scholarly journals Effect of Kinesin-5 Tail Domain on Motor Dynamics for Antiparallel Microtubule Sliding

2021 ◽  
Vol 22 (15) ◽  
pp. 7857
Author(s):  
Yuying Liu ◽  
Yao Wang ◽  
Pengye Wang ◽  
Ping Xie
Keyword(s):  
Experimental Data ◽  
Molecular Mechanism ◽  
Chromosome Segregation ◽  
Numerical Results ◽  
Tail Domain ◽  
Analytical Results ◽  
Proposed Model ◽  
Motor Dynamics

Kinesin-5 motor consists of two pairs of heads and tail domains, which are situated at the opposite ends of a common stalk. The two pairs of heads can bind to two antiparallel microtubules (MTs) and move on the two MTs independently towards the plus ends, sliding apart the two MTs, which is responsible for chromosome segregation during mitosis. Prior experimental data showed that the tails of kinesin-5 Eg5 can modulate the dynamics of single motors and are critical for multiple motors to generate high steady forces to slide apart two antiparallel MTs. To understand the molecular mechanism of the tails modulating the ability of Eg5 motors, based on our proposed model the dynamics of the single Eg5 with the tails and that without the tails moving on single MTs is studied analytically and compared. Furthermore, the dynamics of antiparallel MT sliding by multiple Eg5 motors with the tails and that without the tails is studied numerically and compared. Both the analytical results for single motors and the numerical results for multiple motors are consistent with the available experimental data.

Modelling and calibration of phosphate and glycogen accumulating organism competition for acetate uptake in a sequencing batch reactor

2004 ◽  
Vol 50 (6) ◽  
pp. 241-250 ◽  
Author(s):  
N. Yagci ◽  
G. Insel ◽  
N. Artan ◽  
D. Orhon
Keyword(s):  
Experimental Data ◽  
Mixed Culture ◽  
Sequencing Batch Reactor ◽  
Batch Reactor ◽  
Glycogen Metabolism ◽  
Numerical Results ◽  
Phosphate Removal ◽  
Proposed Model ◽  
New Process ◽  
And Performance

This paper improves the modeling of enhanced biological phosphate removal, by introducing the mechanistic description of a mixed culture of glycogen and phosphate accumulating organisms competing for acetate, and glycogen metabolism of the latter. A new process stoichiometry is defined for the mixed culture based upon previously developed metabolic concepts and models. The proposed model is tested with and used for the calibration of experimental data generated by a sequencing batch reactor operated with acetate feeding at a P/Ac ratio of 0.05 mgP mg-1COD. The calibration yielded acceptable numerical results for all the model coefficients tested and supported the validity of selected metabolic relationships for process stoichiometry. It also defined conditions that allow the system to sustain glycogen accumulating organisms with significant impact on process behaviour and performance.

Dual Release Model to Evaluate Dissolution Profiles from Swellable Drug Polyelectrolyte Matrices

2020 ◽  
Vol 17 (6) ◽  
pp. 511-522 ◽  
Author(s):  
Alicia Graciela Cid ◽  
María Verónica Ramírez-Rigo ◽  
María Celeste Palena ◽  
Elio Emilio Gonzo ◽  
Alvaro Federico Jimenez-Kairuz ◽  
...  
Keyword(s):  
Experimental Data ◽  
Drug Release ◽  
Inflection Point ◽  
Release Profile ◽  
Experimental Point ◽  
Extended Model ◽  
Release Process ◽  
Proposed Model ◽  
Dual Release ◽  
Release Model

Background: Mathematical modeling in modified drug release is an important tool that allows predicting the release rate of drugs in their surrounding environment and elucidates the transport mechanisms involved in the process. Objective: The aim of this work was to develop a mathematical model that allows evaluating the release profile of drugs from polymeric carriers in which the swelling phenomenon is present. Methods: Swellable matrices based on ionic complexes of alginic acid or carboxymethylcellulose with ciprofloxacin were prepared and the effect of adding the polymer sodium salt on the swelling process and the drug release was evaluated. Experimental data from the ciprofloxacin release profiles were mathematically adjusted, considering the mechanisms involved in each stage of the release process. Results: A proposed model, named “Dual Release” model, was able to properly fit the experimental data of matrices presenting the swelling phenomenon, characterized by an inflection point in their release profile. This entails applying the extended model of Korsmeyer-Peppas to estimate the percentage of drug released from the first experimental point up to the inflection point and then a model called Lumped until the final time, allowing to adequately represent the complete range of the drug release profile. Different parameters of pharmaceutical relevance were calculated using the proposed model to compare the profiles of the studied matrices. Conclusion: The “Dual Release” model proposed in this article can be used to predict the behavior of complex systems in which different mechanisms are involved in the release process.

