scholarly journals Distribution of the Condylion-Gonion-Menton (CoGoMe^) Angle in a Population of Patients from Southern Italy

2019 ◽  
Vol 7 (4) ◽  
pp. 104 ◽  
Author(s):  
D’Antò ◽  
Pango Madariaga ◽  
Rongo ◽  
Bucci ◽  
Simeon ◽  
...  
Keyword(s):  
Southern Italy ◽  
Statistical Significance ◽  
Linear Regression Analysis ◽  
Positive Association ◽  
Mean Value ◽  
Growth Patterns ◽  
Lateral Cephalograms ◽  
Beta Coefficient ◽  
Functional Appliances ◽  
Pre Treatment

The condylion-gonion-menton angle (CoGoMe^) is commonly used as a pre-treatment indicator of responsiveness in Class II patients treated with functional appliances. The distribution of this angle in the Caucasian population is still unknown. This study aimed to determine the distribution of the CoGoMe^ and its relationship with age, sagittal jaw relationship (ANPg^), and mandibular inclination (SN^GoGn) in patients from Southern Italy. The sample included 290 subjects (median14 years of age; Interquartile range, IQR, 12–17) with lateral cephalograms taken before the orthodontic treatment. The distribution of the CoGoMe^ was assessed with the Shapiro–Wilk test, and the differences according to the ANPg^ and the SN^GoGn were estimated using one-way ANOVA. Linear regression analysis was performed to evaluate how the CoGoMe^ varied according to age. The statistical significance was set at P < 0.05. The results showed that the CoGoMe^ was normally distributed (P = 0.290) with a mean value of 127.2° ± 7.7°. The distribution of the CoGoMe^ in groups with different SN^GoGn angles was significantly different (P < 0.001). These angles showed a positive association (Beta coefficient B = 0.6; 95% CI: 0.51, 0.67; P < 0.001). In growing patients, the CoGoMe^ decreased every year by 0.6° (B = −0.6; 95% CI: −1.05, −0.12; P = 0.014). In conclusion, the CoGoMe^ was associated with mandibular inclination and could be considered to be a predictor of vertical growth patterns.

scholarly journals Associations between Urinary and Dietary Selenium and Blood Metabolic Parameters in a Healthy Northern Italy Population

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1193
Author(s):  
Teresa Urbano ◽  
Tommaso Filippini ◽  
Daniela Lasagni ◽  
Tiziana De Luca ◽  
Sabrina Sucato ◽  
...  
Keyword(s):  
Linear Regression Analysis ◽  
Positive Association ◽  
Hdl Cholesterol ◽  
Thyroid Stimulating Hormone ◽  
Blood Levels ◽  
Dietary Selenium ◽  
Selenium Intake ◽  
Glucose Levels ◽  
Beta Coefficient ◽  
Essential Nutrient

Selenium is both an essential nutrient and a highly toxic element, depending on its dose and chemical forms. We aimed to quantify urinary selenium excretion and dietary selenium intake in 137 healthy non-smoking blood donors living in the northern Italian province of Reggio Emilia. We assessed selenium status by determining urinary selenium levels (mean 26.77 µg/L), and by estimating dietary selenium intake (mean 84.09 µg/day) using a validated semi-quantitative food frequency questionnaire. Fasting blood levels of glucose, lipids and thyroid-stimulating hormone were measured using automatized laboratory procedures. Dietary and urinary selenium were correlated (beta coefficient (β) = 0.19). Despite this, the association of the two indicators with health endpoints tended to diverge. Using linear regression analysis adjusted for age, sex, body mass index, cotinine levels and alcohol intake, we observed a positive association between urinary selenium and blood triglyceride (β = 0.14), LDL-cholesterol (β = 0.07) and glucose levels (β = 0.08), and an inverse one with HDL-cholesterol (β = −0.12). Concerning dietary selenium, a slightly positive association could be found with glycemic levels only (β = 0.02), while a negative one emerged for other endpoints. The two selenium indicators showed conflicting and statistically highly imprecise associations with circulating TSH levels. Our findings suggest that higher selenium exposure is adversely associated with blood glucose levels and lipid profile. This is the case even at selenium exposures not exceeding tolerable upper intake levels according to current guidelines.

