scholarly journals A Novel Approach for the Design of Fast-Settling Amplifiers for Biosignal Detection

Electronics ◽  
2021 ◽  
Vol 10 (21) ◽  
pp. 2631
Author(s):  
Eduardo Alonso Rivas ◽  
Graziella Scandurra ◽  
Carmine Ciofi ◽  
Carlos Rodríguez-Morcillo García  ◽  
Romano Giannetti
Keyword(s):  
Contact Resistance ◽  
Time Constant ◽  
Input Resistance ◽  
Low Noise ◽  
Measurement Time ◽  
Control Voltage ◽  
Contact Potential ◽  
Pass Filter ◽  
Differential Signal ◽  
Signal Amplifier

The most common method used to pick up biomedical signals is through metallic electrodes coupled to the input of high-gain, low-noise amplifiers. Unfortunately, electrodes, amongst other effects, introduce an undesired contact resistance and a contact potential. The contact potential needs to be rejected since it would otherwise cause the saturation of the input stage of the amplifiers, and this is almost always obtained by inserting a simple RC high-pass filter in the input signal path. The contact resistance needs to be estimated to ensure that it does not impair correct measurements. Methods exist for estimating the contact resistance by dynamically modifying the input network configuration, but because of the presence of the input RC filter, long transients are induced any time a switch occurs between different input configurations, so that the measurement time may become unacceptably long. In this paper, we propose a new topology for a DC removal network at the input of the differential signal amplifier that results in an AC filter whose time constant can be continuously changed by means of a control voltage. As such, we can speed up the recovery from transients by setting very short time constants (during the input resistance estimation process) while maintaining the ability to obtain very low cut-in frequencies by setting a much larger time constant during actual measurements. A prototype of the system was built and tested in order to demonstrate the advantage of the approach we propose in terms of reduced measurement time.

scholarly journals Active Balun with Center-Tapped Inductor and Double-Balanced Gilbert Mixer for GNSS Applications

Electronics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1351
Author(s):  
Daniel Pietron ◽  
Tomasz Borejko ◽  
Witold Adam Pleskacz
Keyword(s):  
Phase Shift ◽  
Noise Figure ◽  
Low Noise ◽  
Global Navigation Satellite Systems ◽  
Cmos Process ◽  
Differential Signal ◽  
Satellite Systems ◽  
Active Balun ◽  
Noise Amplifier ◽  
Global Navigation Satellite

A new 1.575 GHz active balun with a classic double-balanced Gilbert mixer for global navigation satellite systems is proposed herein. A simple, low-noise amplifier architecture is used with a center-tapped inductor to generate a differential signal equal in amplitude and shifted in phase by 180°. The main advantage of the proposed circuit is that the phase shift between the outputs is always equal to 180°, with an accuracy of ±5°, and the gain difference between the balun outputs does not change by more than 1.5 dB. This phase shift and gain difference between the outputs are also preserved for all process corners, as well as temperature and voltage supply variations. In the balun design, a band calibration system based on a switchable capacitor bank is proposed. The balun and mixer were designed with a 110 nm CMOS process, consuming only a 2.24 mA current from a 1.5 V supply. The measured noise figure and conversion gain of the balun and mixer were, respectively, NF = 7.7 dB and GC = 25.8 dB in the band of interest.

scholarly journals A Four-Channel Low-Noise Readout IC for Air Flow Measurement Using Hot Wire Anemometer in 0.18 μm CMOS Technology

Sensors ◽  
2021 ◽  
Vol 21 (14) ◽  
pp. 4694
Author(s):  
Kyeongsik Nam ◽  
Hyungseup Kim ◽  
Yongsu Kwon ◽  
Gyuri Choi ◽  
Taeyup Kim ◽  
...  
Keyword(s):  
Supply Voltage ◽  
Air Flow ◽  
Low Noise ◽  
Cmos Process ◽  
Significant Information ◽  
Flow Measurements ◽  
Pass Filter ◽  
Low Pass Filter ◽  
Op Amp ◽  
Noise Characteristics

Air flow measurements provide significant information required for understanding the characteristics of insect movement. This study proposes a four-channel low-noise readout integrated circuit (IC) in order to measure air flow (air velocity), which can be beneficial to insect biomimetic robot systems that have been studied recently. Instrumentation amplifiers (IAs) with low-noise characteristics in readout ICs are essential because the air flow of an insect’s movement, which is electrically converted using a microelectromechanical systems (MEMS) sensor, generally produces a small signal. The fundamental architecture employed in the readout IC is a three op amp IA, and it accomplishes low-noise characteristics by chopping. Moreover, the readout IC has a four-channel input structure and implements an automatic offset calibration loop (AOCL) for input offset correction. The AOCL based on the binary search logic adjusts the output offset by controlling the input voltage bias generated by the R-2R digital-to-analog converter (DAC). The electrically converted air flow signal is amplified using a three op amp IA, which is passed through a low-pass filter (LPF) for ripple rejection that is generated by chopping, and converted to a digital code by a 12-bit successive approximation register (SAR) analog-to-digital converter (ADC). Furthermore, the readout IC contains a low-dropout (LDO) regulator that enables the supply voltage to drive digital circuits, and a serial peripheral interface (SPI) for digital communication. The readout IC is designed with a 0.18 μm CMOS process and the current consumption is 1.886 mA at 3.3 V supply voltage. The IC has an active area of 6.78 mm2 and input-referred noise (IRN) characteristics of 95.4 nV/√Hz at 1 Hz.

