Neuropathic Pain in Hand Osteoarthritis: A Cross-Sectional Study

Symptomatic hand osteoarthritis (OA) is a severely debilitating condition. Neuropathic pain (NP) has been shown to be a factor affecting pain severity, hand function, psychological wellbeing, body schema, and the number of pain medications in people with OA of other joints. The aim of this study was to assess the prevalence of NP in symptomatic hand OA and assess its association with pain, hand function, measures of psychological wellbeing, sleep, body schema disturbances, and number of pain medications. Participants with symptomatic hand OA diagnosed through the American College of Rheumatology criteria, were recruited and completed a series of online questionnaires. These included the Douleur Neuropathique 4 interview (DN4-interview), Short Form Brief Pain Inventory (SF-BPI), Neglect-like Symptoms questionnaire, Functional Index of Hand Osteoarthritis (FIHOA), Centre for Epidemiologic Studies Depression Scale (CES-D), Pain Catastrophising Scale (PCS), and the Pittsburgh Sleep Quality Index (PSQI). Logistic regression with age, body mass index, and sex as covariates were utilised to assess differences between participants with and without NP as identified through the DN4-interview. Correlation analysis assessed the relationship between pain intensity, body schema alterations, and number of pain medications. A total of 121 participants were included in the present study. Forty-two percent of participants presented with NP. Participants with NP reported higher levels of worst pain (OR: 10.2 95% CI: 2.2 to 48.5; p = 0.007). Worst pain intensity correlated with the number of pain medications (rho = 0.2; p = 0.04), and neglect-like symptoms (rho = 0.4; p < 0.0001). No difference between phenotypes was shown for catastrophising, function, depression, neglect-like symptoms, pain interference, or sleep. A large proportion of people with symptomatic hand OA present with NP. This phenotype is characterised by greater levels of pain intensity. Pain intensity is associated with number of pain relief medications and body schema alteration. Psychological factors, hand function, and sleep do not appear to be affected by the presence of NP.

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Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients: Results of a Multicenter Survey

Anesthesiology Research and Practice ◽

10.1155/2009/827290 ◽

2009 ◽

Vol 2009 ◽

pp. 1-9 ◽

Cited By ~ 16

Author(s):

Janet Weber ◽

Marcus Schley ◽

Matthias Casutt ◽

Helmut Gerber ◽

Guido Schuepfer ◽

...

Keyword(s):

Neuropathic Pain ◽

Side Effects ◽

Pain Intensity ◽

Rating Scale ◽

Short Form ◽

Therapeutic Option ◽

Depression Scale ◽

Numeric Rating Scale ◽

Central Neuropathic Pain ◽

Multicenter Survey

Central neuropathic pain is difficult to treat, but delta 9-Tetrahydrocannabinol (delta 9-THC) may be a promising therapeutic agent. We administered in 172 patients on average 7.5 mg delta 9-THC over 7 months. Of these, 48 patients prematurely withdrew due to side effects, insufficient analgesia, or expense of therapy. Thus, 124 patients were assessed retrospectively in a multicenter telephone survey. Reported changes in pain intensity, recorded on a numeric rating scale (NRS), Pain Disability Index (PDI), Medical Outcomes Short-Form (SF-12), Quality of Life Impairment by Pain (QLIP), Hospital Anxiety Depression Scale (HADS), and amount of concomitant pain medication were recorded. Psychometric parameters (PDI, SF-12, QLIP, HADS) and pain intensity improved significantly during delta 9-THC treatment. Opioid doses were reduced and patients perceived THC therapy as effective with tolerable side effects. About 25% of the patients, however, did not tolerate the treatment. Therapy success and tolerance can be assessed by a transient delta 9-THC titration and its maintained administration for several weeks. The present survey demonstrates its ameliorating potential for the treatment of chronic pain in central neuropathy and fibromyalgia. A supplemental delta 9-THC treatment as part of a broader pain management plan therefore may represent a promising coanalgesic therapeutic option.

