scholarly journals Phospholipids: Identification and Implication in Muscle Pathophysiology

2021 ◽  
Vol 22 (15) ◽  
pp. 8176
Author(s):  
Rezlène Bargui ◽  
Audrey Solgadi ◽  
Bastien Prost ◽  
Mélanie Chester ◽  
Ana Ferreiro ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Cell Metabolism ◽  
Human Diseases ◽  
Structural Elements ◽  
Metabolic Processes ◽  
Pathogenic Variants ◽  
Amphiphilic Molecules ◽  
Detection And Identification ◽  
Long Time ◽  
Main Components

Phospholipids (PLs) are amphiphilic molecules that were essential for life to become cellular. PLs have not only a key role in compartmentation as they are the main components of membrane, but they are also involved in cell signaling, cell metabolism, and even cell pathophysiology. Considered for a long time to simply be structural elements of membranes, phospholipids are increasingly being viewed as sensors of their environment and regulators of many metabolic processes. After presenting their main characteristics, we expose the increasing methods of PL detection and identification that help to understand their key role in life processes. Interest and importance of PL homeostasis is growing as pathogenic variants in genes involved in PL biosynthesis and/or remodeling are linked to human diseases. We here review diseases that involve deregulation of PL homeostasis and present a predominantly muscular phenotype.

The Development Of Society Businesses In Concrete Blocks Production With A Single Vibration System In The Pare Sub-District Kediri Regency

2020 ◽  
Vol 1 (1) ◽  
pp. 19-23
Author(s):  
Diah Willis L ◽  
Thomas Priyasmanu ◽  
Wahyu Panji A ◽  
D. H. Praswanto ◽  
E. Y. Setyawan
Keyword(s):  
Community Service ◽  
Production Cost ◽  
Building Construction ◽  
Vibration System ◽  
Current Development ◽  
Drying Process ◽  
Long Time ◽  
Concrete Blocks ◽  
Good Potential ◽  
Main Components

Development in the current development sector has grown rapidly, in this development we can see a good potential to be developed, namely the development of bricks with good quality compared to using red bricks which production takes a long time. Batako is an alternative that can be used in the construction of a building, because currently the price of red brick is quite high because the production cost is quite expensive. Besides, the price of firewood used for cooking red brick is getting difficult. Meanwhile, the demand for brick gradually increased because brick was one of the main components in building construction. So it needs to be developed in making brick blocks because the time is relatively short in the drying process. Therefore the community service team made a brick making machine with a vibration system for compaction and a faster production process in brick making using a machine that has been made, so that it can increase partner income, who previously produced 120 pieces with a manual system using a machine that could produce 500 pieces of brick per day.

Integrating Qualitative and Quantitative Tools for the Detection and Identification of Lectins in Major Human Diseases

2015 ◽  
Vol 22 (11) ◽  
pp. 954-962 ◽  
Author(s):  
Ghulam Ashraf ◽  
Asma Perveen ◽  
Syed Zaidi ◽  
Shams Tabrez ◽  
Shazi Shakil ◽  
...  
Keyword(s):  
Human Diseases ◽  
Qualitative And Quantitative ◽  
Detection And Identification

Assessment of recreational use of specially protected natural territories of Tatishchevsky district of Saratov region

2019 ◽  
Vol 27 (2) ◽  
pp. 117-127
Author(s):  
Yulia M Andriyanova ◽  
Irina V Sergeeva ◽  
Yulia M Mokhonko ◽  
Natalia N Gusakova
Keyword(s):  
Natural Resources ◽  
Protected Areas ◽  
Saratov Region ◽  
Future State ◽  
Forest Phytocenoses ◽  
Long Time ◽  
Main Components ◽  
First Time ◽  
Recreational Use ◽  
Specially Protected Natural Territories

The influence of recreation being a set of measures to restore health and recreation, on the main components of forest phytocenoses in specially protected natural territories of the Tatishchevsky district of the Saratov region has been studied for the first time. These phytocenoses have been intensively used for tourism for a long time. The intensity and visits activity of protected areas has been determined; the recreational capacity of territorial objects has been studied. The degree of forest landscapes has been revealed in specially protected natural territories. The findings allow predicting the future state of the natural resources of the Saratov region and can be taken into account when assessing their optimal use.

scholarly journals Diagnostic difficulties and possibilities of NF1-like syndromes in childhood

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eva Pinti ◽  
Krisztina Nemeth ◽  
Krisztina Staub ◽  
Anna Lengyel ◽  
Gyorgy Fekete ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Neurofibromatosis Type ◽  
Early Years ◽  
Diagnostic Efficiency ◽  
Clinical Criteria ◽  
Pathogenic Variants ◽  
Clinical Diagnostic ◽  
Long Time ◽  
Diagnostic Difficulties ◽  
Clinical Diagnostic Criteria

