scholarly journals Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1641
Author(s):  
Piotr Zmijewski ◽  
Agata Leońska-Duniec ◽  
Aleksander Stuła ◽  
Marek Sawczuk
Keyword(s):  
Real Time ◽  
Female Athletes ◽  
Self Control ◽  
Competitive Performance ◽  
Sleep Regulation ◽  
Long Distance ◽  
Replication Studies ◽  
Methyltransferase Gene ◽  
Polymerase Chain

Swimmers’ competitive performance is a result of complicated interactions between physiological, biochemical, physical and psychological factors, all of which are strongly affected by water. Recently, great attention has been paid to the role of genetic factors such as the catechol-O-methyltransferase gene (COMT) influencing motivation, emotions, stress tolerance, self-control, sleep regulation, pain processing and perception, addictive behaviour and neurodegeneration, which may underlie differences in achieving remarkable results in sports competition. Thus, this study was performed to investigate the association between the COMT Val158Met (rs4680) polymorphism and athletic performance in Caucasian swimmers. A total of 225 swimmers (171 short distance (SDS) and 54 long distance swimmers (LDS)) of national or international competitive standard and 379 unrelated sedentary controls were genotyped using real-time polymerase chain reaction (real-time PCR). We found no significant differences in genotypic or allelic distributions between (1) male and female athletes; (2) SDS and LDS; (3) all athletes and sedentary controls (under codominant, dominant, recessive, and overdominant genetic models). No association was found between the COMT rs4680 polymorphism and elite swimming athlete status of the studied population. However, more replication studies are needed.

scholarly journals GALNTL6 rs558129: A Novel Polymorphism for Swimming Performance?

2021 ◽  
Vol 80 (1) ◽  
pp. 199-205
Author(s):  
Piotr Zmijewski ◽  
Grzegorz Trybek ◽  
Wojciech Czarny ◽  
Agata Leońska-Duniec
Keyword(s):  
Real Time ◽  
Athletic Performance ◽  
Short Distance ◽  
Swimming Performance ◽  
Short Chain Fatty Acids ◽  
Long Distance ◽  
Replication Studies ◽  
Polymerase Chain ◽  
Positive Effect ◽  
Sports Selection

Abstract The enzyme polypeptide N-acetylgalactosaminyltransferase like 6, encoded by the GALANTL6 gene, plays a role in the gut microbiome regarding regulation of short-chain fatty acids and their anti-inflammatory and resynthesis functions. It was hypothesized that the T allele of the GALNTL6 rs558129 polymorphism could have a positive effect on anaerobic metabolism. Thus, this study was performed to investigate the association between GALNTL6 rs558129 polymorphism and athletic performance in swimmers. A total of 147 Polish short distance (SDS) and 49 long distance swimmers (LDS) of national or international competitive levels and 379 controls were genotyped using the real-time polymerase chain reaction (real-time PCR). We found that the carriers of the T allele (CT+TT) had a 1.56 times higher chance of being SDS (odds ratio (OR): 95%CI 1.06-2.29) than the CC homozygotes. The T allele was overrepresented in the SDS compared with controls (33.7% vs. 25.7%, p = 0.025, OR 1.40, 95% CI 1.04-1.87), but no statistically significant differences were found for LDS. This study provides evidence for an association between the GALNTL6 rs558129 polymorphism and short distance swimming athlete status. Although more replication studies are needed, the preliminary data suggest an opportunity to use the analysis of GALNTL6 polymorphism along with other variants of candidate genes and standard phenotypic assessment in power-oriented sports selection.

scholarly journals The Role of Sexual Self-Control as Moderator between Sexual Desire and Premarital Sexual Behaviors

2020 ◽  
Vol 47 (1) ◽  
pp. 43
Author(s):  
Chindy Kencana Sari ◽  
Marselius Sampe Tondok ◽  
Darmawan Muttaqin
Keyword(s):  
Sexual Behavior ◽  
Emerging Adults ◽  
Sexual Behaviors ◽  
Sexual Desire ◽  
Self Control ◽  
Long Distance ◽  
Sex Drive ◽  
Premarital Sexual ◽  
The Relationship

Sexual desire can be one of the antecedents for individual premarital sexual behavior. Otherwise, sexual self-control can prevent individuals from engaging premarital sexual behavior. This study aimed to examine the role of self-control in moderating the relationship between sexual desire and premarital sexual behavior. This study involved 209 emerging adults (18-25 years old) who were dating and not undergoing a long-distance relationship. The current study used Premarital Sexual Permissiveness measurement, dyadic sexual desire subscale from Sexual Desire Inventory-II, general sex-drive and stimulus-elicited sex-drive subscales from Perceived Sexual Control to measure premarital sexual behavior, sexual desire, and sexual self-control respectively. Results of regression analysis showed that sexual self-control did not moderate the relationship between sexual desire and kissing (∆R2 = 0.006, p > 0.05), as well as sexual desire and petting (∆R2 = 0.001, p > 0.05). However, self-control could be a moderator in the relationship between sexual desire and intercourse (∆R2 = 0.027, p < 0.01).

