scholarly journals Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 474
Author(s):  
Alexei N. Sumin ◽  
Natalia A. Bezdenezhnykh ◽  
Andrey V. Bezdenezhnykh ◽  
Galina V. Artamonova
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Russian Federation ◽  
Population Sample ◽  
Visceral Obesity ◽  
Cardiovascular Complications ◽  
Cross Sectional ◽  
The Russian Federation ◽  
Diabetes Patients

The aim of this study was to evaluate Cardio-Ankle Vascular Index (CAVI) and increased arterial stiffness predictors in patients with carbohydrate metabolism disorders (CMD) in the population sample of Russian Federation. Methods: 1617 patients (age 25–64 years) were enrolled in an observational cross-sectional study Epidemiology of Cardiovascular Diseases and Their Risk Factors in the Regions of the Russian Federation (ESSE-RF). The standard ESSE-RF protocol has been extended to measure the cardio-ankle vascular index (CAVI), a marker of arterial stiffness. Patients were divided into three groups: patients with type 2 diabetes mellitus (n = 272), patients with prediabetes (n = 44), and persons without CMD (n = 1301). Results: Median CAVI was higher in diabetes and prediabetes groups compared with group without CMD (p = 0.009 and p < 0.001, respectively). Elevated CAVI (≥9.0) was detected in 16.8% of diabetes patients, in 15.9% of those with prediabetes, and in 9.0% of those without CMD (p < 0.001). The factors affecting on CAVI did not differ in CVD groups. In logistic regression the visceral obesity, increasing systolic blood pressure (SBP) and decreasing glomerular filtration rate (GFR) were associated with a pathological CAVI in CMD patients, and age, diastolic blood pressure (DBP), and cholesterol in persons without CMD. Conclusions: the CAVI index values in the prediabetes and diabetes patients were higher than in normoglycemic persons in a population sample of the Russian Federation. Since the identified disorders of arterial stiffness in prediabetes are similar to those in diabetes, their identification is important to prevent further cardiovascular complications.

Cardio-ankle vascular index in persons with prediabetes and diabetes mellitus in a population sample of Western Siberia of the Russian Federation

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
AN Sumin ◽  
N Bezdenezhnykh ◽  
AV Bezdenezhnykh ◽  
GV Artamonova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Russian Federation ◽  
Arterial Wall ◽  
Population Sample ◽  
Factors Affecting ◽  
Wall Stiffness ◽  
The Russian Federation ◽  
Diabetes Patients

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Federal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases” The aim of this study was to evaluate the level of cardio-ankle vascular index (CAVI) in the presence of pre-diabetes and diabetes mellitus in the population sample of the Russian Federation, as well as to investigate the factors associated with pathological CAVI in these subjects. Methods 1628 (age 25-64 years) were recruited in a observational cross-sectional study ESSE-RF in the period from 2012 to 2013. The standard protocol of the ESSE-RF has been extended with additional study of CAVI. The final sample included 1617 people, they are divided into 3 groups: group 1 - patients with type 2 diabetes mellitus (n = 272), group 2 - patients with prediabetes - IFG, IGT or their combination (n = 44), and group 3 - persons without CMD (n = 1301). Results The median CAVI was higher in diabetes and pre-diabetes groups (p = 0.009 and p &lt;0.001, respectively, compared with group without CMD). Pathological CAVI (≥9.0) was detected in 16.8% of diabetes patients, in 15.9% of those with prediabetes, and in 9.0% of those without CMD (p &lt;0.001 when comparing diabetes group and group without CMD). The groups with diabetes and prediabetes also did not differ in factors affecting the level of arterial wall stiffness (gender, blood pressure, age, dyslipidemia, uric acid level). According to the result of the correlation analysis in the general sample, CAVI positively correlated with age (p &lt;0.001), male sex (p &lt;0.001), type 2 diabetes (p &lt;0.001), prediabetes (p = 0.002), waist circumference (p &lt;0.001), visceral obesity (p &lt;0.001), total cholesterol (p &lt;0.001), triglycerides (p &lt;0.001), LDL cholesterol (p &lt;0.001), and with the inverse correlation - with glomerular filtration rate (GFR, p &lt;0.001). In multivariate analysis, age and the presence of arterial hypertension were independently associated with pathological CAVI in the groups of patients with CMD, and in the group without CMD, in addition to these factors - a decrease in GFR. Conclusions In the population sample of the Russian Federation, the CAVI index values in the prediabetes and diabetes patients were higher than in the normoglycemia persons. The groups with diabetes and prediabetes also did not differ in factors affecting the level of arterial wall stiffness. Since the identified disorders of arterial stiffness in prediabetes are similar to those in diabetes, their identification is important to prevent further cardiovascular complications.

