Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
2018 ◽
Vol 19
(8)
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pp. 2260
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Keyword(s):
Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence have highlighted that HO-1 expression is associated to neuronal damage and neurodegeneration especially in Alzheimer’s and Parkinson’s diseases. In this review, we summarize the current literature regarding the role of HO-1 in nervous system pointing out different molecular mechanisms possibly responsible for HO-1 up-regulation in nervous system homeostasis and neurodegeneration.
2016 ◽
Vol Volume 13
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pp. 77-85
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1998 ◽
Vol 247
(2-3)
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pp. 103-106
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2009 ◽
Vol 41
(6)
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pp. 1304-1314
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2020 ◽
Vol 19
(2)
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pp. 133-138
Keyword(s):
2018 ◽
Vol 24
(20)
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pp. 2283-2302
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2017 ◽
Vol 18
(6)
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pp. 674-686
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2020 ◽
Vol 21
(15)
◽
pp. 5475
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2004 ◽
Vol 85
(1)
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pp. 34-44
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Keyword(s):