scholarly journals Tetracycline Residues in Bovine Muscle and Liver Samples from Sicily (Southern Italy) by LC-MS/MS Method: A Six-Year Study

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 695 ◽  
Author(s):  
Gaetano Cammilleri ◽  
Andrea Pulvirenti ◽  
Antonio Vella ◽  
Andrea Macaluso ◽  
Gianluigi Lo Dico ◽  
...  
Keyword(s):  
Continuous Improvement ◽  
Southern Italy ◽  
Bovine Liver ◽  
Epidemiological Data ◽  
Good Recovery ◽  
Bovine Muscle ◽  
Low Incidence ◽  
Tetracycline Residues ◽  
First Time

We examined a total of 369 bovine liver and muscle samples for the detection of oxytetracycline (OTC), tetracycline (TC), chlortetracycline (CTC), and doxycycline (DOX) residues by implementation and validation of a LC-MS/MS method. The method showed good recovery values between 86% and 92% at three levels of concentrations. The linearity tests revealed r2 > 0.996 for all the tetracyclines examined. Furthermore, the Youden test revealed that the method was robust. Only 14.4% of the samples showed OTC and TC residues in a concentration range of 10.4–40.2 µg kg−1. No CTC and DOX residues were found in all the samples analyzed. Liver samples showed the highest average values (31.5 ± 20.6 and 21.8 ± 18.9 for OTC and TC, respectively). The results showed a low incidence of TCs in all the samples examined, in comparison with other studies reported in the literature. A significant decrease in TC residues frequency was found from 2013 (p < 0.05). This work reports for the first time epidemiological data on the presence of TC residues in liver and muscle samples of cattle farmed in Sicily (Southern Italy). The very low incidence of TC residues indicates a continuous improvement in farming techniques in Southern Italy, which is essential to ensure consumers’ protection.

scholarly journals Epidemiology of Thyroid Carcinomas in North Macedonia (1999-2015)

2021 ◽  
Vol 12 ◽  
pp. 215013272110042
Author(s):  
Makazlieva Tanja ◽  
Vaskova Olivija ◽  
Stojanoski Sinisha ◽  
Manevska Nevena ◽  
Miladinova Daniela ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Prevalence Rate ◽  
Epidemiological Data ◽  
Female Gender ◽  
The Elderly ◽  
Inclusion Criteria ◽  
Statistical State ◽  
Total Prevalence ◽  
Low Incidence ◽  
Histopathological Type

Objective: We have set as objective to analyze epidemiological data of diagnosed thyroid carcinoma (TC) cases, incidence and prevalence rate by gender, age, histopathological type, and statistical regions in R. of N. Macedonia during the period 1999 to 2015. Material and Methods: Retrospective analysis of medical data collected from the 2 state thyroid departments. Inclusion criteria included newly diagnosed cases of TC in appropriate years for the period 1999 to 2015. We have evaluated: yearly incidence rate, incidence and prevalence by gender, age, the distribution in 8 statistical state regions and histopathological types and subtypes representation. Results: A total number of 422 TC patients were detected, average incidence rate of 1.22/105, with most prevalent papillary TCs79.5%, followed by follicular 10.9%, medullar 4.1%, anaplastic 3.1%, and other rare types with 2.3%. The highest incidence rate was detected in Skopje region, while the lowest in Southeast and the Polog region. The total prevalence rate for the female gender was 32.61/104 and for male 9.27/104 (f/m ratio = 3.52:1), with lowest female/male difference found in the elderly > 65 years (f/m = 2.21/1). Conclusion: Compared with regional epidemiological data we can conclude that Republic of N. Macedonia has very low incidence and prevalence rate, while female/male ratio was similar to that described in the literature. Our low incidence and prevalence rate may be due to 2 possible reasons, 1 would be insufficient diagnosis of only small portion of the real cases in the population, or the second reason may be a real low incidence resulting of specific etiopathogenetic circumstances.

scholarly journals Comparison of Three Fungicide Spray Advisories for Lettuce Downy Mildew

Plant Disease ◽  
2001 ◽  
Vol 85 (8) ◽  
pp. 895-900 ◽  
Author(s):  
B. M. Wu ◽  
K. V. Subbarao ◽  
A. H. C. van Bruggen ◽  
S. T. Koike
Keyword(s):  
Downy Mildew ◽  
Drip Irrigation ◽  
Leaf Wetness ◽  
Lettuce Downy Mildew ◽  
Advisory System ◽  
System 2 ◽  
Forecasting System ◽  
Low Incidence ◽  
System 1 ◽  
First Time