Calcium-dependent potassium conductance in rat supraoptic nucleus neurosecretory neurons

1985 ◽  
Vol 54 (6) ◽  
pp. 1375-1382 ◽  
Author(s):  
C. W. Bourque ◽  
J. C. Randle ◽  
L. P. Renaud
Keyword(s):  
Time Constant ◽  
Action Potentials ◽  
Supraoptic Nucleus ◽  
Potassium Conductance ◽  
Reversal Potential ◽  
Input Resistance ◽  
Mean Amplitude ◽  
Progressive Increase ◽  
Calcium Dependent ◽  
Neurosecretory Neurons

Intracellular recordings of rat supraoptic nucleus neurons were obtained from perfused hypothalamic explants. Individual action potentials were followed by hyperpolarizing afterpotentials (HAPs) having a mean amplitude of -7.4 +/- 0.8 mV (SD). The decay of the HAP was approximated by a single exponential function having a mean time constant of 17.5 +/- 6.1 ms. This considerably exceeded the cell time constant of the same neurons (9.5 +/- 0.8 ms), thus indicating that the ionic conductance underlying the HAP persisted briefly after each spike. The HAP had a reversal potential of -85 mV and was unaffected by intracellular Cl- ionophoresis of during exposure to elevated extracellular concentrations of Mg2+. In contrast, the peak amplitude of the HAP was proportional to the extracellular Ca2+ concentration and could be reversibly eliminated by replacing Ca2+ with Co2+, Mn2+, or EGTA in the perfusion fluid. During depolarizing current pulses, evoked action potential trains demonstrated a progressive increase in interspike intervals associated with a potentiation of successive HAPs. This spike frequency adaptation was reversibly abolished by replacing Ca2+ with Co2+, Mn2+, or EGTA. Bursts of action potentials were followed by a more prolonged afterhyperpolarization (AHP) whose magnitude was proportional to the number of impulses elicited (greater than 20 Hz) during a burst. Current injection revealed that the AHP was associated with a 20-60% decrease in input resistance and showed little voltage dependence in the range of -70 to -120 mV. The reversal potential of the AHP shifted with the extracellular concentration of K+ [( K+]o) with a mean slope of -50 mV/log[K+]o.(ABSTRACT TRUNCATED AT 250 WORDS)

Voltage behavior along the irregular dendritic structure of morphologically and physiologically characterized vagal motoneurons in the guinea pig

1990 ◽  
Vol 63 (2) ◽  
pp. 333-346 ◽  
Author(s):  
R. Nitzan ◽  
I. Segev ◽  
Y. Yarom
Keyword(s):  
Steady State ◽  
Guinea Pig ◽  
Time Constant ◽  
Dendritic Structure ◽  
Input Resistance ◽  
Membrane Properties ◽  
Small Cells ◽  
Physiological Data ◽  
Motor Nucleus ◽  
Cable Length

1. Intracellular recordings from neurons in the dorsal motor nucleus of the vagus (vagal motoneurons, VMs) obtained in the guinea pig brain stem slice preparation were used for both horseradish peroxidase (HRP) labeling of the neurons and for measurements of their input resistance (RN) and time constant (tau 0). Based on the physiological data and on the morphological reconstruction of the labeled cells, detailed steady-state and compartmental models of VM were built and utilized to estimate the range of membrane resistivity, membrane capacitance, and cytoplasm resistivity values (Rm, Cm, and Ri, respectively) and to explore the integrative properties of these cells. 2. VMs are relatively small cells with a simple dendritic structure. Each cell has an average of 5.3 smooth (nonspiny), short (251 microns) dendrites with a low order (2) of branching. The average soma-dendritic surface area of VMs is 9,876 microns 2. 3. Electrically, VMs show remarkably linear membrane properties in the hyperpolarizing direction; they have an average RN of 67 +/- 23 (SD) M omega and a tau 0 of 9.4 +/- 4.1 ms. Several unfavorable experimental conditions precluded the possibility of faithfully recovering ("peeling") the first equalizing time constant (tau 1) and, thereby, of estimating the electrotonic length (Lpeel) of VMs. 4. Reconciling VM morphology with the measured RN and tau 0 through the models, assuming an Ri of 70 omega.cm and a spatially uniform Rm, yielded an Rm estimate of 5,250 omega.cm2 and a Cm of 1.8 microF/cm2. Peeling theoretical transients produced by these models result in an Lpeel of 1.35. Because of marked differences in the length of dendrites within a single cell, this value is larger than the maximal cable length of the dendrites and is twice as long as their average cable length. 5. The morphological and physiological data could be matched indistinguishably well if a possible soma shunt (i.e., Rm, soma less than Rm, dend) was included in the model. Although there is no unique solution for the exact model Rm, a general conclusion regarding the integrative capabilities of VM could be drawn. As long as the model is consistent with the experimental data, the average input resistance at the dendritic terminals (RT) and the steady-state central (AFT----S) and peripheral (AFS----T) attenuation factors are essentially the same in the different models. With Ri = 70 omega.cm, we calculated RT, AFS----T, and AFT----S to be, on the average, 580 M omega, 1.1, and 13, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)

