scholarly journals Development of Microdroplet Generation Method for Organic Solvents Used in Chemical Synthesis

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5360
Author(s):  
Shohei Hattori ◽  
Chenghe Tang ◽  
Daiki Tanaka ◽  
Dong Hyun Yoon ◽  
Yoshito Nozaki ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Organic Solvents ◽  
Chemical Reactions ◽  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Continuous Phase ◽  
Immiscible Liquid ◽  
Droplet Generation ◽  
Scaling Effects ◽  
Reaction Field

Recently, chemical operations with microfluidic devices, especially droplet-based operations, have attracted considerable attention because they can provide an isolated small-volume reaction field. However, analysis of these operations has been limited mostly to aqueous-phase reactions in water droplets due to device material restrictions. In this study, we have successfully demonstrated droplet formation of five common organic solvents frequently used in chemical synthesis by using a simple silicon/glass-based microfluidic device. When an immiscible liquid with surfactant was used as the continuous phase, the organic solvent formed droplets similar to water-in-oil droplets in the device. In contrast to conventional microfluidic devices composed of resins, which are susceptible to swelling in organic solvents, the developed microfluidic device did not undergo swelling owing to the high chemical resistance of the constituent materials. Therefore, the device has potential applications for various chemical reactions involving organic solvents. Furthermore, this droplet generation device enabled control of droplet size by adjusting the liquid flow rate. The droplet generation method proposed in this work will contribute to the study of organic reactions in microdroplets and will be useful for evaluating scaling effects in various chemical reactions.

scholarly journals Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns

The Analyst ◽  
2016 ◽  
Vol 141 (18) ◽  
pp. 5412-5416 ◽  
Author(s):  
C. Dietze ◽  
S. Schulze ◽  
S. Ohla ◽  
K. Gilmore ◽  
P. H. Seeberger ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Chemical Reactions ◽  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Porous Polymer ◽  
Monolithic Columns ◽  
Reaction Monitoring ◽  
On Chip ◽  
Electrochromatographic Separation

Seamless combination of chemical reactions, electrochromatographic separation and electrospray ionization in one single microfluidic device.

scholarly journals Extraction of organic chemistry grammar from unsupervised learning of chemical reactions

2021 ◽  
Vol 7 (15) ◽  
pp. eabe4166
Author(s):  
Philippe Schwaller ◽  
Benjamin Hoover ◽  
Jean-Louis Reymond ◽  
Hendrik Strobelt ◽  
Teodoro Laino
Keyword(s):  
Organic Chemistry ◽  
Neural Networks ◽  
Chemical Synthesis ◽  
Unsupervised Learning ◽  
Chemical Reactions ◽  
Data Driven ◽  
Experimental Task ◽  
Rule Based ◽  
Atom Mapping ◽  
Mapping Information

Humans use different domain languages to represent, explore, and communicate scientific concepts. During the last few hundred years, chemists compiled the language of chemical synthesis inferring a series of “reaction rules” from knowing how atoms rearrange during a chemical transformation, a process called atom-mapping. Atom-mapping is a laborious experimental task and, when tackled with computational methods, requires continuous annotation of chemical reactions and the extension of logically consistent directives. Here, we demonstrate that Transformer Neural Networks learn atom-mapping information between products and reactants without supervision or human labeling. Using the Transformer attention weights, we build a chemically agnostic, attention-guided reaction mapper and extract coherent chemical grammar from unannotated sets of reactions. Our method shows remarkable performance in terms of accuracy and speed, even for strongly imbalanced and chemically complex reactions with nontrivial atom-mapping. It provides the missing link between data-driven and rule-based approaches for numerous chemical reaction tasks.

scholarly journals A Review on Recent Progress of Glycan-Based Surfactant Micelles as Nanoreactor Systems for Chemical Synthesis Applications

2021 ◽  
Vol 2 (1) ◽  
pp. 168-186
Author(s):  
Bahareh Vafakish ◽  
Lee D. Wilson
Keyword(s):  
Chemical Synthesis ◽  
Chemical Reactions ◽  
Recent Progress ◽  
Chemical Species ◽  
Reaction Rates ◽  
Bulk Solution ◽  
Surfactant Micelles ◽  
Conventional Surfactant ◽  
Recent Developments ◽  
To Receive

