scholarly journals Prediction of Protein–ATP Binding Residues Based on Ensemble of Deep Convolutional Neural Networks and LightGBM Algorithm

2021 ◽  
Vol 22 (2) ◽  
pp. 939
Author(s):  
Jiazhi Song ◽  
Guixia Liu ◽  
Jingqing Jiang ◽  
Ping Zhang ◽  
Yanchun Liang
Keyword(s):  
Machine Learning ◽  
Protein Function ◽  
Learning Algorithm ◽  
Area Under The Curve ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Atp Binding ◽  
Deep Convolutional Neural Networks ◽  
Binding Residues

Accurately identifying protein–ATP binding residues is important for protein function annotation and drug design. Previous studies have used classic machine-learning algorithms like support vector machine (SVM) and random forest to predict protein–ATP binding residues; however, as new machine-learning techniques are being developed, the prediction performance could be further improved. In this paper, an ensemble predictor that combines deep convolutional neural network and LightGBM with ensemble learning algorithm is proposed. Three subclassifiers have been developed, including a multi-incepResNet-based predictor, a multi-Xception-based predictor, and a LightGBM predictor. The final prediction result is the combination of outputs from three subclassifiers with optimized weight distribution. We examined the performance of our proposed predictor using two datasets: a classic ATP-binding benchmark dataset and a newly proposed ATP-binding dataset. Our predictor achieved area under the curve (AUC) values of 0.925 and 0.902 and Matthews Correlation Coefficient (MCC) values of 0.639 and 0.642, respectively, which are both better than other state-of-art prediction methods.

Efficient detection of hacker community based on twitter data using complex networks and machine learning algorithm

2021 ◽  
pp. 1-17
Author(s):  
Ahmed Al-Tarawneh ◽  
Ja’afer Al-Saraireh
Keyword(s):  
Machine Learning ◽  
Complex Networks ◽  
Nearest Neighbor ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
K Nearest Neighbor ◽  
Efficient Detection ◽  
Suggested Keywords

Twitter is one of the most popular platforms used to share and post ideas. Hackers and anonymous attackers use these platforms maliciously, and their behavior can be used to predict the risk of future attacks, by gathering and classifying hackers’ tweets using machine-learning techniques. Previous approaches for detecting infected tweets are based on human efforts or text analysis, thus they are limited to capturing the hidden text between tweet lines. The main aim of this research paper is to enhance the efficiency of hacker detection for the Twitter platform using the complex networks technique with adapted machine learning algorithms. This work presents a methodology that collects a list of users with their followers who are sharing their posts that have similar interests from a hackers’ community on Twitter. The list is built based on a set of suggested keywords that are the commonly used terms by hackers in their tweets. After that, a complex network is generated for all users to find relations among them in terms of network centrality, closeness, and betweenness. After extracting these values, a dataset of the most influential users in the hacker community is assembled. Subsequently, tweets belonging to users in the extracted dataset are gathered and classified into positive and negative classes. The output of this process is utilized with a machine learning process by applying different algorithms. This research build and investigate an accurate dataset containing real users who belong to a hackers’ community. Correctly, classified instances were measured for accuracy using the average values of K-nearest neighbor, Naive Bayes, Random Tree, and the support vector machine techniques, demonstrating about 90% and 88% accuracy for cross-validation and percentage split respectively. Consequently, the proposed network cyber Twitter model is able to detect hackers, and determine if tweets pose a risk to future institutions and individuals to provide early warning of possible attacks.

scholarly journals Predicting the Grade of Prostate Cancer Based on a Biparametric MRI Radiomics Signature

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Li Zhang ◽  
Xia Zhe ◽  
Min Tang ◽  
Jing Zhang ◽  
Jialiang Ren ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Machine Learning ◽  
Logistic Regression ◽  
Learning Algorithm ◽  
Area Under The Curve ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Low Grade ◽  
High Grade ◽  
Random Forest Tree

