scholarly journals A Narrative Review of u-HA/PLLA, a Bioactive Resorbable Reconstruction Material: Applications in Oral and Maxillofacial Surgery

Materials ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 150
Author(s):  
Huy Xuan Ngo ◽  
Yunpeng Bai ◽  
Jingjing Sha ◽  
Shinji Ishizuka ◽  
Erina Toda ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Maxillofacial Surgery ◽  
Narrative Review ◽  
In Vivo Studies ◽  
Oral And Maxillofacial Surgery ◽  
Bone Reconstruction ◽  
New Era ◽  
Dental Applications

The advent of bioresorbable materials to overcome limitations and replace traditional bone-reconstruction titanium-plate systems for bone fixation, thus achieving greater efficiency and safety in medical and dental applications, has ushered in a new era in biomaterial development. Because of its bioactive osteoconductive ability and biocompatibility, the forged composite of uncalcined/unsintered hydroxyapatite and poly L-lactic acid (u-HA/PLLA) has attracted considerable interest from researchers in bone tissue engineering, as well as from clinicians, particularly for applications in maxillofacial reconstructive surgery. Thus, various in vitro studies, in vivo studies, and clinical trials have been conducted to investigate the feasibility and weaknesses of this biomaterial in oral and maxillofacial surgery. Various technical improvements have been proposed to optimize its advantages and limit its disadvantages. This narrative review presents an up-to-date, comprehensive review of u-HA/PLLA, a bioactive osteoconductive and bioresorbable bone-reconstruction and -fixation material, in the context of oral and maxillofacial surgery, notably maxillofacial trauma, orthognathic surgery, and maxillofacial reconstruction. It simultaneously introduces new trends in the development of bioresorbable materials that could used in this field. Various studies have shown the superiority of u-HA/PLLA, a third-generation bioresorbable biomaterial with high mechanical strength, biocompatibility, and bioactive osteoconductivity, compared to other bioresorbable materials. Future developments may focus on controlling its bioactivity and biodegradation rate and enhancing its mechanical strength.

scholarly journals CoCrMo alloy as biomaterial for bone reconstruction in oral and maxillofacial surgery: A scoping review.

2020 ◽  
Vol 9 (4) ◽  
pp. 336-349
Author(s):  
Jésica Zuchuat ◽  
◽  
Andrea Cura ◽  
Adriana Manzano ◽  
Oscar Decco ◽  
...  
Keyword(s):  
Scoping Review ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Bone Reconstruction ◽  
Cocrmo Alloy ◽  
Thomson Reuters

Antecedentes: La osteointegración ha permitido un gran avance en biomateriales y técnicas, y ha contribuido un mayor uso de implantes dentales. Sin embargo, la existencia de un nivel óseo insuficiente es un problema frecuente y crea una base anatómicamente menos favorable para la colocación de implantes. El primer procedimiento quirúrgico debe comprender la reconstrucción de la altura del hueso alveolar. Las aleaciones de CoCrMo se consideran hoy en día como materiales altamente resistentes a la corrosión y biocompatibles en odontología y, por lo tanto, se ha sugerido como un biomaterial adecuado para la regeneración ósea guiada y la ingeniería de tejidos. Objetivo: Determinar el uso de la aleación CoCrMo para dispositivos implantables en cirugía oral y maxilofacial y discutir sobre el potencial de esta aleación para la regeneración y reparación ósea a través de una revisión de alcance. Material y Métodos: La búsqueda se realizó utilizando varias bases de datos, incluidas PubMed, Thomson Reuters y Scopus. Se seleccionó literatura inglesa relacionada con estudios que informan sobre las propiedades de CoCrMo y los procesos de fabricación y los hallazgos relacionados con las técnicas de formación de huesos. Los datos se compararon cualitativamente. Resultados: Se seleccionaron 90 estudios según los criterios de inclusión. y se reportaron diferentes técnicas de fabricación y sus ventajas relacionadas con propiedades mecánicas, químicas y biocompatibles. Conclusión: Las reacciones tisulares mejoradas de los dispositivos de implante CoCrMo pueden adquirirse mediante la aplicación de nuevas técnicas y modificaciones de la superficie. Además, varios procesos han demostrado mejorar la biocompatibilidad in vitro e in vivo de la aleación CoCrMo para promover la unión, proliferación y diferenciación guiada de las células de siembra.

scholarly journals Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3207
Author(s):  
Kumaresan Sakthiabirami ◽  
Vaiyapuri Soundharrajan ◽  
Jin-Ho Kang ◽  
Yunzhi Peter Yang ◽  
Sang-Won Park
Keyword(s):  
Bone Regeneration ◽  
Biological Activities ◽  
Three Dimensional ◽  
In Vivo Studies ◽  
High Mechanical Strength ◽  
Real World Applications ◽  
3D Fabrication ◽  
Dental Applications

The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological activities of zirconia-based ceramics for bone-regeneration applications have not been fully investigated, in contrast to the well-established calcium phosphate-based ceramics for bone-regeneration applications. This paper outlines recent research developments and challenges concerning numerous three-dimensional (3D) zirconia-based scaffolds and reviews the associated fundamental fabrication techniques, key 3D fabrication developments and practical encounters to identify the optimal 3D fabrication technique for obtaining 3D zirconia-based scaffolds suitable for real-world applications. This review mainly summarized the articles that focused on in vitro and in vivo studies along with the fundamental mechanical characterizations on the 3D zirconia-based scaffolds.