Modelling of catalyst pellet deactivation

1985 ◽  
Vol 50 (11) ◽  
pp. 2381-2395
Author(s):  
Alena Brunovská ◽  
Ján Buriánek ◽  
Ján Ilavský ◽  
Ján Valtýni
Keyword(s):  
Experimental Data ◽  
Numerical Results ◽  
Benzene Hydrogenation ◽  
Alumina Catalyst ◽  
Temperature Changes ◽  
Catalyst Pellet ◽  
Model Equations ◽  
Catalytic Poison

The diffusion and the shell progressive models of deactivation caused by irreversible chemisorption of a catalytic poison are presented for a single catalyst pellet. The method for solution of the model equations is proposed. The numerical results are compared with experimental data obtained by measuring concentration and temperature changes due to thiophene poisoning in benzene hydrogenation over a nickel-alumina catalyst.

Wear of a Tool in Double-Disk Lapping of Silicon Wafers

2010 ◽  
Author(s):  
Adam Barylski ◽  
Mariusz Deja
Keyword(s):  
Experimental Data ◽  
Integrated Circuits ◽  
Tool Wear ◽  
Silicon Wafers ◽  
Silicon Ingot ◽  
Proposed Model ◽  
Tool Wear Prediction ◽  
Simulation Results ◽  
High Degree ◽  
Kinematical Parameters

Silicon wafers are the most widely used substrates for fabricating integrated circuits. A sequence of processes is needed to turn a silicon ingot into silicon wafers. One of the processes is flattening by lapping or by grinding to achieve a high degree of flatness and parallelism of the wafer [1, 2, 3]. Lapping can effectively remove or reduce the waviness induced by preceding operations [2, 4]. The main aim of this paper is to compare the simulation results with lapping experimental data obtained from the Polish producer of silicon wafers, the company Cemat Silicon from Warsaw (www.cematsil.com). Proposed model is going to be implemented by this company for the tool wear prediction. Proposed model can be applied for lapping or grinding with single or double-disc lapping kinematics [5, 6, 7]. Geometrical and kinematical relations with the simulations are presented in the work. Generated results for given workpiece diameter and for different kinematical parameters are studied using models programmed in the Matlab environment.

Effect of Interaction Modeling in AFM-Based Nanomanipulation

2008 ◽  
Author(s):  
Fakhreddine Landolsi ◽  
Fathi H. Ghorbel ◽  
James B. Dabney
Keyword(s):  
Experimental Data ◽  
Numerical Simulations ◽  
Interaction Model ◽  
Collision Process ◽  
Visual Sensing ◽  
Proposed Model ◽  
Interaction Modeling

AFM-based nanomanipulation is very challenging because of the complex mechanics in tip-sample interactions and the limitations in AFM visual sensing capabilities. In the present paper, we investigate the modeling of AFM-based nanomanipulation emphasizing the effects of the relevant interactions at the nanoscale. The major contribution of the present work is the use of a combined DMT-JKR interaction model in order to describe the complete collision process between the AFM tip and the sample. The coupling between the interactions and the friction at the nanoscale is emphasized. The efficacy of the proposed model to reproduce experimental data is demonstrated via numerical simulations.

