scholarly journals Anti-Classical Swine Fever Virus Strategies

2021 ◽  
Vol 9 (4) ◽  
pp. 761
Author(s):  
Jindai Fan ◽  
Yingxin Liao ◽  
Mengru Zhang ◽  
Chenchen Liu ◽  
Zhaoyao Li ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Classical Swine Fever ◽  
Economic Losses ◽  
High Morbidity ◽  
Host Proteins ◽  
Drug Candidates ◽  
Vaccination Strategies ◽  
Viral Genes ◽  
Swine Disease ◽  
And Control

Classical swine fever (CSF), caused by CSF virus (CSFV), is a highly contagious swine disease with high morbidity and mortality, which has caused significant economic losses to the pig industry worldwide. Biosecurity measures and vaccination are the main methods for prevention and control of CSF since no specific drug is available for the effective treatment of CSF. Although a series of biosecurity and vaccination strategies have been developed to curb the outbreak events, it is still difficult to eliminate CSF in CSF-endemic and re-emerging areas. Thus, in addition to implementing enhanced biosecurity measures and exploring more effective CSF vaccines, other strategies are also needed for effectively controlling CSF. Currently, more and more research about anti-CSFV strategies was carried out by scientists, because of the great prospects and value of anti-CSFV strategies in the prevention and control of CSF. Additionally, studies on anti-CSFV strategies could be used as a reference for other viruses in the Flaviviridae family, such as hepatitis C virus, dengue virus, and Zika virus. In this review, we aim to summarize the research on anti-CSFV strategies. In detail, host proteins affecting CSFV replication, drug candidates with anti-CSFV effects, and RNA interference (RNAi) targeting CSFV viral genes were mentioned and the possible mechanisms related to anti-CSFV effects were also summarized.

Swine influenza vaccines: current status and future perspectives

2010 ◽  
Vol 11 (1) ◽  
pp. 81-96 ◽  
Author(s):  
Wenjun Ma ◽  
Jürgen A. Richt
Keyword(s):  
Influenza A ◽  
Swine Influenza ◽  
Influenza Viruses ◽  
Current Status ◽  
Economic Losses ◽  
Influenza A Viruses ◽  
Swine Industry ◽  
Effective Strategies ◽  
Swine Disease ◽  
And Control

AbstractSwine influenza is an important contagious disease in pigs caused by influenza A viruses. Although only three subtypes of influenza A viruses, H1N1, H1N2 and H3N2, predominantly infect pigs worldwide, it is still a big challenge for vaccine manufacturers to produce efficacious vaccines for the prevention and control of swine influenza. Swine influenza viruses not only cause significant economic losses for the swine industry, but are also important zoonotic pathogens. Vaccination is still one of the most important and effective strategies to prevent and control influenza for both the animal and human population. In this review, we will discuss the current status of swine influenza worldwide as well as current and future options to control this economically important swine disease.

Preparedness for Mitigating Noncommunicable Diseases in Gaindakot Municipality, Nepal: Perspectives of Key informants

2021 ◽  
Vol 6 (1) ◽  
pp. 1320-1324
Author(s):  
Narayan Sapkota ◽  
Damaru Prasad Paneru
Keyword(s):  
Health System ◽  
Health Workforce ◽  
Prevention And Control ◽  
Local Level ◽  
Building Blocks ◽  
Health System Strengthening ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Screening Services ◽  
And Control

Introduction: Non-communicable Diseases (NCDs) are the major public health problem that leads to high morbidity and mortality in the world including Nepal. Government of Nepal has launched the Multi-sectoral NCD Action Plan in 2014 and established NCD and Injuries Poverty Commission in 2016 for the management and control of NCDs nevertheless the implementation status and its outcomes are not identified till date at the local level. Objectives: To explore the preparedness of the local government for the prevention and control of NCDs at Gaindakot, Nawalpur, Nepal. Methodology: A qualitative study was conducted in the Gaindakot municipality; Nawalpur to document the key informant's perspectives on health system's preparedness to prevent the potential impacts of NCDs. Face to face Indepth interview was performed using open-ended questions. Interview guidelines were prepared on the basis of building blocks of health system. Information was processed basis on thematic analysis. Result: The study revealed that health section has NCD preparedness structure but need to strengthening for the better delivery of health services. The study highlights that screening services and the medicine for major NCDs like hypertension and diabetes were available at local level. Limited budget was allocated and health workforce was not trained for NCDs prevention and control. There was no reporting mechanism for NCD related data from local level. Conclusion: Basic medicine and screening services were provided from the local level to the selected NCDs such as hypertension and diabetes. There was no provision of reporting NCD related information and health workforce were not trained to respond NCDs. Local level health system strengthening is an urgent need to address the increasing burden of NCDs.  

