Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age

2018 ◽  
Vol 66 (7) ◽  
pp. 1064-1068 ◽  
Author(s):  
Chang-Ching Wei ◽  
Cheng-Li Lin ◽  
Te-Chun Shen ◽  
An-Chyi Chen
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Disease ◽  
Allergic Conjunctivitis ◽  
Cumulative Effect ◽  
Allergic Diseases ◽  
School Age ◽  
Increasing Trend ◽  
History Of ◽  
Subsequent Risk

The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7–18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis. The allergic diseases included atopic dermatitis, allergic conjunctivitis, allergic rhinitis (AR), and asthma. Children with preceding allergic diseases had a greater subsequent risk of migraine than the controls. Among the four evaluated diseases, AR had the highest adjusted OR (aOR) of 2.17 (95% CI 2.09 to 2.26). Children with all four allergic diseases had the highest aOR of 3.59 (95% CI 2.91 to 4.44). Further, an increasing trend of aORs was observed with more allergic disease-associated medical consulting. Our study indicates that children with allergic diseases are at increased subsequent risk of migraine when they reach school age, and the risk shows a cumulative effect of more allergic diseases and more allergy-related healthcare.

scholarly journals The AAA Risk Factors Scale: A New Model to Screen for the Risk of Asthma, Allergic Rhinitis and Atopic Dermatitis in Children

2018 ◽  
Vol 27 (5) ◽  
pp. 472-480 ◽  
Author(s):  
Souheil Hallit ◽  
Chantal Raherison ◽  
Diana Malaeb ◽  
Rabih Hallit ◽  
Nelly Kheir ◽  
...  
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Disease ◽  
Disease Risk ◽  
Allergic Diseases ◽  
Parental History ◽  
Respiratory Problems ◽  
History Of ◽  
Or History

Objective: To create an allergic disease risk factors scale score that would screen for the risk assessment of asthma, allergic rhinitis and atopic dermatitis (AD) in children from 3 to 17 years. Methods: This case-control study, conducted between December 2015 and April 2016, enrolled 1,274 children. The allergic disease risk factors scale was created by combining environmental, exposure to toxics during pregnancy and breastfeeding and parental history of allergic diseases. Results: Playing on carpets, male gender, child’s respiratory problems or history of eczema before the  age of 2 years, and humidity significantly increased the odds of allergies in the child. Maternal waterpipe smoking, maternal history of rhinitis, history of asthma in the mother or the father, along with the maternal drug intake or alcohol consumption during pregnancy significantly increased the odds of allergies in the child. There was a significant increase in allergy diseases per category of the allergic disease risk factors scale (p < 0.001 for trend). Scores ≤2.60 best represented control individuals, while scores > 5.31 best represented children with allergic diseases. Conclusion: Allergic diseases seem to be linked to several risk factors in our population of school children. Many environmental factors might be incriminated in these allergic diseases.

scholarly journals Factors Associated with Atopic Dermatitis and Allergic Rhinitis among Residents of Two Municipal Areas in South Korea

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 131 ◽  
Author(s):  
Dilaram Acharya ◽  
Bishnu Bahadur Bajgain ◽  
Seok-Ju Yoo
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Family History ◽  
Allergic Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Allergic Diseases ◽  
Factors Associated ◽  
History Of ◽  
Significant Factors

