scholarly journals Profile of the expression of genes and the proteins encoded by them related to the phenomenon of loss of an adequate response to treatment in endometrial cancer

2021 ◽  
Author(s):  
Piotr Januszyk ◽  
Beniamin Grabarek ◽  
Dariusz Boroń
Keyword(s):  
Endometrial Cancer ◽  
Response To Treatment ◽  
Adequate Response ◽  
Expression Of Genes

NUMERICAL COEFFICIENT FOR ENDOMETRIAL CANCER INDIVIDUAL RISK EVALUATION IN POSTMENOPAUSAL WOMEN

2017 ◽  
Vol 63 (3) ◽  
pp. 461-465
Author(s):  
Lev Bershteyn ◽  
Dmitriy Vasilev ◽  
Tatyana Poroshina ◽  
Igor Berlev
Keyword(s):  
Breast Cancer ◽  
Endometrial Cancer ◽  
Risk Evaluation ◽  
Tumor Response ◽  
Molecular Genetic ◽  
Response To Treatment ◽  
Individual Risk ◽  
The Past ◽  
Genetic Landscape ◽  
Numerical Coefficient

Increased frequency of endometrial cancer (EC) since the beginning of this century exceeds that of breast cancer and to a large extent can be attributed to dynamics of parameters, which characterize hormonal and metabolic status of ill women and molecular genetic landscape of transforming endometrium. During the past few years there are suggested several options for a personalized assessment of the risk of EC. The aim of this article is to propose and justify own version of this score with the idea of its further not only retrospective but also prospective testing both in relation to the risk of developing endometrial cancer as well as an additional marker helping to predict tumor response to treatment.

95 Expression of genes relevant for tumour aggressiveness in endometrial cancer

2004 ◽  
Vol 2 (8) ◽  
pp. 31-32
Author(s):  
E. Steiner ◽  
J. Sagemüller ◽  
J. Brieger ◽  
C. Lindner ◽  
M. Werling ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Expression Of Genes

scholarly journals A clinical study on non-resolving pneumonia in tertiary care centre

2018 ◽  
Vol 5 (3) ◽  
pp. 604
Author(s):  
Ramesh P. M. ◽  
Saravanan M.
Keyword(s):  
Bacterial Pneumonia ◽  
Tertiary Care ◽  
Response To Treatment ◽  
Age Group ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Ct Guided ◽  
Adequate Response ◽  
Empirical Antibiotics ◽  
Symptoms And Signs

Background: Non-resolving pneumonia is a problem not only for the patient but also to the treating physician because establishing the cause for the non-resolution of pneumonia takes time and requires invasive investigations. The present study was done with the aim to evaluate the etiology and clinical outcome of non-resolving pneumonia by using fibre-optic bronchoscopy (FOB).Methods: This prospective study was done on 45 patients with symptoms and signs of non-resolving pneumonia attending the Govt. Thiruvotteeswarar Hospital of Thoracic Medicine, Otteri, Chennai, a tertiary care teaching centre, during the period January 2016 to December 2016. All the patients were investigated systematically to find out the etiological factors for non-resolution pneumoniaResults: Males preponderance was seen in the study (80%). Patients of age group 51-60 years are more affected (26.6%). Bacterial pneumonia not responding to empirical antibiotics (42.2%) was the most common cause followed by pulmonary tuberculosis (28.8%) and malignancy (24.4%). On FOB, inflammation with secretions was noticed in most of the patients (66.6%).Conclusion: The findings of the study concluded that apart from bacterial pneumonia not responding to empirical antibiotics, tuberculosis and malignancy were found to be the major causes of non-resolving pneumonia. Hence, it is necessary to observe every patients for the adequate response to treatment and to utilize other modalities of investigations like FOB,CT guided FNAC/biopsy whenever required to offer exact management to the patients.

scholarly journals Interactive Effects of Immunoglobulin Gamma and Human Leucocyte Antigen Genotypes on Response to Interferon Based Therapy of Hepatitis C Virus

2015 ◽  
Vol 3 (2) ◽  
pp. 245-249
Author(s):  
Howayda E. Gomaa ◽  
Mohamed Mahmoud ◽  
Nevine E. Saad ◽  
Amal S. Saad-Hussein ◽  
Somaia Ismail ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Markers ◽  
Human Leucocyte Antigen ◽  
Hcv Infection ◽  
Interactive Effects ◽  
Response To Treatment ◽  
Hcv Treatment ◽  
Adequate Response ◽  
Immunoglobulin Gamma

