scholarly journals Dopamine-Sensing Characteristics and Mechanism by Using N2/O2 Annealing in Pt/Ti/n-Si Structure

Electronics ◽  
2021 ◽  
Vol 10 (24) ◽  
pp. 3146
Author(s):  
Yi-Pin Chen ◽  
Anisha Roy ◽  
Ping-Hsuan Wu ◽  
Shih-Yin Huang ◽  
Siddheswar Maikap
Keyword(s):  
Measurement Method ◽  
Small Volume ◽  
Elevated Temperatures ◽  
Schottky Contact ◽  
Electrolyte Membrane ◽  
Rate Dependent ◽  
Dopamine Detection ◽  
Near Future ◽  
First Time ◽  
Sensing Characteristics

Dopamine detection by using N2/O2 annealing in a Pt/Ti/n-Si structure is investigated for the first time. To achieve repeatable and stable dopamine detection, a Pt membrane is annealed at elevated temperatures of 500 to 700 °C. N2/O2 gas ambient is used to optimize the membrane. The Pt membrane with thicknesses from 5 to 2 nm is optimized. Novel Pt/Ti/n-Si Schottky contact in a metal–electrolyte–membrane–silicon (MEMS) structure detects dopamine with a low concentration of 1 pM. The Pt membrane with N2 ambient annealing shows the lowest concentration of dopamine sensing with a small volume of 10 µL, acceptable stability, and repeatability. Scan rate-dependent dopamine concentration sensing is also investigated in the two-terminal measurement method. This study is useful for the early diagnosis of Parkinson’s disease in the near future.

Dwindling status of Epimedium Elatum (Morren & Decne) and its geographical distribution in Kashmir Himalaya, India

2018 ◽  
pp. 47-52
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Conservation Status ◽  
Natural Populations ◽  
Culture Techniques ◽  
Kashmir Himalayas ◽  
Near Future ◽  
First Time ◽  
Tissue Culture Techniques

Epimedium elatum (Morren & Decne) of family Berberidaceace is a rare perennial medicinal plant, endemic to high altitude forests of Northwestern Himalayas in India. Ethnobotanically, it has been used as an ingredient for treatment of bone-joint disorders, impotence and kidney disorders in Kashmir Himalayas. Phytochemically, it is rich in Epimedin ABC and Icariin; all of these have been demonstrated to possess remarkable biological activities like PDE-5 inhibition (treatment of erectile dysfunction), anticancer, antiosteoporosis antioxidant and antiviral properties. The present investigation reports its traditional usage, comprehensive distribution and conservation status from twenty ecogeographical regions in Kashmir Himalayas, India. The species was reported from Gurez valley for the first time. Numerous threats like excessive grazing, deforestration, habitat fragmentation, tourism encroachment, landslides and excessive exploitation have decreased its natural populations in most of the surveyed habitats. Consequently, its existence may become threatened in near future if timely conservation steps are not taken immediately by concerned stakeholders involved in medicinal plant research. Moreover, use of plant tissue culture techniques is recommended for development of its in vitro propagation protocols. Therefore, introduction of this medicinal plant in botanical gardens, protected sites and development of monitoring programmes are needed for its immediate conservation in Northwestern Himalayas, India.

Organic Reactivity Control by Means of Neighboring Groups and Organometallics. A Personal Account

1994 ◽  
Vol 59 (1) ◽  
pp. 1-74 ◽  
Author(s):  
Pavel Kočovský
Keyword(s):  
Transition Metals ◽  
Cyclopropane Ring ◽  
Allylic Substitutions ◽  
Recent Developments ◽  
Cardioactive Drug ◽  
Novel Method ◽  
Metal Catalyzed ◽  
Electrophilic Additions ◽  
Near Future ◽  
First Time