Purpose. This study aimed to investigate the value of biparametric magnetic resonance imaging (bp-MRI)-based radiomics signatures for the preoperative prediction of prostate cancer (PCa) grade compared with visual assessments by radiologists based on the Prostate Imaging Reporting and Data System Version 2.1 (PI-RADS V2.1) scores of multiparametric MRI (mp-MRI). Methods. This retrospective study included 142 consecutive patients with histologically confirmed PCa who were undergoing mp-MRI before surgery. MRI images were scored and evaluated by two independent radiologists using PI-RADS V2.1. The radiomics workflow was divided into five steps: (a) image selection and segmentation, (b) feature extraction, (c) feature selection, (d) model establishment, and (e) model evaluation. Three machine learning algorithms (random forest tree (RF), logistic regression, and support vector machine (SVM)) were constructed to differentiate high-grade from low-grade PCa. Receiver operating characteristic (ROC) analysis was used to compare the machine learning-based analysis of bp-MRI radiomics models with PI-RADS V2.1. Results. In all, 8 stable radiomics features out of 804 extracted features based on T2-weighted imaging (T2WI) and ADC sequences were selected. Radiomics signatures successfully categorized high-grade and low-grade PCa cases ( P < 0.05 ) in both the training and test datasets. The radiomics model-based RF method (area under the curve, AUC: 0.982; 0.918), logistic regression (AUC: 0.886; 0.886), and SVM (AUC: 0.943; 0.913) in both the training and test cohorts had better diagnostic performance than PI-RADS V2.1 (AUC: 0.767; 0.813) when predicting PCa grade. Conclusions. The results of this clinical study indicate that machine learning-based analysis of bp-MRI radiomic models may be helpful for distinguishing high-grade and low-grade PCa that outperformed the PI-RADS V2.1 scores based on mp-MRI. The machine learning algorithm RF model was slightly better.

scholarly journals A Comparitive Study of E-Mail Spam Detection using Various Machine Learning Techniques

2021 ◽  
Author(s):  
Simarjeet Kaur ◽  
Meenakshi Bansal ◽  
Ashok Kumar Bathla
Keyword(s):  
Machine Learning ◽  
Prediction Accuracy ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Spam Detection ◽  
Learning Techniques ◽  
E Mail ◽  
Email Spam

Due to the rise in the use of messaging and mailing services, spam detection tasks are of much greater importance than before. In such a set of communications, efficient classification is a comparatively onerous job. For an addressee or any email that the user does not want to have in his inbox, spam can be defined as redundant or trash email. After pre-processing and feature extraction, various machine learning algorithms were applied to a Spam base dataset from the UCI Machine Learning repository in order to classify incoming emails into two categories: spam and non-spam. The outcomes of various algorithms have been compared. This paper used random forest, naive bayes, support vector machine (SVM), logistic regression, and the k nearest (KNN) machine learning algorithm to successfully classify email spam messages. The main goal of this study is to improve the prediction accuracy of spam email filters.

scholarly journals Using Machine Learning to Predict Heart Disease

2022 ◽  
Vol 19 ◽  
pp. 1-9
Author(s):  
Nikhil Bora ◽  
Sreedevi Gutta ◽  
Ahmad Hadaegh
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Heart Disease ◽  
Random Forest ◽  
Data Science ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
K Nearest Neighbor

Heart Disease has become one of the most leading cause of the death on the planet and it has become most life-threatening disease. The early prediction of the heart disease will help in reducing death rate. Predicting Heart Disease has become one of the most difficult challenges in the medical sector in recent years. As per recent statistics, about one person dies from heart disease every minute. In the realm of healthcare, a massive amount of data was discovered for which the data-science is critical for analyzing this massive amount of data. This paper proposes heart disease prediction using different machine-learning algorithms like logistic regression, naïve bayes, support vector machine, k nearest neighbor (KNN), random forest, extreme gradient boost, etc. These machine learning algorithm techniques we used to predict likelihood of person getting heart disease on the basis of features (such as cholesterol, blood pressure, age, sex, etc. which were extracted from the datasets. In our research we used two separate datasets. The first heart disease dataset we used was collected from very famous UCI machine learning repository which has 303 record instances with 14 different attributes (13 features and one target) and the second dataset that we used was collected from Kaggle website which contained 1190 patient’s record instances with 11 features and one target. This dataset is a combination of 5 popular datasets for heart disease. This study compares the accuracy of various machine learning techniques. In our research, for the first dataset we got the highest accuracy of 92% by Support Vector Machine (SVM). And for the second dataset, Random Forest gave us the highest accuracy of 94.12%. Then, we combined both the datasets which we used in our research for which we got the highest accuracy of 93.31% using Random Forest.

