scholarly journals Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores

2021 ◽  
Vol 22 (23) ◽  
pp. 12884
Author(s):  
Svetlana Batasheva ◽  
Rawil Fakhrullin
Keyword(s):  
Material Science ◽  
Biomedical Applications ◽  
Review Paper ◽  
Dna Nanotechnology ◽  
Fire Retardant ◽  
Raw Material ◽  
Antimicrobial Coatings ◽  
Sequence Recognition ◽  
Structural Dna Nanotechnology ◽  
Biocompatible Coatings

Biomedical applications of DNA are diverse but are usually associated with specific recognition of target nucleotide sequences or proteins and with gene delivery for therapeutic or biotechnological purposes. However, other aspects of DNA functionalities, like its nontoxicity, biodegradability, polyelectrolyte nature, stability, thermo-responsivity and charge transfer ability that are rather independent of its sequence, have recently become highly appreciated in material science and biomedicine. Whereas the latest achievements in structural DNA nanotechnology associated with DNA sequence recognition and Watson–Crick base pairing between complementary nucleotides are regularly reviewed, the recent uses of DNA as a raw material in biomedicine have not been summarized. This review paper describes the main biomedical applications of DNA that do not involve any synthesis or extraction of oligo- or polynucleotides with specified sequences. These sequence-independent applications currently include some types of drug delivery systems, biocompatible coatings, fire retardant and antimicrobial coatings and biosensors. The reinforcement of DNA properties by DNA complexation with nanoparticles is also described as a field of further research.

scholarly journals Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 429
Author(s):  
Radu Claudiu Fierascu ◽  
Irina Fierascu ◽  
Irina Elena Chican
Keyword(s):  
Cultural Heritage ◽  
Biomedical Applications ◽  
Review Paper ◽  
Composite Coatings ◽  
Critical Discussion ◽  
Functional Coatings ◽  
Coating Materials ◽  
Antimicrobial Coatings ◽  
Future Challenges ◽  
New Challenges

In recent decades, coating materials have gained researchers’ interest, finding applications in different areas such as antimicrobial coatings for biomedical applications, coatings for increasing the shelf-life of commercial products, or coatings for the conservation of cultural heritage artifacts. The use of new types of coating materials based on natural ingredients can lead to the removal of harmful chemicals and contribute to the development of materials having different and promising properties. New challenges can appear both in the production process, as well as in the case of final application, when coating materials must be applied on various supports. The present review paper aims to be a critical discussion regarding the possibility of using natural ingredients as functional coatings, and to prove that the same material can be used in different fields, from the biomedical to environmental, or from cultural heritage protection to the food and cosmetic industries. The paper is based on the newest published studies, and its main goal is to be an inspiration source for researchers, in order to create more functional and applicable composite coatings in specific fields.

Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research

2018 ◽  
Vol 20 (1) ◽  
pp. 375-401 ◽  
Author(s):  
Yonggang Ke ◽  
Carlos Castro ◽  
Jong Hyun Choi
Keyword(s):  
Biomedical Research ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Dna Nanotechnology ◽  
Dna Nanostructures ◽  
Considerable Effort ◽  
Artificial Nanostructures ◽  
Active Pursuit ◽  
External Stimuli ◽  
Structural Dna Nanotechnology

Structural DNA nanotechnology utilizes synthetic or biologic DNA as designer molecules for the self-assembly of artificial nanostructures. The field is founded upon the specific interactions between DNA molecules, known as Watson–Crick base pairing. After decades of active pursuit, DNA has demonstrated unprecedented versatility in constructing artificial nanostructures with significant complexity and programmability. The nanostructures could be either static, with well-controlled physicochemical properties, or dynamic, with the ability to reconfigure upon external stimuli. Researchers have devoted considerable effort to exploring the usability of DNA nanostructures in biomedical research. We review the basic design methods for fabricating both static and dynamic DNA nanostructures, along with their biomedical applications in fields such as biosensing, bioimaging, and drug delivery.