Background and Objectives: The growing burden and deleterious health consequences of allergic diseases, especially of allergic rhinitis (AR) and atopic dermatitis (AD), in developed countries remains an important public health issue. The current study aimed to assess the prevalence and to identify the risk factors of atopic dermatitis and allergic rhinitis among residents of Pohang-Si and Yeongdeok-Gun, two municipal areas in South Korea. Materials and Methods: A cross-sectional study was conducted in both municipal areas between 12 November and 13 December 2017. A total of 302 subjects were recruited from 100 households (25 apartments and 25 houses in each municipality), by system extraction according to district code numbers. Data were collected using International Study of Asthma and Allergies in Childhood (ISAAC) Standard Questionnaires for children and a health questionnaire for adults. Risk factors were identified by multivariate logistic regression analysis. Results: Of the 302 study participants, 12.9% and 25.5% had AD and AR, respectively. The significant factors associated with AD by multivariate logistic regression analysis were age ≥19 years (aOR (adjusted odds ratio) 6.9; 95% CI (confidence interval) (2.9–16.37)), residence in Pohang-Si (aOR 2.5; 95% CI (1.18–5.53)), and family history of allergic disease (aOR 2.3; 95% CI (1.09–4.9)). Similarly, the significant factors associated with AR were male gender (aOR 2.3; 95% CI (1.24–4.42)), age ≥19 years (aOR 4.4; 95% CI (2.28–8.48)), residence in Pohang-Si (aOR 2.8; 95% CI (1.51–5.37)), and family history of allergic disease (aOR 6.7; 95% CI (3.50–12.82)). Conclusion: The present study shows that age ≥19 years, residence in Pohang-Si, and family history of allergic disease are risk factors for AD and AR, and that, additionally, male gender is a risk factor of AR. Understanding the risk factors of allergic diseases can aid the design and implementation of evidence-specific strategies to reduce the long-standing problems associated with allergic disease.

scholarly journals Ten-Year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

2020 ◽  
Vol 63 (7) ◽  
pp. 278-283 ◽  
Author(s):  
Jihyun Ha ◽  
Seung Won Lee ◽  
Dong Keon Yon
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Preschool Children ◽  
Allergic Diseases ◽  
The Elderly ◽  
Korean Population ◽  
School Age Children ◽  
Asthma Prevalence ◽  
School Age ◽  
Cross Sectional Survey

Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017.Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the Korean population (n=85,006) including 2,131 infants, 4,352 preschool children, 12,919 school-age children, 44,200 adults, and 21,404 elderly adults.Results: In the 2016 to 2017 population, the estimated prevalence of asthma was 0.9% in infants, 2.3% in preschool children, 4.1% in school-age children, 2.3% in adults, and 4.1% in the elderly. The estimated prevalence of allergic rhinitis was 9.0%, 20.2%, 27.6%, 17.1%, and 6.9%, respectively. The estimated prevalence of atopic dermatitis was 5.9%, 11.3%, 14.6%, 3.9%, and 1.6%, respectively. Ten-year trends revealed a significant decrease in asthma prevalence in infants, preschool children, and the elderly. and in atopic dermatitis prevalence in infants and preschool children (<i>P</i><0.05 for all trends). Furthermore, 10-year trends demonstrated a significant increase in allergic rhinitis prevalence in school-age children, adults, and the elderly, and in atopic dermatitis prevalence in school-age children and the elderly (<i>P</i><0.05 for all trends).Conclusion: These results improve our understanding of the age-stratified epidemiology of allergic diseases in Korea and suggest the need for the development of tailored and precise strategies to prevent allergic diseases in different age groups.

scholarly journals Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata

2017 ◽  
Vol 5 (3) ◽  
pp. 305-309 ◽  
Author(s):  
Javad Ghaffari ◽  
Ghasem Rahmatpour Rokni ◽  
Armaghan Kazeminejad ◽  
Hosein Abedi
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Alopecia Areata ◽  
Allergic Diseases ◽  
Control Group ◽  
Case Group ◽  
Control Groups ◽  
Significant Difference ◽  
History Of ◽  
And Control

BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals.METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group. Participants filled the questionnaires, and necessary tests were performed.RESULTS: In this study, the mean age of the participants was 2.55 ± 14.26 and 3.19 ± 11.92 in the case and control groups, respectively. Prevalence of asthma was 22% in the case group and 12.5% in control group (P = 0.109). Also, allergic rhinitis and eczema were observed in 20% and 22% of the subjects of the case group, whereas they were reported to be 8% and 10% in the control group (PV = 0.03 and 0.175, respectively). Moreover, 28% and 8% of the participants in the case and control groups had a family history of atopy and allergic disorders, respectively (P = 0.046). A significant difference was observed between the two groups regarding gender, type of delivery and contact with animals.CONCLUSIONS: According to the results of this study, a significant association was observed between the prevalence of alopecia areata and atopic conditions, such as allergic rhinitis and history of atopic dermatitis.