This review summarizes the main topics of our research and covers the period of the last 15 years. The prime interest is focused on various ways of controlling the regio- and stereoselectivity of selected organic reactions, in particular electrophilic additions, cleavage of cyclopropane rings, and allylic substitutions by means of neighboring groups and/or transition and non-transition metals. In the first part, the factors governing the course of electrophilic additions are assessed, culminating in the formulation of selection rules for the reactivity of cyclohexene systems, and in a concise synthesis of the natural cardioactive drug, strophanthidin. These studies also contribute to a better understanding of the mechanisms of electrophilic additions. The second part describes recent developments in the stereo- and regiocontrolled cleavage of cyclopropane rings by non-transition metals (Tl and Hg), and the reactivity and transmetalation (with Pd) of the primary products. This methodology has resulted in novel routes to unique polycyclic structures, and will have synthetic applications in the near future. Evidence for the stereospecific "corner" cleavage of the cyclopropane ring has been provided for the first time for Tl and later for Hg. The third part deals with transition metal-catalyzed allylic substitution. Evidence for a new "syn" mechanism for the formation of the intermediate (π-allyl)palladium complex has been provided, which runs counter to the generally accepted "anti" mechanism. A novel method for a Pd-catalyzed allylic oxidation has been developed and employed in the synthesis of natural sesquiterpenes. The increasing importance of transition and non-transition metals for synthetic organic chemistry is demonstrated by their unique reactivity in a number of the papers included in this review.

scholarly journals Space weather: the solar perspective

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Manuela Temmer
Keyword(s):  
Solar Wind ◽  
Space Weather ◽  
Weather Forecasting ◽  
Interplanetary Space ◽  
Three Dimensions ◽  
Space Weather Forecasting ◽  
Stereo Mission ◽  
Interaction Regions ◽  
Near Future ◽  
First Time

AbstractThe Sun, as an active star, is the driver of energetic phenomena that structure interplanetary space and affect planetary atmospheres. The effects of Space Weather on Earth and the solar system is of increasing importance as human spaceflight is preparing for lunar and Mars missions. This review is focusing on the solar perspective of the Space Weather relevant phenomena, coronal mass ejections (CMEs), flares, solar energetic particles (SEPs), and solar wind stream interaction regions (SIR). With the advent of the STEREO mission (launched in 2006), literally, new perspectives were provided that enabled for the first time to study coronal structures and the evolution of activity phenomena in three dimensions. New imaging capabilities, covering the entire Sun-Earth distance range, allowed to seamlessly connect CMEs and their interplanetary counterparts measured in-situ (so called ICMEs). This vastly increased our knowledge and understanding of the dynamics of interplanetary space due to solar activity and fostered the development of Space Weather forecasting models. Moreover, we are facing challenging times gathering new data from two extraordinary missions, NASA’s Parker Solar Probe (launched in 2018) and ESA’s Solar Orbiter (launched in 2020), that will in the near future provide more detailed insight into the solar wind evolution and image CMEs from view points never approached before. The current review builds upon the Living Reviews article by Schwenn from 2006, updating on the Space Weather relevant CME-flare-SEP phenomena from the solar perspective, as observed from multiple viewpoints and their concomitant solar surface signatures.

Horizontal CCMs in small-capacity metallurgy

2021 ◽  
Vol 77 (7) ◽  
pp. 776-781
Author(s):  
V. V. Reshetov ◽  
A. I. Trushin
Keyword(s):  
Small Volume ◽  
Alloyed Steel ◽  
Rolled Stock ◽  
Light Section ◽  
Wide Range ◽  
Central Porosity ◽  
Steel Grades ◽  
Horizontal Type ◽  
First Time ◽  
Small Capacity

