Recent Bio-Advances in Metal-Organic Frameworks

Metal-organic frameworks (MOFs) have found uses in adsorption, catalysis, gas storage and other industrial applications. Metal Biomolecule Frameworks (bioMOFs) represent an overlap between inorganic, material and medicinal sciences, utilising the porous frameworks for biologically relevant purposes. This review details advances in bioMOFs, looking at the synthesis, properties and applications of both bioinspired materials and MOFs used for bioapplications, such as drug delivery, imaging and catalysis, with a focus on examples from the last five years.

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Upscale synthesis of a binary pillared layered MOF for hydrocarbon gas storage and separation

Green Chemistry ◽

10.1039/c9gc03561c ◽

2020 ◽

Vol 22 (3) ◽

pp. 718-724 ◽

Cited By ~ 15

Author(s):

Mickaele Bonneau ◽

Christophe Lavenn ◽

Patrick Ginet ◽

Ken-ichi Otake ◽

Susumu Kitagawa

Keyword(s):

Metal Organic Frameworks ◽

Scaling Up ◽

Gas Storage ◽

Industrial Applications ◽

Metal Organic ◽

Hydrocarbon Gas

Scaling up the synthesis of metal organic frameworks (MOFs) is necessary in order to demonstrate their potential in industrial applications.

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Deciphering the Behavior of a New MOF and its Composites Under Light at Ensemble and Single Crystal Levels: Relevance to its Photonic Applications

Journal of Materials Chemistry C ◽

10.1039/d1tc01104a ◽

2021 ◽

Author(s):

Eduardo Gomez Garcia ◽

Daisuke Yasumiya ◽

Norimitsu Tonai ◽

miquel moreno ◽

Boiko Cohen ◽

...

Keyword(s):

Drug Delivery ◽

Single Crystal ◽

Metal Organic Frameworks ◽

Gas Storage ◽

Metal Organic

Metal-organic frameworks (MOFs) are being developed for a variety of applications ranging from gas storage and separation, photocatalysis, sensing and lighting to drug delivery and water capture. In relevance to...

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Smart metal organic frameworks: Focus on cancer treatment

Biomaterials Science ◽

10.1039/d0bm01839b ◽

2021 ◽

Author(s):

Monir Falsafi ◽

Amir Shokooh Saljooghi ◽

Khalil Abnous ◽

Seyed Mohammad Taghdisi ◽

Mohammad Ramezani ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Porous Materials ◽

Metal Clusters ◽

Metal Organic Frameworks ◽

Controlled Systems ◽

Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

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Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽

10.1039/d0ra08459j ◽

2020 ◽

Vol 10 (73) ◽

pp. 45130-45138

Author(s):

Li Li ◽

Shasha Han ◽

Sengqun Zhao ◽

Xurui Li ◽

Bingmi Liu ◽

...

Keyword(s):

Drug Delivery ◽

Oral Administration ◽

Drug Delivery System ◽

Delivery System ◽

Oral Drug Delivery ◽

Metal Organic Frameworks ◽

Oral Drug ◽

Metal Organic

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

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Synthesis, designing strategies and photocatalytic charge dynamics of Metal-Organic Frameworks (MOFs): A catalyzed Photo-degradation approach towards Organic Dyes

Catalysis Science & Technology ◽

10.1039/d0cy02275f ◽

2021 ◽

Author(s):

Ayushi Singh ◽

Ashish Kumar Singh ◽

Jian-Qiang Liu ◽

Abhinav Kumar

Keyword(s):

Small Molecule ◽

Coordination Polymers ◽

Organic Dyes ◽

Metal Organic Frameworks ◽

Gas Storage ◽

New Variety ◽

Photo Degradation ◽

Charge Dynamics ◽

Potential Applications ◽

Metal Organic

Metal-organic frameworks (MOFs) or coordination polymers (CPs) are regarded as new variety of materials that find potential applications in plethora of areas such as gas/small molecule absorption/separation, gas storage, membranes...

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Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

New Journal of Chemistry ◽

10.1039/d1nj01913a ◽

2021 ◽

Author(s):

Sirajunnisa P ◽

Liz Hannah George ◽

Narayanapillai Manoj ◽

Prathapan S ◽

G.S. Sailaja

Keyword(s):

Drug Delivery ◽

Porous Structure ◽

High Surface ◽

Metal Organic Frameworks ◽

High Surface Area ◽

Controlled Drug Delivery ◽

Sensing Applications ◽

Porous Carriers ◽

Metal Organic ◽

Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

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A novel route to size-controlled MIL-53(Fe) metal–organic frameworks for combined chemodynamic therapy and chemotherapy for cancer

RSC Advances ◽

10.1039/d0ra09915e ◽

2021 ◽

Vol 11 (18) ◽

pp. 10540-10547

Author(s):

Anxia Li ◽

Xiaoxin Yang ◽

Juan Chen

Keyword(s):

Drug Delivery ◽

Therapeutic Approach ◽

Metal Organic Frameworks ◽

Ionic Surfactant ◽

Controlled Synthesis ◽

New Approach ◽

Metal Organic ◽

Size Controlled

In this study, we reported a new approach for the size-controlled synthesis of uniform iron(iii)-based MIL-53 nanocrystals using the non-ionic surfactant PVP. A combinational therapeutic approach was presented for drug delivery and ROS therapy.

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Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy

Nanomaterials ◽

10.3390/nano11030722 ◽

2021 ◽

Vol 11 (3) ◽

pp. 722

Author(s):

Ioanna Christodoulou ◽

Tom Bourguignon ◽

Xue Li ◽

Gilles Patriarche ◽

Christian Serre ◽

...

Keyword(s):

Drug Delivery ◽

Degradation Mechanism ◽

Metal Organic Frameworks ◽

Porous Metal ◽

Force Microscopy ◽

Atomic Force ◽

Metal Organic ◽

The Media ◽

Ph Conditions

In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs’ stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or initial defects, which influenced the degradation mechanism of the particles. Moreover, MOF stability was investigated under different pH conditions, from acidic to neutral. Interestingly, despite pronounced erosion, especially at neutral pH, the dimensions of the crystals were unchanged. It was revealed that the external surfaces of MOF crystals rapidly respond to in situ changes of the composition of the media they are in contact with. These observations are of a crucial importance for the design of nanosized MOFs for drug delivery applications.

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