The nanoreactor concept and its application as a modality to carry out chemical reactions in confined and compartmentalized structures continues to receive increasing attention. Micelle-based nanoreactors derived from various classes of surfactant demonstrate outstanding potential for chemical synthesis. Polysaccharide (glycan-based) surfactants are an emerging class of biodegradable, non-toxic, and sustainable alternatives over conventional surfactant systems. The unique structure of glycan-based surfactants and their micellar structures provide a nanoenvironment that differs from that of the bulk solution, and supported by chemical reactions with uniquely different reaction rates and mechanisms. In this review, the aggregation of glycan-based surfactants to afford micelles and their utility for the synthesis of selected classes of reactions by the nanoreactor technique is discussed. Glycan-based surfactants are ecofriendly and promising surfactants over conventional synthetic analogues. This contribution aims to highlight recent developments in the field of glycan-based surfactants that are relevant to nanoreactors, along with future opportunities for research. In turn, coverage of research for glycan-based surfactants in nanoreactor assemblies with tailored volume and functionality is anticipated to motivate advanced research for the synthesis of diverse chemical species.

scholarly journals Negative Pressure Provides Simple and Stable Droplet Generation in a Flow-Focusing Microfluidic Device

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 662
Author(s):  
Nikita A. Filatov ◽  
Anatoly A. Evstrapov ◽  
Anton S. Bukatin
Keyword(s):  
Microfluidic Device ◽  
Negative Pressure ◽  
Low Cost ◽  
Control Valve ◽  
Droplet Microfluidics ◽  
Droplet Generation ◽  
Electric Signal ◽  
Absolute Pressure ◽  
Flow Focusing ◽  
Wide Range

Droplet microfluidics is an extremely useful and powerful tool for industrial, environmental, and biotechnological applications, due to advantages such as the small volume of reagents required, ultrahigh-throughput, precise control, and independent manipulations of each droplet. For the generation of monodisperse water-in-oil droplets, usually T-junction and flow-focusing microfluidic devices connected to syringe pumps or pressure controllers are used. Here, we investigated droplet-generation regimes in a flow-focusing microfluidic device induced by the negative pressure in the outlet reservoir, generated by a low-cost mini diaphragm vacuum pump. During the study, we compared two ways of adjusting the negative pressure using a compact electro-pneumatic regulator and a manual airflow control valve. The results showed that both types of regulators are suitable for the stable generation of monodisperse droplets for at least 4 h, with variations in diameter less than 1 µm. Droplet diameters at high levels of negative pressure were mainly determined by the hydrodynamic resistances of the inlet microchannels, although the absolute pressure value defined the generation frequency; however, the electro-pneumatic regulator is preferable and convenient for the accurate control of the pressure by an external electric signal, providing more stable pressure, and a wide range of droplet diameters and generation frequencies. The method of droplet generation suggested here is a simple, stable, reliable, and portable way of high-throughput production of relatively large volumes of monodisperse emulsions for biomedical applications.

Effect of Geometry on Droplet Generation in a Microfluidic T-Junction

2013 ◽  
Author(s):  
Katerina Loizou ◽  
Wim Thielemans ◽  
Buddhika N. Hewakandamby
Keyword(s):  
Aspect Ratio ◽  
Cross Section ◽  
Droplet Formation ◽  
Continuous Phase ◽  
Main Channel ◽  
Superficial Velocity ◽  
Droplet Generation ◽  
Dispersed Phase ◽  
Aspect Ratios ◽  
The Cross

