scholarly journals Hyaluronic Acid-Silver Nanocomposites and Their Biomedical Applications: A Review

Materials ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 234
Author(s):  
Joanna Dulińska-Litewka ◽  
Kacper Dykas ◽  
Dominik Felkle ◽  
Karolina Karnas ◽  
Gohar Khachatryan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Metastasis ◽  
Chronic Wounds ◽  
Rapid Development ◽  
Vital Role ◽  
Anticancer Activities ◽  
Silver Nanocomposites ◽  
Synthesis Properties ◽  
Potential Applications ◽  
Low Cytotoxicity

For the last years scientific community has witnessed a rapid development of novel types of biomaterials, which properties made them applicable in numerous fields of medicine. Although nanosilver, well-known for its antimicrobial, anti-angiogenic, anti-inflammatory and anticancer activities, as well as hyaluronic acid, a natural polysaccharide playing a vital role in the modulation of tissue repair, signal transduction, angiogenesis, cell motility and cancer metastasis, are both thoroughly described in the literature, their complexes are still a novel topic. In this review we introduce the most recent research about the synthesis, properties, and potential applications of HA-nanosilver composites. We also make an attempt to explain the variety of mechanisms involved in their action. Finally, we present biocompatible and biodegradable complexes with bactericidal activity and low cytotoxicity, which properties suggest their suitability for the prophylaxis and therapy of chronic wounds, as well as analgetic therapies, anticancer strategies and the detection of chemical substances and malignant cells. Cited studies reveal that the usage of hyaluronic acid-silver nanocomposites appears to be efficient and safe in clinical practice.

TOWARDS DEVELOPING A SUSTAINABLE HERITAGE TOURISM AND CONSERVATION ACTION PLAN FOR IRBID’S HISTORIC CORE

2016 ◽  
Vol 10 (3) ◽  
pp. 36 ◽  
Author(s):  
Naif Adel Haddad ◽  
Leen Adeeb Fakhoury
Keyword(s):  
Bronze Age ◽  
Local Community ◽  
Action Plan ◽  
Rapid Development ◽  
Vital Role ◽  
Heritage Conservation ◽  
Urban Context ◽  
Conservation Action ◽  
Urban Heritage ◽  
Conservation Action Plan

Tal (mount) Irbid in Irbid city, Jordan, with its continuous human occupation from the Bronze Age until the present, demonstrates the main landmark that has guided the spread of the urban growth of the city. The outcome of studies carried out at Irbid’s historic core, in relation to assessing the loss and degradation of the core’s cultural heritage, shall be analyzed, investigated, and discussed, as also concerns, obstacles, and issues of sustainability to this urban heritage conservation and tourism planning. The paper starts by defining the urban heritage for the historic core, which tends to be set aside, in the city’s rapid development. Actually, the remaining historic buildings can also provide the necessary inter-relationships between the historic core areas and the wider urban context to achieve a sustainable and integrated tourism and conservation action plan for the three heritage neighborhoods around the Tal, while building on tourism opportunities and taking into consideration the needs and the vital role of the local community. The paper concludes that urban heritage conservation and protection of the integrity and identity of the historic core city fabric can assist in its branding, promotion, and management in ways that could enhance the local community belonging, quality of everyday lifestyle, and visitors' experience. 

A brief overview on role of graphene based material in therapeutic management of inflammatory response signalling cascades

2020 ◽  
Vol 21 ◽  
pp. 25-36
Author(s):  
Ruchira Das ◽  
◽  
Priyanka Sow ◽  
Sudatta Dey ◽  
Asmita Samadder ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Water Solubility ◽  
Biomedical Application ◽  
Rapid Development ◽  
Graphene Quantum Dots ◽  
Biological Response ◽  
Vital Role ◽  
Therapeutic Management ◽  
In Vivo Models

