scholarly journals EDTA Chelation Therapy for the Treatment of Neurotoxicity

2019 ◽  
Vol 20 (5) ◽  
pp. 1019 ◽  
Author(s):  
Fulgenzi Alessandro ◽  
Ferrero Maria Elena
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Agent ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Organophosphorus Pesticides ◽  
Chelating Agent ◽  
Oxygen Species ◽  
Anesthetic Drugs ◽  
Disodium Ethylenediaminetetraacetic Acid ◽  
Species Production

Neurotoxicity can be caused by numerous direct agents, of which toxic metals, organophosphorus pesticides, air pollution, radiation and electromagnetic fields, neurotoxins, chemotherapeutic and anesthetic drugs, and pathogens are the most important. Other indirect causes of neurotoxicity are cytokine and/or reactive oxygen species production and adoptive immunotherapy. The development of neurodegenerative diseases has been associated with neurotoxicity. Which arms are useful to prevent or eliminate neurotoxicity? The chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA)—previously used to treat cardiovascular diseases—is known to be useful for the treatment of neurodegenerative diseases. This review describes how EDTA functions as a therapeutic agent for these diseases. Some case studies are reported to confirm our findings.

scholarly journals EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update

Biomedicines ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 269
Author(s):  
Alessandro Fulgenzi ◽  
Daniele Vietti ◽  
Maria Elena Ferrero
Keyword(s):  
Neurodegenerative Diseases ◽  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Human Subjects ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

We have previously described the role played by toxic-metal burdens in the etiology of neurodegenerative diseases (ND). We herein report an updated evaluation of toxic-metal burdens in human subjects affected or not affected by ND or other chronic diseases. Each subject underwent a chelation test with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNA2EDTA or EDTA) to identify the presence of 20 toxic metals in urine samples using inductively coupled plasma mass spectrometry. Our results show the constant presence of toxic metals, such as lead, cadmium, cesium, and aluminum, in all examined subjects but the absence of beryllium and tellurium. Gadolinium was detected in patients undergoing diagnostic magnetic resonance imaging. The presence of toxic metals was always significantly more elevated in ND patients than in healthy controls. Treatment with EDTA chelation therapy removes toxic-metal burdens and improves patient symptoms.

scholarly journals Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Maria Elena Ferrero
Keyword(s):  
Adverse Effects ◽  
Neurodegenerative Diseases ◽  
Toxic Metals ◽  
Chelation Therapy ◽  
Ethylenediaminetetraacetic Acid ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Successful Management ◽  
Human Organs ◽  
Human Burden

Exposure to environmental and occupational toxicants is responsible for adverse effects on human health. Chelation therapy is the only procedure able to remove toxic metals from human organs and tissue, aiming to treat damage related to acute and/or chronic intoxication. The present review focuses on the most recent evidence of the successful use of the chelating agent ethylenediaminetetraacetic acid (EDTA). Assessment of toxic-metal presence in humans, as well as the rationale of EDTA therapy in cardiovascular and neurodegenerative diseases, is reported.

scholarly journals Improvement of Oxidative and Metabolic Parameters by Cellfood Administration in Patients Affected by Neurodegenerative Diseases on Chelation Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Alessandro Fulgenzi ◽  
Rachele De Giuseppe ◽  
Fabrizia Bamonti ◽  
Maria Elena Ferrero
Keyword(s):  
Neurodegenerative Diseases ◽  
Ethylenediaminetetraacetic Acid ◽  
Oxidized Ldl ◽  
Toxic Metal ◽  
Chelating Agent ◽  
Blood Parameters ◽  
Oxidative Status ◽  
Antioxidant Compounds ◽  
Before And After ◽  
Metabolic Conditions

Objective. This prospective pilot study aimed at evaluating the effects of therapy with antioxidant compounds (Cellfood, and other antioxidants) on patients affected by neurodegenerative diseases (ND), who displayed toxic metal burden and were subjected to chelation treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA or EDTA).Methods. Two groups of subjects were studied: (a) 39 patients affected by ND and (b) 11 subjects unaffected by ND (controls). The following blood parameters were analyzed before and after three months’ treatment with chelation + Cellfood or chelation + other antioxidants: oxidative status (reactive oxygen species, ROS; total antioxidant capacity, TAC; oxidized LDL, oxLDL; glutathione), homocysteine, vitamin B12, and folate.Results. After 3-months’ chelation + Cellfood administration oxLDL decreased, ROS levels were significantly lower, and TAC and glutathione levels were significantly higher than after chelation + other antioxidants treatment, both in ND patients and in controls. Moreover, homocysteine metabolism had also improved in both groups.Conclusions. Chelation + Cellfood treatment was more efficient than chelation + other antioxidants improving oxidative status and homocysteine metabolism significantly in ND patients and controls. Although limited to a small number of cases, this study showed how helpful antioxidant treatment with Cellfood was in improving the subjects’ metabolic conditions.

scholarly journals Bacterial phagocytosis and reactive oxygen species production by camel neutrophils and monocytes are influenced by the type of anticoagulation agent

2021 ◽  
pp. 1888-1893
Author(s):  
Naser Abdallah Al Humam
Keyword(s):  
Reactive Oxygen Species ◽  
Ethylenediaminetetraacetic Acid ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
E Coli ◽  
Infection And Inflammation ◽  
Escherichia Coli Bacteria ◽  
Species Production ◽  
Phagocytosis Activity

Background and Aim: Anticoagulants with different modes of action are used in the collection of camel blood samples. In the innate immune response, camel neutrophils and monocytes can play several roles during infection and inflammation. For anticoagulants ethylenediaminetetraacetic acid (EDTA) and heparin, research has described their effects on different parameters of the immune system. However, to date, no research has examined the effects of anticoagulants on the functional activity of camel phagocytes. Therefore, this study analyzed the influence of K3EDTA and lithium heparin on the antimicrobial activity of camel neutrophils and monocytes. Materials and Methods: Camel leukocytes were separated from blood collected in EDTA or heparin tubes, and their phagocytosis and reactive oxygen species (ROS) production activity were analyzed by flow cytometry after stimulation with Staphylococcus aureus or Escherichia coli bacteria. Results: In comparison to the cells collected from the EDTA blood, the camel neutrophils and monocytes separated from the heparin blood showed higher phagocytosis activity of S. aureus and E. coli. In addition, the neutrophils and monocytes produced significantly more ROS when the blood was collected in the heparin tubes. Conclusion: The antimicrobial functions of camel neutrophils and monocytes are significantly affected by the type of anticoagulation agent. Therefore, using heparin rather than EDTA as an anticoagulant is recommended when performing the functional analysis of phagocytosis and ROS production of camel phagocytes.

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