scholarly journals High Mortality Rate due to False Gid in a Sheep Herd

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ali Asghar Mozaffari ◽  
Saeedeh Shojaeepour ◽  
Shahin Ghahremani Ghareh Cheshmeh
Keyword(s):  
Mortality Rate ◽  
High Mortality ◽  
Prevention And Control ◽  
Present Report ◽  
Economic Losses ◽  
Oestrus Ovis ◽  
Pathological Findings ◽  
Sheep Brain ◽  
And Control ◽  
Heavy Infestation

The sheep nasal bot, Oestrus ovis (Diptera: Oestridae), is a cosmopolitan parasite commonly found in sheep and occasionally goats. Rarely a bot will migrate into the sheep brain (false gid). Following the complaint of an animal husbandman about high mortality rate in a sheep herd, the herd was clinically, hematologically, and pathologically examined exactly. Clinical, hematological, and pathological findings were described in the text. Necropsy findings showed heavy infestation with Oestrus ovis larvae. The herd was treated with Ivermectin. After treatment all patients without nervous sings were recovered. Patients with nervous signs did not respond to treatment, but new cases of disease did not occur and the mortality stopped. In the present report, a high mortality rate due to false gid in a sheep herd was described. The prevention and control of the disease are important because of economic losses and the possibility of transmission to the human.

scholarly journals Paratuberculosis: The Hidden Killer of Small Ruminants

Animals ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 12
Author(s):  
Sanaa M. Idris ◽  
Kamal H. Eltom ◽  
Julius B. Okuni ◽  
Lonzy Ojok ◽  
Wisal A. Elmagzoub ◽  
...  
Keyword(s):  
Rural Areas ◽  
Prevention And Control ◽  
Small Ruminants ◽  
Disease Process ◽  
Economic Losses ◽  
Trade Restrictions ◽  
African Countries ◽  
Diagnostic Assays ◽  
Mycobacterium Avium Subsp Paratuberculosis ◽  
And Control

Paratuberculosis (PTB) is a contagious and chronic enteric disease of ruminants and many non-ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP), and is characterised by diarrhoea and progressive emaciation with consequent serious economic losses due to death, early culling, and reduced productivity. In addition, indirect economic losses may arise from trade restrictions. Besides being a production limiting disease, PTB is a potential zoonosis; MAP has been isolated from Crohn’s disease patients and was associated with other human diseases, such as rheumatoid arthritis, Hashimoto’s thyroiditis, Type 1 diabetes, and multiple sclerosis. Paratuberculosis in sheep and goats may be globally distributed though information on the prevalence and economic impact in many developing countries seem to be scanty. Goats are more susceptible to infection than sheep and both species are likely to develop the clinical disease. Ingestion of feed and water contaminated with faeces of MAP-positive animals is the common route of infection, which then spreads horizontally and vertically. In African countries, PTB has been described as a “neglected disease”, and in small ruminants, which support the livelihood of people in rural areas and poor communities, the disease was rarely reported. Prevention and control of small ruminants’ PTB is difficult because diagnostic assays demonstrate poor sensitivity early in the disease process, in addition to the difficulties in identifying subclinically infected animals. Further studies are needed to provide more insight on molecular epidemiology, transmission, and impact on other animals or humans, socio-economic aspects, prevention and control of small ruminant PTB.