Production of light-section rolled products and wire rods of alloyed steel grades differs by small volume of yearly output and wide range of smelted grades. To organize production of light-section rolled products of alloyed steel grades in small volumes, OJSC “Spetsmash” elaborated concept of small-capacity production, which was implemented at several plants. It was shown that horizontal CCM can be effectively applied in the small-capacity production within complexes of light-section rolled stock of alloyed steels production. At the plant “Ferrotrade” (Beloretsk) when creating a complex for production wire rods of 6.5 mm diameter of austenite class steels and nickel-based alloys, a horizontal CCM was constructed. Production of 60 mm diameter billets by the machine was mastered, which enabled to apply a rolling mini-mill, characterizing by small dimensions and power. The horizontal CCM, constructed in 2016 at the steelmaking shop of CJSC “Izhevsk pilot-mechanical plant”, was equipped by electromagnetic stirrer (EMS). It was noted that EMS was applied for the first time in domestic metallurgy at the industrial CCM of horizontal type. In the process of this CCM mastering, more than 60 heats were casted into billets of 80, 200 and 120 mm diameter. EMS application resulted in improving average point on the central porosity to 1.2—1.8 depending on the stirring modes. In 2018 the OJSC “Spetsmash” for the Research Center “Thermodeform” (Magnitogorsk) constructed an experimental horizontal CCM, designed for casting of billets of 40—60 mm diameter by direct casting of melt from the crucible of 60 kg induction furnace into the metal reservoir 776 of the machine. Development of a project of horizontal CCM for PJSC “PlasmaTek” (Ukraine, Vinnitsy) finished, designed for production of billets of 50 and 60 mm diameter within a complex of equipment for manufacturing welding electrodes not only of alloyed but also of carbon steel grades. The designed productivity of the complex is 12,000 t/year. Basic technical characteristics of the CCM presented. Small-capacity production with horizontal CCMs can be organized as independent objects and within existing steel-works for expanding product range.

Political Change in Rhodesia: The South Africa Factor

1975 ◽  
Vol 5 (4) ◽  
pp. 13-20
Author(s):  
Philip E. Chartrand
Keyword(s):  
South Africa ◽  
United Nations ◽  
Majority Rule ◽  
Political Change ◽  
The South ◽  
The United Nations ◽  
Liberation Movements ◽  
Minority Regime ◽  
Near Future ◽  
First Time

In December 1974, Ian Smith, the leader of the white minority regime in Rhodesia, announced for the first time since declaring his country’s independence from Britain in 1965 that his government was willing to begin direct negotiations with the African liberation movements seeking to achieve majority rule in Rhodesia. The prospect of such talks leading to an end to guerrilla fighting in Rhodesia and a termination of the United Nations authorized sanctions against the illegal Smith regime is dimmed by the fact that the Africans demand African rule for Rhodesia in the near future if not immediately, while Smith and his supporters have refused to consider such a development “in his lifetime.” Still the announcement constituted a step forward which few informed observers would have deemed likely even a few weeks before.

Detailed Stress Analysis of a Spherical Acrylic Submersible by 3-D Finite Element Modeling

1999 ◽  
Author(s):  
Partha S. Das
Keyword(s):  
Finite Element ◽  
Numerical Modeling ◽  
Dissimilar Materials ◽  
Analysis Model ◽  
Element Analysis ◽  
Finite Element Analysis Model ◽  
New Model ◽  
Ocean Exploration ◽  
Near Future ◽  
First Time