scholarly journals Broiler chickens can benefit from machine learning: support vector machine analysis of observational epidemiological data

2012 ◽  
Vol 9 (73) ◽  
pp. 1934-1942 ◽  
Author(s):  
Philip J. Hepworth ◽  
Alexey V. Nefedov ◽  
Ilya B. Muchnik ◽  
Kenton L. Morgan
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Learning Algorithm ◽  
Characteristic Curve ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Important Indicator ◽  
Unseen Data

Machine-learning algorithms pervade our daily lives. In epidemiology, supervised machine learning has the potential for classification, diagnosis and risk factor identification. Here, we report the use of support vector machine learning to identify the features associated with hock burn on commercial broiler farms, using routinely collected farm management data. These data lend themselves to analysis using machine-learning techniques. Hock burn, dermatitis of the skin over the hock, is an important indicator of broiler health and welfare. Remarkably, this classifier can predict the occurrence of high hock burn prevalence with accuracy of 0.78 on unseen data, as measured by the area under the receiver operating characteristic curve. We also compare the results with those obtained by standard multi-variable logistic regression and suggest that this technique provides new insights into the data. This novel application of a machine-learning algorithm, embedded in poultry management systems could offer significant improvements in broiler health and welfare worldwide.

HYPER-PARAMETER OPTIMIZATION AND EVALUATION ON SELECTED MACHINE LEARNING ALGORITHM USING HEPATITIS DATASET

2021 ◽  
Vol 5 (2) ◽  
pp. 447-455
Author(s):  
Aminat Yusuf ◽  
Oyelola Akande
Keyword(s):  
Machine Learning ◽  
Expert Knowledge ◽  
Learning Algorithm ◽  
Area Under The Curve ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Grid Search ◽  
Classification Problems ◽  
Comparative Performance ◽  
Learning Techniques

Despite the popularity and utility of most machine learning techniques, expert knowledge is required in guiding choices about the suitable technique and settings that are good for solving a specific problem. The lack of expert information renders the procedures vulnerable to poor parameter settings. Several of these machine learning techniques configurations are offered under default settings. However, since different classification problems required suitable machine learning techniques, selecting the appropriate technique and tuning its settings are vital works that will rightly improve predictions in terms of reliability and accuracy. This study aims to perform grid search parameters tuning on 5-selected machine learning techniques on hepatitis disease. Comparative performance is drawn side-by-side with the default settings. The experimental results of the five tuning techniques show that using the configurations suggested in our work yield predictions of a greatly sophisticated quality than choice under its default settings. The result proves that tuning parameters of Support Vector Machine via grid search yields the best accuracy outcomes of 90% and has a competitive performance relative towards criteria of precision, recall, accuracy and Area Under the Curve. Present combinations of parameter settings for each of the techniques by identifying ranges of values for each setting that give good Hepatitis disease outcomes

Using Machine Learning Algorithms on Prediction of Stock Price

2020 ◽  
Vol 12 (2) ◽  
pp. 84-99
Author(s):  
Li-Pang Chen
Keyword(s):  
Machine Learning ◽  
Stock Price ◽  
Short Term Memory ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Short Term ◽  
Learning Techniques ◽  
Historical Database ◽  
Long Short Term Memory

In this paper, we investigate analysis and prediction of the time-dependent data. We focus our attention on four different stocks are selected from Yahoo Finance historical database. To build up models and predict the future stock price, we consider three different machine learning techniques including Long Short-Term Memory (LSTM), Convolutional Neural Networks (CNN) and Support Vector Regression (SVR). By treating close price, open price, daily low, daily high, adjusted close price, and volume of trades as predictors in machine learning methods, it can be shown that the prediction accuracy is improved.