The Role of Information Technology in Managing the Conflicts of Long-Distance Partners

2019 ◽  
Author(s):  
Gremil Alessandro Naz
Keyword(s):  
Information Technology ◽  
Personal Characteristics ◽  
Text Messages ◽  
Self Control ◽  
Long Distance ◽  
The Common ◽  
Communication Practices ◽  
Study Participants ◽  
Role Of Information

This study sought to understand the role of information technology (IT) in managing the conflicts of Filipinos in long-distance relationships (LDRs). Specifically, it aimed to know the conflicts Filipinos in LDRs usually experience, how these conflicts are managed with the help of IT, their conflict communication practices, and the values necessary for LDR maintenance. Ten Filipinos in LDRs were interviewed in depth. Results showed that the common conflicts identified by the study participants were on childrearing, failure to communicate on the appointed date and time, delayed and unsent text messages, the husband’s drinking, and gossips related to the husband’s alleged infidelity. IT was a big help in managing these conflicts because it allowed effective communication, with video telephony as the most preferred technology. According to the study participants, the personal characteristics that contribute to LDR maintenance are cool-headedness, self-control, patience, and humility.

The Role of Information Technology in Managing the Conflicts of Long-Distance Partners

2021 ◽  
Vol 13 (1) ◽  
pp. 65-78
Author(s):  
Gremil Alessandro Alcazar Naz
Keyword(s):  
Information Technology ◽  
Personal Characteristics ◽  
Text Messages ◽  
Self Control ◽  
Long Distance ◽  
The Common ◽  
Communication Practices ◽  
Study Participants ◽  
Role Of Information

This study sought to understand the role of information technology (IT) in managing the conflicts of Filipinos in long-distance relationships (LDRs). Specifically, it aimed to know the conflicts Filipinos in LDRs usually experience, how these conflicts are managed with the help of IT, their conflict communication practices, and the values necessary for LDR maintenance. Ten Filipinos in LDRs were interviewed in depth. Results showed that the common conflicts identified by the study participants were on childrearing, failure to communicate on the appointed date and time, delayed and unsent text messages, the husband's drinking, and gossips related to the husband's alleged infidelity. IT was a big help in managing these conflicts because it allowed effective communication, with video telephony as the most preferred technology. According to the study participants, the personal characteristics that contribute to LDR maintenance are cool-headedness, self-control, patience, and humility.

Periodontitis Salivary Microbiota Worsens Colitis

2021 ◽  
pp. 002203452110497
Author(s):  
J. Qian ◽  
J. Lu ◽  
Y. Huang ◽  
M. Wang ◽  
B. Chen ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Polymerase Chain Reaction ◽  
Real Time ◽  
Bowel Disease ◽  
Chain Reaction ◽  
Salivary Microbiota ◽  
Inflammatory Bowel ◽  
Polymerase Chain

Evidence suggests that periodontitis contributes to the pathogenesis of inflammatory bowel disease, including Crohn’s disease and ulcerative colitis. However, few studies have examined the role of swallowing and saliva in the pathogenesis of gastrointestinal diseases. Saliva contains an enormous number of oral bacteria and is swallowed directly into the intestine. Here, we explored the influence of periodontitis salivary microbiota on colonic inflammation and possible mechanisms in dextran sulfate sodium (DSS)–induced colitis. The salivary microbiota was collected from healthy individuals and those with periodontitis and gavaged to C57BL/6 mice. Periodontitis colitis was induced by DSS for 5 d and ligature for 1 wk. The degree of colon inflammation was evaluated through hematoxylin and eosin staining, ELISA, and quantitative real-time polymerase chain reaction. Immune parameters were measured with quantitative real-time polymerase chain reaction, flow cytometry, and immunofluorescence. The gut microbiota and metabolome analyses were performed via 16S rRNA gene sequencing and liquid chromatography–mass spectrometry. Although no significant colitis-associated phenotypic changes were found under physiologic conditions, periodontitis salivary microbiota exacerbated colitis in a periodontitis colitis model after DSS induction. The immune response more closely resembled the pathology of ulcerative colitis, including aggravated macrophage M2 polarization and Th2 cell induction (T helper 2). Inflammatory bowel disease–associated microbiota, such as Blautia, Helicobacter, and Ruminococcus, were changed in DSS-induced colitis after periodontitis salivary microbiota gavage. Periodontitis salivary microbiota decreased unsaturated fatty acid levels and increased arachidonic acid metabolism in DSS-induced colitis, which was positively correlated with Aerococcus and Ruminococcus, suggesting the key role of these metabolic events and microbes in the exacerbating effect of periodontitis salivary microbiota on experimental colitis. Our study demonstrated that periodontitis contributes to the pathogenesis of colitis through the swallowing of salivary microbiota, confirming the role of periodontitis in systemic disease and providing new insights into the etiology of gastrointestinal inflammatory diseases.