Cystic echinococcosis in animals and humans of Maharashtra State, India

2018 ◽  
Vol 63 (2) ◽  
pp. 232-243 ◽  
Author(s):  
V.M. Vaidya ◽  
R.J. Zende ◽  
A.M. Paturkar ◽  
M.L. Gatne ◽  
D.G. Dighe ◽  
...  
Keyword(s):  
Public Health ◽  
Cystic Echinococcosis ◽  
Prevention And Control ◽  
Public Health Authority ◽  
Economic Losses ◽  
Animal Population ◽  
Pcr Assay ◽  
Faecal Samples ◽  
And Control ◽  
Sera Samples

AbstractEchinococcosis/hydatidosis which is a neglected parasitic zoonosis in the developing country like India. The study was conducted during April, 2010 to March, 2017 to determine the prevalence among slaughtered food animals, dogs and human. The samples were collected from the various slaughterhouses situated in different regions of Maharashtra state. A total of 9464 cattle (male), 3661 buffalo, 47189 sheep, 33350 goats and 13579 pigs were scientifically examined during PM inspection at different slaughterhouses. The study revealed that the prevalence of disease in cattle (3.00%) was highest followed by buffalo (2.05%), pig (1.28%), sheep (0.09%) and goat (0.01%), by PM examination. The average estimated economic losses (direct and indirect) due to hydatidosis were Rs. 8,65,83,566 in cattle, Rs. 44,33,93,900 in buffalo, Rs. 7,24,50,615 in sheep, Rs. 1,88,29,359 in goat and Rs. 5,20,49,081 in pigs. Dog faecal samples analyzed and showed the prevalence of echinococcosis as 4.34% (19/438) by sedimentation method and positive samples were confirmed by PCR assay, whereas in high risk human, 11.09% sera samples were found to be positive for echinococcosis. However, based on data collection for seven years, 58 patients were found to be surgically operated for hydatid cyst removal. The results of the present study indicated that cystic echinococcosis/hydatidosis is prevalent in both human and animal population in study areas which attracts serious attention from veterinary and public health authority to reduce economic burden and in designing appropriate strategy for prevention and control of disease.

scholarly journals The impact of management practices to prevent and control mycotoxins in the European food supply chain: MyToolBox project results

2021 ◽  
Vol 14 (2) ◽  
pp. 139-154
Author(s):  
M. Focker ◽  
H.J. van der Fels-Klerx ◽  
N. Magan ◽  
S.G. Edwards ◽  
M. Grahovac ◽  
...  
Keyword(s):  
Supply Chain ◽  
Impact Assessment ◽  
Prevention And Control ◽  
Control Measures ◽  
Economic Losses ◽  
Crop Losses ◽  
Mycotoxin Contamination ◽  
Prevention And Control Measures ◽  
And Control ◽  
The Impact

The presence of mycotoxins in cereals has led to large economic losses in Europe. In the course of the European project MyToolBox, prevention and control measures to reduce mycotoxin contamination in cereals were developed. This study aimed to estimate the impact of these prevention and control measures on both the reduction in crop losses and the increased volume of crops suitable for food and/or feed. It focused on the following measures: the use of fungicides during wheat cultivation, the use of resistant maize cultivars and/or biocontrol during maize cultivation, the use of real time sensors in storage silos, the use of innovative milling strategies during the pasta making process, and the employment of degrading enzymes during the process of bioethanol and Dried Distillers Grains with Solubles (DDGS) production. The impact assessment was based on the annual volume of cereals produced, the annual levels of mycotoxin contamination, and experimental data on the prevention and control measures collected in the course of the MyToolBox project. Results are expressed in terms of reduced volumes of cereals lost, or as additional volumes of cereals available for food meeting the current European legal limits. Results showed that a reduction in crop losses as well as an increase in the volume of crops suitable as food and/or feed is feasible with each proposed prevention or control measure along the supply chain. The impact was the largest in areas and in years with the highest mycotoxin contamination levels but would have less impact in years with low mycotoxin levels. In further research, the impact assessment may be validated using future data from more years and European sites. Decision makers in the food and feed supply chain can use this impact assessment to decide on the relevant prevention and control strategies to apply.