scholarly journals Economic evaluation of type 2 diabetes mellitus burden and its main cardiovascular complications in the Russian Federation

2016 ◽  
Vol 19 (6) ◽  
pp. 518-527 ◽  
Author(s):  
Ivan I. Dedov ◽  
Anna V. Koncevaya ◽  
Marina V. Shestakova ◽  
Yuriy B. Belousov ◽  
Julia A. Balanova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Russian Federation ◽  
Complex Analysis ◽  
Vascular Complications ◽  
Cardiovascular Complications ◽  
Permanent Disability ◽  
Clinical Investigations ◽  
The Russian Federation ◽  
Cardio Vascular

Background. Diabetes Mellitus Type 2 (DMT2) is a complex medical and social problem in the world and in the Russian Federation also due to prevalence and probability of cardio-vascular complications (CVC).Aim. Economic burden evaluation of DMT2 in the Russian Federation.Methods. Complex analysis of expenditures (direct and non-direct costs) based on epidemiological, pharmacoeconomics and clinical investigations, population and medical statistics data.Results. Calculated expenditures for DMT2 are 569 bln RUR per year, that is correspond to 1% of the Russian GDP, and 34,7% of that are expenditures for main CVC (ischemic heart disease, cardiac infarction, stroke). Main part of expenses are non-medical (losses GDP) due to temporary and permanent disability, untimely mortality – 426,7 bln RUR per year. Expenditures in estimated group of patients with non-diagnosed DMT2 but with already having CVC were at least 107 bln per year (18,8% from total cost). Relationship between cost of DMT2 and degree of it’s control was found in the Russian conditions. Estimated cost for compensated patient (HbA1c6,5%) per year was 88 982 RUR, in the same time cost of non-control patient (HbA1c9,5%) was in 2,8 times higher due to more often main CVC in this group.Conclusion. DMT2 diagnosis improvement as well as effective treatment of early stages of illness can decrease probability of CVC and social economic expenditures. 

Modern approach to the treatment of arterial hypertension

2021 ◽  
pp. 28-34
Author(s):  
Dmitriy Sergeevich Kovalev
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Arterial Hypertension ◽  
Pathological Condition ◽  
Cardiovascular Complications ◽  
European Population ◽  
Modern Approach ◽  
Appropriate Treatment ◽  
Literary Sources ◽  
The Impact

Arterial hypertension (AH) refers to an increase in blood pressure above the level of 140/90 mm Hg; the risk of cardiovascular complications increases significantly with this pathological condition. Thus, arterial hypertension is an independent risk factor for the development of prediabetes / type 2 diabetes mellitus, heart failure, coronary heart disease, chronic kidney damage, and multifocal atherosclerosis. The frequency of arterial hypertension occurrence varies in different countries: in particular, it is from 23 to 36% for the European population, according to various literary sources. The main goal of treatment is to minimize the overall risk of developing cardiovascular complications. This involves the impact on all identified reversible risk factors, such as smoking and high cholesterol levels, and most importantly, appropriate treatment of concomitant diseases (diabetes mellitus, thyroid gland pathology, kidney disease, etc.), as well as the correction of high blood pressure.

Features of the acid-base balance of the prosthetic cavity in patients with diabetes mellitus

2021 ◽  
pp. 111-115
Author(s):  
N.S. Alkhateeb, ◽  
◽  
M.A. Frolov ◽  
V.V. Shklyaruk ◽  
K.N. Odinaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Russian Federation ◽  
Acid Base Balance ◽  
Acid Base ◽  
Diabetes Mellitus Group ◽  
Ocular Prosthesis ◽  
Patients With Diabetes ◽  
Base Balance ◽  
Eye Prosthesis ◽  
The Russian Federation

