scholarly journals Aerobic Vaginitis—Underestimated Risk Factor for Cervical Intraepithelial Neoplasia

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 97
Author(s):  
Olga Plisko ◽  
Jana Zodzika ◽  
Irina Jermakova ◽  
Kristine Pcolkina ◽  
Amanda Prusakevica ◽  
...  
Keyword(s):  
Histological Finding ◽  
Intraepithelial Neoplasia ◽  
Vaginal Microbiota ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Aerobic Vaginitis ◽  
Abnormal Cervical Cytology ◽  
Low Education ◽  
Independent Risk Factors

The aim of this study is to analyse the association between vaginal microbiota and the histological finding of CIN. From July 2016 until June 2017, we included 110 consecutive patients with abnormal cervical cytology results referred for colposcopy to Riga East Clinical University Hospital Outpatient department in the study group. 118 women without cervical pathology were chosen as controls. Certified colposcopists performed interviews, gynaecological examinations and colposcopies for all participants. Material from the upper vaginal fornix was taken for pH measurement and wet-mount microscopy. Cervical biopsy samples were taken from all subjects in the study group and in case of a visual suspicion for CIN in the control group. Cervical pathology was more often associated with smoking (34.6% vs. 11.0%, p < 0.0001), low education level (47.2% vs. 25.5%, p = 0.001), increased vaginal pH (48.2% vs. 25.4%, p < 0.0001), abnormal vaginal microbiota (50% vs. 31.4%, p = 0.004) and moderate to severe aerobic vaginitis (msAV) (13.6% vs. 5.9%, p = 0.049) compared to controls. The most important independent risk factors associated with CIN2+ were smoking (OR 3.04 (95% CI 1.37–6.76), p = 0.006) and msAV (OR 3.18 (95% CI 1.13–8.93), p = 0.028). Bacterial vaginosis (BV) was found more often in CIN1 patients (8/31, 25.8%, p = 0.009) compared with healthy controls (8/118, 6.8%), or CIN2+ cases (8/79, 10.1%). In the current study msAV and smoking were the most significant factors in the development of CIN in HPV-infected women, especially high grade CIN. We suggest that AV changes are probably more important than the presence of BV in the pathogenesis of CIN and progression to cervix cancer and should not be ignored during the evaluation of the vaginal microbiota.

scholarly journals Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case–control study

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Lian Luo ◽  
Mingli Zhu ◽  
Jiajun Zhou
Keyword(s):  
Cerebral Infarction ◽  
Case Control Study ◽  
Case Control ◽  
Cathepsin S ◽  
Control Group ◽  
Study Group ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Independent Risk Factors ◽  
Control Study

Objective: To investigate the association between the gene polymorphisms of rs774320676, rs768437857, rs928508030, and rs2275235 loci of Cathepsin S (CTSS) and risk of acute atherosclerotic cerebral infarction. Methods: A total of 315 patients with acute atherosclerotic cerebral infarction (study group) and 220 healthy subjects (control group) were enrolled in the present study. The genetic polymorphism of rs774320676, rs768437857, rs928508030, and rs2275235 loci of CTSS of subjects was analyzed by PCR-Sanger sequencing. Results: The proportion of carriers with mutant T allele at rs774320676 locus and mutant G allele at rs928508030 locus of CTSS in study group was significantly higher than the proportion in control group (P=0.000, adjusted odds ratio (OR) = 1.332, 95% confidence interval (CI) = 1.200–1.460; P<0.001, adjusted OR = 1.185, 95% CI = 1.055–1.314; P=0.002). The T allele at rs774320676 locus and the G allele at rs928508030 locus of CTSS were independent risk factors for acute atherosclerotic cerebral infarction (OR = 2.534, 95% CI = 1.020–4.652, P=0.006; OR = 2.016, 95% CI = 1.031–4.385, P=0.031). Conclusion: The single nucleotide polymorphisms (SNPs) of rs774320676 and rs928508030 of CTSS gene were related with risk for acute atherosclerotic cerebral infarction. The T allele at rs774320676 locus and G allele at rs928508030 locus of CTSS were genetic susceptibility genes of acute atherosclerotic cerebral infarction.

