scholarly journals Supercritical Carbon Dioxide (scCO2) Extraction of Phenolic Compounds from Lavender (Lavandula angustifolia) Flowers: A Box-Behnken Experimental Optimization

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3354 ◽  
Author(s):  
Katarzyna Tyśkiewicz ◽  
Marcin Konkol ◽  
Edward Rój
Keyword(s):  
Carbon Dioxide ◽  
Phenolic Compounds ◽  
Supercritical Carbon Dioxide ◽  
Extraction Method ◽  
Positive Influence ◽  
Total Phenolic ◽  
Statistical Experimental Design ◽  
Lavandula Angustifolia ◽  
Phenolic Contents ◽  
Supercritical Carbon

Due to their numerous health benefits associated with various diseases and anti-oxidation properties, the phenolic compounds collectively referred to as phytochemicals have attracted a lot of interest, however, a single extraction method for polyphenols has not been developed yet. Supercritical fluid extraction, a green extraction method, provides the final product without organic solvent residues. In this work the extraction of lavender was performed using supercritical carbon dioxide. A statistical experimental design based on the Box-Behnken (B-B) method was planned, and the extraction yields and total phenolic contents were measured for three different variables: pressure, temperature and extraction time. The ranges were 200–300 bar, 40–60 °C and 15–45 min. The extracts yields from scCO2 extraction were in the range of 4.3–9.2 wt.%. The highest yield (9.2 wt.%) was achieved at a temperature of 60 °C under the pressure of 250 bar after 45 min. It also corresponded to the highest total phenolic content (10.17 mg GAE/g extract). Based on the study, the statistically generated optimal extraction conditions to obtain the highest total phenolic compounds concentration from flowers of Lavandula angustifolia were a temperature of 54.5 °C, pressure of 297.9 bar, and the time of 45 min. Based on the scavenging activity percentage (AA%) of scCO2 extracts, it is concluded that the increase of extraction pressure had a positive influence on the increase of AA% values.

scholarly journals Enhancing Phenolic Contents and Antioxidant Potentials ofAntidesma thwaitesianumby Supercritical Carbon Dioxide Extraction

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Warut Poontawee ◽  
Surapol Natakankitkul ◽  
Orawan Wongmekiat
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Added Value ◽  
Total Phenolic ◽  
Antioxidant Power ◽  
Phenolic Contents ◽  
Phenolic Constituents ◽  
Supercritical Carbon

Supercritical fluid extraction (SFE) has increasingly gained attention as an alternative technique for extraction of natural products without leaving toxic residues in extracts.Antidesma thwaitesianumMuell. Arg. (Phyllanthaceae), or ma mao, has been reported to exhibit antioxidant health benefits due to its phenolic constituents. To determine whether SFE technique could impact on phenolic contents and associated antioxidant potentials, ripe fruits ofAntidesma thwaitesianum(Phyllanthaceae) were extracted using supercritical carbon dioxide (SC-CO2) and conventional solvents (ethanol, water). The results showed that the SC-CO2extract contained significantly higher yield, total phenolic, flavonoid, and proanthocyanidin contents than those obtained from ethanol and water. It also demonstrated the greatest antioxidant activities as assessed by ABTS radical cation decolorization, DPPH radical scavenging, and ferric reducing antioxidant power (FRAP) assays. Further analysis using high-performance liquid chromatography with diode array and mass spectrometry detectors (HPLC-DAD/MSD) revealed the presence of catechin as a major phenolic compound ofAntidesma thwaitesianum(Phyllanthaceae), with the maximum amount detected in the SC-CO2extract. These data indicate that SFE technology improves both quantity and quality ofAntidesma thwaitesianumfruit extract. The findings added more reliability of using this technique to produce high added value products from this medicinal plant.

scholarly journals Characterization and Biological Activities of Seed Oil Extracted from Berberis dasystachya Maxim. by the Supercritical Carbon Dioxide Extraction Method

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1836
Author(s):  
Lijuan Han ◽  
Qingqing Han ◽  
Yongjing Yang ◽  
Honglun Wang ◽  
ShuLin Wang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Fatty Acids ◽  
Gas Chromatography ◽  
Supercritical Carbon Dioxide ◽  
Extraction Method ◽  
Unsaturated Fatty Acids ◽  
Biological Activities ◽  
Maximum Yield ◽  
Dependent Manner ◽  
Supercritical Carbon

Characterization of the structure and pharmacological activity of Berberis dasystachya Maxim., a traditional Tibetan medicinal and edible fruit, has not yet been reported. In this study, central composite design (CCD) combined with response surface methodology (RSM) was applied to optimize the extraction conditions of B. dasystachya oil (BDSO) using the supercritical carbon dioxide (SC-CO2) extraction method, and the results were compared with those obtained by the petroleum ether extraction (PEE) method. The chemical characteristics of BDSO were analyzed, and its antioxidant activity and in vitro cellular viability were studied by DPPH, ABTS, reducing power assay, and MTT assay. The results showed that the maximum yield of 12.54 ± 0.56 g/100 g was obtained at the optimal extraction conditions, which were: pressure, 25.00 MPa; temperature 59.03 °C; and CO2 flow rate, 2.25 SL/min. The Gas chromatography (GC) analysis results showed that BDSO extracted by the SC-CO2 method had higher contents of unsaturated fatty acids (85.62%) and polyunsaturated fatty acids (57.90%) than that extracted by the PEE method. The gas chromatography used in conjunction with ion mobility spectrometry (GC–IMS) results showed that the main volatile compounds in BDSO were aldehydes and esters. BDSO also exhibited antioxidant ability in a dose-dependent manner. Moreover, normal and cancer cells incubated with BDSO had survival rates of more than 85%, which indicates that BDSO is not cytotoxic. Based on these results, the BDSO extracted by the SC-CO2 method could potentially be used in other applications, e.g., those that involve using berries of B. dasystachya.