Graphene is a novel, sp2 carbon atoms bonded, two-dimensional nano-material. Due to their favorable electronic, thermal, optical, and mechanical property, graphene and its derivatives, like graphene oxide (GO) and graphene quantum dots (GQDs) are used in widespread applications. The outstanding potentials of these compounds in the field of nanoelectronics, composite materials, sensors, energy technology etc helped in the rapid development in their functionalization, modulatory effects on various systems of our body. GQDs has been suggested as a new nanomaterial with improved biocompatibility, biodegradability, water solubility and considerably low cytotoxic effects in in vivo models, and are applicable for altering immune responses based on quantum confinement and edge effect properties. The review particularly elucidates the mechanistic approach by which graphene and/ or its derivatives and/ or their nano-compound aid in therapeutic management against myriads of immunological perspectives. GQDs have unique physiochemical properties with carbon sheets showcases out-standing biological response against immunological interventions by altering the activities of t-cell lymphocytes. On the contrary GO plays a vital role in eliciting inflammatory signaling factors by controlling proinflammation and an anti-inflammatory response. Therefore, this review shall help the readers to have an overview of the biomedical application of graphene and its derivatives to design target specific drugs to regulate the immune response based prognosis andcure.

scholarly journals Probiotic: An Uprising Human Health Concept

2021 ◽  
Author(s):  
Amishi Bhatt ◽  
Dhyey Kothari ◽  
Charmy Kothari ◽  
Ramesh Kothari
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Scientific Evidence ◽  
Vital Role ◽  
Health Food ◽  
Food Industries ◽  
Health Concept ◽  
Agricultural Applications ◽  
Potential Applications ◽  
Metabolic Activities

Most of our gut microbiota live with us in a mutually beneficial life-long relationship. The gut microbiota plays a vital role in the host’s overall health through its metabolic activities. Human microbiota might be supported by consuming friendly bacteria (probiotics) and consuming foods to improve the microbiota (prebiotics). During the last two decades, probiotics’ interest has increased with rising scientific shreds of evidence of benefits on human health. Hence, they have been exploited as various food products, mainly fermented foods. Probiotics as a treatment modality may restore normal microbiota and functioning of the gastrointestinal (GI) tract. Strong scientific evidence is associating these bacteria with the prevention and therapy of various GI disorders. (In light of the ongoing trend of probiotics, further research is needed to obtain the perspective of potential applications for better health. Probiotic applications have been extended from health applications to food and agricultural applications. The benefits of probiotics led to its applications in probiotic ‘health food’ industries and agricultural sectors.

Recent Progress on Apoptotic Activity of Triazoles

2021 ◽  
Vol 22 ◽  
Author(s):  
Pelin Çıkla-Süzgün ◽  
Ş. Güniz Küçükgüzel
Keyword(s):  
Cancer Progression ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Rational Design ◽  
Vital Role ◽  
Anticancer Activities ◽  
The Past ◽  
Small Molecule Drugs ◽  
Apoptotic Activity ◽  
New Generation

Abstract: Apoptosis, often called programmed cell death, is a self-directed cell destruction process. It differs from classical necrosis by activation of caspases. Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis. All cytotoxic drugs and radiation therapy programs initiates apoptosis in tumor cells. Today, studies show that heterocyclic compounds that contain triazole funtionality have anticancer activities. Triazoles are 5-membered rings, which contain two carbon and three nitrogen atoms Therefore, many researchers have synthesized these small active compounds as target structures and evaluated their apoptotic activities. The present review describs more recent medicinal aspects of triazoles as anticancer agents reported during the past few years. We hope that the bioactivity of triazole derivatives will be beneficial for the rational design of new generation of small molecule drugs.