AIM: We examined the role that immunoglobulin GM 23 and KM allotypes—genetic markers of γ and κ chains, respectively—play in response to treatment of hepatitis C virus (HCV) infection in Egyptian patients.MATERIAL AND METHODS: A total of 120 persons who had responded to HCV treatment and 125 with persistent HCV infection were genotyped for the presence of GM23 and KM determinants. HLA –C genotyping was also done.RESULTS: Association of GM 23+ and KM3 was significantly associated with non response to treatment (P < 0.0001). Individuals who lacked this GM genotype (but were positive for KM1,2 and 3) were likely to respond to treatment (P=0.045). Association of heterozygous GM23 (+/-) with KM 1,2 and 3 or KM3 alone was significantly associated with SVR (P = 0.001) and (P = 0.0001) respectively. Particular combinations of HLA and GM genotypes were associated significantly with the response to HCV treatment. The combination of HLAC2C2 and GM23+ was associated with persistence of infection (P = 0.027) while the association of HLAC2C2 and heterozygous GM23+/- was associated with SVR (P = 0.001).The association of HLAC1C1 and heterozygous GM23+/- was significantly associated with SVR (P = 0.001) and also subjects with HLA C1/C2 and heterozygous GM23+/- were likely to respond to treatment (P = 0.003) while subjects with HLA C1/C2 and GM23+ show tendency to resist to treatment (P = 0.0001).CONCLUSION: Our results didn’t support a role for KM allotypes, GM23 allotype plays a role in the persistence of HCV infection in the presence or absence of KM1,3. Interaction between certain GM and HLA-C genotypes may favor adequate response to interferon based therapies.

Analysis of the differences in the Expression of mRNAs and miRNAs Asso-ciated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin

2020 ◽  
Vol 21 ◽  
Author(s):  
Piotr Januszyk ◽  
Krzysztof Januszyk ◽  
Magdalena Wierzbik-Strońska ◽  
Dariusz Boroń ◽  
Beniamin Grabarek
Keyword(s):  
Drug Resistance ◽  
Endometrial Cancer ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Cancer Cell Line ◽  
Control Culture ◽  
New Drugs ◽  
Cancer Drug ◽  
Cancer Drug Resistance ◽  
Expression Of Genes

Background: It is important to understand the molecular mechanisms involved in cancer drug resistance and to study the activity of new drugs, e.g. salinomycin. Objective: The purpose of the study was to analyze changes in the expression of genes associated with drug resistance in the Ishikawa endometrial cancer cell line when treated with salinomycin. In addition, changes in the level of miRNA potentially regulating these mRNAs were evaluated. Results: The following was observed about the number of mRNAs differentiating the cell culture exposed to the drug compared to a control culture: H-12 vs C - 9 mRNAs, H_24 vs C – 6 mRNAs, H_48 vs C - 1 mRNA. It was noted that 4 of the 9 differentiating mRNAs were characteristic for 12 hours of exposure to the salinomycin and they correspond to the following genes: TUFT1, ABCB1, MTMR11, MX2. After 24 hours, 2 mRNAs were characteristic for this time of incubation cells with salinomycin: TUFT1, MYD88 and after 48 hours, SLC30A5 could also be observed. The highest differences in expression were indicated for TUFT1, MTMR11, SLC30A5. The highest influence probability was determined between TUFT1 and hsamiR-3188 (FC + 2.48), MTMR11and has-miR-16 (FC -1.74), and between SLC30A5 and hsa-miR-30d (FC -2.01). Materials and Methods: Endometrial cancer cells were treated with 1 µM of salinomycin for 12, 24 and 48 hour periods. Untreated cells were a control culture. The molecular analysis consists of mRNA and miRNA microarray analysis and the RTqPCR technique. Conclusions: Salinomycin induces changes in the activity of mRNA and miRNA participating in drug resistance, however the observed changes in character are an expected result of anti-cancer treatment.

Human skin biomarkers and his relation with the response to treatment to tyrosine kinase inhibitors in advanced EGFR mutated lung adenocarcinoma.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e21544-e21544
Author(s):  
Jeronimo Rafael Rafael Rodriguez Cid ◽  
Anahi Castañeda-Zárraga ◽  
Rodrigo Rodrigo Flores-Mariñelarena ◽  
María Elisa Vega-Memije ◽  
Valeria Michelle Fernández Garibay ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Kinase Inhibitors ◽  
Progression Free Survival ◽  
Response To Treatment ◽  
Free Survival ◽  
A Value ◽  
Number Of Layers ◽  
Adequate Response ◽  
Skin Biopsies ◽  
Egfr Mutated