scholarly journals Oil/gas pre-treatment plants and air quality hazards: PM<sub>1</sub> measurements in Agri Valley (southern Italy)

2014 ◽  
Vol 2 (4) ◽  
pp. 2377-2403
Author(s):  
S. Trippetta ◽  
R. Caggiano ◽  
S. Sabia
Keyword(s):  
Southern Italy ◽  
Treatment Plant ◽  
Principal Component ◽  
Mean Value ◽  
Atmospheric Reactions ◽  
Local Soil ◽  
Range Transport ◽  
Plant Emissions ◽  
Pre Treatment ◽  
Oil Gas

Abstract. A PM1 (i.e., aerosol particles with aerodynamic diameter less 1.0 μm) short term monitoring campaign was carried out in Agri Valley (southern Italy) in September 2012. This area is of international concern since it houses the largest European on-shore reservoir and the largest oil/gas pre-treatment plant (i.e., Centro Olio Val d'Agri – COVA) within an anthropized context. PM1 measurements were performed in Viggiano, the nearest town to the COVA plant and one of the most populated town of the Agri Valley. During the study period, the PM1 daily concentrations ranged from 1.2 to 8.4 μg m−3 with a mean value of 4.6 μg m−3. Regarding the PM1 chemical composition, it can be observed that S and typical crustal elements were the most abundant constituents of the PM1 collected. By applying the Principal Component Analysis, it was pointed out that crustal soil, biomass and wood burning, secondary atmospheric reactions involving COVA plant emissions and local soil particles, and traffic were the main sources contributing to the PM1 measured in the area under study. Moreover, a possible contribution of the long-range transport of African dust was observed.

scholarly journals PM<sub>1</sub> measurements at a site close to an oil/gas pre-treatment plant (Agri Valley – southern Italy): a preliminary study

2014 ◽  
Vol 14 (9) ◽  
pp. 2337-2346 ◽  
Author(s):  
S. Trippetta ◽  
R. Caggiano ◽  
S. Sabia
Keyword(s):  
Southern Italy ◽  
Treatment Plant ◽  
Principal Component ◽  
Mean Value ◽  
Local Soil ◽  
Range Transport ◽  
Plant Emissions ◽  
Pre Treatment ◽  
A Site ◽  
Oil Gas

Abstract. A PM1 (i.e. particulate matter with an aerodynamic diameter less than 1.0 μm) short-term monitoring campaign was carried out in the Agri Valley (southern Italy) in September 2012. This area is of international concern, since it houses one of the largest European on-shore reservoirs and the largest oil/gas pre-treatment plant (i.e. the Centro Olio Val d'Agri – COVA) within an anthropised context. PM1 measurements were performed in Viggiano, the nearest town to the COVA plant and one of the most populated towns of the Agri Valley. During the study period, the PM1 daily concentrations ranged from 1.2 to 8.4 μg m−3, with a mean value of 4.6 μg m−3. Regarding the PM1 chemical composition, it can be observed that S and typical crustal elements were the most abundant constituents of the PM1 collected. By applying principal component analysis (PCA), it was pointed out that crustal soil, biomass and wood burning, secondary atmospheric reactions involving COVA plant emissions and local soil particles, and traffic were the main sources contributing to the PM1 measured in the area under study. Moreover, a possible contribution of the long-range transport of African dust was observed.

scholarly journals Lower incisor changes following non-extraction orthodontic decompensation in Class III surgical cases

2021 ◽  
Vol 28 ◽  
pp. 15-22
Author(s):  
Nor Nadia Zakaria ◽  
Yasmin Kamarudin ◽  
Kah Shin Ong ◽  
Zi Qing Koo
Keyword(s):  
Strong Predictor ◽  
Linear Regression Analysis ◽  
P Value ◽  
Class Iii ◽  
Weak Correlation ◽  
Lower Incisor ◽  
Lateral Cephalograms ◽  
Pre Treatment ◽  
Moderate Positive Correlation ◽  
Lower Incisors

