scholarly journals Julbernardia paniculata and Pterocarpus angolensis: From Ethnobotanical Surveys to Phytochemical Characterization and Bioactivities Evaluation

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1828 ◽  
Author(s):  
Eugénia Solange Santos ◽  
Ângelo Luís ◽  
Joana Gonçalves ◽  
Tiago Rosado ◽  
Luísa Pereira ◽  
...  
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
High Performance ◽  
Array Detector ◽  
Plant Parts ◽  
Pterocarpus Angolensis ◽  
Therapeutic Uses ◽  
Anti Inflammatory ◽  
Wound Healing Activity ◽  
Comprehensive Study

Julbernardia paniculata and Pterocarpus angolensis are two plant species with important application in African traditional medicine, particularly in Angola, in the treatment of several diseases. However, scientific studies concerning these species are scarce. The goal of this work was to know better which medicinal approaches are used by the Huíla population in Angola by means of ethnobotanical surveys. Furthermore, extracts of both plants were phytochemically characterized. Antioxidant, anti-inflammatory, wound-healing activities, and potential cytotoxicity were also studied. With this study it was possible to verify that 67% of the individuals that use medicinal plants are women, and their main therapeutic uses are the treatment of problems of the digestive system and skin disorders. Barks of J. paniculata and leaves of P. angolensis are the most often used plant parts. Through high-performance liquid chromatography coupled to diode-array detector (HPLC-DAD) and GC-MS it was possible to characterize the chemical composition of the two species, which are rich in phenolic compounds, terpenes, terpenoids, sesquiterpenoids and fatty acids. Both plants showed to possess antioxidant, anti-inflammatory proprieties, and wound-healing activity. To the best of our knowledge, this is the most comprehensive study of these two species and the first ethnobotanical and ethnopharmacological study of medicinal plants from this region of Angola.

scholarly journals Medicinal Plants Used to Heal Wound in Karandamalai of Dindigul District in Tamil Nadu, Southern India

2021 ◽  
Vol 11 (2) ◽  
pp. 72-75
Author(s):  
N Yasothkumar
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Tamil Nadu ◽  
Southern India ◽  
Mode Of Administration ◽  
Therapeutic Uses ◽  
Research Theme ◽  
Treatment Of Wounds ◽  
Scientific Name

Due to the presence of antibiotic or antiseptic nature’s chemicals, plants are remarkable for the treatment of wounds. Having this fact as research theme, the present study was carried out to document the therapeutic uses of medicinal plants used to heal wound in Karandamalai of Dindigul district in Tamil Nadu. The frequent fieldwork was conducted from October 2019 to January 2020 for this study. The scientific name, family name, local name (in Tamil), part(s) used, mode of preparation, and mode of administration of medicine were recorded. A total of 24 medicinal remedies prepared from 24 plants were recorded. Further research on the phytochemistry and pharmacology of these medicinal plants should be conducted. Keywords: Medicinal plants, Wound healing, Karandamalai, Dindigul district, Tamil Nadu.

scholarly journals Evaluation of the In Vitro Wound-Healing Activity and Phytochemical Characterization of Propolis and Honey

2020 ◽  
Vol 10 (5) ◽  
pp. 1845 ◽  
Author(s):  
Alexandra M. Afonso ◽  
Joana Gonçalves ◽  
Ângelo Luís ◽  
Eugenia Gallardo ◽  
Ana Paula Duarte
Keyword(s):  
Wound Healing ◽  
Phenolic Compounds ◽  
Protein Denaturation ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Natural Substances ◽  
Anti Inflammatory ◽  
Free Radical Scavenging Assay ◽  
Wound Healing Activity

Honey and propolis are natural substances produced by Apis mellifera that contain flavonoids, phenolic acids, and several other phytochemicals. The aim of this study was to phytochemically characterize three different types of honey and propolis, both separately and mixed, and to evaluate their wound-healing activity. Total phenolic compounds and flavonoids were determined using the Folin–Ciocalteu’s and aluminum chloride colorimetric methods, respectively. The antioxidant activity was evaluated by both the DPPH free radical scavenging assay and β-carotene bleaching test, and the anti-inflammatory activity was determined by a protein denaturation method. To evaluate the wound-healing activity of the samples, NHDF cells were subjected to a wound scratch assay. The obtained results showed that dark-brown honey presents a higher concentration of phenolic compounds and flavonoids, as well as higher antioxidant and anti-inflammatory activities. Propolis samples had the highest concentrations in bioactive compounds. Examining the microscopic images, it was possible to verify that the samples promote cell migration, demonstrating the wound-healing potential of honey and propolis.

scholarly journals Medicinal plants used by the Kaiowá and Guarani indigenous populations in the Caarapó Reserve, Mato Grosso do Sul, Brazil

