simmons

Drops contained in an immiscible liquid phase are attractive as microreactors, enabling sound statistical analysis of reactions performed on ensembles of samples in a microfluidic device. Many applications have specific requirements for the values of local shear stress inside the drops and, thus, knowledge of the flow field is required. This is complicated in commonly used rectangular channels by the flow of the continuous phase in the corners, which also affects the flow inside the drops. In addition, a number of chemical species are present inside the drops, of which some may be surface-active. This work presents a novel experimental study of the flow fields of drops moving in a rectangular microfluidic channel when a surfactant is added to the dispersed phase. Four surfactants with different surface activities are used. Flow fields are measured using Ghost Particle Velocimetry, carried out at different channel depths to account for the 3-D flow structure. It is shown that the effect of the surfactant depends on the characteristic adsorption time. For fast-equilibrating surfactants with a characteristic time scale of adsorption that is much smaller than the characteristic time of surface deformation, this effect is related only to the decrease in interfacial tension, and can be accounted for by the change in capillary number. For slowly equilibrating surfactants, Marangoni stresses accelerate the corner flow, which changes the flow patterns inside the drop considerably.

2021 ◽  
Author(s):  
Sebastian W. Krauss ◽  
Pierre-Yves Gires ◽  
Matthias Weiss

Analyzing and sorting particles and/or biological cells in microfluidic devices is a topical problem in soft-matter and biomedical physics. An easy and rapid screening of the deformation of individual cells in constricted microfluidic channels allows, for example, the identification of sick or aberrant cells with altered mechanical properties, even in vast cell ensembles. The subsequently desired softness-specific segregation of cells is, however, still a major challenge. Moreover, aiming at an intrinsic and unsupervised approach raises a very general question: How can one achieve a softness-dependent net migration of particles in a microfluidic channel? Here we show that this is possible by exploiting a deformation-induced actuation of soft cells in asymmetric periodic flow fields in which rigid beads show a vanishing net drift.


Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 65
Author(s):  
Puneet Manocha ◽  
Gitanjali Chandwani

Molecular communication is a bioinspired communication that enables macro-scale, micro-scale and nano-scale devices to communicate with each other. The molecular communication system is prone to severe signal attenuation, dispersion and delay, which leads to performance degradation as the distance between two communicating devices increases. To mitigate these challenges, relays are used to establish reliable communication in microfluidic channels. Relay assisted molecular communication systems can also enable interconnection among various entities of the lab-on-chip for sharing information. Various relaying schemes have been proposed for reliable molecular communication systems, most of which lack practical feasibility. Thus, it is essential to design and develop relays that can be practically incorporated into the microfluidic channel. This paper presents a novel design of passive in-line relay for molecular communication system that can be easily embedded in the microfluidic channel and operate without external energy. Results show that geometric modification in the microfluidic channel can act as a relay and restore the degraded signal up-to 28%.


Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 335
Author(s):  
Anna Yagodnitsyna ◽  
Alexander Kovalev ◽  
Artur Bilsky

Immiscible liquid–liquid flows in microchannels are used extensively in various chemical and biological lab-on-a-chip systems when it is very important to predict the expected flow pattern for a variety of fluids and channel geometries. Commonly, biological and other complex liquids express non-Newtonian properties in a dispersed phase. Features and behavior of such systems are not clear to date. In this paper, immiscible liquid–liquid flow in a T-shaped microchannel was studied by means of high-speed visualization, with an aim to reveal the shear-thinning effect on the flow patterns and slug-flow features. Three shear-thinning and three Newtonian fluids were used as dispersed phases, while Newtonian castor oil was a continuous phase. For the first time, the influence of the non-Newtonian dispersed phase on the transition from segmented to continuous flow is shown and quantitatively described. Flow-pattern maps were constructed using nondimensional complex We0.4·Oh0.6 depicting similarity in the continuous-to-segmented flow transition line. Using available experimental data, the proposed nondimensional complex is shown to be effectively applied for flow-pattern map construction when the continuous phase exhibits non-Newtonian properties as well. The models to evaluate an effective dynamic viscosity of a shear-thinning fluid are discussed. The most appropriate model of average-shear-rate estimation based on bulk velocity was chosen and applied to evaluate an effective dynamic viscosity of a shear-thinning fluid. For a slug flow, it was found that in the case of shear-thinning dispersed phase at low flow rates of both phases, a jetting regime of slug formation was established, leading to a dramatic increase in slug length.