Preamplifier With Ultra Low Frequency Cutoff for Infrasonic Condenser Microphone

2012 ◽  
Author(s):  
Rasmus Trock Kinnerup ◽  
Arnold Knott ◽  
Ole Cornelius Thomsen ◽  
Kresten Marbjerg ◽  
Per Rasmussen
Keyword(s):  
Input Impedance ◽  
Dynamic Range ◽  
Cutoff Frequency ◽  
Low Frequency ◽  
Input Resistance ◽  
Bias Current ◽  
Microphone Signal ◽  
Low Frequencies ◽  
Pass Filter ◽  
Condenser Microphone

Measuring infrasonic sound sets high requirements on the instruments used. Typically the measurement chain consists of a microphone and a preamplifier. As the input resistance of the preamplifier forms a high pass filter with the capacitance of the microphone in the picofarad range, measuring ultra low frequencies becomes a challenge. The electric preamplifier presented in this paper together with a prepolarized condenser microphone form a measurement system. The developed preamplifier connects the microphone signal directly to the input of an operational amplifier with ultra high input impedance. The bias current for the preamplifier further complicates the signal amplification. A configuration of two diode-connected FETs provide the input bias current. The resulting input impedance of nearly 1 TΩ yields a total lower limiting −3 dB cutoff frequency of 8 mHz and a dynamic range of 95 dB. Being able to measure down to ultra low frequencies in the infrasonic frequency range will aid actors in the debate on wind turbine noise. Sonic booms from supersonic flights include frequencies down to 10 mHz and the preamplifier proposed in this paper will aid scientists trying to modify the N-shaped shock wave at high level which prohibits flights in land zones.

An Integrated Two-Mode Tunable Channelized Low-Noise Active Filter

2018 ◽  
Vol 27 (06) ◽  
pp. 1850090
Author(s):  
Amin Alahyari ◽  
Massoud Dousti ◽  
Mohammad Bagher Tavakoli
Keyword(s):  
Bandpass Filter ◽  
Impedance Matching ◽  
Low Noise ◽  
Active Filter ◽  
Center Frequency ◽  
Pass Filter ◽  
Filter Output ◽  
Band Stop Filter ◽  
Circuit Input

In this paper, a new structure for an integrated channelized active filter is proposed. This filter can be used as a channelized bandpass filter and again as a channelized band-stop filter. This is fulfilled by using one biasing voltage. In designing a three-channel bandpass filter, a recursive differential structure is used. Moreover, by subtracting bandpass filter output from an all-pass output, the proposed three-channel band-stop filter is achieved. A wideband amplifier plays the role of an all-pass filter. In addition, to decrease the noise of this filter, a noise-canceling circuit is adopted. By using this circuit, input impedance matching is obtained simultaneously. The center frequencies of the two-mode channelized filter are 2, 4 and 6[Formula: see text]GHz. In each of them, the center frequency is controlled via two biasing voltages. The maximum center frequency shift is 450[Formula: see text]MHz. For designing the proposed circuit, GaAs 0.15[Formula: see text][Formula: see text]m technology is applied. The occupied area is [Formula: see text][Formula: see text]mm2.