scholarly journals The Application of Hazard Vulnerability Analysis in the Prevention and Control of COVID-19 in Medical Institutions

2021 ◽  
Author(s):  
Li MA ◽  
Shiyue ZOU ◽  
Yanyi LIU ◽  
Jing LA ◽  
Junhua YANG
Keyword(s):  
Prevention And Control ◽  
Vulnerability Analysis ◽  
Primary Objective ◽  
Control Measures ◽  
Economic Losses ◽  
Average Score ◽  
Disaster Plan ◽  
Improvement Measures ◽  
Hazard Vulnerability ◽  
And Control

Background: Coronavirus disease 2019 (COVID-19) has caused massive casualties, severe economic losses, and poses a threat to the world. This study's primary objective was to analyze the hospital's potential hazards of COVID-19 prevention and control. The second objective was to review the disaster plan and make recommendations to minimize the spread of COVID-19 in hospitals. Methods: An expert group for the prevention and control of COVID-19 in the First People's Hospital of Longquanyi Dis-trict, Chengdu, China was established. We adopted the hazard vulnerability analysis (HVA) to riskstratify potential hazards and calculated relative risk values. We used the Delphi expert consultation method to propose and implement targeted improvement measures for the top five potential hazards. Then, the effects before and after the intervention were compared. Results: The top five hazards were: insufficient Personal Protective Equipment (PPE) (25.68%), inadequate diagnosis ability of clinicians (22.55%), and inadequate management strategies of patients and caregivers (22.38%), lack of professional ability of pre-checking and triage staff (16.96%), lack of knowledge of COVID-19 of medical staff (15.59%). After taking targeted improvement measures, the average score of the hospital staff's COVID-19 knowledge test increased from 73.26 points to 90.44 points, the average test score of the outsourcing company employees increased from 68.55 to 89.75 points. The differences were statistically significant (P<0.05). Conclusion: HVA can be used to systematically risk-stratify potential threats, measure the probability of those potential hazards, and develop various hospital prevention and control measures for COVID-19 epidemics.

scholarly journals The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins

2020 ◽  
Vol 11 ◽  
Author(s):  
Jindai Fan ◽  
Mengru Zhang ◽  
Chenchen Liu ◽  
Mengjiao Zhu ◽  
Zilin Zhang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Protein Interaction ◽  
Protein Interaction Network ◽  
Interaction Network ◽  
Classical Swine Fever ◽  
Cellular Protein ◽  
Host Cells ◽  
Cellular Proteins ◽  
Economic Losses ◽  
Host Proteins

Classical swine fever (CSF) is a highly contagious viral disease causing severe economic losses to the swine industry. As viroporins of viruses modulate the cellular ion balance and then take over the cellular machinery, blocking the activity of viroporin or developing viroporin-defective attenuated vaccines offers new approaches to treat or prevent viral infection. Non-structural protein p7 of CSF virus (CSFV) is a viroporin, which was highly involved in CSFV virulence. Deciphering the interaction between p7 and host proteins will aid our understanding of the mechanism of p7-cellular protein interaction affecting CSFV replication. In the present study, seven host cellular proteins including microtubule-associated protein RP/EB family member 1 (MAPRE1), voltage-dependent anion channel 1 (VDAC1), proteasome maturation protein (POMP), protein inhibitor of activated STAT 1 (PIAS1), gametogenetin binding protein 2 (GGNBP2), COP9 signalosome subunit 2 (COPS2), and contactin 1 (CNTN1) were identified as the potential interactive cellular proteins of CSFV p7 by using yeast two-hybrid (Y2H) screening. Plus, the interaction of CSFV p7 with MAPRE1 and VDAC1 was further evaluated by co-immunoprecipitation and GST-pulldown assay. Besides, the p7-cellular protein interaction network was constructed based on these seven host cellular proteins and the STRING database. Enrichment analysis of GO and KEGG indicated that many host proteins in the p7-cellular protein interaction network were mainly related to the ubiquitin-proteasome system, cGMP-PKG signaling pathway, calcium signaling pathway, and JAK-STAT pathway. Overall, this study identified potential interactive cellular proteins of CSFV p7, constructed the p7-cellular protein interaction network, and predicted the potential pathways involved in the interaction between CSFV p7 and host cells.