scholarly journals Strategies to Build Hybrid Protein–DNA Nanostructures

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1332
Author(s):  
Armando Hernandez-Garcia
Keyword(s):  
Dynamic Systems ◽  
Dna Nanotechnology ◽  
Chemical Properties ◽  
Hybrid Nanostructures ◽  
Advanced Materials ◽  
Dna Nanostructures ◽  
Hybrid Protein ◽  
Structural Protein ◽  
The Individual ◽  
Structural Dna Nanotechnology

Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale. This review focuses on the strategies deployed to create hybrid protein–DNA nanostructures. Here, we discuss strategies such as polymerization, spatial directing and organizing, coating, and rigidizing or folding DNA into particular shapes or moving parts. The enrichment of structural DNA nanotechnology by incorporating protein nanotechnology has been clearly demonstrated and still shows a large potential to create useful and advanced materials with cell-like properties or dynamic systems. It can be expected that structural protein–DNA nanotechnology will open new avenues in the fabrication of nanoassemblies with unique functional applications and enrich the toolbox of bionanotechnology.

scholarly journals Special Issue: Biointerface Coatings for Biomaterials and Biomedical Applications

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 423
Author(s):  
Hsien-Yeh Chen ◽  
Peng-Yuan Wang
Keyword(s):  
Surface Properties ◽  
Material Science ◽  
Biomedical Applications ◽  
Material Surface ◽  
Special Issue

The success of recent material science and applications in biotechnologies should be credited to developments of malleable surface properties, as well as the adaptation of conjugation reactions to the material surface [...]

scholarly journals Hybrid Nanoassemblies from Viruses and DNA Nanostructures

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1413
Author(s):  
Sofia Ojasalo ◽  
Petteri Piskunen ◽  
Boxuan Shen ◽  
Mauri A. Kostiainen ◽  
Veikko Linko
Keyword(s):  
Cell Activation ◽  
Immune Cell ◽  
Dna Nanotechnology ◽  
Biological Properties ◽  
Dna Nanostructures ◽  
Dna Structures ◽  
Nanoscale Structures ◽  
Immune Cell Activation ◽  
Wide Range ◽  
Structural Dna Nanotechnology

Viruses are among the most intriguing nanostructures found in nature. Their atomically precise shapes and unique biological properties, especially in protecting and transferring genetic information, have enabled a plethora of biomedical applications. On the other hand, structural DNA nanotechnology has recently emerged as a highly useful tool to create programmable nanoscale structures. They can be extended to user defined devices to exhibit a wide range of static, as well as dynamic functions. In this review, we feature the recent development of virus-DNA hybrid materials. Such structures exhibit the best features of both worlds by combining the biological properties of viruses with the highly controlled assembly properties of DNA. We present how the DNA shapes can act as “structured” genomic material and direct the formation of virus capsid proteins or be encapsulated inside symmetrical capsids. Tobacco mosaic virus-DNA hybrids are discussed as the examples of dynamic systems and directed formation of conjugates. Finally, we highlight virus-mimicking approaches based on lipid- and protein-coated DNA structures that may elicit enhanced stability, immunocompatibility and delivery properties. This development also paves the way for DNA-based vaccines as the programmable nano-objects can be used for controlling immune cell activation.

scholarly journals Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Udisha Singh ◽  
Vinod Morya ◽  
Bhaskar Datta ◽  
Chinmay Ghoroi ◽  
Dhiraj Bhatia
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Dna Nanotechnology ◽  
Research Area ◽  
Biological Applications ◽  
Stimuli Responsive ◽  
Future Prospects ◽  
Dna Structures ◽  
Challenges And Opportunities

Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multiples areas to explore for basic and applied science using dynamic DNA nanotechnology. Herein, we take the stake in the recent progress of this fast-growing sub-area of DNA nanotechnology. We discuss different stimuli, motifs, scaffolds, and mechanisms of stimuli-responsive behaviours of DNA nanodevices with appropriate examples. Similarly, we present a multitude of biological applications that have been explored using DNA nanodevices, such as biosensing, in vivo pH-mapping, drug delivery, and therapy. We conclude by discussing the challenges and opportunities as well as future prospects of this emerging research area within DNA nanotechnology.

scholarly journals The Helicity of a DNA-2’-Fluoro DNA Hybrid Duplex Structure

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Double Helix ◽  
Dna Nanotechnology ◽  
Helical Structure ◽  
Hydrogen Atoms ◽  
Atomic Force ◽  
Hybrid Duplex ◽  
Dna Backbone ◽  
Helical Turn ◽  
Dna 2 ◽  
Structural Dna Nanotechnology

Structural DNA nanotechnology is a system whereby branched DNA molecules are fashioned into objects, or 1D, 2D and 3D lattices, as well as nanomechanical devices. Normally, one is dealing with the usual B-form DNA molecule, but variations on this theme can lead to alterations in both the structures and the properties of the constructs. 2’-Fluoro DNA (FDNA), wherein one of the hydrogen atoms of the 2’ carbon is replaced by a fluorine atom, is a minimal steric perturbation on the structure of the DNA backbone. The helical structure of this duplex is of great interest for applications in structural DNA nanotechnology, because the DNA-FDNA hybrid assumes an A-form double helix, without the instabilities associated with RNA. Here we have used an atomic force microscopic method to estimate the helicity of DNA-FDNA hybrids, and we find that the structure contains 11.8 nucleotide pairs per helical turn with an error of ± 0.6 nucleotide pairs, similar to other A-form molecules.

scholarly journals Synthesis and Biological Application of Polylactic Acid

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5023
Author(s):  
Ge Li ◽  
Menghui Zhao ◽  
Fei Xu ◽  
Bo Yang ◽  
Xiangyu Li ◽  
...  
Keyword(s):  
Physical Properties ◽  
Polylactic Acid ◽  
Biomedical Applications ◽  
Raw Materials ◽  
Raw Material ◽  
Biomedical Materials ◽  
Biomedical Material ◽  
Sugar Fermentation ◽  
Low Toxicity ◽  
Good Biocompatibility

Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.

Nanocomposite Layers Obtained by Electro-Co-Deposition: Corrosion and Tribocorrosion Properties

2015 ◽  
Vol 227 ◽  
pp. 243-246 ◽  
Author(s):  
Lidia Benea
Keyword(s):  
Biomedical Applications ◽  
Industrial Applications ◽  
Hybrid Coatings ◽  
Nanostructured Surfaces ◽  
Micro Particles ◽  
Nickel Electroplating ◽  
Dispersed Phases ◽  
Electroplating Process ◽  
Ultra High Molecular Weight ◽  
Biocompatible Coatings

High dispersed nano and micro particles as ceramics (SiC, TiC, WC, Al2O3), polymers (UHMWPE) or bioceramics (TiO2, CeO2, ZrO2) have been deposited by electrochemical method with nichel or cobalt on metallic substrate to obtain novel structured composites, cermet or hybrid coatings with specific properties to be used in industrial or biomedical applications. The industrial applications for metal matrix based nanocomposites are increasing and open a way to biocompatible coatings. electrodeposition is considered to be one of the most important techniques for producing nanocomposites and nanostructured surfaces. Electrodeposition is exceptionally versatile, so that new and exciting applications are still being invented. The paper presents some results regarding the electro-co-deposition of dispersed phases as ZrO2, CeO2, SiC, WC, TiC or polymeric dispersed phases as UHMWPE (ultra high molecular weight polyethylene) during cobalt or nickel electroplating process in view of obtaining new advanced functional surfaces with improved properties to corrosion or tribocorrosion systems.

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