Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

The genus Callyspongia (Callyspongiidae) encompasses a group of demosponges including 261 described species, of which approximately 180 have been accepted after taxonomic reviews. The marine organisms of Callyspongia are distributed in tropical ecosystems, especially in the central and western Pacific, but also in the regions of the Indian, the West Atlantic, and the East Pacific Oceans. The reason for the interest in the genus Callyspongia is related to its potential production of bioactive compounds. In this review, we group the chemical information about the metabolites isolated from the genus Callyspongia, as well as studies of the biological activity of these compounds. Through NMR data, 212 metabolites were identified from genus Callyspongia (15 species and Callyspongia sp.), belonging to classes such as polyacetylenes, terpenoids, steroids, alkaloids, polyketides, simple phenols, phenylpropanoids, nucleosides, cyclic peptides, and cyclic depsipeptides. A total of 109 molecules have been reported with bioactive activity, mainly cytotoxic and antimicrobial (antibacterial and antifungal) action. Thus, we conclude that polyacetylenes, terpenoids and steroids correspond to the largest classes of compounds of the genus, and that future research involving the anticancer action of the species’ bioactive metabolites may become relevant.

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Investigation of Compounds and Biological Activity of Selected Indonesian Marine Sponges

The Natural Products Journal ◽

10.2174/2210315509666190627105237 ◽

2020 ◽

Vol 10 (3) ◽

pp. 312-321

Author(s):

Idin Sahidin ◽

Carla W. Sabandar ◽

Wahyuni ◽

Rini Hamsidi ◽

Sandra Aulia Mardikasari ◽

...

Keyword(s):

Biological Activity ◽

Antioxidant Activities ◽

Chemical Constituents ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Marine Sponges ◽

Chemical Screening ◽

Methanol Extracts ◽

Ms Analysis ◽

Antioxidant Agents

Background: Marine sponges provided a great source of natural products with promising biological activity. This study was aimed to investigate the chemical constituents of methanol extracts of selected Indonesian marine sponges (Callyspongia sp., Clathria sp., Melophlus sarasinorum, and Xestospongia sp.), collected from the Saponda Islands, Southeast Sulawesi, Indonesia as well as to evaluate their antimicrobial and antioxidant activities. Methods: LCMS/MS analysis used to identify the compounds. Agar well diffusion and DPPH assays were used to evaluate the antimicrobial and antioxidant activities. Results: Chemical screening reported alkaloids, terpenoids, steroids, and saponins from all investigated sponges. The LC-MS/MS analysis identified various compounds which mainly contained steroids. Antimicrobial activity (against Bacillus subtilis, Escherichia coli, Salmonella enterica, and Candida albicans) was only shown by the Xestospongia sp. extract. Meanwhile, extracts of M. sarasinorum, Xestospongia sp., and Callyspongia sp. exhibited potent radical scavenging activity. Conclusion: The study concluded that the selected sponges could provide various groups of compounds. Methanol extracts of these sponges could be used as sources of antimicrobial and antioxidant agents.

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Antimicrobial Activities of Marine Sponge-Associated Bacteria

Microorganisms ◽

10.3390/microorganisms9010171 ◽

2021 ◽

Vol 9 (1) ◽

pp. 171

Author(s):

Yitayal S. Anteneh ◽

Qi Yang ◽

Melissa H. Brown ◽

Christopher M. M. Franco

Keyword(s):

Pathogenic Bacteria ◽

South Australia ◽

Multidrug Resistant ◽

Antimicrobial Activities ◽

Marine Sponges ◽

Bioactive Metabolites ◽

Human Pathogens ◽

Sponge Associated Bacteria ◽

Microbial Symbionts ◽

Bacteria And Fungi

The misuse and overuse of antibiotics have led to the emergence of multidrug-resistant microorganisms, which decreases the chance of treating those infected with existing antibiotics. This resistance calls for the search of new antimicrobials from prolific producers of novel natural products including marine sponges. Many of the novel active compounds reported from sponges have originated from their microbial symbionts. Therefore, this study aims to screen for bioactive metabolites from bacteria isolated from sponges. Twelve sponge samples were collected from South Australian marine environments and grown on seven isolation media under four incubation conditions; a total of 1234 bacterial isolates were obtained. Of these, 169 bacteria were tested in media optimized for production of antimicrobial metabolites and screened against eleven human pathogens. Seventy bacteria were found to be active against at least one test bacterial or fungal pathogen, while 37% of the tested bacteria showed activity against Staphylococcus aureus including methicillin-resistant strains and antifungal activity was produced by 21% the isolates. A potential novel active compound was purified possessing inhibitory activity against S. aureus. Using 16S rRNA, the strain was identified as Streptomyces sp. Our study highlights that the marine sponges of South Australia are a rich source of abundant and diverse bacteria producing metabolites with antimicrobial activities against human pathogenic bacteria and fungi.