The number of patients with diabetes mellitus in the Russian Federation on January 1, 2019 is more than 4.5 million people, which is 3.12% of the population of the Russian Federation. Metabolic disorders in diabetes mellitus cause physicochemical changes, including a violation of acid-base balance (pH). Aim. To study the effect of diabetes mellitus and ocular prosthetics on the acid-base balance of the prosthetic cavity. Materials and methods. From 2018 to 2021 - 185 patients of both sexes from 21 to 80 years old (57.73±17.34 years old) were examined. 47 patients using an eye prosthesis and without diabetes mellitus (group I); 93 patients using an eye prosthesis with diabetes (group II), which were divided into two subgroups depending on the level of glycated hemoglobin (HbA1c): II-a subgroup - 47 patients with HbA1c up to 7.5%, II-b group – 46 patients with HbA1c more than 7.5%; 45 patients, without an eye prosthesis and without diabetes mellitus (group III). Results. In patients with an ocular prosthesis and without diabetes, a shift in pH to the side of acidosis was observed. In patients with an ocular prosthesis and with diabetes mellitus, the greatest shift in the pH of the conjunctival cavity to the side of acidosis, depending on the level of HbA1c (8-8.5 – in 25.8% of cases, 9-9.5 – in 43% of cases, and <10 – in 31.2% of cases). Conclusions. The presence of an ocular prosthesis in the conjunctival cavity leads to a shift in pH to the side of the alkaline side. The progression of the pH shift to the side of acidosis directly depends on the HbA1c level in patients, and the combination of two factors (the use of an ocular prosthesis in the conjunctival cavity and the presence of diabetes in the anamnesis) leads to an aggressive shift in the pH of the conjunctival cavity to the side of acidosis. Key words: acid-base balance, ocular prosthesis, diabetes mellitus.

scholarly journals Depression among patients with diabetes mellitus in a Nigerian teaching hospital

2010 ◽  
Vol 16 (2) ◽  
pp. 4 ◽  
Author(s):  
Bawo Onesirosan James ◽  
Joyce Ohiole Omoaregba ◽  
George Eze ◽  
Olufemi Morakinyo
Keyword(s):  
Diabetes Mellitus ◽  
Control Group ◽  
Depression Symptoms ◽  
Depression Symptom ◽  
Treatment Goals ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Prevalence Of Depression ◽  
Patients With Diabetes ◽  
Diabetes Patients

<p><strong>Objectives.</strong> Depression is associated with diabetes mellitus and affects treatment goals negatively. We aimed to determine the prevalence of depression and identify its socio-demographic or clinical correlates among patients with diabetes mellitus attending an out-patient clinic in Nigeria.</p><p><strong>Methods.</strong> Two hundred consecutively recruited diabetes patients (index group) were compared with a similar number of apparently healthy controls in a cross-sectional survey. In both groups, in addition to obtaining socio-demographic details, depression was diagnosed using the Schedule for the Clinical Assessment in Neuropsychiatry (SCAN), while the Beck Depression Inventory (BDI) was used to assess depression symptom severity. <strong></strong></p><p><strong>Results.</strong> Sixty (30%) diabetes patients met a SCAN diagnosis for clinical depression, compared with 19 (9.5%) in the control group. Having a smaller income and more children were significantly correlated with higher depression symptoms on the BDI.</p><p><strong>Conclusion.</strong> Depression is highly co-morbid with diabetes mellitus. The care of individuals with diabetes mellitus should include the screening and possible treatment for depression in order to achieve and sustain treatment goals.</p>

Abstract P067: Association of Number of Eating Episodes per Day with Blood Pressure: INTERMAP Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Ghadeer S Aljuraiban ◽  
Queenie Chan ◽  
Ian Brown ◽  
Martha Daviglus ◽  
Jeremiah Stamler ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Food Intake ◽  
Population Sample ◽  
Average Energy ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Health History ◽  
Special Diet ◽  
Meal Timing ◽  
History Of

Background: Greater meal frequency per day may relate favorably to blood pressure (BP) levels of individuals. Aims: Explore associations of BP with frequency of food intake and meal timing among American participants of the INTERMAP Study. Whether differential nutrient intakes are contributing to observed BP differences is also explored. Methods: The INTERMAP Study is a cross-sectional epidemiologic investigation of 4,680 men and women ages 40–59 years in China, Japan, United Kingdom and United States (US). Data include findings from four 24-hour dietary recalls, two 24-hour urine collections, 8 BP measurements and health history questionnaires. Meals and snacks will be referred to as “eating episodes” (EP), where an eating episode is an intake of energy separated from the previous intake of food by a period of time. Results: Among 2,195 US participants, mean number of EP was 5.8 (SD 1.7) and average energy/EP was 423.0 kcal (SD 160.6) per day. About 57% of participants had less than 6 EP per day and had significantly higher systolic BP (SBP) compared to 43% of participants having 6 or more EP per day (119.3 mmHg, SD 13.9 vs. 117.7 mmHg, SD 13.9 P=0.01). Mean energy/EP, adjusted for sex, age, population sample and body mass index (BMI), was significantly higher among those having less than 6 EP per day then those with 6 or more EP per day (P<0.0001). Association of average number of EP with SBP was consistently negative in linear regression models adjusted for energy, sex, age, BMI, special diet, physical activity, cigarette smoking, and family history of hypertension (b=−0.04, P=0.04). Conclusions: Smaller more frequent intake of meals/snacks relates favorably to BP levels. Several mechanisms may be involved, e.g., improved glucose tolerance and insulin sensitivity, with spreading food intake throughout the day.