The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children ‐ Polish Mother and Child Cohort Study

2020 ◽  
Vol 41 (1) ◽  
pp. e19-e25
Author(s):  
Monika Bobrowska-Korzeniowska ◽  
Joanna Jerzyńska ◽  
Kinga Polańska ◽  
Jolanta Gromadzińska ◽  
Wojciech Hanke ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Cord Blood ◽  
Antioxidant Defense ◽  
Allergic Diseases ◽  
School Age Children ◽  
School Age ◽  
Early School ◽  
Mother And Child ◽  
Early School Age

Purpose: Based on the available data, alterations of the antioxidant defense as well as the vitamin status in mothers may affect the prenatal process of lung and immune system development as a pathophysiological background of increased prevalence of allergic diseases. The primary aim of the current study was to assess the associations among cord blood concentrations of zinc (Zn); copper (Cu); selenium (Se); β-carotene; and vitamin A, E, and D, and the occurrence of atopic dermatitis, food allergy, allergic rhinitis, and asthma in early school-age children. Methods: We evaluated 211 children, 7‐9 years old, from the Polish Mother and Child Cohort Study. the women were interviewed during pregnancy to collect demographic and socioeconomic data, and the medical and reproductive history. At delivery, umbilical cord blood plasma was sampled. Seven to nine years after the birth, the child's exposure and health status (including skin-prick test and spirometry for allergy assessment and urine sample for cotinine level) were examined. In the analyses, a multivariable model was applied. Results: Statistically significant relationships were found among Zn; Cu; Se; and vitamin A, E, and D concentrations in cord blood; and the prevalence of food allergy, allergic rhinitis, atopic dermatitis, and asthma in children ages 7‐9 years after adjustment for several confounders. Conclusion: We showed an imbalance in the antioxidant defense system in cord blood, which may lead to the occurrence of allergic diseases later in life. The maternal diet may have substantial potential to modify immune tolerance and, consequently, the development of allergic disease in the offspring.Clinical trial NCT01861548, <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</ext-link>

scholarly journals Impact of Environmental Factors on the Prevalence Changes of Allergic Diseases in Elementary School Students in Ulsan, Korea: A Longitudinal Study

2020 ◽  
Vol 17 (23) ◽  
pp. 8831
Author(s):  
Jiho Lee ◽  
Seokhyun Yun ◽  
Inbo Oh ◽  
Min-ho Kim ◽  
Yangho Kim
Keyword(s):  
Physical Activity ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Elementary School Students ◽  
Allergic Conjunctivitis ◽  
Allergic Diseases ◽  
School Students ◽  
Weekly Physical Activity ◽  
Low Levels

We examined the effect of long-term changes in environmental factors on the prevalence of allergic diseases in elementary school students in Ulsan, Korea. This longitudinal study was conducted among 390 students who were enrolled from three elementary schools in Ulsan in both the first (2009–2010) and second survey (2013–2014). The International Study of Asthma and Allergies in Childhood questionnaire was used to determine the prevalence of allergic diseases and hazardous environmental factors. Generalized estimating equations (GEE) were used to investigate the impact of environmental factors on the change in the prevalence of allergic diseases. The survey revealed that an increased risk of allergic rhinitis was associated with exposure to secondhand smoke, the remodeling of a room, the replacement of wallpaper or flooring, the use of a humidifier, and irritation symptoms of air pollution. Atopic dermatitis was associated with the relocation to or repairs of a new house, and allergic conjunctivitis was associated with low levels of weekly physical activity, the use of insecticides, and irritation symptoms of air pollution. The results indicate that (1) allergic rhinitis and atopic dermatitis are associated with indoor pollution, (2) allergic conjunctivitis is associated with exposure to indoor chemical compounds and low levels of weekly physical activity. This study suggested that the proper evaluation and decrease in the number of environmental risk factors could effectively manage allergic diseases.

