scholarly journals Encapsulation of β-Carotene by Emulsion Electrospraying Using Deep Eutectic Solvents

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 981 ◽  
Author(s):  
Ahmet Ozan Basar ◽  
Cristina Prieto ◽  
Erwann Durand ◽  
Pierre Villeneuve ◽  
Hilal Turkoglu Sasmazel ◽  
...  
Keyword(s):  
Choline Chloride ◽  
Oxidation Stability ◽  
Deep Eutectic Solvents ◽  
Water Soluble ◽  
Whey Protein Concentrate ◽  
Photo Oxidation ◽  
Wide Range ◽  
Poorly Water Soluble ◽  
Solubilized Form ◽  
Β Carotene

The encapsulation β-carotene in whey protein concentrate (WPC) capsules through the emulsion electrospraying technique was studied, using deep eutectic solvents (DES) as solvents. These novel solvents are characterized by negligible volatility, a liquid state far below 0 °C, a broad range of polarity, high solubilization power strength for a wide range of compounds, especially poorly water-soluble compounds, high extraction ability, and high stabilization ability for some natural products. Four DES formulations were used, based on mixtures of choline chloride with water, propanediol, glucose, glycerol, or butanediol. β-Carotene was successfully encapsulated in a solubilized form within WPC capsules; as a DES formulation with choline chloride and butanediol, the formulation produced capsules with the highest carotenoid loading capacity. SEM micrographs demonstrated that round and smooth capsules with sizes around 2 µm were obtained. ATR-FTIR results showed the presence of DES in the WPC capsules, which indirectly anticipated the presence of β-carotene in the WPC capsules. Stability against photo-oxidation studies confirmed the expected presence of the bioactive and revealed that solubilized β-carotene loaded WPC capsules presented excellent photo-oxidation stability compared with free β-carotene. The capsules developed here clearly show the significant potential of the combination of DES and electrospraying for the encapsulation and stabilization of highly insoluble bioactive compounds.

scholarly journals Thermal Conductivities of Choline Chloride-Based Deep Eutectic Solvents and Their Mixtures with Water: Measurement and Estimation

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3816
Author(s):  
Taleb H. Ibrahim ◽  
Muhammad A. Sabri ◽  
Nabil Abdel Jabbar ◽  
Paul Nancarrow ◽  
Farouq S. Mjalli ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Standard Uncertainty ◽  
Heat Transfer Fluids ◽  
Wide Range ◽  
Different Temperatures ◽  
Experimental Values ◽  
Water Measurement ◽  
Thermal Conductivities

The thermal conductivities of selected deep eutectic solvents (DESs) were determined using the modified transient plane source (MTPS) method over the temperature range from 295 K to 363 K at atmospheric pressure. The results were found to range from 0.198 W·m−1·K−1 to 0.250 W·m−1·K−1. Various empirical and thermodynamic correlations present in literature, including the group contribution method and mixing correlations, were used to model the thermal conductivities of these DES at different temperatures. The predictions of these correlations were compared and consolidated with the reported experimental values. In addition, the thermal conductivities of DES mixtures with water over a wide range of compositions at 298 K and atmospheric pressure were measured. The standard uncertainty in thermal conductivity was estimated to be less than ± 0.001 W·m−1·K−1 and ± 0.05 K in temperature. The results indicated that DES have significant potential for use as heat transfer fluids.

Investigation of Nanoscale Structure of Self-Emulsifying Drug Delivery System Containing Poorly Water-Soluble Model Drug

2014 ◽  
Vol 970 ◽  
pp. 272-278 ◽  
Author(s):  
Mont Kumpugdee-Vollrath ◽  
Yotsanan Weerapol ◽  
Karin Schrader ◽  
Pornsak Sriamornsak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Correlation Spectroscopy ◽  
Water Soluble ◽  
Wide Range ◽  
Poorly Water Soluble ◽  
Nanoscale Structure ◽  
Model Drug ◽  
20 Nm

This work has a focus on the self-emulsifying drug delivery system (SEDDS), which can be used in pharmaceutical field for increasing bioavailability of poorly water-soluble drugs. The model drug resveratrol was used because of its poor water-solubility and is of interest because of its wide range of pharmacological effects. It is beneficial to understand the mechanism of SEDDS formation in the human body, therefore, the determination of nanoscale structure was carried out. For this purpose, small angle X-ray scattering (SAXS), photon correlation spectroscopy (PCS), and transmission electron microscopy (TEM) techniques were applied. We have found that the size and size distribution of particles were in nanometers. The inner structure of SEDDS was ordered with the lamellar distances (d-spacing) of < 20 nm. It seems that the prepared SEDDS in water form large oil drops (200-400 nm) in water as well as small micelles with the droplet size of 10-20 nm.