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Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

Molecules ◽

10.3390/molecules23082013 ◽

2018 ◽

Vol 23 (8) ◽

pp. 2013 ◽

Cited By ~ 16

Author(s):

Ricardo Murcia ◽

Sandra Leal ◽

Martha Roa ◽

Edgar Nagles ◽

Alvaro Muñoz-Castro ◽

...

Keyword(s):

Electrical Conductivity ◽

Biological Activity ◽

Melting Point ◽

Inhibitory Concentration ◽

Vero Cells ◽

Visible Spectroscopy ◽

Antifungal Activities ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal ◽

New Compounds

In this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3–7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL−1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.

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Development of new 5-chromenyl-2,4-thiazolidinediones as antimicrobial agents

Medicine and Pharmacy Reports ◽

10.15386/cjmed-509 ◽

2015 ◽

Vol 89 (1) ◽

pp. 122-127 ◽

Cited By ~ 5

Author(s):

Cristina Mariana Nastasă ◽

Mihaela Duma ◽

Adrian Pîrnău ◽

Laurian Vlase ◽

Brîndușa Tiperciuc ◽

...

Keyword(s):

Antimicrobial Agents ◽

Treatment Strategies ◽

Inhibition Zone ◽

Diffusion Method ◽

Future Research ◽

Physico Chemical ◽

New Chemical Entities ◽

New Treatment ◽

Antibacterial And Antifungal ◽

New Compounds

Background and aims. In the context of the increasing phenomenon of microbial resistance to usual drugs, the development of new treatment strategies and new therapeutic protocols is a constant need. Thiazolidinedione and chromone represent two important scaffolds in medicinal chemistry due to their large pharmacological applicability.Methods. We synthesized a new 5-(chromene-3-yl)methylene-2,4-thiazolidinedione starting from 6,8-dichloro-4-oxo-4H-chromene-3-carbaldehyde. Then, by treating with different α-bromoalkylarylketones, we obtained N-substituted derivatives. All new compounds were investigated for their antimicrobial potential, using the diffusion method, against Listeria monocytogenes ATCC 13932, Staphylococcus aureus ATCC 49444, Escherichia coli ATCC 25922, Salmonella typhimurium ATCC 14028 and Candida albicans ATCC 10231. Three concentrations, 10 mg/ml, 5 mg/ml and 1 mg/ml of compounds were used. The results were evaluated by the measurement of the inhibition zone diameters and compared to those of gentamicin and fluconazole respectively, as reference drugs.Results. All new synthesized compounds were characterized using physico-chemical and spectrometric methods. They displayed modest to good antimicrobial activity. New molecules 8, 9 and 10 may represent promising candidates, showing zone inhibition diameters superior to those of reference drugs.Conclusions. This work presents chemical synthesis, characterization and investigation of the antibacterial and antifungal potential of 5-(chromene-3-yl)methylene-2,4-thiazolidinedione derivatives, which may be worthy of future research for designing new chemical entities.

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Expanding the chemical information science gateway

F1000Research ◽

10.12688/f1000research.12772.1 ◽

2017 ◽

Vol 6 ◽

pp. 1764 ◽

Cited By ~ 1

Author(s):

Jürgen Bajorath

Keyword(s):

Biological Activity ◽

Chemical Structure ◽

Information Science ◽

Open Science ◽

Chemical Information ◽

High Quality ◽

Activity Data ◽

Science Gateway ◽

Interdisciplinary Field ◽

Scientific Environment

Broadly defined, chemical information science (CIS) covers chemical structure and data analysis including biological activity data as well as processing, organization, and retrieval of any form of chemical information. The CIS Gateway (CISG) of F1000Research was created to communicate research involving the entire spectrum of chemical information, including chem(o)informatics. CISG provides a forum for high-quality publications and a meaningful alternative to conventional journals. This gateway is supported by leading experts in the field recognizing the need for open science and a flexible publication platform enabling off-the-beaten path contributions. This editorial aims to further rationalize the scope of CISG, position it within its scientific environment, and open it up to a wider audience. Chemical information science is an interdisciplinary field with high potential to interface with experimental work.

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Chemical constituents of Chaenomeles sinensis twigs and their biological activity

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.16.257 ◽

2020 ◽

Vol 16 ◽

pp. 3078-3085

Author(s):

Joon Min Cha ◽

Dong Hyun Kim ◽

Lalita Subedi ◽

Zahra Khan ◽

Sang Un Choi ◽

...

Keyword(s):

Biological Activity ◽

Data Analysis ◽

Cell Lines ◽

Chemical Structure ◽

Biological Effects ◽

Chemical Constituents ◽

2D Nmr ◽

Nmr Data ◽

Chaenomeles Sinensis ◽

Modified Mosher’S Method

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher’s method, and LC–MS analysis. The characterized compounds’ biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

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