e21544 Background: A relationship between EGFR signaling pathway expression in skin and the use of targeted cancer therapies has been consistently demonstrated. Nonetheless, consistent evidence to support the use of skin biopsies as a surrogate for therapeutic evaluation. Methods: The present study is a prospective single-blind analysis of skin biopsies of patients with confirmed advanced EGFR mutated lung adenocarcinoma. Immunohistochemistry was performed with EGFR, p27, Ki67, STAT3, and MAPK, as well as an H&E histopathological analysis, looking for their relationship with the response to treatment with tyrosine kinase inhibitors. ROC curve analysis was used to determine the cutoff value for each biomarker selected dichotomizing the response to treatment as mentioned in the tissue samples section (adequate response or no response). Kaplan Meier analysis for progression-free survival was performed. Results: From the 35 biopsies obtained, 21 (60%) of the patients were women and 14 (40%) men; the mean age of participants was 60.6±11.7 years. Twelve patients (34.3%) were at the pre-treatment group, 12 (34.3%) had an adequate response to treatment and 11 (31.4%) were at the no response to treatment group. The median progression-free survival was 9 months. The next biomarkers were significantly related to an adequate response to treatment by using a bivariate correlation test: EGFR (p = 0.025), Ki67 (p = 0.015), STAT3 (p = 0.017), stratum corneum thickness (p = 0.039) and the number of layers of the stratum corneum(p = 0.041). A better median of progression-free survival was obtained on those with a value above of the cutoff preestablished of EGFR (21 months versus 7 months, 95% CI 0-46 versus 4.23-9.77, p = 0.025) and number of layers of the stratum corneum (21 months versus 8 months, 95% CI 0-43.81 versus 6.72-9.28, p = 0.030), however, for p27 a better median of progression-free survival was shown in those with a value below the cutoff before mentioned (21 months versus 8 months, 95% CI 8.17-33.83 versus 6.87-9.13, p = 0.031). Conclusions: We found a relationship between EGFR, Ki67, STAT3, stratum corneum, number of layers of stratum corneum, with the response to treatment, and better progression-free survival for high expression EGFR, number of layers of the stratum corneum and low expression for p27. The present study should incite to perform a further investigation to validate these markers as potential prognostic and predictive factors.

Phytochemicals targeting genes relevant for type 2 diabetes

2013 ◽  
Vol 91 (6) ◽  
pp. 397-411 ◽  
Author(s):  
Carani Venkatraman Anuradha
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intervention ◽  
Treatment Strategies ◽  
Nutritional Therapy ◽  
Response To Treatment ◽  
Clear Understanding ◽  
Nucleotide Polymorphisms ◽  
Expression Of Genes ◽  
The Individual

Nutrigenomic approaches based on ethnopharmacology and phytotherapy concepts have revealed that type 2 diabetes mellitus (T2DM) may be susceptible to dietary intervention. Interaction between bioactive food components and the genome may influence cell processes and modulate the onset and progression of the disease. T2DM, characterized by insulin resistance and beta cell dysfunction, is one of the leading causes of death and disability. Despite the great advances that have been made in the understanding and management of this complex, multifactorial disease, T2DM has become a worldwide epidemic in the 21st century. Population and family studies have revealed a strong genetic component of T2DM, and a number of candidate genes have been identified in humans. Variations in the gene sequences such as single nucleotide polymorphisms, explain the individual differences in traits like disease susceptibility and response to treatment. A clear understanding of how nutrients affect the expression of genes should facilitate the development of individualized intervention and, eventually, treatment strategies for T2DM. Review of the literature identified many phytochemicals/extracts from traditional medicinal plants that can target diabetogenic genes. This review focuses on the genetic aspects of T2DM, nutrient modification of genes relevant for diabetes, and future prospects of nutritional therapy of T2DM.

scholarly journals Experiencia en el manejo de feocromocitoma en los últimos 10 años: serie de casos

2017 ◽  
Vol 3 (3) ◽  
pp. 33-36
Author(s):  
Erika P. Navarro ◽  
Maria Camila Osejo ◽  
Luz Ángela Casas ◽  
Luis Guillermo Arango ◽  
Guillermo Guzmán
Keyword(s):  
Blood Pressure ◽  
Tumor Resection ◽  
Low Frequency ◽  
Response To Treatment ◽  
Blood Pressure Medication ◽  
Postoperative Course ◽  
Adequate Response ◽  
Rare Diagnosis

El feocromocitoma es un tumor productor de catecolaminas. Se describe la experiencia en el diagnóstico, manejo y seguimiento de pacientes con este diagnóstico en una institución de alta complejidad en Cali, Colombia, en los últimos 10 años. Se encontraron 11 casos con diagnóstico de feocromocitoma llevados a cirugía, dos de estos extraadrenal y uno maligno. Fueron asintomáticos 18%, 81% presentaron hipertensión arterial. La evolución posquirúrgica de los pacientes fue favorable, 33% persistieron con hipertensión arterial (HTA) luego de la resección del tumor, requiriendo menor dosis de antihipertensivos. El único caso de malignidad tuvo una respuesta no satisfactoria. A pesar de ser un diagnóstico infrecuente, su abordaje es importante debido a la morbilidad que representa. Las características de nuestra población son similares a lo reportado en la literatura, con baja frecuencia de complicaciones y adecuada respuesta al tratamiento.Abstract Pheochromocytoma is a catecholamine-producing tumor. We describe the experience in the diagnosis, management and monitoring of patients with pheochromocytoma in a highly complex institution in Cali, Colombia, in the last 10 years. We identified 11 cases with diagnosis of pheochromocytoma, who were taken to surgery, being two of these extraadrenal and one of these malignant. 18% were asymptomatic, 81% had hypertension. The postoperative course of patients was favorable, 33% persisted hypertensive after tumor resection, although less doses of blood pressure medication were required. The only case of malignancy had an unsatisfactory response. Despite being a rare diagnosis, the approach is important because morbidity in our population is similar to those reported in the literature, with a low frequency of complications and adequate response to treatment.

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