scholarly journals EFFECTS OF THE SCHROTH METHOD FOR TRUNK MUSCLES’ STATIC ENDURANCE AND SPINE MOBILITY IN GIRLS WITH IDIOPATHIC SCOLIOSIS

2017 ◽  
Vol 27 (5) ◽  
pp. 71-75
Author(s):  
Vaiva Strukčinskaitė ◽  
Juozas Raistenskis ◽  
Aurelija Šidlauskienė ◽  
Birutė Strukčinskienė ◽  
Sigitas Griškonis
Keyword(s):  
Idiopathic Scoliosis ◽  
Treatment Method ◽  
University Hospital ◽  
Trunk Muscles ◽  
Control Group ◽  
Abdominal Muscles ◽  
Study Group ◽  
Trunk Flexion ◽  
Rehabilitation Centre ◽  
Spine Mobility

The prevalence of scoliosis in the paediatric population is increasing every year. The treatment of idiopathic scoliosis in Lithuania is based on traditional physical therapy, and it is not always the most effective. Schroth method recently is widely globally used evidence-based conservative scoliosis treatment method. The aim of the study was to assess the effects of the Schroth method treatment for trunk muscles’ static endurance and spine mobility in girls with idiopathic scoliosis. The study was conducted in 2016-2017 at the Physical Medicine and Rehabilitation Centre, Children’s Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos. In the study participated 50 girls aged 9-17 years with idiopathic scoliosis. The patients were divided into two groups: the study group (n = 25) and the control group (n = 25). Schroth treatment method for the study group and a traditional physiotherapy for the control group were used. For patients were applied 10 procedures of physiotherapy (for 30 minutes, 5 times a week). The study showed that trunk muscles’ static endurance results after rehabilitation were significantly higher in the study group than in the control group (p&lt;0.05). The analysis of the average changes in the results between the groups revealed that in the study group the results of abdominal muscles (16.08 s more), left side trunk muscles (6.98 s more), and right side trunk muscles (7.84 s more) had changed significantly. Results of spine mobility significantly improved in both groups after rehabilitation (p&lt;0.05). Trunk flexion amplitude estimated to have significantly greater improvement in the study group. The treatment using Schroth method had significantly improved the indicators of trunk muscles’ static endurance and mobility of the spine during spinal flexion. When compare the results inside the groups, the significant change was shown in the majority of spine and posture-related parameters in the study group. Special physiotherapy, especially Schroth method for children with idiopathic scoliosis have been shown to be an effective conservative treatment for scoliosis.

Squamous Epithelium in the Middle Ear and Sinus

1994 ◽  
Vol 73 (1) ◽  
pp. 47-48
Author(s):  
Alper Tutkun ◽  
Caglar Batman ◽  
Cüneyt Üneri ◽  
Mehmet Ali Sehitoglu
Keyword(s):  
Middle Ear ◽  
Statistical Difference ◽  
Squamous Epithelium ◽  
Normal Skin ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
External Ear ◽  
Ear Canal ◽  
Superior Part

This study has been performed between December 1990—March 1991 in the Microsurgery laboratory of the Marmara University Hospital. Twelve healthy albino guinea pigs were used as a study group while the control group consists of three animals. The potentials for cholesteatoma formation of the squamous epithelium, namely the squamous epithelium of the posterior superior part of the external ear canal skin and normal skin, were investigated. Among 24 subjects who were implanted by canal skin, cholesteatoma was fanned in 21 of them. Likewise, 19 of 24 animals implanted by normal skin came out with cholesteatoma formation. Between these two types of epithelium, there is no statistical difference in cholesteatoma formation (p >0.5).

scholarly journals The nutritional status of nurses working shifts: A pilot study in Turkey

2016 ◽  
Vol 29 (4) ◽  
pp. 589-596 ◽  
Author(s):  
Semra NAVRUZ VARLI ◽  
Saniye BILICI
Keyword(s):  
Nutritional Status ◽  
Night Shift ◽  
Study Data ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Food Services ◽  
Food Record ◽  
The Mean ◽  
Female Nurses