2005 ◽  
Vol 19 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Norlene Regina Bueno ◽  
Rachel Oliveira Castilho ◽  
Reginaldo Brito da Costa ◽  
Arnildo Pott ◽  
Vali J. Pott ◽  
...  
Keyword(s):  
Wound Healing ◽  
Abdominal Pain ◽  
Medicinal Plants ◽  
Folk Medicine ◽  
Indigenous Populations ◽  
Ethnobotanical Survey ◽  
Mato Grosso ◽  
Plant Parts ◽  
Medicinal Properties ◽  
Mato Grosso Do Sul

This ethnobotanical survey carried out with the Kaiowá and Guarani populations in the Caarapó Reserve (Mato Grosso do Sul, Brazil) showed that 34 plant species of 22 families with medicinal properties, are used for treating diverse pathologies. Local names in Portuguese and Guarani are provided, along with therapeutic indications, modes of preparation, and a description of the plant parts used. These folk-medicine plants have been mostly used for the treatment of influenza, abdominal pain, fever and rheumatism, and for wound healing.

scholarly journals Wound Healing Potential of Selected Drug molecules Obtained From Terpenoids

2020 ◽  
Vol 11 (4) ◽  
pp. 7345-7352
Author(s):  
Mogan Babu N ◽  
Harikrishnan N
Keyword(s):  
Wound Healing ◽  
Significant Role ◽  
Modern Medicine ◽  
Pharmaceutical Products ◽  
High Exposure ◽  
Cytoprotective Activity ◽  
Drug Molecules ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Wound Healing Activity

Skin is the vital organ of the human system; however, due to its high exposure to the external environment, it was susceptible to various traumatic conditions. During the time of trauma human body played a significant role in the activation of various biological processes for enhancing the wound healing activity in case of damaged tissues. However, in case of skin tissue defects, to enhance the angiogenesis minimal scar formation, several pharmaceutical products were paving their way into the market. Now a days there was a rising worldwide utilization of several bioactive compounds obtained from terpenoids. Terpenoids are 5-carbon compound isoprene with oxygen-containing functional groups were isolated from several plants demonstrates a wide range of activities such as antioxidant, anti-inflammatory and anti-microbial activity. Furthermore, due to their excellent cytoprotective activity, terpenoids based products had played a significant role in wound healing activity. Moreover, in our study, because of their excellent wound healing capability, we reviewed about the few drug molecules such as Tocopherol, Farnesol, Betulin, Retenoic acid, Coenzyme Q10. However, now a day's terpenoids were utilized in several wound-healing formulations because of their excellent anti-inflammatory, re-vascularization and re-epithelization characteristics. Finally, this review focuses on the role of a few drug products obtained from terpenoids as an ideal topical wound healing agent in modern medicine.

scholarly journals Distribution of an Analgesic Palmitoylethanolamide and Other N-Acylethanolamines in Human Placental Membranes

2021 ◽  
Author(s):  
Alzbeta Svobodova ◽  
Vladimir Vrkoslav ◽  
Ingrida Smeringaiova ◽  
Katerina Jirsova
Keyword(s):  
Wound Healing ◽  
Analgesic Effect ◽  
High Performance ◽  
Fold Increase ◽  
Mass Spectrometry Analysis ◽  
Neuroprotective Effects ◽  
Endogenous Fatty Acid ◽  
Spectrometry Analysis ◽  
Fatty Acid Amides ◽  
Anti Inflammatory

Abstract Human amniotic and amniochorionic membranes (AM, ACM) are the most often used grafts accelerating wound healing due to their anti-inflammatory, anti-microbial, anti-fibrotic, and analgesic properties. We assessed the distribution of endogenous fatty acid amides N-acylethanolamines (NAEs): palmitoylethanolamide (PEA), oleoylethanolamide (OEA) and anandamide (AEA) in placental tissues, as they could participate in wound healing properties of AM/ACM grafts. Ten placentas were collected after caesarean delivery. NAEs were detected using ultra-high-performance liquid chromatography-tandem mass spectrometry analysis in fresh samples of AM, ACM, placental disc, umbilical cord, umbilical serum and vernix caseosa), and decontaminated samples of AM and ACM. NAEs were present in all studied tissue types, with mean concentrations in fresh tissues ranging: 76 – 350 (PEA); 31 – 220 (OEA); 7 – 30 ng/g (AEA). The highest mean concentrations were found in AM (PEA: 350 ng/g) or placenta (OEA: 220 ng/g; AEA: 30 ng/g), respectively. Low levels of NAEs were found in serum and vernix. Decontamination of AM, but not ACM, induced a significant (3 – 3.5-fold) increase in the levels of NAEs. PEA is the first compound with direct analgesic effect detected in AM and ACM. We thus propose NAEs, especially PEA, as one of the possible factors responsible for the anti-hyperalgesic, anti-inflammatory and neuroprotective effects of AM/ACM grafts, stimulating their wound healing effect. The increase of NAE levels in AM and ACM after tissue decontamination indicates that tissue processing may play an important role in maintaining the analgesic effect.