Lettuce growers in coastal California have relied mainly on protective fungicide sprays to control downy mildew. Thus, timing of sprays before infection is critical for optimal results. A leaf-wetness-driven, infection-based advisory system, previously developed, did not always perform satisfactorily. In this study, the advisory system was modified by incorporating a pathogen survival component (system 1) or both survival and sporulation components (system 2). These systems were then evaluated in commercial lettuce fields in coastal California during 1996-1998. Three or four treatments were carried out in each field: (i) no spray; (ii) sprays as scheduled by the growers; (iii) sprays following modified system 1; and (iv) sprays following the original advisory system (1996) or modified system 2 (1998). Downy mildew incidence was evaluated every 2 to 9 days. In fields with drip irrigation, the number of fungicide applications was reduced by one or two regardless of the advisory system used compared to the grower's calendar-based schedule, although one unnecessary spray was recommended in 1996 at Soledad and 1997 at Salinas. Under all three systems, disease levels were low (incidence <25% and about 1 lesion per plant) for fields with drip irrigation, but not for fields with sprinklers (incidence up to 100% and 5 to 10 lesions per plant). For the first time, we established that survival and sporulation components are not needed for a lettuce downy mildew forecasting system. Instead, a threshold with a shorter period of morning leaf wetness and high temperatures were found to have potential for improving forecasting efficiency.

scholarly journals The Registry as a Basis for Epidemiological Surveillance and Optimization of Care in Out-of-hospital Cardiac Arrest

2018 ◽  
Vol 7 (3) ◽  
pp. 234-243 ◽  
Author(s):  
A. A. Birkun ◽  
A. V. Altukhov
Keyword(s):  
Epidemiological Data ◽  
Epidemiological Studies ◽  
Wide Distribution ◽  
General Concept ◽  
Epidemiological Surveillance ◽  
Low Efficiency ◽  
Low Incidence ◽  
And Performance ◽  
Main Instrument ◽  
Hospital Cardiac Arrest

Despite significant progress in medicine, out-of-hospital cardiac (OHCA) remains one of the leading causes of death around the world. Epidemiological data suggest wide distribution of OHCA, low incidence of cardiopulmonary resuscitation attempts and low efficiency of resuscitation in the Russian Federation. Both implementation of measures for reducing mortality from OHCA and monitoring of their efficiency should be based on up-to-date, reliable data on national and regional OHCA epidemiology and performance of emergency medical services. The aim of this review is to provide a rationale for establishment of the national OHCA registry as a main instrument of collection, arrangement, storage, processing and presentation of data on OHCA epidemiology and efficiency of care provided. The review includes the analysis of OHCA epidemiological studies carried out in Russia, describes general concept and international experience of developing OHCA registries, and discusses Utstein guidelines for uniform reporting of OHCA data.

scholarly journals On the Use of Satellite Rainfall Data to Design a Dam in an Ungauged Site

Water ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3028
Author(s):  
Claudia Bertini ◽  
Luca Buonora ◽  
Elena Ridolfi ◽  
Fabio Russo ◽  
Francesco Napolitano
Keyword(s):  
Hydrological Model ◽  
Southern Italy ◽  
Storm Events ◽  
Satellite Precipitation ◽  
Design Storm ◽  
Area Of Interest ◽  
High Return ◽  
Precipitation Estimates ◽  
First Time ◽  
Climate Prediction Center

The estimation of the design peak discharge is crucial for the hydrological design of hydraulic structures. A commonly used approach is to estimate the design storm through the intensity–duration–area–frequency (IDAF) curves and then use it to generate the design discharge through a hydrological model. In ungauged areas, IDAF curves and design discharges are derived throughout regionalization studies, if any exist for the area of interest, or from using the hydrological information of the closest and most similar gauged place. However, many regions around the globe remain ungauged or are very poorly gauged. In this regard, a unique opportunity is provided by satellite precipitation products developed and improved in the last decades. In this paper, we show weaknesses and potentials of satellite data and, for the first time, we evaluate their applicability for design purposes. We employ CMORPH—Climate Prediction Center MORPHing technique satellite precipitation estimates to build IDAF curves and derive the design peak discharges for the Pietrarossa dam catchment in southern Italy. Results are compared with the corresponding one provided by a regionalization study, i.e., VAPI—VAlutazione delle Piene in Italia project, usually used in Italy in ungauged areas. Results show that CMORPH performed well for the estimation of low duration and small return periods storm events, while for high return period storms, further research is still needed.

scholarly journals A relict population of Cymbalophora rivularis on the Pollino Massif, southern Italy (Lepidoptera: Erebidae)

2018 ◽  
pp. 37-41
Author(s):  
Silvia Greco ◽  
Francesco Luigi Leonetti ◽  
Stefano Scalercio
Keyword(s):  
Plant Species ◽  
National Park ◽  
Southern Italy ◽  
First Record ◽  
South Italy ◽  
Refuge Area ◽  
Relict Populations ◽  
Relict Population ◽  
A Site ◽  
First Time

The first record for South Italy of Cymbalophora rivularis (Ménétriès, 1832) is reported, until now recorded in Italy only for Central Apennine. Three specimens were collected during August-September 2017, in an Acer spp. forest located on Monte Sparviere, a Site of Community Importance within the Pollino National Park. Furthermore, this species was successfully barcoded for the first time. This finding reinforces the biogeographic importance of Pollino Massif as refuge area for relict populations of several animal and plant species.

scholarly journals Systemic sclerosis phase III clinical trials: Hope on the horizon?