Alteration of Bone’s Nonlinear Elastic and Viscoelastic Nanomechanical Properties Is Triggered by Low Intensity Pulsed Ultrasound

2009 ◽  
Author(s):  
Suzanne Ferreri ◽  
Yi-Xian Qin
Keyword(s):  
Mechanical Strength ◽  
Material Properties ◽  
Signal Intensity ◽  
In Vivo Studies ◽  
Dynamic Mechanical ◽  
Mechanical Signals ◽  
Ultrasound Signal ◽  
Ultrasound Signals

Dynamic mechanotransduction, particularly under high frequency, low amplitude signals, has been proven effective in mediating bone loss and improving mechanical strength for tissues affected by estrogen deficient osteopenia. Ultrasound, which behaves as an alternating pressure wave in bone, may offer an effective, non-invasive technology for delivery of anabolic signals. In vitro, dynamic mechanical signals delivered using ultrasound have been shown to increase osteoblast proliferation [1], and in vivo studies have established ultrasound as an effective treatment for delayed and non-union fractures [2]. Previously, we showed that ultrasound signals similar to those currently used in a clinical setting for fracture healing were effective in mediating decreases in bone volume and mechanical strength at the millimeter length-scale in response to estrogen deficient osteopenia [3]. Due to bone’s inherent viscoelasticity and the dynamic nature of the applied ultrasound signals, it is particularly important to consider both elastic and viscous components of bone’s adaptive response to applied loads. In light of these findings, the goal of this study was to determine the role of therapeutic ultrasound signal intensity in modulating changes in bone’s nanoscale elastic and viscoelastic material properties associated with estrogen deficient osteopenia. We hypothesize that bone is sensitive to dynamic mechanical signals delivered via ultrasound and that bone’s tissue level nano-scale material properties, particularly nonlinear viscoelastic properties, are sensitive to ultrasound signal intensity.

scholarly journals The ulnar collateral ligament loading paradox between in-vitro and in-vivo studies on baseball pitching (narrative review)

2021 ◽  
Vol 8 (1) ◽  
pp. 19-29
Author(s):  
Bart Van Trigt ◽  
Liset (W) Vliegen ◽  
Ton (Ajr) Leenen ◽  
DirkJan (Hej) Veeger
Keyword(s):  
Ulnar Collateral Ligament ◽  
Narrative Review ◽  
In Vivo Studies ◽  
Collateral Ligament

scholarly journals Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds

Metals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1192
Author(s):  
Anida-Maria Băbțan ◽  
Daniela Timuș ◽  
Olga Sorițău ◽  
Bianca Adina Boșca ◽  
Reka Barabas ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Cellular Response ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Physical Interaction ◽  
High Porosity ◽  
Tissue Integration ◽  
Mesh Terms

Background: SLM (Selective Laser Melting)–manufactured Titanium (Ti) scaffolds have a significant value for bone reconstructions in the oral and maxillofacial surgery field. While their mechanical properties and biocompatibility have been analysed, there is still no adequate information regarding tissue integration. Therefore, the aim of this study is a comprehensive systematic assessment of the essential parameters (porosity, pore dimension, surface treatment, shape) required to provide the long-term performance of Ti SLM medical implants. Materials and methods: A systematic literature search was conducted via electronic databases PubMed, Medline and Cochrane, using a selection of relevant search MeSH terms. The literature review was conducted using the preferred reporting items for systematic reviews and meta-analysis (PRISMA). Results: Within the total of 11 in vitro design studies, 9 in vivo studies, and 4 that had both in vitro and in vivo designs, the results indicated that SLM-generated Ti scaffolds presented no cytotoxicity, their tissue integration being assured by pore dimensions of 400 to 600 µm, high porosity (75–88%), hydroxyapatite or SiO2–TiO2 coating, and bioactive treatment. The shape of the scaffold did not seem to have significant importance. Conclusions: The SLM technique used to fabricate the implants offers exceptional control over the structure of the base. It is anticipated that with this technique, and a better understanding of the physical interaction between the scaffold and bone tissue, porous bases can be tailored to optimize the graft’s integrative and mechanical properties in order to obtain structures able to sustain osseous tissue on Ti.

scholarly journals The RNA Methyltransferase METTL3 Promotes Endothelial Progenitor Cell Angiogenesis in Mandibular Distraction Osteogenesis via the PI3K/AKT Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Weidong Jiang ◽  
Peiqi Zhu ◽  
Fangfang Huang ◽  
Zhenchen Zhao ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Distraction Osteogenesis ◽  
Ex Vivo ◽  
Maxillofacial Surgery ◽  
Akt Pathway ◽  
Oral And Maxillofacial Surgery ◽  
Endothelial Progenitor ◽  
Mandibular Distraction Osteogenesis