The amount of incisor decompensation during pre-surgical orthodontics may affect the outcome of Class III orthognathic cases. The purpose of this study was to assess the lower incisor changes post-orthodontic decompensation in Class III surgical cases and to investigate the amount of crowding as a predictive factor. This was a retrospective study reporting on 22 Class III orthognathic cases. The lower incisor angulation (LIA) and distance of the lower incisor edge to the A-Pogonion line (Li-APo) were measured on pre-treatment and pre-surgical lateral cephalograms whereas crowding was measured on digitised pre-treatment study models. Pearson’s correlation (p <0.05) was used to assess the correlation of crowding with LIA and Li-APo changes, and prediction of the lower incisor decompensation was conducted using linear regression analysis. Results showed lower incisors were retroclined at 79.84° ± 7.08° and positioned ahead of APo line by 6.52 mm ± 2.97 mm at the start of treatment. Pre-surgical LIA and Li-APo were found to increase following orthodontic decompensation to 90.43° ± 5.96° and 10.34 mm ± 3.25 mm, respectively. There was a moderate positive correlation (r = 0.592) between crowding and Li-APo changes which was statistically significant, p value = 0.004, and had a strong predictor with 31.8% predictability. However, LIA showed a weak correlation (r = 0.329) with crowding and was not statistically significant (p = 0.135). Li-APo changes during orthodontic decompensation can be predicted with 31.8% predictability using the formula; Li-APo change = 2.064 + 0.503 (crowding).

scholarly journals Parathyroid hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism

2021 ◽  
Vol 11 (5) ◽  
pp. 369
Author(s):  
Erika Calvano Küchler ◽  
Caio Luiz Bitencourt Reis ◽  
Guido Marañón-Vásquez ◽  
Paulo Nelson-Filho ◽  
Mírian Aiko Nakane Matsumoto ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Interaction Model ◽  
Distribution Analysis ◽  
Nucleotide Polymorphisms ◽  
Allele Distribution ◽  
Vitamin D Levels ◽  
Lateral Cephalograms ◽  
Genes Encoding ◽  
Chi Squared ◽  
Mandibular Retrognathism

In this study we evaluated whether single nucleotide polymorphisms (SNPs) in the genes encoding PTH, VDR, CYP24A1, and CYP27B1 were associated with mandibular retrognathism (MR). Samples from biologically-unrelated Brazilian patients receiving orthodontic treatment were included in this study. Pre-orthodontic lateral cephalograms were used to determine the phenotype. Patients with a retrognathic mandible were selected as cases and those with an orthognathic mandible were selected as controls. Genomic DNA was used for genotyping analysis of SNPs in PTH (rs694, rs6256, and rs307247), VDR (rs7975232), CYP24A1 (rs464653), and CYP27B1 (rs927650). Chi-squared or Fisher’s tests were used to compare genotype and allele distribution among groups. Haplotype analysis was performed for the SNPs in PTH. The established alpha was p < 0.05. Multifactor dimensionality reduction (MDR) was used to identify SNP–SNP interactions. A total of 48 (22 males and 26 females) MR and 43 (17 males and 26 females) controls were included. The linear mandibular and the angular measurements were statistically different between MR and controls (p < 0.05). In the genotype and allele distribution analysis, the SNPs rs694, rs307247, and rs464653 were associated with MR (p < 0.05). MDR analyses predicted the best interaction model for MR was rs694–rs927650, followed by rs307247–rs464653–rs927650. Some haplotypes in the PTH gene presented statistical significance. Our results suggest that SNPs in PTH, VDR, CYP24A1, and CYP27B1 genes are associated with the presence of mandibular retrognathism.

scholarly journals Height in Adolescence as a Risk Factor for Glioma Subtypes: a Nationwide Retrospective Cohort Study of 2.2 Million Subjects

2021 ◽  
Author(s):  
Roi Tschernichovsky ◽  
Lior H Katz ◽  
Estela Derazne ◽  
Matan Ben-Zion Berliner ◽  
Maya Simchoni ◽  
...  
Keyword(s):  
Risk Factor ◽  
Statistical Significance ◽  
Positive Association ◽  
High Grade Glioma ◽  
Low Grade ◽  
Cox Proportional Hazard ◽  
Cox Proportional Hazard Models ◽  
Glioma Risk ◽  
Incident Cases