The main aim of this study is to examine how the droplet formation in microfluidic T-junctions is influenced by the cross-section and aspect ratio of the microchannels. Several studies focusing on droplet formation in microfluidic devices have investigated the effect of geometry on droplet generation in terms of the ratio between the width of the main channel and the width of the side arm of the T-junction. However, the contribution of the aspect ratio and thus that of the cross-section on the mechanism of break up has not been examined thoroughly with most of the existing work performed in the squeezing regime. Two different microchannel geometries of varying aspect ratios are employed in an attempt to quantify the effect of the ratio between the width of the main channel and the height of the channel on droplet formation. As both height and width of microchannels affect the area on which shear stress acts deforming the dispersed phase fluid thread up to the limit of detaching a droplet, it is postulated that geometry and specifically cross-section of the main channel contribute on the droplet break-up mechanisms and should not be neglected. The above hypothesis is examined in detail, comparing the volume of generated microdroplets at constant flowrate ratios and superficial velocities of continuous phase in two microchannel systems of two different aspect ratios operating at dripping regime. High-speed imaging has been utilised to visualise and measure droplets formed at different flowrates corresponding to constant superficial velocities. Comparing volumes of generated droplets in the two geometries of area ratio near 1.5, a significant increase in volume is reported for the larger aspect ratio utilised, at all superficial velocities tested. As both superficial velocity of continuous phase and flowrate ratio are fixed, superficial velocity of dispersed phase varies. However this variation is not considered to be large enough to justify the significant increase in the droplet volume. Therefore it can be concluded that droplet generation is influenced by the aspect ratio and thus the cross-section of the main channel and its effect should not be depreciated. The paper will present supporting evidence in detail and a comparison of the findings with the existing theories which are mainly focused on the squeezing regime.

Alternating droplet generation and controlled dynamic droplet fusion in microfluidic device for CdS nanoparticle synthesis

Lab on a Chip ◽  
2006 ◽  
Vol 6 (2) ◽  
pp. 174 ◽  
Author(s):  
Lung-Hsin Hung ◽  
Kyung M. Choi ◽  
Wei-Yu Tseng ◽  
Yung-Chieh Tan ◽  
Kenneth J. Shea ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Nanoparticle Synthesis ◽  
Droplet Generation ◽  
Cds Nanoparticle

scholarly journals Liquid–Liquid Flows with Non-Newtonian Dispersed Phase in a T-Junction Microchannel

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 335
Author(s):  
Anna Yagodnitsyna ◽  
Alexander Kovalev ◽  
Artur Bilsky
Keyword(s):  
Flow Pattern ◽  
Dynamic Viscosity ◽  
Slug Flow ◽  
Shear Thinning ◽  
Continuous Phase ◽  
Immiscible Liquid ◽  
Dispersed Phase ◽  
Effective Dynamic ◽  
Liquid Flows ◽  
Shear Thinning Fluid

Immiscible liquid–liquid flows in microchannels are used extensively in various chemical and biological lab-on-a-chip systems when it is very important to predict the expected flow pattern for a variety of fluids and channel geometries. Commonly, biological and other complex liquids express non-Newtonian properties in a dispersed phase. Features and behavior of such systems are not clear to date. In this paper, immiscible liquid–liquid flow in a T-shaped microchannel was studied by means of high-speed visualization, with an aim to reveal the shear-thinning effect on the flow patterns and slug-flow features. Three shear-thinning and three Newtonian fluids were used as dispersed phases, while Newtonian castor oil was a continuous phase. For the first time, the influence of the non-Newtonian dispersed phase on the transition from segmented to continuous flow is shown and quantitatively described. Flow-pattern maps were constructed using nondimensional complex We0.4·Oh0.6 depicting similarity in the continuous-to-segmented flow transition line. Using available experimental data, the proposed nondimensional complex is shown to be effectively applied for flow-pattern map construction when the continuous phase exhibits non-Newtonian properties as well. The models to evaluate an effective dynamic viscosity of a shear-thinning fluid are discussed. The most appropriate model of average-shear-rate estimation based on bulk velocity was chosen and applied to evaluate an effective dynamic viscosity of a shear-thinning fluid. For a slug flow, it was found that in the case of shear-thinning dispersed phase at low flow rates of both phases, a jetting regime of slug formation was established, leading to a dramatic increase in slug length.