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Do Comorbidities Play a Role in Hand Osteoarthritis Disease Burden? Data from the Hand Osteoarthritis in Secondary Care Cohort

The Journal of Rheumatology ◽

10.3899/jrheum.170208 ◽

2017 ◽

Vol 44 (11) ◽

pp. 1659-1666 ◽

Cited By ~ 16

Author(s):

Wendy Damman ◽

Rani Liu ◽

Féline P.B. Kroon ◽

Monique Reijnierse ◽

Tom W.J. Huizinga ◽

...

Keyword(s):

Secondary Care ◽

Disease Burden ◽

Short Form ◽

Hand Function ◽

Tender Joint Count ◽

Hand Osteoarthritis ◽

Tender Joint ◽

Cross Sectional ◽

American College Of Rheumatology ◽

Mean Differences

Objective.Because the association and its clinical relevance between comorbidities and primary hand osteoarthritis (OA) disease burden is unclear, we studied this in patients with hand OA from our Hand OSTeoArthritis in Secondary care (HOSTAS) cohort.Methods.Cross-sectional data from the HOSTAS study were used, including consecutive patients with primary hand OA. Nineteen comorbidities were assessed: 18 self-reported (modified Charlson index and osteoporosis) and obesity (body mass index ≥ 30 kg/m2). Mean differences were estimated between patients with versus without comorbidities, adjusted for age and sex: for general disease burden [health-related quality of life (HRQOL), Medical Outcomes Study Short Form-36 physical component scale (0–100)] and disease-specific burden [self-reported hand function (0–36), pain (0–20; Australian/Canadian Hand OA Index), and tender joint count (TJC, 0–30)]. Differences above a minimal clinically important improvement/difference were considered clinically relevant.Results.The study included 538 patients (mean age 61 yrs, 86% women, 88% fulfilled American College of Rheumatology classification criteria). Mean (SD) HRQOL, function, pain, and TJC were 44.7 (8), 15.6 (9), 9.3 (4), and 4.8 (5), respectively. Any comorbidity was present in 54% (287/531) of patients and this was unfavorable [adjusted mean difference presence/absence any comorbidity (95% CI): HRQOL −4.4 (−5.8 to −3.0), function 1.9 (0.4–3.3), pain 1.4 (0.6–2.1), TJC 1.3 (0.4–2.2)]. Number of comorbidities and both musculoskeletal (e.g., connective tissue disease) and nonmusculoskeletal comorbidities (e.g., pulmonary and cardiovascular disease) were associated with disease burden. Associations with HRQOL and function were clinically relevant.Conclusion.Comorbidities showed clinically relevant associations with disease burden. Therefore, the role of comorbidities in hand OA should be considered when interpreting disease outcomes and in patient management.

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Evaluation of Malnutrition and Depression in Elderly People: An Epidemiological Study in Turkey

European Journal of Public Health ◽

10.1093/eurpub/ckz187.033 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

S Aydoğan ◽

A Ünsal ◽

D Arslantaş

Keyword(s):

Health Care Providers ◽

Nutritional Assessment ◽

Short Form ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Mini Nutritional Assessment ◽