A Comparative Study of Different Machine Learning Algorithms for Disease Prediction

2017 ◽  
Vol 7 (7) ◽  
pp. 172
Author(s):  
Anantvir Singh Romana
Keyword(s):  
Machine Learning ◽  
Subsequent Treatment ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Disease Prediction ◽  
Classification Problems ◽  
Learning Techniques ◽  
Neural Network Classifiers ◽  
Diagnostic Detection

Accurate diagnostic detection of the disease in a patient is critical and may alter the subsequent treatment and increase the chances of survival rate. Machine learning techniques have been instrumental in disease detection and are currently being used in various classification problems due to their accurate prediction performance. Various techniques may provide different desired accuracies and it is therefore imperative to use the most suitable method which provides the best desired results. This research seeks to provide comparative analysis of Support Vector Machine, Naïve bayes, J48 Decision Tree and neural network classifiers breast cancer and diabetes datsets.

scholarly journals Predictive Modelling of Employee Turnover in Indian IT Industry Using Machine Learning Techniques

2019 ◽  
Vol 23 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Shikha N. Khera ◽  
Divya
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Confusion Matrix ◽  
Predictive Modelling ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
It Industry ◽  
Knowledge Based ◽  
Employee Attrition

Information technology (IT) industry in India has been facing a systemic issue of high attrition in the past few years, resulting in monetary and knowledge-based loses to the companies. The aim of this research is to develop a model to predict employee attrition and provide the organizations opportunities to address any issue and improve retention. Predictive model was developed based on supervised machine learning algorithm, support vector machine (SVM). Archival employee data (consisting of 22 input features) were collected from Human Resource databases of three IT companies in India, including their employment status (response variable) at the time of collection. Accuracy results from the confusion matrix for the SVM model showed that the model has an accuracy of 85 per cent. Also, results show that the model performs better in predicting who will leave the firm as compared to predicting who will not leave the company.

scholarly journals Early Prediction of Seven-Day Mortality in Intensive Care Unit Using a Machine Learning Model: Results from the SPIN-UTI Project

2021 ◽  
Vol 10 (5) ◽  
pp. 992
Author(s):  
Martina Barchitta ◽  
Andrea Maugeri ◽  
Giuliana Favara ◽  
Paolo Marco Riela ◽  
Giovanni Gallo ◽  
...  
Keyword(s):  
Machine Learning ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Learning Algorithm ◽  
Area Under The Curve ◽  
Support Vector ◽  
Icu Admission ◽  
Risk Of Death ◽  
Saps Ii ◽  
Svm Algorithm

Patients in intensive care units (ICUs) were at higher risk of worsen prognosis and mortality. Here, we aimed to evaluate the ability of the Simplified Acute Physiology Score (SAPS II) to predict the risk of 7-day mortality, and to test a machine learning algorithm which combines the SAPS II with additional patients’ characteristics at ICU admission. We used data from the “Italian Nosocomial Infections Surveillance in Intensive Care Units” network. Support Vector Machines (SVM) algorithm was used to classify 3782 patients according to sex, patient’s origin, type of ICU admission, non-surgical treatment for acute coronary disease, surgical intervention, SAPS II, presence of invasive devices, trauma, impaired immunity, antibiotic therapy and onset of HAI. The accuracy of SAPS II for predicting patients who died from those who did not was 69.3%, with an Area Under the Curve (AUC) of 0.678. Using the SVM algorithm, instead, we achieved an accuracy of 83.5% and AUC of 0.896. Notably, SAPS II was the variable that weighted more on the model and its removal resulted in an AUC of 0.653 and an accuracy of 68.4%. Overall, these findings suggest the present SVM model as a useful tool to early predict patients at higher risk of death at ICU admission.

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