Abstract Background Gliomas manifest in a variety of histological phenotypes with varying aggressiveness. The etiology of glioma remains largely unknown. Taller stature in adulthood has been linked with glioma risk. The aim of this study was to discern whether this association can be detected in adolescence. Methods The cohort included 2,223,168 adolescents between the ages of 16-19. Anthropometric measurements were collected at baseline. Incident cases of glioma were extracted from the Israel National Cancer Registry over a follow-up period spanning 47,635,745 person-years. Cox proportional hazard models were used to estimate the hazard ratio for glioma and glioma subtypes according to height, body mass index (BMI) and sex. Results 1,195 patients were diagnosed with glioma during the study period. Mean(SD) age at diagnosis was 38.1 (11.7) years. Taller adolescent height (per 10cm increase) was positively associated with the risk for glioma of any type (HR 1.15; p=0.002). The association was retained in subgroup analyses for low-grade glioma (HR 1.17; p=0.031), high-grade glioma (HR 1.15; p=0.025), oligodendroglioma (HR 1.31; p=0.015), astrocytoma (HR 1.12; p=0.049), and a category of presumed IDH-mutated glioma (HR 1.17; p=0.013). There was a trend towards a positive association between height and glioblastoma, however this had borderline statistical significance (HR: 1.15; p=0.07). After stratification of the cohort by sex, height remained a risk factor for men, but not for women. Conclusions The previously - established association between taller stature in adulthood and glioma risk can be traced back to adolescence. The magnitude of association differs by glioma subtype.

scholarly journals Colonoscopy does not induce small intestinal bacterial overgrowth

2017 ◽  
Vol 08 (01) ◽  
pp. 12-16
Author(s):  
Ioana Gabriela Moraru ◽  
Dan Lucian Dumitraşcu
Keyword(s):  
Statistical Significance ◽  
False Negative ◽  
Bacterial Overgrowth ◽  
Intestinal Bacteria ◽  
Small Intestinal Bacterial Overgrowth ◽  
Mean Value ◽  
Intestinal Bacterial Overgrowth ◽  
Gastrointestinal Pathology ◽  
The Mean ◽  
Small Intestinal

Abstract Background and Aim: Small intestinal bacterial overgrowth (SIBO) is associated with gastrointestinal pathology and colonoscopy. This endoscopic investigation could cause changes in gut flora including the occurrence of SIBO. We looked in this study for the effect of colonoscopy (preparation and intubation) on the occurrence of SIBO. Materials and Methods: Prospective study including thirty patients with irritable bowel syndrome (IBS) diagnosed according to Rome III criteria. Two groups were designed: Twenty IBS patients that performed colonoscopy (G1) and ten IBS patients (G2) not referred to colonoscopy. All patients have been tested for the presence of SIBO using glucose hydrogen breath tests (GHBT) at the beginning of the study, on day 1. G1 patients have also been tested before colonoscopy (day 2) and 1 week after (day 9). G2 patients performed GHBT on day 1 and on day 9. Results: The peak value of expired H2 was assessed, and the mean value was calculated. There were no significant statistical differences between the mean H2 values in the 2 groups of patients on day 1. The mean level of H2 significantly decreased after preparing for colonoscopy in G1 patients (P < 0.0001). There were no significant statistical differences between the mean levels of H2 on day 2 versus day 9 in G1 patients (P = 0.176). The mean level of H2 1 week after performing colonoscopy (7.65 ppm) is higher than that obtained after preparing for it (6.3 ppm), but no statistical significance. Patients from G2 showed no statistical differences between the mean levels of H2 on day 1 versus day 9 (P = 0.6132). Patients in G1 had a significantly lower mean H2 level versus G2 patients on day 9. Conclusions: Colonoscopy does not produce SIBO. Preparing for colonoscopy influences the level of expired H2, it reduces the number of intestinal bacteria, probably trough a mechanic effect or by inflating air during the procedure. Performing GHBT too soon after colonoscopy might result in false negative results of GHBT.