2018 ◽  
Vol 3 (3) ◽  
pp. 193-200 ◽  
Author(s):  
Martin Aringer ◽  
Christopher P Denton
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Cannabinoid Receptor ◽  
Good News ◽  
Phase Iii ◽  
Phase Iii Clinical Trials ◽  
Cell Antibody ◽  
Interleukin 6 Receptor ◽  
Low Incidence ◽  
First Time

While significant progress has been made in treating systemic sclerosis, many patients still have an outcome that is far from satisfactory. For the first time in history, several drugs are now in phase III randomized controlled trials. Approaches tested include the anti-B cell antibody rituximab, the anti-interleukin-6 receptor antibody tocilizumab, the antifibrotic drugs nintedanib and pirfenidone, and the cannabinoid receptor mimetic lenabasum. That all these drugs are in advanced clinical trials despite the relatively low incidence of the disease therefore is good news. Not only is there realistic hope that at least some of the approaches will work, this also indicates growing industry interest, for most of the trials are company-sponsored. This review attempts to delineate the ongoing trials and to summarize the underlying evidence of these candidate systemic sclerosis drugs.

Communication of commitment towards sustainable development of certified Portuguese organisations

2019 ◽  
Vol 36 (4) ◽  
pp. 458-484 ◽  
Author(s):  
Filipe Carvalho ◽  
Pedro Domingues ◽  
Paulo Sampaio
Keyword(s):  
Sustainable Development ◽  
Human Resources ◽  
Continuous Improvement ◽  
Health And Safety ◽  
Iso 14001 ◽  
Annual Reports ◽  
Content Type ◽  
The Public ◽  
Theoretical Assumptions ◽  
First Time

Purpose The purpose of this paper is twofold: first, it aims at the identification and assessment of the commitments towards sustainable development (SD) communicated to all interested parties (stakeholders) by top management; and second, mapping the profile of the organisations which prominently communicate those commitments. Design/methodology/approach The research methodology was supported on the content analysis of the organisations’ statements (disclosed on the institutional website) that sustain the strategy and policies (organisational culture). A total of 540 certified Portuguese organisations in Quality, Environment and Occupational Health and Safety (QEOHS) comprised the sample. Findings According to this research, it is possible to identify three main commitments towards SD addressing customers (consumers), human resources (employees) and continuous improvement. Furthermore, results suggest that commitments towards customers and human resources fit properly into the theoretical assumptions of the stakeholder theory and, in turn, the commitment towards continuous improvement fits accurately into the assumptions of the “normative isomorphism” of the institutional theory. Moreover, the results pointed out the characteristics of Portuguese organisations (QEOHS) that prominently communicate commitments towards SD: large business volume, located in Lisbon or Setubal, fall within the public business sector, are members of the BCSD Portugal and publish annual reports on the institutional website. Research limitations/implications Solely organisations operating in Portugal and simultaneously encompassing three certified management subsystems (against the clauses of ISO 9001, ISO 14001 and OHSAS 18001 standards) were considered throughout this study. So it is not possible to ascertain at which extent the conclusions are valid. However, although the statistical generalisation of the results may be precluded, there is not any peculiar reason preventing the analytical generalisation, namely, in organisations operating in countries with similar macro-characteristics of Portugal. Originality/value To the best of authors’ knowledge this is the first time that such a comprehensive, detailed and thorough analysis of the communicated commitments towards SD is carried out regardless the activity sector. The conclusions from this paper are useful both for practitioners and scholars. On one hand companies have now information on the more often communicated statements, while on the other hand academics and scholars will benefit from this research and hopefully be able to replicate it in other contexts.