The Elderly ◽

Cluster Sampling ◽

Care Providers ◽

Cross Sectional

Abstract Background Malnutrition is an important cause of morbidity and mortality. Malnutrition increases the number of hospitalizations and prolongs the length of hospitalization by disrupting organ functions, increasing the number and severity of infections and delaying wound healing. The aim of this study was to determine the frequency of suspected malnutrition in the elderly, to examine some related variables and to evaluate the depression. Methods The study is a cross-sectional study conducted between March-April 2019 in individuals aged 60 years and older living in Sivrihisar. Sample size was calculated as 579. Cluster sampling method used. Data was collected by door to door in 4 neighborhoods determined by randomly. Mini Nutritional Assessment Test-Short Form (for malnutrition), Katz Daily Living Activities Scale (for dependency) and Geriatric Depression Scale-Short Form (for depression) were used. Chi-square test, Mann Whitney U test and logistic regression analysis were used for the analyzes. Results The study group consisted of 220 (38%) women and 359 (62%) men. The mean age was 68.9±6.4 (ranged 60-93). Frequency of suspected malnutrition was 25% (n = 145). Being 80 years of age or older (OR:3.24, CI:1.53-6.85), having a primary and lower education level (OR:2.54, CI:1.32-4.90), history of chronic illness (OR:2.34, CI:1.33-4.03), using dentures (OR:1.62, CI:1.03-2.55) and suspected depression (OR:4.97, CI:3.17-7.78) are important risk factors for malnutrition. Those with suspicion of malnutrition had lower scores on DLA (z = 8.982;p=0.001). Conclusions Malnutrition was found to be an important health problem for the elderly. The frequency of suspected malnutrition is higher in individuals with depression. Those with suspected malnutrition have higher level of dependency. In order to reduce the frequency of malnutrition, it may be beneficial to increase the awareness of the elderly and caregivers and to give importance to the elderly nutrition of primary health care providers. Key messages Depression is an important risk factor for malnutrition. Malnutrition increases the dependence of the individual on daily activities.

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Pain Intensity and Pain Interference in Older Adults: Role of Gender, Obesity and High-Sensitivity C-Reactive Protein

Gerontology ◽

10.1159/000446651 ◽

2016 ◽

Vol 63 (1) ◽

pp. 3-12 ◽

Cited By ~ 16

Author(s):

Vahid Eslami ◽

Mindy J. Katz ◽

Robert S. White ◽

Erin Sundermann ◽

Julie M. Jiang ◽

...

Keyword(s):

Older Adults ◽

Pain Intensity ◽

Short Form ◽

High Sensitivity ◽

Pain Interference ◽

C Reactive Protein ◽

Medical Outcomes ◽

Cross Sectional ◽

Reactive Protein ◽

Aging Study

Background: Among older adults, pain intensity and pain interference are more common in women than men and associated with obesity and inflammatory markers. Objective: We examined whether the obesity and pain relationship is mediated by the high-sensitivity C-reactive protein (hsCRP), a nonspecific marker of systemic inflammation, and whether this relationship differs by sex. Methods: Items from Medical Outcomes Study Short Form-36 were used to measure pain intensity and pain interference in daily life. Ordinal logistic regression was used to assess the cross-sectional association among body mass index (BMI), hsCRP levels, pain intensity and pain interference using gender-stratified models adjusted for demographic variables. Results: Participants included 667 community-residing adults over the age of 70 years, free of dementia, enrolled in the Einstein Aging Study (EAS). In women (n = 410), pain intensity was associated with obesity [BMI ≥30 vs. normal, odds ratio (OR) = 2.29, 95% confidence interval (CI) 1.43-3.68] and higher hsCRP (OR = 1.28, 95% CI 1.08-1.51). In a model with obesity and hsCRP, both remained significant, but the association between hsCRP and pain intensity was somewhat attenuated. Obesity (OR = 3.04, 95% CI 1.81-5.11) and higher hsCRP levels (OR = 1.30, 95% CI 1.08-1.56) were also independently associated with greater pain interference in women. After adjustment for pain intensity and BMI, hsCRP was no longer associated with pain interference in women. Greater pain intensity and being overweight or obese continued to be significantly associated with pain interference in women. In men (n = 257), obesity and hsCRP were not associated with pain intensity or pain interference. Conclusions: In women, the relationship between obesity and higher levels of pain intensity or interference may be accounted for by factors related to hsCRP.