Abstract Harbor Branch Oceanographic Institution (HBOI) designed, built and has operated two JOHNSON-SEA-LINK (JSL) manned submersibles for the past 25 years. The JSL submersibles each incorporate a 66–68 in. (1.6764–1.7272 m) OD, 4–5.25 in. (0.1016–0.13335 m) thick acrylic two-man sphere as a Pressure Vessel for Human Occupancy (PVHO). This type of spherical acrylic sphere or submersible was first introduced in around 1970 and is known as Naval Experimental Manned Observatory (NEMO) submersibles. As the demand increases for ocean exploration to 3000 ft. (914.4 m) depth to collect samples, to study the ocean surfaces, the problem of developing cracks at the interface of these manned acrylic submersibles following few hundred dives have become a common phenomena. This has drawn considerable attentions for reinvestigation of the spherical acrylic submersible in order to overcome this crack generation problem at the interface. Therefore, a new full-scale 3-D nonlinear FEA (Finite Element Analysis) model, similar to the spherical acrylic submersible that HBOI uses for ocean exploration, has been developed for the first time in order to simulate the structural behavior at the interface and throughout the sphere, for better understanding of the mechanical behavior. Variation of the stiffness between dissimilar materials at the interface, lower nylon gasket thickness, over designed aluminum hatch are seemed to be few of the causes for higher stresses within acrylic sphere at the nylon gasket/acrylic interface. Following the basic understanding of the stresses and relative displacements at the interface and within different parts of the submersible, various models have been developed on the basis of different shapes and thickness of nylon gaskets, openings of the acrylic sphere, hatch geometry and its materials, specifically to study their effect on the overall performance of the acrylic submersible. Finally, the new model for acrylic submersible has been developed by redesigning the top aluminum hatch and hatch ring, the sphere openings at both top and bottom, as well as the nylon gasket inserts. Altogether this new design indicates a significant improvement over the existing spherical acrylic submersible by reducing the stresses at the top gasket/acrylic interface considerably. Redesigning of the bottom penetrator plate, at present, is underway. In this paper, results from numerical modeling only are reported in details. Correlation between experimental-numerical modeling results for the new model will be reported in the near future.

scholarly journals Temperature and UV light affect the activity of marine cell-free enzymes

2017 ◽  
Vol 14 (17) ◽  
pp. 3971-3977 ◽  
Author(s):  
Blair Thomson ◽  
Christopher David Hepburn ◽  
Miles Lamare ◽  
Federico Baltar
Keyword(s):  
Organic Matter ◽  
Extracellular Enzymes ◽  
Elevated Temperatures ◽  
Uv Light ◽  
Control Mechanisms ◽  
Potential Control ◽  
Control Factors ◽  
Rate Limiting Step ◽  
Ocean Environment ◽  
First Time

Abstract. Microbial extracellular enzymatic activity (EEA) is the rate-limiting step in the degradation of organic matter in the oceans. These extracellular enzymes exist in two forms: cell-bound, which are attached to the microbial cell wall, and cell-free, which are completely free of the cell. Contrary to previous understanding, cell-free extracellular enzymes make up a substantial proportion of the total marine EEA. Little is known about these abundant cell-free enzymes, including what factors control their activity once they are away from their sites (cells). Experiments were run to assess how cell-free enzymes (excluding microbes) respond to ultraviolet radiation (UVR) and temperature manipulations, previously suggested as potential control factors for these enzymes. The experiments were done with New Zealand coastal waters and the enzymes studied were alkaline phosphatase (APase), β-glucosidase, (BGase), and leucine aminopeptidase (LAPase). Environmentally relevant UVR (i.e. in situ UVR levels measured at our site) reduced cell-free enzyme activities by up to 87 % when compared to controls, likely a consequence of photodegradation. This effect of UVR on cell-free enzymes differed depending on the UVR fraction. Ambient levels of UV radiation were shown to reduce the activity of cell-free enzymes for the first time. Elevated temperatures (15 °C) increased the activity of cell-free enzymes by up to 53 % when compared to controls (10 °C), likely by enhancing the catalytic activity of the enzymes. Our results suggest the importance of both UVR and temperature as control mechanisms for cell-free enzymes. Given the projected warming ocean environment and the variable UVR light regime, it is possible that there could be major changes in the cell-free EEA and in the enzymes contribution to organic matter remineralization in the future.

scholarly journals Mass bleaching of soft coral, Sarcophyton spp. in Thailand and the role of temperature and salinity stress

2009 ◽  
Vol 66 (7) ◽  
pp. 1515-1519 ◽  
Author(s):  
Suchana Chavanich ◽  
Voranop Viyakarn ◽  
Thepsuda Loyjiw ◽  
Priyapat Pattaratamrong ◽  
Anchalee Chankong
Keyword(s):  
Salinity Stress ◽  
Soft Coral ◽  
Elevated Temperatures ◽  
Gulf Of Thailand ◽  
Field Observations ◽  
Experimental Trial ◽  
First Time ◽  
Upper Gulf Of Thailand ◽  
Mass Bleaching