scholarly journals Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Sami A. Gabr ◽  
Ahmad H. Alghadir
Keyword(s):  
Wound Healing ◽  
Enzyme Activity ◽  
Scar Formation ◽  
Wound Contraction ◽  
Collagen Deposition ◽  
Staph Aureus ◽  
Microbial Infections ◽  
Rhus Coriaria ◽  
Anti Inflammatory ◽  
Wound Healing Activity

Impaired wound healing was mainly associated with severe microbial infections which significantly affect diagnostic and therapeutic strategies. Thus, in this study, the potential wound healing activity, anti-inflammatory, and antimicrobial activity of an aqueous extract of Rhus coriaria extract (AERc) were evaluated by wound contraction, scar formation, period of epithelization, MPO enzyme activity, collagenase-2 (MMP-8), hydroxyproline (HPX), and collagen deposition as markers of wound healing at different days of postwound. Phytoconstituents, microbial activity, and fibrogenic markers were screened by HPLC, disc-diffusion, and colorimetric assays. The animals were treated with Rhus coriaria extract (AERc) concentrations at doses of 5 mg.kg−1and 10 mg.kg−1, respectively. On days 6 and 9, the AERc-treated animals at doses of 5 mg.mL−1 and 10 mg.mL−1 exhibited a significant reduction in the wound area, increased deposition of collagen, HPX, and reduction in MMP-8, and MPO enzyme activity when compared with controls. Scar formation and epithelization were completed in 10 days compared to controls. In addition, in wounds infected separately with Staph. aureus or P. aeruginosa, the AERc extract significantly improved wound contraction, deposition of collagen, and HPx and reduced MMP-8 and MPO concentrations, with complete epithelization of wounds in 10-13 days compared to the saline-treated group. Hydrolyzable tannins, gallic acid, quercetin, and myricetin were the most common active components of AERc. In vitro, the AERc and its components were effective against a set of microbes especially Staph. aureus, P. aeruginosa, and Staph. aureus (MRSA). In conclusion, the results showed that antimicrobial, anti-inflammatory, and antioxidant activity of Rhus coriaria extract suggested its importance as a target for formulation of novel drugs against many microbial infections with minimal side effects and could play a good potential role in accelerating wound healing activity via promoting myofibroblast activity, increase of hydroxyproline and collagen deposition, and regulation of MMP-8 and MPO enzyme activities.

scholarly journals Nutraceutical Properties of Mulberries Grown in Southern Italy (Apulia)

Antioxidants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 223 ◽  
Author(s):  
Carmine Negro ◽  
Alessio Aprile ◽  
Luigi De Bellis ◽  
Antonio Miceli
Keyword(s):  
High Performance ◽  
Southern Italy ◽  
Morus Alba ◽  
Array Detector ◽  
Morus Nigra ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Mulberry Fruits ◽  
First Time ◽  
Gallic Acid Equivalent

In this work, for the first time, were analyzed mulberry genotypes grown in Apulia (Southern Italy, Salento region) were analyzed. Two local varieties of Morus alba (cv. Legittimo nero and cv. Nello) and one of Morus nigra were characterized for content in simple sugars, organic acids, phenols, anthocyanins; fruit antioxidant activity (AA) was also evaluated by three different methods (2,2-Diphenyl-1-picrylhydrazyl, DPPH; 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ABTS; and Ferric reducing antioxidant potential, FRAP test). The results showed that the sugars amount ranged between 6.29 and 7.66 g/100 g fresh weight (FW) while the malic and citric acids content was low, at about 0.1–1 g/100 g FW. Mulberries are a good source of phenols which are present in higher values in M. nigra and M. alba cv. Legittimo nero (485 and 424 mg Gallic Acid Equivalent (GAE)/ 100 g FW, respectively). The high performance liquid chromatography/diode array detector/mass spectrometry (HPLC/DAD/MS) analysis identified 5 main anthocyanin compounds present in different concentrations in each variety of mulberry: cyanidin 3-sophoroside, cyanidin 3-glucoside, cyanidin 3-rutinoside, pelargonidin 3-glucoside, pelargonidin 3-rutinoside. The highest concentration of anthocyanins was determined in Morus alba Legittimo (about 300 mg/100 g FW) while the lowest content (about 25 mg/100 g FW) was measured in M. alba cv. Nello. Morus nigra showed a good AA in comparison with the different M. alba genotypes with all the used methods; its AA was equal to 33, 26 and 21 μmols Trolox/g FW when using DPPH, ABTS and FRAP tests, respectively. All genotypes showed an anti-inflammatory activity (measured by cyclooxygenase (COX) inhibitory assay) which was also compared with two commercial anti-inflammatory drugs. The data obtained support the high biological qualities of mulberry fruits and their diffusion in human nutrition.

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