scholarly journals LIQUISOLID TECHNIQUE: A NOVEL APPROACH FOR DOSAGE FORM DESIGN

2017 ◽  
Vol 9 (3) ◽  
pp. 8
Author(s):  
Satyajit Panda ◽  
R. Varaprasad ◽  
K. Priyanka ◽  
Ranjit P. Swain
Keyword(s):  
Sustained Release ◽  
Dissolution Rate ◽  
Pharmaceutical Formulations ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Coating Materials ◽  
Bioavailability Enhancement ◽  
Novel Approach ◽  
Wide Range ◽  
Poorly Water Soluble

The liquisolid technique is a novel approach for delivery of drugs through the oral route. This technique is suitable for poorly soluble or water insoluble drugs, highly permeable drugs (BCS Class II drugs) and also for immediate or sustained release formulations. It is a novel "Powder Solution Technology" that involves absorption and adsorption efficiencies, making use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non-adherent and compressible powder forms. The design of liquisolid systems are mainly intended for enhancement of solubility, dissolution rate and bioavailability of poorly water-soluble and highly lipophilic drugs. Improvement in bioavailability may be due to increased surface area, increased aqueous solubility and increased the wettability of the drug. Liquisolid technique also has the potential to be optimized for the reduction of drug dissolution rate and thereby production of sustained release systems. Overall, liquisolid technique is a most promising and novel technique for enhancing the dissolution and bioavailability of poorly water soluble drugs and sustaining drug release from tablet matrices. The current review mainly focuses on theory and applicability of liquisolid compact technique towards solubility or bioavailability enhancement. Different carriers, solvents and coating materials employed are elucidated. Literature reports on the applicability of liquisolid compact techniques over a wide range of pharmaceutical formulations are also explicated.

scholarly journals Lipid-Based Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Hina Shrestha ◽  
Rajni Bala ◽  
Sandeep Arora
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Parenteral Delivery ◽  
Wide Range ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Principle Objective

The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. These formulations are also a commercially viable strategy to formulate pharmaceuticals, for topical, oral, pulmonary, or parenteral delivery. In addition, lipid-based formulations have been shown to reduce the toxicity of various drugs by changing the biodistribution of the drug away from sensitive organs. However, the number of applications for lipid-based formulations has expanded as the nature and type of active drugs under investigation have become more varied. This paper mainly focuses on novel lipid-based formulations, namely, emulsions, vesicular systems, and lipid particulate systems and their subcategories as well as on their prominent applications in pharmaceutical drug delivery.

scholarly journals Solubility and Stability of Some Pharmaceuticals in Natural Deep Eutectic Solvents-Based Formulations

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2645
Author(s):  
Natali Rianika Mustafa ◽  
Vincent Simon Spelbos ◽  
Geert-Jan Witkamp ◽  
Robert Verpoorte ◽  
Young Hae Choi
Keyword(s):  
Amino Acids ◽  
Chloral Hydrate ◽  
Tube Feeding ◽  
Deep Eutectic Solvents ◽  
Water Soluble ◽  
Molar Ratios ◽  
Natural Deep Eutectic Solvents ◽  
Potential Applications ◽  
Poorly Soluble ◽  
Poorly Water Soluble

Some medicines are poorly soluble in water. For tube feeding and parenteral administration, liquid formulations are required. The discovery of natural deep eutectic solvents (NADES) opened the way to potential applications for liquid drug formulations. NADES consists of a mixture of two or more simple natural products such as sugars, amino acids, organic acids, choline/betaine, and poly-alcohols in certain molar ratios. A series of NADES with a water content of 0–30% (w/w) was screened for the ability to solubilize (in a stable way) some poorly water-soluble pharmaceuticals at a concentration of 5 mg/mL. The results showed that NADES selectively dissolved the tested drugs. Some mixtures of choline-based NADES, acid-neutral or sugars-based NADES could dissolve chloral hydrate (dissociated in water), ranitidine·HCl (polymorphism), and methylphenidate (water insoluble), at a concentration of up to 250 mg/mL, the highest concentration tested. Whereas a mixture of lactic-acid–propyleneglycol could dissolve spironolacton and trimethoprim at a concentration up to 50 and 100 mg/mL, respectively. The results showed that NADES are promising solvents for formulation of poorly water-soluble medicines for the development of parenteral and tube feeding administration of non-water-soluble medicines. The chemical stability and bioavailability of these drug in NADES needs further studies.