Larger-Eddy Simulation of Velocity Fluctuation in a Mixing T-Junction

2012 ◽  
Vol 152-154 ◽  
pp. 1313-1318
Author(s):  
Tao Lu ◽  
Su Mei Liu ◽  
Ping Wang ◽  
Wei Yyu Zhu
Keyword(s):  
Experimental Data ◽  
Velocity Fluctuation ◽  
Flow Model ◽  
Numerical Results ◽  
Mean Square ◽  
Main Duct ◽  
Velocity Fluctuations ◽  
Eddy Simulation ◽  
Large Eddy ◽  
Les Model

Velocity fluctuations in a mixing T-junction were simulated in FLUENT using large-eddy simulation (LES) turbulent flow model with sub-grid scale (SGS) Smagorinsky–Lilly (SL) model. The normalized mean and root mean square velocities are used to describe the time-averaged velocities and the velocities fluctuation intensities. Comparison of the numerical results with experimental data shows that the LES model is valid for predicting the flow of mixing in a T-junction junction. The numerical results reveal the velocity distributions and fluctuations are basically symmetrical and the fluctuation at the upstream of the downstream of the main duct is stronger than that at the downstream of the downstream of the main duct.

Modeling of Coupled Bending and Torsion in Elastic Structures

1993 ◽  
Author(s):  
H. T. Banks ◽  
C. A. Smith
Keyword(s):  
Experimental Data ◽  
Numerical Results ◽  
Computational Results ◽  
Elastic Structures ◽  
Approximation Techniques ◽  
Flexural Vibrations ◽  
And Control

Abstract In this presentation we will report on joint efforts with D.J. Inman and his colleagues at MSL, SUNY at Buffalo, to develop viable models for the analysis and control of elastic structures exhibiting coupled torsional and flexural vibrations. A model for coupled torsion and bending is developed which incorporates Kelvin Voigt damping and warping. Approximation techniques are introduced and preliminary numerical results are discussed. Experimental data is presented and used to test our computational results.

scholarly journals Modelling Macrophage Infiltration into Avascular Tumours

2002 ◽  
Vol 4 (1) ◽  
pp. 21-38 ◽  
Author(s):  
C. E. Kelly ◽  
R. D. Leek ◽  
H. M. Byrne ◽  
S. M. Cox ◽  
A. L. Harris ◽  
...  
Keyword(s):  
Experimental Data ◽  
Mathematical Model ◽  
Spatial Structure ◽  
Random Motion ◽  
Numerical Results ◽  
Macrophage Infiltration ◽  
Numerical Techniques ◽  
Model Predictions ◽  
Independent Experimental Data

In this paper a mathematical model that describes macrophage infiltration into avascular tumours is presented. The qualitative accuracy of the model is assessed by comparing numerical results with independent experimental data that describe the infiltration of macrophages into two types of spheroids: chemoattractant-producing (hepa-1) and chemoattractant-deficient (or C4) spheroids. A combination of analytical and numerical techniques are used to show how the infiltration pattern depends on the motility mechanisms involved (i.e. random motion and chemotaxis) and to explain the observed differences in macrophage infiltration into the hepa-1 and C4 spheroids. Model predictions are generated to show how the spheroid's size and spatial structure and the ability of its constituent cells influence macrophage infiltration. For example, chemoattractant-producing spheroids are shown to recruit larger numbers of macrophages than chemoattractant-deficient spheroids of the same size and spatial structure. The biological implications of these results are also discussed briefly.

scholarly journals Numerical and Experimental Investigation of a Rich Quench Lean Combustor Sector

1996 ◽  
Author(s):  
Johannes W. Koopman ◽  
Peter Griebel ◽  
Christoph Hassa
Keyword(s):  
Experimental Data ◽  
Experimental Investigation ◽  
Numerical Results ◽  
Detailed Knowledge ◽  
Complementary Information ◽  
Species Concentration ◽  
Flow Temperature ◽  
Nox Formation ◽  
Sector Model ◽  
Decisive Importance

The flow in a three sector model, representing a segment of an annular rich quench lean combustor for an aeroengine is investigated. Detailed knowledge of flow, temperature and species concentration distributions is of decisive importance to control the NOx formation, essential to the RQL concept. Velocities, temperatures and species concentrations are measured. They are partly used to aquire data on the inlet boundaries in the numerical calculation and partly used to compare with the numerical results. The calculation reveals many details which are not accesable in the experiment. It also shows the effects of the specific inlet dataset. Experimental data and numerical results furnish complementary information.

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