LOW-NOISE SMALL-SIGNAL AMPLIFIER

1963 ◽  
Author(s):  
D. NEUF ◽  
P. LOMBARDO
Keyword(s):  
Low Noise ◽  
Small Signal ◽  
Signal Amplifier

Input Resistance, Time Constants, and Spike Initiation

1998 ◽  
Author(s):  
Christof Koch
Keyword(s):  
Membrane Potential ◽  
Time Constant ◽  
Action Potentials ◽  
Input Resistance ◽  
Current Injection ◽  
Membrane Conductances ◽  
Voltage Dependent ◽  
Dc Component ◽  
Definition Of ◽  
A Current

This chapter represents somewhat of a tephnical interlude. Having introduced the reader to both simplified and more complex compartmental single neuron models, we need to revisit terrain with which we are already somewhat familiar. In the following pages we reevaluate two important concepts we defined in the first few chapters: the somatic input resistance and the neuronal time constant. For passive systems, both are simple enough variables: Rin is the change in somatic membrane potential in response to a small sustained current injection divided by the amplitude of the current injection, while τm is the slowest time constant associated with the exponential charging or discharging of the neuronal membrane in response to a current pulse or step. However, because neurons express nonstationary and nonlinear membrane conductances, the measurement and interpretation of these two variables in active structures is not as straightforward as before. Having obtained a more sophisticated understanding of these issues, we will turn toward the question of the existence of a current, voltage, or charge threshold at which a biophysical faithful model of a cell triggers action potentials. We conclude with recent work that suggests how concepts from the subthreshold domain, like the input resistance or the average membrane potential, could be extended to the case in which the cell is discharging a stream of action potentials. This chapter is mainly for the cognoscendi or for those of us that need to make sense of experimental data by comparing therp to theoretical models that usually fail to reflect reality adequately. In Sec. 3.4, we defined Kii (f) for passive cable structures as the voltage change at location i in response to a sinusoidal current injection of frequency f at the same location. Its dc component is also referred to as input resistance or Rin. Three difficulties render this definition of input resistance problematic in real cells: (1) most membranes, in particular at the soma, show voltage-dependent nonlinearities, (2) the associated ionic membrane conductances are time dependent and (3) instrumental aspects, such as the effect of the impedance of the recording electrode on Rin, add uncertainty to the measuring process.

Electronic structure of motoneurons in spinal cord slice cultures: a comparison of compartmental and equivalent cylinder models

1994 ◽  
Vol 72 (2) ◽  
pp. 861-871 ◽  
Author(s):  
D. Ulrich ◽  
R. Quadroni ◽  
H. R. Luscher
Keyword(s):  
Spinal Cord ◽  
Surface Area ◽  
Voltage Clamp ◽  
Time Constant ◽  
Membrane Surface ◽  
Input Resistance ◽  
Dendritic Trees ◽  
Membrane Surface Area ◽  
The Mean ◽  
Total Membrane

1. Voltage-clamp, current-clamp, and morphological data were obtained from visually identified motoneurons in organotypic cocultures of rat embryonic spinal cord, dorsal root ganglia, and skeletal muscle. The cells were injected with Biocytin during whole-cell patch-clamp recordings and stained with horseradish peroxidase. 2. The somata and dendritic trees of the cells were reconstructed with a semiautomatic reconstruction system. The motoneurons had a common multipolar shape. An elliptic soma gave rise to 3-9 stem dendrites with a mean diameter of 2.5 +/- 0.9 (SD) micron terminating in 24 +/- 7 dendritic endings. The mean total dendritic path length was 3,306 +/- 1,075 microns. The mean total membrane surface area was 15,594 +/- 10,404 microns 2 with a dendritic to somatic membrane surface area ratio of 3.4 +/- 1.4 (n = 7 cells). 3. The ratio between the sum of the diameters of the two daughter branches and the diameter of the parental branch each raised to the 3/2 power at all branch points was 1.3 +/- 0.28 (n = 8 cells). The dendritic trees of the cells tapered continuously from the soma to the distal ends. The mean normalized dendritic trunk parameter of all cells was 0.62 +/- 0.22. 4. The motoneurons had a mean input resistance RN of 498 +/- 374 M delta, a mean membrane time constant (tau m) of 22 +/- 4.6 ms, and a mean dendritic dominance (rho) of 2.7 +/- 0.86 (n = 5 cells). The mean electronic length (L) calculated from tau m and the slowest voltage-clamp time constant (tau VC1) was 0.7 +/- 0.04 (n = 7 cells). 5. The specific membrane capacitance (Cm) estimated from the charge of the capacitive current during a voltage step and the total membrane surface area was 1.08 +/- 0.3 microF/cm2 (n = 6 cells). 6. Compartmental computer models were constructed of individual cells. Experimental and simulated voltage transients were matched with Cm = 1 microF/cm2, a uniform membrane resistivity (Rm) = tau m/Cm and a cytosolic resistivity (Ri) of 308 +/- 39 omega.cm (n = 3 cells). 7. The mean electrotonic length of the dendritic paths was 0.83 +/- 0.2 (n = 5 cells). The mean input resistance at the dendritic terminals (RT) was 1,413 +/- 260 M omega. Synaptic conductances were applied at all distal dendritic compartments of the model cells. The resulting synaptic currents were calculated at the input site and at the soma. The mean transient current attenuation ratio was 4.7 +/- 1.7 under idealized voltage-clamp conditions.(ABSTRACT TRUNCATED AT 400 WORDS)

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