Smart metal organic frameworks: Focus on cancer treatment

Inorganic Materials ◽

Synthetic Methods ◽

Concise Review ◽

Metal Organic ◽

Organic Framework

Metal organic frameworks (MOFs) are one of those compounds which have drawn attention in various applications due to their several interesting properties like tunable shape, size, pore size, easy functionalization, high surface area, pore volume, etc. Metal organic frameworks due to their uniform structures, tunable porosity, wide variety and stability on various topology, geometry, dimension and chemical functions of the molecular network give a remarkable structural diversity in comparison to other porous materials. This enables scientists to handle numerous framework structures, porosity and functionality effectively. The unique structural architecture and tunable properties of MOF’s makes them an interesting hybrid material consisting of organic and inorganic materials. MOF can be randomly constructed like Lego bricks and superior in terms of versatility in comparisson to other porous materials. A number of MOFs containing a wide variety of metal e.g. zinc, copper, iron, aluminium, magnesium, chromium, zirconium, gadolinium, manganese are gaining rapid growth in commercial markets for gas storage, adsorption, separation and catalytic applications. This concise review emphasizes various synthetic methods e.g. solvothermal process, hydrothermal synthesis, electrochemical synthesis, microwave synthesis, sonochemical synthesis, mechanochemical synthesis, of metal organic framework developed in the last few decades. It also addresses various applications of metal organic framework e.g. hydrogen storage, gas adsorption, drug delivery systems and bioimaging agents, biocatalysts, biosensors, electrochemical sensors, etc. It also comments on various challenges and futuristic applications of metal organic frameworks in various field e.g. liquid wate management, gaseous waste management, sunlight assisted catalysis, water purification, building materials, electronic devices, battery technologies, targeted drug delivery, solar cells, etc. of science and technology in coming decades.

Recent advances in Fe-MOF compositions for in biomedical applications

Current Medicinal Chemistry ◽

10.2174/0929867328666210511014129 ◽

2021 ◽

Vol 28 ◽

Author(s):

Yuyu Zhong ◽

Weicong Liu ◽

Congying Rao ◽

Baohong Li ◽

Xiaoxiong Wang ◽

...

Keyword(s):

Drug Delivery ◽

Porous Materials ◽

Antibacterial Agent ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Biomedical Application ◽

Medical Applications ◽

Future Perspectives ◽

Background: To date, a number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity, and weak ability of targeting have hampered most of the materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a typical subclass of metal-organic frameworks (MOFs), owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic conclusions and analyses of Fe-based MIL on medical applications are rare, even though the majority of documents have discussed one research branch of the porous materials MOFs. Discussion: In this review, we're going to focus mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly.. Further studies with the use of different therapies will be of great interest. Conclusion: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.

Selective host–guest interactions in metal–organic frameworks via multiple hydrogen bond donor–acceptor recognition sites

Journal of Materials Chemistry A ◽

10.1039/c8ta12190g ◽

2019 ◽

Vol 7 (17) ◽

pp. 10379-10388 ◽

Cited By ~ 8

Author(s):

T. Wittmann ◽

C. B. L. Tschense ◽

L. Zappe ◽

C. Koschnick ◽

R. Siegel ◽

...

Keyword(s):

Drug Delivery ◽

Hydrogen Bond ◽

Porous Materials ◽

Hydrogen Bond Donor ◽

Recognition Sites ◽

Molecular Separation ◽

Multiple Hydrogen Bond ◽

Donor Acceptor ◽

Targeted recognition of medium sized molecules with mixed hydrogen bond units is essential for using porous materials for molecular separation, sensing and drug delivery.

Facile preparation of metal−organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment

Talanta ◽

10.1016/j.talanta.2018.10.101 ◽

2019 ◽

Vol 194 ◽

pp. 703-708 ◽

Cited By ~ 23

Author(s):

Kai Dong ◽

Yan Zhang ◽

Lu Zhang ◽

Zhenzhen Wang ◽

Jinsong Ren ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Anticancer Drug ◽

Anticancer Drug Delivery ◽

Metal Organic ◽

Facile Preparation

Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽

10.1039/d0ra08459j ◽

2020 ◽

Vol 10 (73) ◽

pp. 45130-45138

Author(s):

Li Li ◽

Shasha Han ◽

Sengqun Zhao ◽

Xurui Li ◽

Bingmi Liu ◽

...