Abstract 412: Obesity is an Independent Predictor Of Arterial Stiffness

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Mohan Thanikachalam ◽  
Shasha Bai ◽  
Vijayakumar Harivanzan ◽  
Ragavendra R Baliga ◽  
William T Abraham ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Analysis ◽  
Arterial Stiffness ◽  
Multivariate Regression ◽  
Independent Predictor ◽  
Density Lipoprotein ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Cross Sectional Survey ◽  
Cross Sectional

Background Arterial stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an independent predictor of cardiovascular morbidity and mortality. We aimed to investigate how various measures of obesity affect arterial stiffness. Methods We conducted a population-based cross-sectional survey in 8,042 South Indians above the age of 20 years. Following completion of a detailed medical history questionnaire, all participants underwent haemodynamic screening including brachial and central blood pressure, and PWV measurements using a high-fidelity applanation tonometry. The study included anthropometric measurements and fasting blood for total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose (BG) levels. After the exclusion of people with previous history of diabetes, hypertension and dyslipidemia on drug therapy, 5,841 subjects (mean age 41.6 years; 58% women) constituted the study sample Results In an univariate analysis, PWV correlated positively with age, mean blood pressure (MAP), heart rate (HR), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percent (BF%), TC, TG, LDL and BG levels (P <0.001) and negatively with HDL levels (P=0.005). In a multivariate regression analysis, majority of the PWV variability in the model was accounted for by MAP and age, (cumulative adjusted R2 change of 32.79% as compared to the total adjusted R2 change of 35.25%). However, BMI (β= 0.042; adjusted R2 change=2.83%; p<0.001) independently correlated with PWV and its contribution to the PWV variability was far more significant compared to LDL, BG and TG (cumulative adjusted R2 change=1.08%). Multivariate regression analysis using the WC, WHR, or BF% instead of the BMI continued to demonstrate a significant independent effect of obesity parameters on PWV. Conclusion: In a large a population-based cross-sectional survey the study demonstrates a positive, independent association between obesity parameters and increased arterial stiffness.

scholarly journals Self-rated health among migrants from the former Soviet Union in Germany: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e022947
Author(s):  
Susanne Stolpe ◽  
Mary Ouma ◽  
Volker Winkler ◽  
Christa Meisinger ◽  
Heiko Becher ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Soviet Union ◽  
High Blood Pressure ◽  
Former Soviet Union ◽  
Missing Values ◽  
Logistic Models ◽  
Cross Sectional ◽  
Limited Mobility ◽  
Self Rated Health

ObjectivesTo assess the status and change in self-rated health among Aussiedler, ethnic German immigrants from the former Soviet Union, as a predictor for premature death 10 years after first assessment. Moreover, to identify subgroups which are particular at risk of anticipated severe health impairment.DesignCross-sectional questionnaire.SettingThe study was conducted in the catchment area of Augsburg, a city in southern Bavaria, Germany, in 2011/2012 that has a large community of Aussiedler.Participants595 Aussiedler (231 male, 364 female, mean age 55 years) who in majority migrated to Germany between 1990 and 1999.OutcomePrimary outcome: self-rated health (very good/good/not so good/bad) and its association with demographic, social and morbidity related variables.MethodsSelf-rated health was dichotomised as ‘very good’ and ‘good’ versus ‘not so good’ and ‘bad’. Multivariable logistic models were created. Missing values with regard to pain were addressed by a second analysis.ResultsAlthough low response suggests a healthier sample, the findings are alarming. Altogether47% of the Aussiedler perceived their health as less than good, which is worse compared with the first assessment in 2000 (25% compared with 20% of the general public). Prevalence of high blood pressure was present in 52% of Aussiedler, 34.5% were obese, 40.7% suffered from frequent pain and 13.1% had diabetes mellitus. According to the multivariable models, individuals suffering from pain, limited mobility, diabetes mellitus and high blood pressure are particularly in jeopardy.Conclusions10 years after the first assessment of self-rated health among Aussiedler their situation deteriorated. Tailored risk factor counselling of general practitioners is highly recommended.

Sign in / Sign up

Export Citation Format

Share Document