scholarly journals From Tutoring Gross Anatomy to Pancreatic Surgery Innovation

2021 ◽  
Vol 19 (1) ◽  
pp. 359
Author(s):  
Alberto Balduzzi ◽  
Giovanni Marchegiani
Keyword(s):  
Pancreatic Surgery ◽  
Gross Anatomy ◽  
Academic Programs ◽  
Human Anatomy ◽  
Technological Innovations ◽  
Future Perspectives ◽  
Surgical Residents ◽  
Time Required ◽  
Pancreatic Gland

The training for pancreatic surgery still is not conducted according to standardized protocols, and academic programs differ between countries and hospitals. Moreover, due to recent technological innovations such as minimally invasive and robotic surgery, and the broader indications for complex pancreatic procedures due to the use of neoadjuvant chemotherapy, training is continuously redefining itself. The historical paradigm of “see one, do one, teach one” has been challenged and might have become obsolete. Finally, the rising number of surgical residents along with the limited time required practicing during residency might represent a major limitation to becoming an independent surgeon. Gross anatomy is a solid practice for the active learning of human anatomy during medical school. With regards to the pancreas, it offers a unique opportunity to both actively study the pancreatic gland anatomy during dissection and simulate actual surgical procedures. A critical review of the literature was conducted, aiming to assess the role of gross anatomy in surgical training and possible future perspectives.

The Role of Industry-Academia Collaborative Research in Mineral Exploration

2020 ◽  
Author(s):  
James Marlatt
Keyword(s):  
Collaborative Research ◽  
New Technologies ◽  
Mineral Exploration ◽  
Board Members ◽  
Technological Innovations ◽  
Development Programs ◽  
The University ◽  
Insight Into ◽  
Economic Mineral

ABSTRACT Many people may not be aware of the extent of Kurt Kyser's collaboration with mineral exploration companies through applied research and the development of innovative exploration technologies, starting at the University of Saskatchewan and continuing through the Queen's Facility for Isotope Research. Applied collaborative, geoscientific, industry-academia research and development programs can yield technological innovations that can improve the mineral exploration discovery rates of economic mineral deposits. Alliances between exploration geoscientists and geoscientific researchers can benefit both parties, contributing to the pure and applied geoscientific knowledge base and the development of innovations in mineral exploration technology. Through a collaboration that spanned over three decades, we gained insight into the potential for economic uranium deposits around the world in Canada, Australia, USA, Finland, Russia, Gabon, Namibia, Botswana, South Africa, and Guyana. Kurt, his research team, postdoctoral fellows, and students developed technological innovations related to holistic basin analysis for economic mineral potential, isotopes in mineral exploration, and biogeochemical exploration, among others. In this paper, the business of mineral exploration is briefly described, and some examples of industry-academic collaboration innovations brought forward through Kurt's research are identified. Kurt was a masterful and capable knowledge broker, which is a key criterion for bringing new technologies to application—a grand, curious, credible, patient, and attentive communicator—whether talking about science, business, or life and with first ministers, senior technocrats, peers, board members, first nation peoples, exploration geologists, investors, students, citizens, or friends.

Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives

2018 ◽  
Vol 23 (37) ◽  
pp. 5760-5765 ◽  
Author(s):  
Antonio Gambardella ◽  
Angelo Labate ◽  
Laura Mumoli ◽  
Iscia Lopes-Cendes ◽  
Fernando Cendes
Keyword(s):  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Current Status ◽  
Future Perspectives ◽  
Antiepileptic Drug Therapy

scholarly journals Towards 6G IoT: Tracing Mobile Sensor Nodes with Deep Learning Clustering in UAV Networks

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3936
Author(s):  
Yannis Spyridis ◽  
Thomas Lagkas ◽  
Panagiotis Sarigiannidis ◽  
Vasileios Argyriou ◽  
Antonios Sarigiannidis ◽  
...  
Keyword(s):  
Deep Learning ◽  
Heuristic Method ◽  
Sensor Nodes ◽  
Convolutional Network ◽  
Received Signal Strength Indicator ◽  
Anchor Nodes ◽  
Time Required ◽  
Rf Signal ◽  
Deep Learning Model

Unmanned aerial vehicles (UAVs) in the role of flying anchor nodes have been proposed to assist the localisation of terrestrial Internet of Things (IoT) sensors and provide relay services in the context of the upcoming 6G networks. This paper considered the objective of tracing a mobile IoT device of unknown location, using a group of UAVs that were equipped with received signal strength indicator (RSSI) sensors. The UAVs employed measurements of the target’s radio frequency (RF) signal power to approach the target as quickly as possible. A deep learning model performed clustering in the UAV network at regular intervals, based on a graph convolutional network (GCN) architecture, which utilised information about the RSSI and the UAV positions. The number of clusters was determined dynamically at each instant using a heuristic method, and the partitions were determined by optimising an RSSI loss function. The proposed algorithm retained the clusters that approached the RF source more effectively, removing the rest of the UAVs, which returned to the base. Simulation experiments demonstrated the improvement of this method compared to a previous deterministic approach, in terms of the time required to reach the target and the total distance covered by the UAVs.

scholarly journals Therapeutic Role of Tocilizumab in SARS-CoV-2-Induced Cytokine Storm: Rationale and Current Evidence

2021 ◽  
Vol 22 (6) ◽  
pp. 3059
Author(s):  
Corrado Pelaia ◽  
Cecilia Calabrese ◽  
Eugenio Garofalo ◽  
Andrea Bruni ◽  
Alessandro Vatrella ◽  
...  
Keyword(s):  
Review Article ◽  
Lung Damage ◽  
Current Evidence ◽  
Therapeutic Effects ◽  
Cytokine Storm ◽  
Future Perspectives ◽  
Pathogenic Role ◽  
Refractory Rheumatoid Arthritis ◽  
Life Threatening

Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the worst possible scenarios is represented by the critical lung damage caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced cytokine storm, responsible for a potentially very dangerous hyperinflammatory condition. Within such a context, interleukin-6 (IL-6) plays a key pathogenic role, thus being a suitable therapeutic target. Indeed, the IL-6-receptor antagonist tocilizumab, already approved for treatment of refractory rheumatoid arthritis, is often used to treat patients with severe COVID-19 symptoms and lung involvement. Therefore, the aim of this review article is to focus on the rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as to discuss current evidence and future perspectives, especially with regard to ongoing trials referring to the evaluation of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection.

scholarly journals Current role of ultrasound in hemodialysis access evaluation

2021 ◽  
pp. 112972982110346
Author(s):  
Meola Mario ◽  
Jose Ibeas ◽  
Jan Malik
Keyword(s):  
Turning Point ◽  
Point Of Care ◽  
Low Cost ◽  
Wireless Systems ◽  
Future Perspectives ◽  
Maturation Period ◽  
Surveillance Programs ◽  
Dialysis Nurses

Physical examination (PE) is considered the backbone before vascular access (VA) placement, during maturation period and for follow-up. However, it may be inadequate in identifying suitable vasculature, mainly in comorbid patients, or in detecting complications. This review highlights the advantages of ultrasound imaging to manage VA before placement, during maturation and follow-up. Furthermore, it analyses the future perspectives in evaluating early and late VA complications thank to the availability of multiparametric platforms, point of care of ultrasound, and portable/wireless systems. Technical improvements and low-cost systems should favor the widespread ultrasound-based VA surveillance programs. This significant turning point needs an adequate training of nephrologists and dialysis nurses and the standardization of exams, parameters, and procedures.

scholarly journals Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 15
Author(s):  
Aishat Motolani ◽  
Matthew Martin ◽  
Mengyao Sun ◽  
Tao Lu
Keyword(s):  
Transcription Factor ◽  
Cardiovascular Diseases ◽  
Cancer Progression ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Malignant Diseases ◽  
Future Perspectives ◽  
Post Translational Modifications ◽  
Site Specific

The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including phosphorylation, one of the most popular PTM formats in NF-κB signaling. The regulation by phosphorylation modification is not limited to NF-κB subunits, but it also encompasses the diverse regulators of NF-κB signaling. The differential site-specific phosphorylation of NF-κB itself or some NF-κB regulators can result in dysregulated NF-κB signaling, often culminating in events that induce cancer progression and other hyper NF-κB related diseases, such as inflammation, cardiovascular diseases, diabetes, as well as neurodegenerative diseases, etc. In this review, we discuss the regulatory role of phosphorylation in NF-κB signaling and the mechanisms through which they aid cancer progression. Additionally, we highlight some of the known and novel NF-κB regulators that are frequently subjected to phosphorylation. Finally, we provide some future perspectives in terms of drug development to target kinases that regulate NF-κB signaling for cancer therapeutic purposes.

Role of arterial variants in pancreatic surgery

2013 ◽  
Vol 39 (9) ◽  
pp. S49
Author(s):  
C. Benucci ◽  
M. Santilli ◽  
C. Roberto ◽  
E. Casciani ◽  
G. Prezioso ◽  
...  
Keyword(s):  
Pancreatic Surgery

The role of dalbavancin for Gram positive infections in the COVID-19 era: state of the art and future perspectives

2021 ◽  
pp. 1-10
Author(s):  
Massimo Andreoni ◽  
Matteo Bassetti ◽  
Salvatore Corrao ◽  
Francesco Giuseppe De Rosa ◽  
Vincenzo Esposito ◽  
...  
Keyword(s):  
State Of The Art ◽  
Future Perspectives ◽  
Gram Positive

Sugar Rush: Sugar and Science in the British Caribbean

2021 ◽  
Vol 14 (2) ◽  
pp. 128-150
Author(s):  
Nicole A. Jacoberger
Keyword(s):  
Nineteenth Century ◽  
Eighteenth Century ◽  
Sugar Beet ◽  
Local Knowledge ◽  
Cane Sugar ◽  
Technological Innovations ◽  
Foreign Competition ◽  
The Caribbean ◽  
A Site

This article examines the contrasting evolution in sugar refining in Jamaica and Barbados incentivized by Mercantilist policies, changes in labor systems, and competition from foreign sugar revealing the role of Caribbean plantations as a site for experimentation from the eighteenth through mid-nineteenth century. Britain's seventeenth- and eighteenth-century protectionist policies imposed high duties on refined cane-sugar from the colonies, discouraging colonies from exporting refined sugar as opposed to raw. This system allowed Britain to retain control over trade and commerce and provided exclusive sugar sales to Caribbean sugar plantations. Barbadian planters swiftly gained immense wealth and political power until Jamaica and other islands produced competitive sugar. The Jamaica Assembly invested heavily in technological innovations intended to improve efficiency, produce competitive sugar in a market that eventually opened to foreign competition such as sugar beet, and increase profits to undercut losses from duties. They valued local knowledge, incentivizing everyone from local planters to chemists, engineers, and science enthusiasts to experiment in Jamaica and publish their findings. These publications disseminated important findings throughout Britain and its colonies, revealing the significance of the Caribbean as a site for local experimentation and knowledge.

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