ABSTRACT Objective: This study was carried out to determine the nutritional status of shift-working female nurses at a university hospital in Ankara, Turkey. Methods: A total of 110 volunteer female nurses (n=56 control group, n=54 study group) were included in the study. A questionnaire with a three day food record collected the study data. Results: The mean daily energy intake of the study group was higher than that of the control group (1756±659 kcal versus 1694±431 kcal, p>0.05). While the carbohydrate intake (196.3±85.5 g versus 185.9±54.7 g) and fat intake (79.5±29.5 g versus 77.1±22.6 g) were higher in the study group, the protein intake was higher in the control group (59.4±17.6 g versus 57.6±21.6 g). The mean iron intake was statistically higher in the control group (10.6±2.9 mg versus 10.0±4.0 mg, p<0.05). Conclusion: To improve night shift workers' performance and nutritional status it is important to provide accessible, healthy, and quality food services.

scholarly journals Pancreatoduodenectomy for Periampullary Tumors Presenting with Acute Pancreatitis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Xuefeng Cao ◽  
Xixiu Wang ◽  
Xiaoliang Xu ◽  
Yanmin Lu ◽  
Baolei Zhao ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Operative Time ◽  
Laboratory Data ◽  
Biliary Fistula ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Course Of Disease ◽  
Periampullary Tumors ◽  
Medical University

Background. Periampullary tumors (PT) may rarely present as acute pancreatitis (AP) or acute recurrent pancreatitis (ARP). Unlike other cases of AP and ARP, these conditions necessitate pancreaticoduodenectomy (PD), and timely diagnosis is crucial. Materials and Methods. A retrospective review of clinical, radiological, surgical, and pathological data was conducted for patients admitted to the Binzhou Medical University Hospital during the period from January 2010 to December 2017, for AP or ARP caused by PT. All patients included in the study group had undergone PD. The perioperative data for these patients was compared with data for patients with PT but without AP or ARP who underwent PD during the same period (control group). Results. During the study period, 412 patients with AP or ARP were treated; among this group, 15 patients had PT. Compared with controls, patients in the study group were younger in age and had a longer course of disease, more frequent hospitalizations, and more severe derangements in laboratory data (P<0.05). Operative time and intraoperative blood loss were significantly higher in the study group, but the incidence of postoperative outcomes such as pancreatic/biliary fistula, abdominal infection, postoperative hospital stay, and mortality were similar between groups (P>0.05). Conclusions. Neither AP nor ARP has any adverse impact on the outcomes of PD. However, in the treatment of younger patients suffering from AP or ARP, unexplained pancreatic duct dilation and weight loss should raise the suspicion of PT. EUS and EUS-FNA may be helpful in making the diagnosis.

Prognostic value of mean platelet volume on tinnitus

2015 ◽  
Vol 130 (2) ◽  
pp. 162-165 ◽  
Author(s):  
O Kemal ◽  
T Müderris ◽  
F Başar ◽  
G Kutlar ◽  
F Gül
Keyword(s):  
Mean Platelet Volume ◽  
Healthy Subjects ◽  
Clinical Findings ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Pathophysiological Mechanism ◽  
Platelet Volume ◽  
Significant Difference ◽  
Healthy Control

AbstractObjective:This study aimed to determine whether there was any relationship between tinnitus and mean platelet volume.Methods:This retrospective study was conducted between January 2013 and January 2014 in Ankara Atatürk Hospital and Ondokuz Mayıs University Hospital, Turkey, on a study group of 86 patients with tinnitus and a control group of 84 healthy subjects. Mean platelet volume was recorded and comparisons were made between the two groups.Results:Mean (± standard deviation) platelet volume was 7.67 ± 0.83 μm3 in the study group and 7.28 ± 0.56 μm3 in the control group. There was a statistically significant difference in mean platelet volume between the tinnitus patients and the healthy subjects (p < 0.05).Conclusion:The clinical findings indicated that tinnitus patients had a higher mean platelet volume than the healthy control subjects; however, the pathophysiological mechanism remains unclear.

scholarly journals Evaluation of Intensity of Sleep Bruxism in Arterial Hypertension

2018 ◽  
Vol 7 (10) ◽  
pp. 327 ◽  
Author(s):  
Helena Martynowicz ◽  
Pawel Dymczyk ◽  
Marzena Dominiak ◽  
Klaudia Kazubowska ◽  
Robert Skomro ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Muscle Activity ◽  
Oral Care ◽  
Sleep Bruxism ◽  
Control Group ◽  
Study Group ◽  
Group Data ◽  
Independent Risk Factors ◽  
Normotensive Subjects