Abstract Background Neurofibromatosis type 1 (NF1), which is caused by heterozygous inactivating pathogenic variants in the NF1, has poor phenotypic expressivity in the early years of life and there are numerous conditions, including many other tumor predisposition syndromes, that can mimic its appearance. These are collectively termed NF1-like syndromes and are also connected by their genetic background. Therefore, the NF1’s clinical diagnostic efficiency in childhood could be difficult and commonly should be completed with genetic testing. Methods To estimate the number of syndromes/conditions that could mimic NF1, we compiled them through an extensive search of the scientific literature. To test the utility of NF1’s National Institutes of Health (NIH) clinical diagnostic criteria, which have been in use for a long time, we analyzed the data of a 40-member pediatric cohort with symptoms of the NF1-like syndromes’ overlapping phenotype and performed NF1 genetic test, and established the average age when diagnostic suspicion arises. To facilitate timely identification, we compiled strongly suggestive phenotypic features and anamnestic data. Results In our cohort the utility of NF1’s clinical diagnostic criteria were very limited (sensitivity: 80%, specificity: 30%). Only 53% of children with clinically diagnosed NF1 had a detectable NF1 pathogenic variation, whereas 40% of patients without fulfilled clinical criteria tested positive. The average age at first genetic counseling was 9 years, and 40% of children were referred after at least one tumor had already been diagnosed. These results highlight the need to improve NF1-like syndromes’ diagnostic efficiency in childhood. We collected the most extensive spectrum of NF1-like syndromes to help the physicians in differential diagnosis. We recommend the detailed, non-invasive clinical evaluation of patients before referring them to a clinical geneticist. Conclusions Early diagnosis of NF1-like syndromes can help to prevent severe complications by appropriate monitoring and management. We propose a potential screening, diagnostic and management strategy based on our findings and recent scientific knowledge.

scholarly journals PFKFB3: A Potential Key to Ocular Angiogenesis

2021 ◽  
Vol 9 ◽  
Author(s):  
Zi-Yi Zhou ◽  
Lin Wang ◽  
Yu-Sheng Wang ◽  
Guo-Rui Dou
Keyword(s):  
Cell Metabolism ◽  
Current Treatment ◽  
Potential Treatment ◽  
Ocular Angiogenesis ◽  
Pathological Angiogenesis ◽  
Novel Treatment ◽  
Promising Target ◽  
Long Time ◽  
New Evidence ◽  
Endothelial Cell Metabolism

The current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attention as a potential treatment by an increasing number of researchers. Emerging evidence has shown that regulation of endothelial glycolysis can influence vessel sprouting. This new evidence has raised the potential for novel treatment targets that have been overlooked for a long time. In this review, we discuss the process of endothelial glycolysis as a promising target and consider regulation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as treatment for ocular pathological angiogenesis.

Wybrane właściwości miodu szczególnie przydatne w kosmetologii

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Gabriela Dubiago ◽  
Anna Nowak ◽  
Adam Klimowicz
Keyword(s):  
Amino Acids ◽  
Antioxidant Activity ◽  
Apis Mellifera ◽  
Dry Matter ◽  
Gastrointestinal Diseases ◽  
Flower Nectar ◽  
Long Time ◽  
Therapeutic Properties ◽  
Main Components ◽  
Natural Honey

Honey is produced by bees (Apis mellifera) from flower nectar and insect secretions. Like other bee products it is used as an adjuvant for treatment of many diseases. It also finds its uses for producing cosmetics. The main components of honey include carbohydrates, which represent approximately 80% of the dry matter, and water. Monosaccharides, mainly fructose and glucose, constitute approximately 70% of the sugars, whilst the remaining saccharides are disaccharides and oligosaccharides. Moreover, honey consists vitamins, minerals, polyphenols, amino acids and enzymes. Beneficial effect of natural honey on human health has been known for a long time because of its biological and therapeutic properties. It is used to treat some cardiovascular and gastrointestinal diseases. Among the best-known properties of honey are its antibacterial, antifungal, antiviral and anti-inflammatory activities. Important is also its antioxidant activity, which could be useful for producing anti-aging cosmetics.