Bovine Anaplasmosis and Control

2021 ◽  
pp. 221-242
Author(s):  
Sebastian Kironji Waruri ◽  
James Muriuki Wanjohi ◽  
Leonard Khaluhi ◽  
Sam Ndungu Gichuhi ◽  
Erick O. Mungube
Keyword(s):  
Geographical Location ◽  
Tick Control ◽  
Control Measures ◽  
Economic Losses ◽  
High Morbidity ◽  
Blood Smears ◽  
The Common ◽  
Bovine Anaplasmosis ◽  
Cattle Herds ◽  
And Control

Bovine anaplasmosis is one of the most important tick borne diseases of ruminants worldwide causing significant economic losses in the livestock industries due to the high morbidity and mortality in susceptible cattle herds. Bovine anaplasmosis, caused by Anaplasma marginale, is an infectious but non-contagious disease. The mode of transmission of bovine anaplasmosis includes mechanical (blood contaminated fomites (needles, ear tagging, dehorning and castration equipment), biological (tick bites) and transplacental (mother to fetus). Bovine Anaplasmosis occurs in tropical and subtropical regions worldwide. Cattle of all ages are susceptible to infection with A. marginale, but the severity of disease increases with age. The common clinical sign of bovine anaplsmosis includes; fever, anorexia, rapid loss of body condition, severe decrease in milk production, pale and icteric mucous membranes, increased heart and respiratory rates, muscle weakness and depression. Diagnosis of bovine anaplasmosis can be made by demonstration of A. marginale on stained blood smears from clinically infected animals during the acute phase of the disease, but it is not reliable for detecting infection in pre-symptomatic or carrier animals. Instead, serological demonstration of antibodies and confirmation of antigen with molecular detection tools are used for diagnosis. Anaplasmosis can be treated by administration of oxytetracyclines, however oxytetracyclines do not clear the parasite from carrier animals. Control measures for bovine anaplasmosis vary with geographical location and include maintenance of Anaplasma free herds, vector control, administration of antibiotics and vaccination. Intensive acaridae application to control ticks has a number of limitations, therefore, immunization together with strategic tick control is recommended for exotic and crossbred cattle. Further studies on epidemiology of bovine anaplasmosis is needed

Molecular detection and epidemiology of chicken infectious anaemia virus in India

2013 ◽  
Vol 3 (4) ◽  
pp. 145-151
Author(s):  
M. Y. Wani ◽  
K. Dhama ◽  
R. Barathidasan ◽  
V. Gowthaman ◽  
R. Tiwari ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Molecular Detection ◽  
Control Strategies ◽  
Age Groups ◽  
Epidemiological Studies ◽  
Control Measures ◽  
Economic Losses ◽  
Field Samples ◽  
And Control ◽  
Young Chicks

Chicken infectious anemia (CIA) is an economically important disease affecting poultry, especially young chicks, characterized by poor weight gain, anemia, immunosuppression and production losses. Recent reports indicate that the virus is emerging and re-emerging worldwide.  Also, scarce reports regarding the molecular detection and epidemiology of virus from India are available. The aim of this study was to determine the prevalence of the virus in the commercial poultry farms of the country employing polymerase chain reaction (PCR). Out of the suspected 424 field samples tested from 12 different states of the country during the last five years (2007-2012), 311 (73.3%) samples were found positive for CIAV-DNA indicating the wide prevalence of the virus in India. The age wise prevalence of the virus indicated high prevalence in young chicks of up to three weeks (80.3%) of age compared to 3-7 (66.6%) and 7-12 (25%) week age groups. Being an immunosuppressive emerging pathogen circulating among the poultry flocks of the country, suitable prevention and control measures need to be adopted timely. This is a first elaborative report on the molecular epidemiology of CIAV in poultry flocks of the country. Extensive epidemiological studies are suggested to know the magnitude of the virus affecting poultry industry of the country, and design and formulate effective disease prevention and control strategies to reduce economic losses being caused by emerging virus.

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