Keyword(s):

Drug Delivery ◽

Oral Administration ◽

Drug Delivery System ◽

Delivery System ◽

Oral Drug Delivery ◽

Oral Drug ◽

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

Porphyrin and phthalocyanine-based Metal Organic Frameworks beyond metal-carboxylates

Dalton Transactions ◽

10.1039/d0dt03903a ◽

2020 ◽

Author(s):

Siddhartha De ◽

Thomas Devic ◽

Alexandra Fateeva

Keyword(s):

Porous Materials ◽

Metal Carboxylates ◽

Natural Systems ◽

Given the ubiquitous role of porphyrins in natural systems, these molecules and related derivatives such as phthalocyanines are fascinating building units to achieve functional porous materials. Porphyrin-based MOFs have been...

Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

New Journal of Chemistry ◽

10.1039/d1nj01913a ◽

2021 ◽

Author(s):

Sirajunnisa P ◽

Liz Hannah George ◽

Narayanapillai Manoj ◽

Prathapan S ◽

G.S. Sailaja

Keyword(s):

Drug Delivery ◽

Porous Structure ◽

High Surface ◽

High Surface Area ◽

Controlled Drug Delivery ◽

Sensing Applications ◽

Porous Carriers ◽

Metal Organic ◽

Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

Recent Bio-Advances in Metal-Organic Frameworks

Molecules ◽

10.3390/molecules25061291 ◽

2020 ◽

Vol 25 (6) ◽

pp. 1291 ◽

Cited By ~ 4

Author(s):

Isobel Tibbetts ◽

George Kostakis

Keyword(s):

Drug Delivery ◽

Inorganic Material ◽

Gas Storage ◽

Industrial Applications ◽

Biologically Relevant ◽

Bioinspired Materials ◽

Synthesis Properties ◽

Metal-organic frameworks (MOFs) have found uses in adsorption, catalysis, gas storage and other industrial applications. Metal Biomolecule Frameworks (bioMOFs) represent an overlap between inorganic, material and medicinal sciences, utilising the porous frameworks for biologically relevant purposes. This review details advances in bioMOFs, looking at the synthesis, properties and applications of both bioinspired materials and MOFs used for bioapplications, such as drug delivery, imaging and catalysis, with a focus on examples from the last five years.

A novel route to size-controlled MIL-53(Fe) metal–organic frameworks for combined chemodynamic therapy and chemotherapy for cancer

RSC Advances ◽

10.1039/d0ra09915e ◽

2021 ◽

Vol 11 (18) ◽

pp. 10540-10547

Author(s):

Anxia Li ◽

Xiaoxin Yang ◽

Juan Chen

Keyword(s):

Drug Delivery ◽

Therapeutic Approach ◽

Ionic Surfactant ◽

Controlled Synthesis ◽

New Approach ◽

Metal Organic ◽

Size Controlled

In this study, we reported a new approach for the size-controlled synthesis of uniform iron(iii)-based MIL-53 nanocrystals using the non-ionic surfactant PVP. A combinational therapeutic approach was presented for drug delivery and ROS therapy.

Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy

Nanomaterials ◽

10.3390/nano11030722 ◽

2021 ◽

Vol 11 (3) ◽

pp. 722

Author(s):

Ioanna Christodoulou ◽

Tom Bourguignon ◽

Xue Li ◽

Gilles Patriarche ◽

Christian Serre ◽

...

Keyword(s):

Drug Delivery ◽

Degradation Mechanism ◽

Porous Metal ◽

Force Microscopy ◽

Atomic Force ◽

Metal Organic ◽

The Media ◽

Ph Conditions

In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs’ stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or initial defects, which influenced the degradation mechanism of the particles. Moreover, MOF stability was investigated under different pH conditions, from acidic to neutral. Interestingly, despite pronounced erosion, especially at neutral pH, the dimensions of the crystals were unchanged. It was revealed that the external surfaces of MOF crystals rapidly respond to in situ changes of the composition of the media they are in contact with. These observations are of a crucial importance for the design of nanosized MOFs for drug delivery applications.