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Study Of Depression in Elderly: Prevalence and Factors Associated

Journal of Psychiatrists Association of Nepal ◽

10.3126/jpan.v7i2.24609 ◽

2018 ◽

Vol 7 (2) ◽

pp. 16-23

Author(s):

S. Subedi ◽

P. Shrestha ◽

D.K. Thapa

Keyword(s):

Elderly People ◽

Short Form ◽

Demographic Data ◽

Community Sample ◽

Depression Scale ◽

Structured Interview ◽

Mild Depression ◽

Cross Sectional ◽

Factors Associated ◽

Prevalence Of Depression

Introduction: Ageing is a normal phenomenon. Various studies shows that there is a sharp rise in the elderly population in the last few years. Prevalence of depression in elderly is found to around 13% in the community sample in various countries. There is a dearth of study related to psychiatric illness in elderly in Nepal. This study was aimed to find the prevalence of depression in elderly and see for various factors associated with elderly depression. Material And Method: This was a cross-sectional study conducted at Siddharthnagar Municipality, Bhairahawa, Rupandehi. 316 elderly were selected by using systematic random sampling technique. A Semi- structured interview schedule was developed to collect Socio-demographic data. The Short Form Geriatric Depression Scale (SF-GDS) was used to find out the prevalence of depression among elderly people. Ethical Approval was obtained from the Institutional Review Committee, Chitwan Medical College and permission was obtained from Siddharthnagar Municipality, Bhairahawa, Rupandehi. The collected data was entered in Epidata 3.1 and the data was exported and analyzed in IBM SPSS 20. Results: There were a total of 316 samples in this study. The mean age of respondents was 68.47 years of age. Majority of the respondents (54.1%) were female and living in joint Family (72.2%). Almost 45.9% respondents were from upper caste groups, 90.5% of respondents were Hindus. Among the married (100%) respondents, 54.6% of respondents were living with spouse and 3.2% were divorced and separated from spouse. Depression was present in 49.4% of respondents were depressed. Among depressed respondents, 46.7% of respondents were having mild depression, 39.2% moderate depression and 14.1% severe depression. Conclusion: The finding of this study concluded that depression among elderly people was a substantial problem in Siddharthnagar Municipality, Bhairahawa, Rupandehi.

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The Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF): a validation study in Iranian mothers

BMC Research Notes ◽

10.1186/s13104-019-4656-7 ◽

2019 ◽

Vol 12 (1) ◽

Cited By ~ 1

Author(s):

Payam Amini ◽

Reza Omani-Samani ◽

Mahdi Sepidarkish ◽

Amir Almasi-Hashiani ◽

Mostafa Hosseini ◽

...

Keyword(s):

Self Efficacy ◽

Short Form ◽

Depression Scale ◽

Reliability And Validity ◽

Significant Negative Correlation ◽

Cross Sectional Study ◽

Cross Sectional ◽

Persian Version ◽

Registration Number ◽

Valid Instrument

Abstract Objective The Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) is a widely used instrument that measures breastfeeding self-efficacy. This study aimed to examine the reliability and validity of the Persian version of BSES-SF in Iranian mothers. Results The English version of BSES-SF was translated into Persian using the standard forward–backward translation procedure. No changes (i.e., neither delete nor rephrase the items) were made to the BSES-SF items. The mean BSES-SF total score was 50.80 ± 8.91. The Cronbach’s alpha coefficient for internal consistency for the BSES-SF was 0.910. The confirmatory factor analysis results provided evidence for unidimensionality of the scale (χ2/df = 4.42; CFI = 0.96; NFI = 0.95; IFI = 0.96; RMSEA = 0.095 and SRMR = 0.054). The divergent validity of the BSES-SF was proved via a significant negative correlation with scores of the Edinburgh Postnatal Depression Scale (r = − 0.273, P < 0.001). In sum, the Persian version of the BSES-SF is a reliable and valid instrument for measuring breastfeeding self-efficacy in Iranian mothers. Trial registration number This was a cross-sectional study (not clinical trial).

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Coping Strategies and Health-Related Quality of Life in Pregnant Women with SARS-CoV-2 Infection

Medicina ◽

10.3390/medicina57101113 ◽

2021 ◽

Vol 57 (10) ◽

pp. 1113

Author(s):

Madalina Timircan ◽

Felix Bratosin ◽

Iulia Vidican ◽

Oana Suciu ◽

Mirela Turaiche ◽

...