Abstract Chavanich, S., Viyakarn, V., Loyjiw, T., Pattaratamrong, P., and Chankong, A. 2009. Mass bleaching of soft coral, Sarcophyton spp. in Thailand and the role of temperature and salinity stress. – ICES Journal of Marine Science, 66: 1515–1519. From June to October 2006 and 2007, mass bleaching of the soft coral, Sarcophyton spp., occurred for the first time in the upper Gulf of Thailand. Approximately 90% of the populations experienced extensive bleaching, and almost 95% of colonies were affected. Field observations also revealed that fragmentation of Sarcophyton spp. set in 1 month after the onset of bleaching. Some colonies started to recover to some extent by the end of July, with 95% of the population of Sarcophyton spp. recovering by October. Both acute and chronic trials were conducted to determine whether temperature and/or salinity triggered bleaching. In the acute tests, Sarcophyton spp. at 40°C and salinity 20 psu were completely bleached, and death occurred after 57 and 204 h, respectively. However, the colonies at 40 psu could survive through the experimental trial. In the chronic tests, Sarcophyton spp. died when exposed to 34°C, whereas complete bleaching and mortality of Sarcophyton spp. occurred at salinities of 10 and 49 psu. We conclude that elevated temperatures had a greater effect on the bleaching of Sarcophyton spp. than did salinity.

scholarly journals V Plenum of the Central Bureau of the Medical Section

1929 ◽  
Vol 25 (2) ◽  
pp. 241-243
Author(s):  
A. Ya. Pleschitser
Keyword(s):  
Complex System ◽  
Central Bureau ◽  
Obstetrics And Gynecology ◽  
Advanced Training ◽  
Cyclic System ◽  
Medical Section ◽  
Leningrad Institute ◽  
Near Future ◽  
First Time

On January 10-15 with. For the first time the reports of the institutes for advanced training of doctors (Leningrad and Kazan) were heard in the Plenum of Ts. B. for the first time. In both in-tah the cyclic system is practiced, however in its content it differs from each other. The cyclic system of the Kazan Institute is a complex system of a number of disciplines (internal diseases, nervous, physical, children's make up a therapeutic cycle, surgery, obstetrics and gynecology and orthopedics a surgical cycle, and an eye cycle). Listening to the subjects of these cycles is mandatory for students during the semester, only a bias in one discipline or another is allowed. The cycles at the Leningrad Institute cover a number of courses in one discipline: a separate cycle of internal diseases, a cycle of nervous diseases, etc .; a visiting physician has the opportunity to freely define himself for two cycles at his own discretion. The debate on this issue revealed that each of these systems has its own advantages and the regulations adopted on the reports will preserve these systems for the near future. The proposal to unify systems for both institutes did not meet with support.

The Temperature-Dependent Ideal Shear Strength of Solid Single Crystals

2018 ◽  
Vol 85 (3) ◽  
Author(s):  
Tianbao Cheng ◽  
Daining Fang ◽  
Yazheng Yang
Keyword(s):  
Shear Strength ◽  
Theoretical Model ◽  
Melting Point ◽  
Single Crystals ◽  
Elevated Temperatures ◽  
Absolute Zero ◽  
Temperature Dependent ◽  
Temperature Changes ◽  
First Time ◽  
The Ideal

Knowledge of the ideal shear strength of solid single crystals is of fundamental importance. However, it is very hard to determine this quantity at finite temperatures. In this work, a theoretical model for the temperature-dependent ideal shear strength of solid single crystals is established in the view of energy. To test the drawn model, the ideal shear properties of Al, Cu, and Ni single crystals are calculated and compared with that existing in the literature. The study shows that the ideal shear strength first remains approximately constant and then decreases almost linearly as temperature changes from absolute zero to melting point. As an example of application, the “brittleness parameter” of solids at elevated temperatures is quantitatively characterized for the first time.

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