scholarly journals Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March

2020 ◽  
Vol 21 (23) ◽  
pp. 9011
Author(s):  
Émile Bélanger ◽  
Anne-Marie Madore ◽  
Anne-Marie Boucher-Lafleur ◽  
Marie-Michelle Simon ◽  
Tony Kwan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Immunoglobulin E ◽  
Clinical Manifestations ◽  
Skin Barrier ◽  
Allergic Diseases ◽  
Forced Expiratory Volume ◽  
Inflammatory Reactions ◽  
Atopic March ◽  
History Of

(1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leading to allergic diseases such as allergic asthma and allergic rhinitis. The eosinophil, a pro-inflammatory cell that contributes to epithelial damage, is one of the various cells recruited in the inflammatory reactions characterizing these diseases. Few studies were conducted on the transcriptome of this cell type and even less on their specific microRNA (miRNA) profile, which could modulate pathogenesis of allergic diseases and clinical manifestations post-transcriptionally. Actually, their implication in allergic diseases is not fully understood, but they are believed to play a role in inflammation-related patterns and epithelial cell proliferation. (2) Methods: Next-generation sequencing was performed on RNA samples from eosinophils of individuals with atopic dermatitis, atopy, allergic rhinitis and asthma to obtain differential counts of primary miRNA (pri-miRNA); these were also analyzed for asthma-related phenotypes such as forced expiratory volume in one second (FEV1), immunoglobulin E (IgE) and provocative concentration of methacholine inducing a 20% fall in forced expiratory volume in 1 s (PC20) levels, as well as FEV1 to forced vital capacity (FEV1/FVC) ratio. (3) Results: Eighteen miRNAs from eosinophils were identified to be significantly different between affected individuals and unaffected ones. Based on counts from these miRNAs, individuals were then clustered into groups using Ward’s method on Euclidian distances. Groups were found to be explained by asthma diagnosis, familial history of respiratory diseases and allergic rhinitis as well as neutrophil counts. (4) Conclusions: The 18 differential miRNA counts for the studying phenotypes allow a better understanding of the epigenetic mechanisms underlying the development of the allergic diseases included in the atopic march.

scholarly journals Clinical manifestations of allergic rhinitis in children at Denpasar Hospital

2001 ◽  
Vol 41 (3) ◽  
pp. 160
Author(s):  
Gary Adhianto ◽  
Hendra S
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Allergic Diseases ◽  
Prick Test ◽  
Pediatric Allergy ◽  
The Family ◽  
History Of ◽  
Reported Data

This is a retrospective study by collecting data from the medical record of children diagnosed as allergic rhinitis at the Pediatric Allergy & Immunology out patient clinic at Denpasar Hospital between January 1996 and December 2000. Reported data including identifying patient, signs and symptoms, atopic history of the family, skin prick test (SPT) result and the environmental factors. Fifty-five from 297 children (18.5%) attending the Pediatric Allergy & Immunology out patient clinic were diagnosed as allergic rhinitis. Thirty nine were male and 16 female. The age ranged from 6 months to 15 years old. The majority of signs and symptom were sneezing and rhinorrhea (26%), itchy nose (23%), blocked nose (14%) and itchy eyes(12%).. Four children had history of atopic dermatitis, 1 food allergy, 10 asthma, 3 urticaria, 2 drug allaaaergy, 4 h-ad history of both atopic dermatitis and urticaria, 13 both asthma and urticaria, 2 both asthma and drug allergy and 6 children had no history of allergic diseases. Thirty three (60%) one of the parents and 12 (21.8%) both parents ever had allergic diseases. According to SPT, 27 (55.1%) of this children had positive reaction to inhalant allergen, 13 (26.5%) to food allergen and 13 (26.5%) had negative reaction.