Sleep bruxism (SB) is a masticatory muscle activity during sleep that is characterized as rhythmic (phasic) or non-rhythmic (tonic). The recent hypothesis on the etiology of SB supports the role of the central and autonomic nervous systems. Therefore, in this study, we aimed to assess the intensity of SB in patients with arterial hypertension. A total of 70 adults participated in this study: 35 patients with hypertension (study group) and 35 normotensive subjects (control group). Data were recorded using home portable cardiorespiratory polygraphy. The bruxism episode index (BEI) in the study group was found to be significantly higher compared to the control group (3.4 ± 3.25 vs. 2.35 ± 2.29, p = 0.04). Hypertension, higher body mass index (BMI), lower values of mean oxygen saturation (SpO2), and a higher percentage of SpO2 < 90% constituted independent risk factors for increased BEI. These results suggest the need for special oral care in hypertensive patients, patients with higher BMI, lower values of SpO2 and a higher percentage of SpO2 < 90%.

scholarly journals Effect of designed nursing guidelines on acute anal fissure treatment outcomes

2018 ◽  
Vol 8 (10) ◽  
pp. 1
Author(s):  
Esmat Sayed Abd-Elmaged ◽  
Amna Abdallh Desoky ◽  
Tarik Abd-Elazem Abd-Elrahem
Keyword(s):  
Wound Healing ◽  
Anal Fissure ◽  
General Surgery ◽  
Rating Scale ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Pain Level ◽  
Significant Difference ◽  
Nursing Guidelines

Objective: Anal fissure is a common problem through the world, it causes considerable morbidity. The aim of the study was to evaluate the effect of designed nursing guidelines on acute anal fissure treatment outcomes.Methods: Research design: Quasi-experimental design. Setting: General Surgery Wards and Outpatient Clinics of General Surgery at Assiut University Hospital. Sample: A purposive sample of 60 male and female adult patients diagnosed of having acute anal fissure. Patients were equally divided on random basis into two equal groups (study and control) 30 patients for each. Tools: Tool I-Patient assessment sheet. Tool II-Numeric Pain Rating Scale. Tool III-Bates-Jensen Wound Assessment Tool.Results: No statistically significant difference was found between the study and the control groups as regard demographic data. There was a statistically significant improvement in the pain level and wound healing among the study group (1.63 ± 2.08 and 11.93 ± 4.5 respectively) than in the control group (2.87 ± 2.33 and 14.43 ± 4.29 respectively). Also, there was a high statistically significant improvement in the level of knowledge of the study group than their level before applying the guidelines (p < .001).Conclusions: Designed nursing guidelines had a statistically significant effect on improving patients' knowledge, pain level, and wound healing among the study group patients than among the control group ones with acute anal fissure. Recommendations: Patients teaching should be an integral part of the nurses' duty in all hospitals. Further studies on larger sample from different geographical areas in Egypt to generalize the results.

scholarly journals Vaginal hygiene to prevent postoperative complications in various gynecological diseases

2021 ◽  
Vol 4 (4) ◽  
pp. 322-327
Author(s):  
I.B. Manukhin ◽  
◽  
E.I. Manukhina ◽  
I.R. Safaryan ◽  
◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Bacterial Vaginosis ◽  
Preoperative Evaluation ◽  
Vaginal Microbiota ◽  
Control Group ◽  
Vaginal Smear ◽  
Study Group ◽  
Gynecological Diseases ◽  
Before And After ◽  
Oral Metronidazole