scholarly journals Tailoring Properties of Acidic Types of Natural Deep Eutectics Solvents (NADES): Enhanced Solubility of Curcuminoids from Curcuma zeodaria

2018 ◽  
Vol 156 ◽  
pp. 01011 ◽  
Author(s):  
Orchidea Rachmaniah ◽  
Lailatul Jumiati Fazriyah ◽  
Nurul Hesti Seftiyani ◽  
M. Rachimoellah
Keyword(s):  
Water Content ◽  
Dry Weight ◽  
Deep Eutectic Solvents ◽  
High Viscosity ◽  
Water Soluble ◽  
Green Solvents ◽  
Time Duration ◽  
Natural Deep Eutectic Solvents ◽  
Enhanced Solubility ◽  
Poorly Water Soluble

Recently Natural Deep Eutectic Solvents (NADES) show their potential as a promising green solvents at 21th century for extraction of natural products. Rutin, a poorly water soluble flavonoid, was reported better solubilized in NADES than in water as well as a paclitaxel and ginkgolide B, a completely water-insoluble compound. In case of curcuminoids, phenolic compounds from powder of Curcuma Zeodaria shown better solubilized in acidic type of NADES such malic acid-sucrose-water (MAS-H2O = 1:1:11, mole ratio) and citric acid-sucrose-water (CAS-H2O = 1:2:15, mole ratio) compare to water and ethanol. Indicating that NADES, a water-based solvent, appropriate for extracting curcuminoids. However, the inherent high viscosity of NADES hamper the process extraction. Lowering the viscosity, water content of NADES is varied, adding a certain amount of water up to 60% of water content. All the varied water content of both CAS-H2O and MAS-H2O were successfully extracted curcuminoids. Yielded 0.06-0.16 mg curcuminoids/g dry weight. However, 60% of water content of both CAS-H2O and MAS-H2O gave more or less similar value of curcuminoids to CAS-H2O (20% of water) and MAS-H2O (30% of water). Curcuminoids is more stable in CAS-H2O compare to MAS-H2O for 96 h of time duration.

scholarly journals Natural Deep Eutectic Solvent-Assisted Pectin Extraction from Pomelo Peel Using Sonoreactor: Experimental Optimization Approach

Processes ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 416 ◽  
Author(s):  
Amal Elgharbawy ◽  
Adeeb Hayyan ◽  
Maan Hayyan ◽  
Mohamed Mirghani ◽  
Hamzah Salleh ◽  
...  
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Optimization Approach ◽  
Degree Of Esterification ◽  
Screening Design ◽  
Natural Deep Eutectic Solvents ◽  
Wide Range ◽  
Definitive Screening ◽  
Water Ratio

Background: Natural deep eutectic solvents (NADESs) can be used for extracting a wide range of biomaterials, such as pectin. This study introduces a new generation of natural solvents for pectin extraction which could replace the conventional solvents in the food industry. Methods: In this study, NADESs were used for pectin extraction from pomelo (Citrus grandis (L.) Osbeck) peels using a sonoreactor. Definitive screening design (DSD) was used to screen the influence of time, temperature, solid/liquid ratio, and NADES/water ratio on the pectin yield and degree of esterification (DE). Results: The primary screening revealed that the best choices for the extraction were choline chloride–malonic acid (ChCl-Mal) and choline chloride–glucose–water (ChCl:Glc:W). Both co-solvents yielded 94% pectin and 52% DE after optimization at 80 °C, with 60 min of sonication, pH < 3.0, and a NADES-to-water ratio of 1:4.5 (v/v). Morphological screening showed a smooth and compact surface of the pectin from ChCl-Mal where glucose-based pectin had a rough surface and lower DE. Conclusions: NADESs proved to be promising co-solvents for pectin extraction with a high degree of esterification (>55%).

scholarly journals Inclusion Complex of Iloperidone with Sulfobutyl Ether Beta-Cyclodextrin: Characterization and Dissolution Studies