Incidence, Comorbidity and Treatment Survey of Chronic Myeoloid Leukemia in Germany.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2964-2964 ◽  
Author(s):  
Joerg Hasford ◽  
Martin Tauscher ◽  
Andreas Hochhaus
Keyword(s):  
Heart Diseases ◽  
Epidemiological Data ◽  
Cerebrovascular Diseases ◽  
Current Treatment ◽  
Crude Incidence ◽  
True Incidence ◽  
Incidence Estimate ◽  
Standard Population ◽  
One Year ◽  
First Time

Abstract Background and objectives Reliable epidemiological data about the incidence of CML, the treatment and the comorbidity profile of patients in Germany was not available. Methods Thus, we used the data base of the Bavarian association of statutory health insurance accredited physicians, which covers 83.5% of all outpatient care in Bavaria with 10.4 million people. A CML-patient was defined as the combination of an ICD 92.1 CML diagnosis plus treatment with either imatinib, interferon alfa, hydroxyurea or busulfan for at least one year. Results In 2004, there were 201 new CML cases seen which results in a crude incidence of 1.93 / 100,000 / year. Adjusted to the World Standard Population the figures are 1.357 for males and 1.063 for females. The median age was 63 (m) and 65 (f) years. Comparing the comorbidities of CML patients with all other patients > 60 years non infectious enteritis and colitis (RR: 2.99), diseases of the oral cavity, salivary glands or jaws (RR: 2.49); infectious of the skin or subcutis (RR: 2.28), surgical complications (RR: 2.13) and symptoms of the GI-tract or abdomen (RR: 2.09) occurred more often in CML-patients, whereas hypertension (RR: 0.81), IHD (RR: 0.93); other heart diseases (RR: 0.87) and cerebrovascular diseases (RR: 0.78) occurred less often. In 2006, 58.8% of the CML-patients received imatinib alone; 10.2% imatinib in combination either with HU or IFN alfa, 25.8% HU, and 7.6% IFN alfa. Discussion and conclusions The true incidence may be slightly lower (about 10%) as some chronic myeloproliferative diseases may have been miscoded as CML, but we may have missed some CML-patients who have been treated as inpatients only, too. Thus, we think that our incidence estimate, and the age and sex distribution is fairly accurate. In addition and for the first time, current treatment comorbidity data of CML-patients in Germany are available.

scholarly journals Charcoal Canker of Pear, Plum, and Quince Trees Caused by Biscogniauxia rosacearum sp. nov. in Southern Italy

Plant Disease ◽  
2016 ◽  
Vol 100 (9) ◽  
pp. 1813-1822 ◽  
Author(s):  
Maria Luisa Raimondo ◽  
Francesco Lops ◽  
Antonia Carlucci
Keyword(s):  
New Species ◽  
Southern Italy ◽  
Molecular Data ◽  
Minor Importance ◽  
Actin Gene ◽  
Forest Trees ◽  
The Family ◽  
Pathogenicity Tests ◽  
First Time ◽  
A New Species

The genus Biscogniauxia is paraphyletic to members of the family Xylariaceae and includes at least 52 species to date that are mainly pathogens of dicotyledonous angiosperm trees. Most of these are forest trees, such as those in the genera Acacia, Acer, Alnus, Eucalyptus, Fraxinus, Populus, and Quercus, and other species of minor importance. Biscogniauxia spp. have been reported as endophytes or secondary invaders that attack only stressed plants. During a survey in rosaceous orchards in southern Italy, several charcoal cankers were observed and stroma samples were collected. A collection of 31 Biscogniauxia isolates was analyzed. Their phylogenetic relationships were determined through study of the internal transcribed spacer, β-tubulin, and actin gene sequences. Combining morphological, cultural, and molecular data, a new species of Biscogniauxia is described here as Biscogniauxia rosacearum. This new species was isolated for the first time from rosaceous hosts in Apulia. Pathogenicity tests showed that it causes symptoms on stems when artificially inoculated and produces stromata on the bark surface.

Rhipicephalus turanicus, a new vector of Hepatozoon canis

Parasitology ◽  
2016 ◽  
Vol 144 (6) ◽  
pp. 730-737 ◽  
Author(s):  
ALESSIO GIANNELLI ◽  
RICCARDO PAOLO LIA ◽  
GIADA ANNOSCIA ◽  
CANIO BUONAVOGLIA ◽  
ELEONORA LORUSSO ◽  
...  
Keyword(s):  
Southern Italy ◽  
Rhipicephalus Sanguineus ◽  
Hepatozoon Canis ◽  
Time Data ◽  
Tick Vector ◽  
First Time ◽  
Potential Use ◽  
Potential Tool

SUMMARYThe distribution of Hepatozoon canis mainly encompasses areas where its main tick vector, Rhipicephalus sanguineus sensu lato, is present. However, the detection of this pathogen in dogs, foxes and golden jackals well outside the areas inhabited by this tick species reinforced the hypothesis that additional ixodids are involved in the life cycle and transmission of this protozoon. The present study provides, for the first time, data supporting the sporogonic development of H. canis in specimens of Rhipicephalus turanicus collected from a naturally infected fox from southern Italy. The epidemiological role of R. turanicus as a vector of H. canis is discussed, along with information on the potential use of cell cultures for the experimental infection with H. canis sporozoites. The in vitro infection of canine leucocytes by sporozoites from ticks is proposed as a potential tool for future in-depth studies on the biology of H. canis.

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