scholarly journals Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 387
Author(s):  
Carlos Toshiyuki Matsumi ◽  
Wilson José da Silva ◽  
Fábio Kurt Schneider ◽  
Joaquim Miguel Maia ◽  
Rigoberto E. M. Morales ◽  
...  
Keyword(s):  
Electric Fields ◽  
Microfluidic Device ◽  
Soft Lithography ◽  
Low Cost ◽  
Characteristic Curve ◽  
Microfluidic Devices ◽  
Average Diameter ◽  
Internal Diameter ◽  
Medical Diagnostic ◽  
Average Size

Microbubbles have various applications including their use as carrier agents for localized delivery of genes and drugs and in medical diagnostic imagery. Various techniques are used for the production of monodisperse microbubbles including the Gyratory, the coaxial electro-hydrodynamic atomization (CEHDA), the sonication methods, and the use of microfluidic devices. Some of these techniques require safety procedures during the application of intense electric fields (e.g., CEHDA) or soft lithography equipment for the production of microfluidic devices. This study presents a hybrid manufacturing process using micropipettes and 3D printing for the construction of a T-Junction microfluidic device resulting in simple and low cost generation of monodisperse microbubbles. In this work, microbubbles with an average size of 16.6 to 57.7 μm and a polydispersity index (PDI) between 0.47% and 1.06% were generated. When the device is used at higher bubble production rate, the average diameter was 42.8 μm with increased PDI of 3.13%. In addition, a second-order polynomial characteristic curve useful to estimate micropipette internal diameter necessary to generate a desired microbubble size is presented and a linear relationship between the ratio of gaseous and liquid phases flows and the ratio of microbubble and micropipette diameters (i.e., Qg/Ql and Db/Dp) was found.

scholarly journals Manufacturing of Microfluidic Devices with Interchangeable Commercial Fiber Optic Sensors

Sensors ◽  
2021 ◽  
Vol 21 (22) ◽  
pp. 7493
Author(s):  
Krystian L. Wlodarczyk ◽  
William N. MacPherson ◽  
Duncan P. Hand ◽  
M. Mercedes Maroto-Valer
Keyword(s):  
Porous Structure ◽  
Steady Flow ◽  
Microfluidic Device ◽  
Fiber Optic ◽  
Dynamic Pressure ◽  
Pressure Sensors ◽  
Microfluidic Devices ◽  
Fiber Optic Sensors ◽  
Valuable Insight ◽  
Local Pressure

In situ measurements are highly desirable in many microfluidic applications because they enable real-time, local monitoring of physical and chemical parameters, providing valuable insight into microscopic events and processes that occur in microfluidic devices. Unfortunately, the manufacturing of microfluidic devices with integrated sensors can be time-consuming, expensive, and “know-how” demanding. In this article, we describe an easy-to-implement method developed to integrate various “off-the-shelf” fiber optic sensors within microfluidic devices. To demonstrate this, we used commercial pH and pressure sensors (“pH SensorPlugs” and “FOP-MIV”, respectively), which were “reversibly” attached to a glass microfluidic device using custom 3D-printed connectors. The microfluidic device, which serves here as a demonstrator, incorporates a uniform porous structure and was manufactured using a picosecond pulsed laser. The sensors were attached to the inlet and outlet channels of the microfluidic pattern to perform simple experiments, the aim of which was to evaluate the performance of both the connectors and the sensors in a practical microfluidic environment. The bespoke connectors ensured robust and watertight connection, allowing the sensors to be safely disconnected if necessary, without damaging the microfluidic device. The pH SensorPlugs were tested with a pH 7.01 buffer solution. They measured the correct pH values with an accuracy of ±0.05 pH once sufficient contact between the injected fluid and the measuring element (optode) was established. In turn, the FOP-MIV sensors were used to measure local pressure in the inlet and outlet channels during injection and the steady flow of deionized water at different rates. These sensors were calibrated up to 140 mbar and provided pressure measurements with an uncertainty that was less than ±1.5 mbar. Readouts at a rate of 4 Hz allowed us to observe dynamic pressure changes in the device during the displacement of air by water. In the case of steady flow of water, the pressure difference between the two measuring points increased linearly with increasing flow rate, complying with Darcy’s law for incompressible fluids. These data can be used to determine the permeability of the porous structure within the device.

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