Aim: to assess the efficacy of vaginal care hygiene in women with various gynecological disorders requiring surgical interventions to reduce postoperative complications. Patients and Methods: eighty women aged 39–60 with various gynecological diseases diagnosed with vaginal microbiota abnormalities (E.F. Kir vaginal smear cleanliness grade 3–4) during the preoperative evaluation before a scheduled surgery underwent a complex clinical laboratory examination and treatment. The study group included 60 women who received a complex vaginal preparation containing 100 mg metronidazole and 100 mg miconazole nitrate (1 capsule at night) plus oral metronidazole (500 mg daily) five days before and after surgery. In the control group, vaginal hygiene was performed according to the general management standards (vaginal chlorhexidine 16 mg twice daily or oral metronidazole 500 mg daily for five days) in the presence of complaints and/or abnormalities in vaginal smears identified by microscopy. Results: 14 days after surgery, normal vaginal microbiota was reported in all study group women (vaginal smear cleanliness grade 1–2), while in the control group, vaginal smear cleanliness grade III-IV was reported in 8 women. Postoperative complications occurred in the control group only, i.e., two women were diagnosed with postoperative wound dehiscence after procedures for genital prolapse and two women were diagnosed with subacute infectious inflammatory pelvic disorders. Conclusion: our findings show the efficacy of vaginal hygiene with a complex vaginal preparation before and after pelvic floor surgery, as demonstrated by preventing bacterial vaginosis recurrences and reducing the rate of postoperative complications. KEYWORDS: bacterial vaginosis, vulvovaginal candidiasis, vaginal infection, postoperative complications, vaginal hygiene, metronidazole, miconazole. FOR CITATION: Manukhin I.B., Manukhina E.I., Safaryan I.R. Vaginal hygiene to prevent postoperative complications in various gynecological diseases. Russian Journal of Woman and Child Health. 2021;4(4):322–327 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-322-327.

scholarly journals Tear Film Osmolarity of the Eye after Cataract Surgery. Summary of the Doctoral Thesis

2021 ◽  
Author(s):  
◽  
Ēriks Elksnis ◽  
Keyword(s):  
Cataract Surgery ◽  
Postoperative Period ◽  
Ocular Surface ◽  
Tear Film ◽  
Visual Outcome ◽  
Early Postoperative Period ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Significant Difference

Almost every cataract surgeon has encountered a situation during the postoperative period when, even though, the primary goal – improvement of visual acuity – has been achieved, yet the patient felt frustrated because of subjective discomfort in the operated eye. Sometimes this issue is more disturbing for the patient than the hope for a perfect visual outcome. Although it has been established that the ocular surface is affected during the postoperative period, there is still no generally accepted opinion about the changes in tear osmolarity after cataract surgery despite several studies dedicated to evaluation of these changes. The present study was designed to elucidate the effect of cataract surgery on the characteristic feature of ocular surface homeostasis – tear film osmolarity in the early postoperative period. Aim. The aim of the study was to evaluate the changes in tear film osmolarity after a cataract surgery in a healthy ocular surface. Methods. For this purpose two examination groups were formed. The study group included voluntary patients undergoing cataract surgery not having any complaints about subjective symptoms typical of dry eye disease. In order to correspond to the criteria of healthy ocular surface, the study group excludes the following types of patients and conditions: contact lens wearers, patients with diabetes, pseudoexfoliation, pterygia and eye drop users. The eye that has not undergone the surgery was classified as the control group. This single–center, prospective study was held at Ophthalmology department of Pauls Stradins Clinical university hospital. All cataract surgeries were done by the same surgeon. The tear osmolarity tests were evaluated with TearLab Osmolarity System (TearLab Corporation, San Diego, CA, the USA) before surgery, in the next morning, one week and one month after the surgery. Results. No statistically significant difference was observed between the groups before operation when comparing the mean tear osmolarity – in the study group it was 296.87 mOsm/L, and in the control group it was 297.27 mOsm/L (p = 0.84). The tear osmolarity results changed significantly during early postoperative period in the study group (p < 0.001), while in non–operated eye no significant tear film osmolarity changes were observed (p = 0.86). Significant changes were recognized on the next day after the surgery – the tears became hypoosmolar (< 275 mOsm/L). One week later the tear osmolarity increased significantly, and the tears became hyperosmolar (312.64 mOsm/L). Over the course of one month, the test values for the study and control groups equalized (297.87 in the study group and 298.93 in the control group (p = 0.66)), when compared to preoperative tear osmolarity results. Conclusion. The results achieved lead towards a more detailed understanding of the changes in the ocular surface homeostasis after a cataract surgery. The obtained data indicate that tear osmolarity changes considerably during the first postoperative month after a cataract surgery. Also, there is a huge difference in measurements between operated and non–operated eye on the next day and one week after the surgery. One month after the surgery tear osmolarity returns to preoperative test results, and there is no difference determined between the eyes.

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