scholarly journals Atg16L1 as a Novel Biomarker and Autophagy Gene for Diabetic Retinopathy

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Xinxiao Gao ◽  
Yunhui Du ◽  
Wayne Bond Lau ◽  
Yu Li ◽  
Siquan Zhu ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Real Time ◽  
Potential Role ◽  
Critical Role ◽  
Differentially Expressed ◽  
Chain Reactions ◽  
Polymerase Chain Reactions ◽  
Polymerase Chain ◽  
Microarray Analyses

Objective. Accumulating evidence suggests the critical role of autophagy in the pathogenesis of diabetic retinopathy (DR). In the current study, we aim to identify autophagy genes involved in DR via microarray analyses. Methods. Gene microarrays were performed to identify differentially expressed lncRNAs/mRNAs between normal and DR retinas. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of lncRNA-coexpressed mRNAs were used to determine the related pathological pathways and biological modules. Real-time polymerase chain reactions (PCR) were conducted to validate the microarray analyses. Results. A total of 2474 significantly dysregulated lncRNAs and 959 differentially expressed mRNAs were identified in the retina of DR. Based upon Signalnet analysis, Bcl2, Gabarapl2, Atg4c, and Atg16L1 participated the process of cell death in DR. Moreover, real-time PCR revealed significant upregulation of Atg16L1. Conclusion. This study indicated the importance and potential role of Atg16L1, one of the autophagy genes, as a biomarker in DR development and progression.

Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome

Blood ◽  
2005 ◽  
Vol 105 (12) ◽  
pp. 4784-4791 ◽  
Author(s):  
Marco Ladetto ◽  
Sonia Vallet ◽  
Andreas Trojan ◽  
Maria Dell'Aquila ◽  
Luigia Monitillo ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Real Time ◽  
Plasma Cells ◽  
Cyclooxygenase 2 ◽  
Cytokine Network ◽  
Poor Outcome ◽  
Polymerase Chain ◽  
Cox 2 ◽  
Potential Use

Abstract Cyclooxygenase 2 (COX-2) is an inflammation-associated enzyme involved in the pathogenesis of many solid tumors, but little is known about its presence and role in hematologic neoplasms. Multiple myeloma (MM) is known to involve a deregulated cytokine network with secretion of inflammatory mediators. We thus decided to investigate the involvement of COX-2 in this neoplasm. Western blotting (WB) was used to evaluate 142 bone marrow (BM) specimens, including MM and monoclonal gammopathy of undetermined significance (MGUS). Selected cases under-went further evaluation by WB on purified CD138+ cells, immunohistochemistry (IC), and real-time polymerase chain reaction (PCR) for mRNA expression. COX-2 was expressed in 11% (2 of 18) of MGUS specimens, 31% (29 of 94) of MM at diagnosis, and 47% (14 of 30) of MM with relapsed/refractory disease. COX-2 positivity was associated with a poor outcome in terms of progression-free (18 vs 36 months; P &lt; .001) and overall survival (28 vs 52 months; P &lt; .05). Real-time PCR showed COX-2 mRNA overexpression. IC and cell separation studies demonstrated COX-2 expression to be restricted to malignant plasma cells. This is the first report of the presence and prognostic role of COX-2 expression in MM. Future studies will assess COX-2 involvement in other hematologic tumors and its potential use as a therapeutic or chemo-preventive target in onco-hematology. (Blood. 2005; 105:4784-4791)

The Role of Information Technology in Managing the Conflicts of Long-Distance Partners

2019 ◽  
Author(s):  
Gremil Alessandro Naz
Keyword(s):  
Information Technology ◽  
Personal Characteristics ◽  
Text Messages ◽  
Self Control ◽  
Long Distance ◽  
The Common ◽  
Communication Practices ◽  
Study Participants ◽  
Role Of Information

This study sought to understand the role of information technology (IT) in managing the conflicts of Filipinos in long-distance relationships (LDRs). Specifically, it aimed to know the conflicts Filipinos in LDRs usually experience, how these conflicts are managed with the help of IT, their conflict communication practices, and the values necessary for LDR maintenance. Ten Filipinos in LDRs were interviewed in depth. Results showed that the common conflicts identified by the study participants were on childrearing, failure to communicate on the appointed date and time, delayed and unsent text messages, the husband’s drinking, and gossips related to the husband’s alleged infidelity. IT was a big help in managing these conflicts because it allowed effective communication, with video telephony as the most preferred technology. According to the study participants, the personal characteristics that contribute to LDR maintenance are cool-headedness, self-control, patience, and humility.

Sign in / Sign up

Export Citation Format

Share Document