Thermodynamic Equilibrium Analysis of Rice Husk Pyrolysis

2008 ◽  
Author(s):  
Baofeng Zhao ◽  
Li Sun ◽  
Xiaodong Zhang ◽  
Lei Chen ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Rice Husk ◽  
Thermodynamic Equilibrium ◽  
Equilibrium Analysis ◽  
Biomass Pyrolysis ◽  
Long Time ◽  
Biomass Materials ◽  
Main Components ◽  
Energy Products ◽  
Increasing Temperature ◽  
Pyrolysis Of Biomass

Pyrolysis of biomass materials can implement the efficient conversion of biomass to gaseous, liquid and solid energy products. Compared with experimental research which needs massive apparatus and funds and also takes long time, the computer simulation of biomass pyrolysis is more convenient and flexible to achieve the main characteristics of the process. Simulation of thermodynamic equilibrium for the pyrolysis of rice husk was studied in this paper. Based on the minimization of Gibbs free energy, MATLAB was used to calculate thermodynamic equilibrium for the pyrolysis of rice husk in the temperatures ranges from 523 K to 1723 K at intervals of 100 K. The results showed that the contents of H2 and CO increased rapidly with the temperature from 723 K to 1223 K, while the contents of H2O, CH4, CO2 and C decreased sharply. When the temperature was higher than 1223 K, the yields of H2 and CO reached the maximum of 51 mol% and 48 mol% respectively, and then kept stable. In order to be closer to experimental results, the constrain conditions of element C in tar was introduced in the calculations. The results indicated that, in the main components of tar from 523 K to 1223 K, the contents of naphthalene and toluene both decreased and then toluene vanished gradually. However, the content of benzene increased with increasing temperature and finally became the dominant product when the temperature was above 1300 K.

Scaffold Proteins and their Roles in Human Diseases

2020 ◽  
Vol 14 (01) ◽  
pp. 15-29
Author(s):  
Somsubhro Mukherjee ◽  
Boon Chuan Low
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Drug Targets ◽  
Metabolic Diseases ◽  
Scaffold Proteins ◽  
Human Diseases ◽  
Normal Functions ◽  
Cellular Pathways ◽  
Cell Signaling Pathways

Scaffold proteins are critical regulators of important cell signaling pathways. Though scaffolds are not stringently defined in meaning, they are known to interact with numerous components of a signaling pathway, binding and bridging them into distinct and functional complexes. They control signal transduction and assist the localization of pathway components (organized in complexes) to definite regions of the cell such as the endosomes, plasma membrane, the cytoplasm, mitochondria, Golgi, and the nucleus. Years of research in this field have revealed the versatility of this class of protein and the important role it plays in maintaining the normal functions of the human body. Here, we discuss the role of several scaffold proteins which are implicated in important signaling pathways that play important roles in cardiac diseases, metabolic diseases, neurological disorders, and cancer. Their versatility and functions in human diseases make them attractive drug targets, several of which have been investigated in clinical trials. Future studies of scaffold proteins should give us an in-depth knowledge of how cell signaling works in normal and pathological conditions and would offer avenues to disrupt harmful cellular pathways to circumvent diseases.

THEORETICAL FOUNDATIONS AND METHODOLOGICAL SCHEME FOR THE ASSESSMENT OF INDIVIDUAL EDUCATIONAL RESULTS OF STUDENTS IN THE PROCESS OF ADDITIONAL EDUCATION

2019 ◽  
Vol 10 (6/2) ◽  
pp. 75-80
Author(s):  
Svetlana S. IGNATOVICH ◽  
Vladlen K. IGNATOVICH
Keyword(s):  
Structural Elements ◽  
Adequate Understanding ◽  
Joint Solution ◽  
The Subject ◽  
Main Components ◽  
The Individual ◽  
Additional Education ◽  
Theoretical Foundations ◽  
Creative Tasks

The article is devoted to the problem of assessing the individual educational results of students in the process of additional education. This assessment in the concept of the authors is considered as the most important condition for the independent progress of the student along the individual educational trajectory. In this case, the student is the subject of its design. A model for assessing the individual educational results of students in the format of an educational event is proposed. The basic principle is formulated, which consists in fixing activity manifestations in a given situation, which testify to the student's ability to independently solve a creative task. These manifestations include: adequate understanding of the meaning of the problem being solved, competent determination of means and methods for solving it, competent access to various resources, and implementation of productive communications, ability to present and defend the solutions obtained. It is shown that the main components of such an educational event should be: joint solution of original creative tasks by students, expert-analytical support of this activity and free creative communication of different participants. A methodological scheme for the preparation and conduct of such an educational event is described. Its structural elements are: a preliminary analysis of data monitoring the development of students' creative activities; development and testing of a package of creative tasks; preparing a team of experts and equipping it with the necessary tools; development of the Festival program using a variety of creative communication formats of the participants; organization of information and analytical support of the Festival. Recommendations on the preparation of local working spaces for various types of activities of the Festival participants are given.

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