1993 ◽  
Vol 115 (4) ◽  
pp. 751-759 ◽  
Author(s):  
Tsuneaki Ishima ◽  
Koichi Hishida ◽  
Masanobu Maeda

A particle dispersion has been experimentally investigated in a two-dimensional mixing layer with a large relative velocity between particle and gas-phase in order to clarify the effect of particle residence time on particle dispersion. Spherical glass particles 42, 72, and 135 μm in diameter were loaded directly into the origin of the shear layer. Particle number density and the velocities of both particle and gas phase were measured by a laser Doppler velocimeter with modified signal processing for two-phase flow. The results confirmed that the characteristic time scale of the coherent eddy apparently became equivalent to a shorter characteristic time scale due to a less residence time. The particle dispersion coefficients were well correlated to the extended Stokes number defined as the ratio of the particle relaxation time to the substantial eddy characteristic time scale which was evaluated by taking account of the particle residence time.


2001 ◽  
Author(s):  
D. Palaniappan

Abstract Exact analytical solutions for steady-state axisymmetric creeping flows in and around a compound multiphase droplet are presented. The solutions given here explain the droplet fluid interactions in uniform and nonuniform flow fields. The compound droplet has a two-sphere geometry with the two spherical surfaces (of unequal radii) intersecting orthogonally. The surface tension forces are assumed to be sufficiently large so that the interfaces have uniform curvature. The singularity solutions for the uniform and paraboloidal flows in the presence of a compound droplet are derived using the method of reflections. The exact solutions for the velocity and pressure fields in the continuous and dispersed phases are given in terms of the fundamental singularities (Green’s functions) and their derivatives. It is found that flow fields and the drag forces depend on two parameters namely, the viscosity ratio and the radii ratio. In the case of paraboloidal flows, a single or a pair of eddies is noticed in the continuous phase for various values of these parameters. The eddies changes their size and shape if the size of the droplet is altered. These observations may be useful in the study of hydrodynamic interactions of compound droplets in complex situations. It is found that the Stokes resistance is greater when the liquid volume is large compared to the vapor volume in uniform flow. It is also noticed that the maximum value of the drag in paraboloidal flow depends on the viscosity ratio and significantly on the liquid volume in the dispersed phase. The exact solutions presented here may be useful for boundary integral formulations that are based on special kernels and also in validating numerical algorithms and codes on multiphase flow and droplet-fluid interactions.


1992 ◽  
Vol 02 (03) ◽  
pp. 715-719
Author(s):  
CHRIS LARNDER ◽  
NICOLAS DESAULNIERS-SOUCY ◽  
SHAUN LOVEJOY ◽  
DANIEL SCHERTZER ◽  
CLAUDE BRAUN ◽  
...  

In the 1970's it was found that; for low frequencies (<10 Hz), speech is scaling: it has no characteristic time scale. Now such scale invariance is associated with multiscaling statistics, and multifractal structures. Just as Gaussian noises frequently arise because they are generically produced by sums of many independent noise processes, scaling noises have an analogous universal behavior arising from nonlinear mixing of processes. We show that low frequency speech is consistent with these ideas, and use the measured parameters to produce stochastic speech simulations which are strikingly similar to real speech.


2017 ◽  
Vol 2017 (1) ◽  
pp. 000569-000575 ◽  
Author(s):  
André Cardoso ◽  
Raquel Pinto ◽  
Elisabete Fernandes ◽  
Steffen Kroehnert