Keyword(s):

Quality Of Life ◽

Pregnant Women ◽

Rural Areas ◽

Short Form ◽

Depression Scale ◽

Morbidity Rate ◽

Cross Sectional ◽

Mortality And Morbidity ◽

Physical Burden

Background and Objectives: As maternal deaths associated with the SARS-CoV-2 infection remain at several times greater than the general population, significant factors that might contribute to the higher mortality and morbidity rate are the psychological impact of the disease and pregnancy itself. Therefore, the current study’s main objective was to assess how pregnant women react and cope with the stress of COVID-19 disease and how it influences their overall health and quality of life in healthcare facilities. Materials and Methods: In this cross-sectional study, we included 304 pregnant women who successfully completed standardized forms to assess our topics of interest, comprising of the Hospital Anxiety and Depression Scale, the Short Form Health Survey-12, the Coping Orientation to Problems Experienced Inventory scale, the CORE-Outcome Measure Questionnaire, and the Quality from the Patient’s Perspective questionnaire. Results: Unemployed, pregnant women living in poverty in the rural areas had higher SARS-CoV-2 infection rates during pregnancy. They faced higher anxiety levels and depression rates, with associated increased physical burden and exhaustion. However, these findings are not influenced by hospital care since it remained unchanged among COVID-19 and non-COVID-19 maternity units, excepting significantly lower technical competence scores of COVID-19 facilities. Conclusions: As the pandemic’s consequences emerge and additional outbreaks occur, care must prioritize the additional physical burden experienced by pregnant women who have contracted COVID-19, as well as psychological, emotional, and mental health support.

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Assessment and determinants of aesthetic discomfort in hand osteoarthritis

Annals of the Rheumatic Diseases ◽

10.1136/ard.2011.153965 ◽

2011 ◽

Vol 71 (1) ◽

pp. 45-49 ◽

Cited By ~ 20

Author(s):

Bridget Hodkinson ◽

Emmanuel Maheu ◽

Mathilde Michon ◽

Fabrice Carrat ◽

Francis Berenbaum

Keyword(s):

Short Form ◽

Depression Scale ◽

Female Gender ◽

Hand Osteoarthritis ◽

Tender Joint ◽

Erosive Osteoarthritis ◽

Erosive Disease ◽

Factors Associated ◽

Pain Scores ◽

Number Of Patients

BackgroundDissatisfaction with hand appearance is frequently the presenting complaint of patients with hand osteoarthritis (HOA), yet no tool exists for its measurement and few studies have examined aesthetic discomfort.ObjectivesThe aims of this study were to measure the extent and to explore the associations of aesthetic concerns in HOA.Methods172 patients with HOA were assessed with tender joint and node count, global and pain scores, Functional Index for Hand Osteoarthritis, Short Form-12, Hospital Anxiety and Depression Scale and posterior–anterior hand radiographs. Patients scored the aesthetic impact of the disease on a Visual Analogue Scale of 0–100 mm and were classified into low, intermediate and high aesthetic concern (HAC) based on this score.ResultsOf 172 patients (155 women), the majority (92%) had nodes and 46% had erosive disease. The mean aesthetic score was 44.8 mm (SD 35.9), and 59 (34.3%) patients scored their aesthetic discomfort ≥66 mm. Factors associated with HAC were female gender, a high number of tender joints and nodes, high global and pain scores, high radiological damage scores, the presence of erosions and high depression and anxiety levels. The multivariate analysis identified two independent factors associated with HAC: patient's global assessment (p=0.0005) and radiographic erosions (p=0.03).ConclusionsAesthetic discomfort is a major concern for a significant number of patients with HOA, particularly women, those with a high burden of HOA disease and those with erosive osteoarthritis, and is also associated with depression, anxiety and poor health-related quality of life.