Bio-inspired gene carriers with low cytotoxicity constructed via the assembly of dextran nanogels and nano-coacervates

Nanomedicine ◽  
2020 ◽  
Vol 15 (13) ◽  
pp. 1285-1296 ◽  
Author(s):  
Chenglong Wang ◽  
Jiayi You ◽  
Miaomiao Gao ◽  
Peipei Zhang ◽  
Guoxiong Xu ◽  
...  
Keyword(s):  
Positive Charge ◽  
Transfection Efficiency ◽  
Gene Carrier ◽  
Gene Carriers ◽  
Environmentally Responsive ◽  
Potential Applications ◽  
Internal Peptide ◽  
The Common ◽  
Low Cytotoxicity ◽  
Peptide Gene

Aim: To achieve safe and biocompatible gene carriers. Materials & methods: A core/shell-structured hierarchical carrier with an internal peptide/gene coacervate ‘core’ and a dextran nanogel ‘shell’ on the surface has been designed. Results: The dextran nanogels shield coacervate (DNSC) can effectively condense genes and release them in reducing environments. The dextran nanogel-based ‘shell’ can effectively shield the positive charge of the peptide/gene coacervate ‘core’, thus reducing the side effects of cationic gene carriers. In contrast with the common nonviral gene carriers that had high cytotoxicities, the DNSC showed a high transfection efficiency while maintaining a low cytotoxicity. Conclusion: The DNSC provides an effective environmentally responsive gene carrier with potential applications in the fields of gene therapy and gene carrier development.

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

Drug Research ◽  
2019 ◽  
Vol 70 (01) ◽  
pp. 6-11 ◽  
Author(s):  
Elham Ahmadian ◽  
Solmaz Maleki Dizaj ◽  
Aziz Eftekhari ◽  
Elaheh Dalir ◽  
Parviz Vahedi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Wound Repair ◽  
Stem Cell Differentiation ◽  
Clinical Applications ◽  
Cellular Behavior ◽  
Hydrogel Formation ◽  
Potential Applications ◽  
Basic Concepts ◽  
Elastic Sheets

AbstractHyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.

scholarly journals The Development of Functional Non-Viral Vectors for Gene Delivery

2019 ◽  
Vol 20 (21) ◽  
pp. 5491 ◽  
Author(s):  
Patil ◽  
Gao ◽  
Lin ◽  
Li ◽  
Dang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Targeted Delivery ◽  
Viral Vectors ◽  
High Efficiency ◽  
Transfection Efficiency ◽  
Cationic Lipids ◽  
Gene Vectors ◽  
Potential Applications ◽  
Low Toxicity ◽  
Low Cytotoxicity

Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases. This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or RNA, into the cell. Because of their negative charge and considerable larger size, the delivery of these molecules, in general, should be mediated by gene vectors. Non-viral vectors, as promising delivery systems, have received considerable attention due to their low cytotoxicity and non-immunogenicity. As research continued, more and more functional non-viral vectors have emerged. They not only have the ability to deliver a gene into the cells but also have other functions, such as the performance of fluorescence imaging, which aids in monitoring their progress, targeted delivery, and biodegradation. Recently, many reviews related to non-viral vectors, such as polymers and cationic lipids, have been reported. However, there are few reviews regarding functional non-viral vectors. This review summarizes the common functional non-viral vectors developed in the last ten years and their potential applications in the future. The transfection efficiency and the transport mechanism of these materials were also discussed in detail. We hope that this review can help researchers design more new high-efficiency and low-toxicity multifunctional non-viral vectors, and further accelerate the progress of gene therapy.

scholarly journals Alkaloids Produced by Endophytic Fungi: A Review

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Yanyan Zhang ◽  
Ting Han ◽  
Qianliang Ming ◽  
Lingshang Wu ◽  
Khalid Rahman ◽  
...  
Keyword(s):  
Endophytic Fungi ◽  
Host Plants ◽  
Biological Activities ◽  
Biological Properties ◽  
Research Progress ◽  
Indole Derivatives ◽  
Anticancer Activities ◽  
Action Mechanisms ◽  
The Future ◽  
Potential Applications

In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for producing bioactive alkaloids such as quinoline and isoquinoline, amines and amides, indole derivatives, pyridines, and quinazolines. The biological activities and action mechanisms of these alkaloids from endophytic fungi are also introduced. Furthermore, the relationships between alkaloid-producing endophytes and their host plants, as well as their potential applications in the future are discussed.

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