Abstract Due to its versatility for high density, heterogeneous integration, Wafer Level Fan Out (WLFO) packaging has recently seen a tremendous growth in a broad array of applications, from telecommunications and automotive, to optical and environmental sensing, while addressing the challenges of the next big wave of the Internet of Things (IoT). In this context, WLFO is continuously being challenged to include new families of MEMS/NEMS/MOEMS sensors, low thermal budget devices and biochips with microfluidics for biomedical applications. Recent developments in WLFO technology by NANIUM [1] demonstrated the implementation of a keep-out-zone (KOZ) mechanism intended to 1st) protect sensitive sensor areas during the backend processing of WLFO wafers and 2nd) create open zones on the Re-Distribution Layers (RDL). This way, the KOZ mechanism provides a physical, direct path from the embedded device to the environment. This is a necessary feature for environment sensing (e.g., pressure) or to create optical paths free of dielectric and protected from the harsh chemistry steps of the WLFO process. This paper describes new developments on KOZ, implemented with SU-8 photoresist as a WLFO dielectric, whose application is a novelty in the WLFO platform. The use of SU-8 and the KOZ with it, addresses some gaps of the current WLFO technology towards the integration of chips with bio-sensitive areas and sensors with low thermal budget. Due to its well-known bio-compatibility and inert behavior, SU-8 can be used as a neutral dielectric to be in direct contact to target fluids (e.g., sera, blood). Also, due to its low curing temperature, SU-8 allows a very low temperature WLFO process and thus the embedding of temperature-limited devices that have been outside the WLFO realm, for example, magneto-resistive or magnetic-spin sensor chips, which degrades its performance above 160°C. More interestingly, SU-8 exhibits a particular non-conformal behavior, which creates very smooth surfaces even over the mildly rough mold compound area of a fan-out package. Adding to this, SU-8 is readily available in the market in a wide range of thicknesses, spanning from 0.5 μm to &gt;100 μm, and further allowing multiple spin coatings to build thick layers. Thus, SU-8 can provide smooth and deep enough channels for microfluidic flow over the chip sensing areas and, at the same time, provide the necessary layer thickness discrimination for the KOZ mechanism. Combining these features, the SU-8 layers in WLFO can play the triple role of 1) RDL dielectric insulation, 2) KOZ mechanism and 3) embedded microfluidic channels as part of the RDL. In summary, besides the unprecedented use of SU-8 in WLFO packaging, KOZ implementation on SU-8 provides a true, attainable bridge between WLFO and integrated microfluidic applications, for biosensing and biomedical applications in general. Outlooking the potentialities of such a merge, a Fan-Out package can embed several chips interconnected by RDL lines, as it currently allows, and also connected by microfluidic channel for multi-point, multi-function biosensing, constituting a true Lab-on-Package, cost-effective solution. Instead of building all sensing areas and microfluidic channels over a large silicon (Si) chip, this solution builds the feed-in, feed-out areas of the microfluidic channel over the inexpensive fan-out area, minimizing the sensing chip area, with the consequent front-end cost reduction.


Author(s):  
Toshifumi Ohkubo ◽  
Nobuyuki Terada ◽  
Yoshikazu Yoshida

A resin-based optical total analysis system (O-TAS) which consists both of microfluidic channels and light waveguides [1] is thought to be one of the most promising components in developing a “ubiquitous human healthcare system” in the near future. Along with this technology trend, we have already developed a transparent epoxy-resin-based optical TAS chip which has a specially prepared light waveguide structure of radially arranged configuration at an intersection portion with a microfluidic channel, in order to detect directivity of fluorescence from fluorescent substance attached micro particles [2],[3]. Schematic diagram of the optical TAS is shown in Figure 1. In the latest research, utilizing an AC modulated laser source and time-series averaging function on detected signal waveforms, we could have successfully obtained directivities of fluorescence from 5-μm-diameter particles with higher signal to noise (S/N) ratio [3].


Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 870
Author(s):  
Kerem Kaya ◽  
Ahmet Yasin Celik ◽  
Senol Mutlu

This work reports for the first-time integration of continuous microfluidic channels to the paper-based electro-osmotic pumps (EOPs) with liquid bridges. In addition, 0.2 μm pore sized cellulose acetate (CA) membrane filter is used to eliminate pressure-driven flow instead of filter paper which is common in paper microfluidics and has an average pore size of 10 μm. A factor of 57 increase in hydraulic resistance is achieved with the new paper. Fabrication of the pumps and microfluidic channels using paper, wax, adhesive film and PMMA plates is explained. Volumetric flow rate of 19 nL/min is achieved in the microfluidic system with 61 V/cm electrical field magnitude applied to DI water. The capability of the integrated system is shown with precise liquid motion in a Y-shaped microfluidic channel integrated with two EOPs.


2011 ◽  
Vol 73 (11-12) ◽  
pp. 1555-1559 ◽  
Author(s):  
C.M. Denardini ◽  
H.C. Aveiro ◽  
P.D.S.C. Almeida ◽  
L.C.A. Resende ◽  
L.M. Guizelli ◽  
...  

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