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Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania

Medicina ◽

10.3390/medicina56110596 ◽

2020 ◽

Vol 56 (11) ◽

pp. 596

Author(s):

Greta Veličkaitė ◽

Neringa Jucevičiūtė ◽

Renata Balnytė ◽

Ovidijus Laucius ◽

Antanas Vaitkus

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Neuropathic Pain ◽

Short Form ◽

Depression Scale ◽

Structured Interview ◽

Anxiety And Depression ◽

Control Group ◽

And Control

Background and objectives: Even though pain in multiple sclerosis (MS) patients is common and possibly associated with reduced quality of life, its exact prevalence and characteristics remain vaguely understood. We aimed to estimate the true extent of pain and its associations with quality of life in Lithuanian MS patients and to compare this data with that of a control group. Materials and Methods: Data were collected prospectively at the Department of Neurology, Lithuanian University of Health Sciences Kaunas Clinics. A face-to-face structured interview and a questionnaire were used to collect demographic and clinical data of the MS (n = 120) and control (n = 120) groups. The Expanded Disability Status Scale (EDSS) was used to quantify disability in the MS group. Scores ≥4/10 in the Douleur Neuropathique 4 questionnaire were classified as neuropathic pain. Patients were evaluated using the anxiety and depression subsets of the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), the physical and mental component subsets of the Short Form-12 questionnaire (PSC-12 and MSC-12). Results: The MS and control groups did not differ in pain prevalence (76.7% vs. 65.9%, p = 0.064) or intensity. Lhermitte sign, lower limb, and face pain were more common in the MS group, whereas subjects in the control group were more often affected by lower back, neck, and joint pain. Neuropathic pain and pain lasting longer than 2 years were more common among pain-affected MS patients than among controls. MS patients with pain had higher EDSS, HADS-D, and HADS-A and lower PSC-12 scores than those without pain; however, no difference was found regarding the duration of MS or age. Males with MS and pain had higher MSC-12 and HADS-D scores in comparison to the same subset of females. Conclusions: Pain affects approximately three out of four patients with MS in Lithuania and is negatively associated with the mental and physical aspects of quality of life.

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Association of shift work with depression and anxiety in middle-aged adults: a large cross-sectional study among Iranian industrial manufacturing employees

Journal of Public Mental Health ◽

10.1108/jpmh-12-2019-0103 ◽

2020 ◽

Vol 19 (4) ◽

pp. 291-300

Author(s):

Zeinab Alizadeh ◽

Hamidreza Roohafza ◽

Awat Feizi ◽

Nizal Sarrafzadegan

Keyword(s):

Mental Health ◽

Shift Work ◽

Short Form ◽

Depression Scale ◽

Cross Sectional Study ◽

Depression And Anxiety ◽

Sectional Study ◽

Steel Company ◽

Cross Sectional ◽

Content Type

Purpose This study aimed to examine the association of shift work with depression and anxiety in a large sample of formal and contractual employees of a mill steel company, Isfahan, Iran. Design/methodology/approach This cross-sectional study was performed in 2014 among 3,060 formal and contractual employees of a mill steel company Isfahan, Iran, randomly selected from 16,000 people. Data gathering was done by some validated Iranian version of self-administered questionnaires including, International Physical Activity – Short Form, Effort–Reward Imbalance, Hospital Anxiety and Depression Scale. Logistic regression was used as the main statistical method. Findings The results showed individuals in the rotating shift compared with day shift had a higher risk of depression (OR: 1.43; 95% CI: 1.12–1.84). Whereas after adjustment for various confounders, this relationship was not significant (OR: 1.19; 95% CI: 0.81–1.76). Anxiety was not associated with shift work, both in crude and adjusted models (OR: 1.08; 95% CI: 0.81–1.44) and (OR: 0.90; 95% CI: 0.67–1.19), respectively. Research limitations/implications Owing to the cross-sectional design of this study, cause–effect relationships could not be inferred from our findings. All the data used in the present analysis were collected by self-administered questionnaires. Practical implications Although our findings did not show significant association between shift work and mental health, further studies are suggested for obtaining informative data worldwide in this regard among workforce particularly among industrial employees. Originality/value Few studies have addressed the effects of shift work on mental health among industrial employees worldwide, and there is no study in developing countries.

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