2021 ◽  
Author(s):  
Rupali Sanjay Bhadale ◽  
Vaishali Yogesh Londhe
Keyword(s):  
Classification Systems ◽  
Water Soluble ◽  
First Line ◽  
Scanning Calorimetry ◽  
Bcs Class Ii ◽  
Kneading Method ◽  
Wide Range ◽  
Poorly Water Soluble ◽  
Sulfobutyl Ether

Iloperidone (ILO) is a second-generation antipsychotic drug and a first-line treatment approved by USFDA in May 2009. Iloperidone belongs to Biopharmaceutical Classification Systems (BCS) class II; thus, it is poorly water-soluble, highly permeable, and has pH-dependent solubility. Cyclodextrins and their derivatives have a wide range of applications in different formulations due to their complexation ability, which improves the solubility, stability, safety, and bioavailability of a drug. We have tried the complexation of iloperidone with sulfobutyl ether-β-cyclodextrin (SEβCD) to improve its solubility and dissolution. Complexation was done by the kneading method. The characterization of the SEβCD complexes with Iloperidone was done by FTIR, differential scanning calorimetry (DSC), saturation solubility, etc. A multimedia dissolution of the complex was carried out and compared with the plain drug. A significant improvement in drug release was found from SEβCD complexes in all media when compared with the drug alone.

scholarly journals Enhancement of Solubility of Diclofenac Sodium by Pastillation Method

2021 ◽  
Vol 11 (2) ◽  
pp. 6-10
Author(s):  
Sopan Pund ◽  
Nilesh Mahajan ◽  
Purushottam Gangane ◽  
Amol Warokar
Keyword(s):  
Dissolution Rate ◽  
Diclofenac Sodium ◽  
Water Soluble ◽  
Solubility Study ◽  
Wide Range ◽  
Water Soluble Drugs ◽  
Ft Ir ◽  
Poorly Water Soluble ◽  
Low Solubility ◽  
Selection Of

The Diclofenac Sodium is BCS class II drug which comes under the antipyretic class drug, and has a wide range of use. But due to its low solubility it has low dissolution rate and hence reduced bioavailability. There are several methods for the enhancement of solubility and dissolution rate. Pastillation technique is widely employed in chemical industry for solidification and better handling. Pastilles are solidified discrete units, acquired directly from the melt mass. However, this method of pastillation has not been explored for the drug delivery system yet. Literature revels that it can be used as a novel, effective and easiest method for the enhancement of solubility and dissolution rate. The selection of polymer was done by the solubility studies and Kolliphor HS 15 was used to make the pastilles of Diclofenac Sodium. Formation of pastilles were confirmed by FT-IR and further evaluated for % yield, drug contents, solubility study and dissolution test. From the results it was concluded that, solubility of Diclofenac Sodium was increased by pastillation method by 2-fold and dissolution rate was also enhanced by double than that of the drug. Thus, pastillation can be an effective and easiest method to enhance the solubility, dissolution rate and bioavailability of poorly water-soluble drugs having good permeability.  Keywords: Diclofenac Sodium, Pastillation, Kolliphor HS 15, Solubility enhancement, Solid dispersion.

scholarly journals Purification of model biogas from toluene using deep eutectic solvents

2019 ◽  
Vol 116 ◽  
pp. 00078 ◽  
Author(s):  
Edyta Słupek ◽  
Patrycja Makoś ◽  
Jacek Gębicki ◽  
Andrzej Rogala
Keyword(s):  
Wastewater Treatment ◽  
Aromatic Compounds ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Absorption Capacity ◽  
Wide Range ◽  
Volatile Organic ◽  
Treatment Facilities ◽  
Nitrogen Stream ◽  
High Absorption

Biogas from landfills and wastewater treatment facilities typically contain a wide range of volatile organic compounds (VOCs), that can cause severe operational problems when biogas is used as fuel. Among the contaminants commonly occur aromatic compounds, i.e. benzene, ethylbenzene, toluene and xylenes (BTEX). In order to remove BTEX from biogas, different processes can be used. A promising process for VOCs removal is their absorption in deep eutectic solvents (DES). In this work, three DES: ([ChCl] U TEG [choline chloride]:urea:tetraethylene glycol (1:2:2), [ChCl] U [choline chloride]:urea (1:2), [ChCl] DEG [choline chloride]:diethylene glycol (1:2)) and water were tested to toluene absorption in concentration of 2000 ppm v/v in nitrogen stream. The results demonstrated the high absorption capacity of toluene using DES based on glycols.

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