Kawasaki Disease and Atopic Diseases: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
pp. 1-9
Author(s):  
Zihan Wang ◽  
Jintao Zhang ◽  
Hao Yan ◽  
Liang Dong
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Kawasaki Disease ◽  
Observational Studies ◽  
Allergic Conjunctivitis ◽  
Meta Analysis ◽  
Allergic Diseases ◽  
Cardiovascular Disorder ◽  
Atopic Diseases ◽  
Cross Sectional

<b><i>Introduction:</i></b> The etiology of Kawasaki disease (KD), an inflammatory and cardiovascular disorder, remains largely unexplained after more than 50 years of intensive research. In recent years, the association between KD and atopic diseases had been explored by some observational studies. We systematically reviewed and summarized the literature on the relationship between KD and atopic diseases. <b><i>Methods:</i></b> MEDLINE and EMBASE were searched to identify observational studies on the association between KD and atopic diseases from inception to May 2021. Odds ratio (OR) was pooled using random-effects models. Heterogeneity was assessed using the <i>I</i><sup>2</sup> and Cochran Q statistics. Primary outcomes were to compare the prevalence of KD among individuals with atopic diseases to nonatopic disease controls and the prevalence of atopic diseases among individuals with KD to non-KD controls. <b><i>Results:</i></b> Thirteen studies, including 12,651 cases and 170,708 controls, were included in this meta-analysis. In cross-sectional studies, KD was associated with allergic rhinitis (<i>n</i> = 6; OR, 1.69; 95% CI, 1.52–1.87), asthma (<i>n</i> = 3; OR, 1.72; 95% CI, 1.38–2.14), allergic conjunctivitis (<i>n</i> = 2; OR, 1.95; 95% CI, 1.68–2.27), and atopic dermatitis (<i>n</i> = 3; OR, 1.35; 95% CI, 1.22–1.49). In case-control and cohort studies, KD was associated with allergic rhinitis (<i>n</i> = 3; OR, 1.35; 95% CI, 1.28–1.43), asthma (<i>n</i> = 8; OR, 1.40; 95% CI, 1.19–1.65), allergic conjunctivitis (<i>n</i> = 1; OR, 1.74; 95% CI, 1.45–2.09), and atopic dermatitis (<i>n</i> = 3; OR, 1.39; 95% CI, 1.26–1.53). <b><i>Conclusion:</i></b> KD diagnosed was associated with four common atopic diseases. Among the four allergic diseases, allergic conjunctivitis and asthma have the highest correlation with KD, which may provide a direction for exploring the etiology of KD.

scholarly journals Increased Risk of Asthma and Allergic Rhinitis in Patients With a Past History of Kawasaki Disease: A Systematic Review and Meta-Analyses

2021 ◽  
Vol 9 ◽  
Author(s):  
Wei-Te Lei ◽  
Chih-Wei Hsu ◽  
Po-Cheng Chen ◽  
Ping-Tao Tseng ◽  
Ho-Chang Kuo ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Kawasaki Disease ◽  
Past History ◽  
Meta Analysis ◽  
Allergic Diseases ◽  
Previous Diagnosis ◽  
Increased Risk ◽  
History Of ◽  
Meta Analyses

Background: Allergic diseases are frequently observed in children with Kawasaki disease (KD). However, the evidence supporting the association between KD and allergies has been conflicting. The objective of the current study is to examine the association between KD and allergic diseases.Methods: We conducted an electronic search using PubMed, Embase, and the Cochrane through 24 July 2021. The inclusion criteria consisted of studies that examined the prevalence of allergic diseases in children with a previous diagnosis of KD and in a comparison group. We pooled studies by using a random effects model. The effects of KD on the subsequent risk of allergic diseases were expressed as odds ratio (OR) with 95% confidence intervals (CI).Results: We included a total of four studies that assessed the effect of KD on asthma, allergic rhinitis, and atopic dermatitis vs. non-KD children (KD individuals for asthma, four studies, n = 8,474; allergic rhinitis, four studies, n = 8,474; atopic dermatitis, three studies, n = 8,330). The overall prevalence of asthma, allergic rhinitis, and atopic dermatitis was 9.12, 27.63, and 6.55% among patients with previous KD. The meta-analysis showed a significantly increased risk of asthma (OR:1.437, CI: 1.067–1.937) and allergic rhinitis (OR: 1.726, CI: 1.291–2.307) in patients with KD, compared with the control groups. However, patients with KD did not have a significantly different level of risk of atopic dermatitis (OR: 1.243, 95% CI: 0.857–1.802).Conclusion: This meta-analysis supports that individuals with KD are more likely to have asthma and allergic rhinitis compared to controls.

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