Effect of Ultrasound and Calf Stretching in relieving Gastrocnemius Tightness in subjects with Plantar Fascitis

2021 ◽  
pp. 3025-3028
Author(s):  
Sowmya M V ◽  
Nandhini S ◽  
Manigandan V
Keyword(s):  
Functional Ability ◽  
Combined Therapy ◽  
Statistical Significance ◽  
Mean Value ◽  
P Value ◽  
Functional Activities ◽  
Post Test ◽  
Foot Function ◽  
The Difference ◽  
Gastrocnemius Tightness

Objective: To evaluate the efficacy of ultrasound and calf stretching in subjects with gastrocnemius tightness in plantar fascitis to reduce pain and improve functional ability. Method: 30 patients with plantar fascitis selected from Saveetha college of physiotherapy and rehabilitation center (SPARC) based on inclusion and exclusion criteria. The patients were treated with ultrasound therapy and calf stretching. The pre and post test values of pain and functional ability was be calculated using Silfverskiold test and Foot Function Index as an outcome measure. Results: The mean value and standard errors were calculated for different variables and the difference in mean value was tested for statistical significance using paired t test. P value of <0.0001 was considered as statistically significant. Conclusion: From the statistical analysis and graphical interpretation the final derived results concluded that combined therapy of ultrasound and calf stretching is found to be effective in relieving gastrocnemius tightness in patient suffering with plantar fascitis and it can be used to improve the functional activities.

scholarly journals A combined prosodic and linguistic treatment approach for language-communication skills in children with autism spectrum disorders: A proof-of-concept study

2016 ◽  
Vol 6 (1) ◽  
pp. 8
Author(s):  
Silva Kuschke ◽  
Bart Vinck ◽  
Salomé Geertsema
Keyword(s):  
Social Interaction ◽  
Statistical Significance ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Listening Skills ◽  
Language Therapy ◽  
Baseline Design ◽  
Traditional Language ◽  
Pragmatic Skills ◽  
Pre Treatment

<p>This study aimed to determine whether the use of prosodically varied speech within a traditional language therapy framework had any effect on the listening skills, pragmatic skills and social interaction behaviour of three children with autism spectrum disorder (ASD). A single participant multiple baseline design across behaviours was implemented. Three participants with ASD were selected for this research. The listening skills, pragmatic skills and social interaction behaviour of the participants were compared before treatment, after a 3-week <br />period of treatment and after a 2-week withdrawal period from treatment, utilising prosodically varied speech within a traditional language therapy approach. Statistical significance was not calculated for each individual due to the limited data, but visual inspection indicated that all the participants showed positive behavioural changes in performance across all areas after 3 weeks of treatment, independent of their pre-treatment performance level. The use of <br />prosodically varied speech within a traditional language therapy framework appears to be a viable form of treatment for children with ASD.</p>

scholarly journals Toxoplasma gondii and pre-treatment protocols for polymerase chain reaction analysis of milk samples: a field trial in sheep from Southern Italy

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Alice Vismarra ◽  
Elena Barilli ◽  
Maura Miceli ◽  
Carlo Mangia ◽  
Cristina Bacci ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Real Time ◽  
Dna Extraction ◽  
Real Time Pcr ◽  
Southern Italy ◽  
Raw Milk ◽  
Type I ◽  
Treatment Protocols ◽  
Milk Samples ◽  
Pre Treatment

Toxoplasmosis is a zoonotic disease caused by the protozoan <em>Toxoplasma gondii</em>. Ingestion of raw milk has been suggested as a risk for transmission to humans. Here the authors evaluated pre-treatment protocols for DNA extraction on <em>T. gondii</em> tachyzoite-spiked sheep milk with the aim of identifying the method that resulted in the most rapid and reliable PCR positivity. This protocol was then used to analyze milk samples form sheep from three different farms in southern Italy, including Real Time PCR for DNA quantification and PCR-RFLP for genotyping. The pre-treatment protocol using EDTA and Tris-HCl to remove casein gave the best results in the least amount of time compared to the others on spiked milk samples. One sample of 21 collected from sheep farms was positive on one-step PCR, Real Time PCR and resulted in a Type I genotype at one locus (SAG3). Milk usually contains a low number of tachyzoites and this could be a limiting factor for molecular identification. Our preliminary data has evaluated a rapid, cost-effective and sensitive protocol to treat milk before DNA extraction. The results of the present study also confirm the possibility of <em>T. gondii</em> transmission through consumption of raw milk and its unpasteurized derivatives.

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