Distraction osteogenesis (DO) is used to treat large bone defects in the field of oral and maxillofacial surgery. Successful DO-mediated bone regeneration is dependent upon angiogenesis, and endothelial progenitor cells (EPCs) are key mediators of angiogenic processes. The N6-methyladenosine (m6A) methyltransferase has been identified as an important regulator of diverse biological processes, but its role in EPC-mediated angiogenesis during DO remains to be clarified. In the present study, we found that the level of m6A modification was significantly elevated during the process of DO and that it was also increased in the context of EPC angiogenesis under hypoxic conditions, which was characterized by increased METTL3 levels. After knocking down METTL3 in EPCs, m6A RNA methylation, proliferation, tube formation, migration, and chicken embryo chorioallantoic membrane (CAM) angiogenic activity were inhibited, whereas the opposite was observed upon the overexpression of METTL3. Mechanistically, METTL3 silencing reduced the levels of VEGF and PI3Kp110 as well as the phosphorylation of AKT, whereas METTL3 overexpression reduced these levels. SC79-mediated AKT phosphorylation was also able to restore the angiogenic capabilities of METTL3-deficient EPCs in vitro and ex vivo. In vivo, METTL3-overexpressing EPCs were additionally transplanted into the DO callus, significantly enhancing bone regeneration as evidenced by improved radiological and histological manifestations in a canine mandibular DO model after consolidation over a 4-week period. Overall, these results indicate that METTL3 accelerates bone regeneration during DO by enhancing EPC angiogenesis via the PI3K/AKT pathway.

scholarly journals Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update

Crystals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 674
Author(s):  
Silvia Balhuc ◽  
Radu Campian ◽  
Anca Labunet ◽  
Marius Negucioiu ◽  
Smaranda Buduru ◽  
...  
Keyword(s):  
Dental Materials ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Hydroxyapatite Nanoparticles ◽  
Randomized Controlled ◽  
Dental Applications ◽  
Oral Implantology

Hydroxyapatite is one of the most studied biomaterials in the medical and dental field, because of its biocompatibility; it is the main constituent of the mineral part of teeth and bones. In dental science, hydroxyapatite nanoparticles (HAnps) or nano-hydroxyapatite (nano-HA) have been studied, over the last decade, in terms of oral implantology and bone reconstruction, as well in restorative and preventive dentistry. Hydroxyapatite nanoparticles have significant remineralizing effects on initial enamel lesions, and they have also been used as an additive material in order to improve existing and widely used dental materials, mainly in preventive fields, but also in restorative and regenerative fields. This paper investigates the role of HAnps in dentistry, including recent advances in the field of its use, as well as their advantages of using it as a component in other dental materials, whether experimental or commercially available. Based on the literature, HAnps have outstanding physical, chemical, mechanical and biological properties that make them suitable for multiple interventions, in different domains of dental science. Further well-designed randomized controlled trials should be conducted in order to confirm all the achievements revealed by the in vitro or in vivo studies published until now.

scholarly journals Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 94 ◽  
Author(s):  
Denise Murgia ◽  
Rodolfo Mauceri ◽  
Giuseppina Campisi ◽  
Viviana De Caro
Keyword(s):  
Biological Effects ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Positive Effects ◽  
Natural Polyphenol ◽  
Regeneration Of Bone Tissue ◽  
Experimental Findings ◽  
Regeneration Of Bone

The natural polyphenol Resveratrol (RSV) claims numerous positive effects on health due to the well documented biological effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts’ proliferation and antagonist of osteoclasts’ differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together experimental findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents.

scholarly journals Potential of Lyophilized Platelet Concentrates for Craniofacial Tissue Regenerative Therapies

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 517
Author(s):  
Nurul Aida Ngah ◽  
Jithendra Ratnayake ◽  
Paul R. Cooper ◽  
George J. Dias ◽  
Darryl C. Tong ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Platelet Concentrates ◽  
Comprehensive Search ◽  
Craniofacial Tissue ◽  
Regenerative Therapies

Objective: The use of platelet concentrates (PCs) in oral and maxillofacial surgery, periodontology, and craniofacial surgery has been reported. While PCs provide a rich reservoir of autologous bioactive growth factors for tissue regeneration, their drawbacks include lack of utility for long-term application, low elastic modulus and strength, and limited storage capability. These issues restrict their broader application. This review focuses on the lyophilization of PCs (LPCs) and how this processing approach affects their biological and mechanical properties for application as a bioactive scaffold for craniofacial tissue regeneration. Materials and Methods: A comprehensive search of five electronic databases, including Medline, PubMed, EMBASE, Web of Science, and Scopus, was conducted from 1946 until 2019 using a combination of search terms relating to this topic. Results: Ten manuscripts were identified as being relevant. The use of LPCs was mostly studied in in vitro and in vivo craniofacial bone regeneration models. Notably, one clinical study reported the utility of LPCs for guided bone regeneration prior to dental implant placement. Conclusions: Lyophilization can enhance the inherent characteristics of PCs and extends shelf-life, enable their use in emergency surgery, and improve storage and transportation capabilities. In light of this, further preclinical studies and clinical trials are required, as LPCs offer a potential approach for clinical application in craniofacial tissue regeneration.

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