scholarly journals The Application of Supercritical Carbon Dioxide and Ethanol for the Extraction of Phenolic Compounds from Chokeberry Pomace

2017 ◽  
Vol 7 (4) ◽  
pp. 322 ◽  
Author(s):  
Łukasz Woźniak ◽  
Krystian Marszałek ◽  
Sylwia Skąpska ◽  
Renata Jędrzejczak
Keyword(s):  
Carbon Dioxide ◽  
Phenolic Compounds ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Carbon

Optimizing the supercritical carbon dioxide extraction of sweet cherry (Prunus avium L.) leaves and UPLC-MS/MS analysis

2020 ◽  
Vol 12 (23) ◽  
pp. 3004-3013
Author(s):  
Huimin Zhang ◽  
Quan Li ◽  
Guang Qiao ◽  
Zhilang Qiu ◽  
Zhuang Wen ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Extraction Method ◽  
Sweet Cherry ◽  
Prunus Avium ◽  
Supercritical Carbon Dioxide Extraction ◽  
Ms Analysis ◽  
Carbon Dioxide Extraction ◽  
Prunus Avium L ◽  
Supercritical Carbon

To study the application value of sweet cherry leaves before abscission, a supercritical carbon dioxide (SFE-CO2) extraction method was established for sweet cherry (Prunus avium L.) leaves.

Determination of Supercritical Carbon Dioxide Extraction Parameters for Quercus infectoria Galls and the Effects on Extraction Yield and Antioxidant Activity

2014 ◽  
Vol 67 (2) ◽  
Author(s):  
Liza Md Salleh ◽  
Hasmida Mohd Nasir ◽  
Harisun Yaakob ◽  
Mohd Azizi Che Yunus
Keyword(s):  
Carbon Dioxide ◽  
Antioxidant Activity ◽  
Supercritical Carbon Dioxide ◽  
Medicinal Plant ◽  
Flow Rate ◽  
Total Phenolic ◽  
Extraction Parameters ◽  
Quercus Infectoria ◽  
Supercritical Carbon

Currently, finding alternative ways of extracting medicinal plant gain more interest from the researchers.  Quercus infectoria, a medicinal plant, is rich with bioactive compound being extracted using supercritical carbon dioxide (SC-CO2) extraction which helps to maintain the quality of the product as well as green environment. CO2 is widely used as solvent due to moderate critical conditions, nontoxic and easily removed from the products. This work was performed to determine the optimum extraction parameters of SC-CO2 extraction and their effects on the total phenolic content and antioxidant activity of Q.infectoria extract. Hence, two different parameters have been investigated which were extraction time and CO2 flow rate (2, 3, 4 ml/min) while pressure (P) and temperature (T) were fixed at highest density (P = 30 MPa, T = 40oC). The results obtained from this study show that the solvent flow rate of 2 ml/min gives the highest percentage of yield (0.3652%) and the complete extraction of the sample was achieved at 80 minutes. Better quality of the extract was shown at 2 ml/min as resulted in high amount of phenolic compound in the extract presented as gallic acid equivalent (GAE) (2.04×102 mg GAE/g sample). The extracts were screened for possible antioxidant activity by 2,2-diphenyl-1-picryl hydrazyl (DPPH) free radical scavenging assays. In this study, the best result obtained for antioxidant activity was at flow rate of 3 ml/min with inhibition percentage of 96.97%.

scholarly journals Optimisation of oil extraction from quinoa seeds with supercritical carbon dioxide with co-solvents

2018 ◽  
Vol 36 (No. 1) ◽  
pp. 81-87 ◽  
Author(s):  
Grażyna Wejnerowska ◽  
Anna Ciaciuch
Keyword(s):  
Carbon Dioxide ◽  
Particle Size ◽  
Supercritical Carbon Dioxide ◽  
Oil Recovery ◽  
Extraction Method ◽  
Oil Extraction ◽  
Carbon Dioxide Extraction ◽  
Temperature Time ◽  
Total Extraction ◽  
Supercritical Carbon

In the present work supercritical fluid extraction with carbon dioxide was performed to obtain oil from quinoa seeds. The effects of extraction variables – namely pressure, temperature, time, particle size, and co-solvent, on supercritical carbon dioxide extraction are investigated. Total extraction yields and compositions using pure CO<sub>2</sub> and CO<sub>2</sub> + selected co-solvents are compared. The maximum recovery for quinoa oil is found to be about 89%, and is obtained when extractions are carried out at 25 MPa, 40°C for 80 minutes. A significant effect on the oil recovery is exerted by size reduction of seeds to a particle size ≤ 0.50 mm and addition of co-solvent to seed in an amount of 20% – methanol/ethanol (1 : 1, w/w). Irrespective of the extraction method and conditions, the fatty acid composition is not substantially changed.

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