scholarly journals Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4481
Author(s):  
Meng Cheng ◽  
Qiaoming Liu ◽  
Tiantian Gan ◽  
Yuanying Fang ◽  
Pengfei Yue ◽  
...  
Keyword(s):  
Thin Film ◽  
Retention Time ◽  
Blood Circulation ◽  
Crystalline State ◽  
Circulation System ◽  
Particle Sizes ◽  
High Pressure Homogenization ◽  
Rapid Dissolution ◽  
Efficient Route

Prolonging in vivo circulation has proved to be an efficient route for enhancing the therapeutic effect of rapidly metabolized drugs. In this study, we aimed to construct a nanocrystal-loaded micelles delivery system to enhance the blood circulation of docetaxel (DOC). We employed high-pressure homogenization to prepare docetaxel nanocrystals (DOC(Nc)), and then produced docetaxel nanocrystal-loaded micelles (DOC(Nc)@mPEG-PLA) by a thin-film hydration method. The particle sizes of optimized DOC(Nc), docetaxel micelles (DOC@mPEG-PLA), and DOC(Nc)@mPEG-PLA were 168.4, 36.3, and 72.5 nm, respectively. The crystallinity of docetaxel was decreased after transforming it into nanocrystals, and the crystalline state of docetaxel in micelles was amorphous. The constructed DOC(Nc)@mPEG-PLA showed good stability as its particle size showed no significant change in 7 days. Despite their rapid dissolution, docetaxel nanocrystals exhibited higher bioavailability. The micelles prolonged the retention time of docetaxel in the circulation system of rats, and DOC(Nc)@mPEG-PLA exhibited the highest retention time and bioavailability. These results reveal that constructing nanocrystal-loaded micelles may be a promising way to enhance the in vivo circulation and bioavailability of rapidly metabolized drugs such as docetaxel.

scholarly journals Characterization and Stability Evaluation of Thymoquinone Nanoemulsions Prepared by High-Pressure Homogenization

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Zaki Tubesha ◽  
Zuki Abu Bakar ◽  
Maznah Ismail
Keyword(s):  
High Pressure ◽  
Water Solubility ◽  
Particle Sizes ◽  
High Pressure Homogenization ◽  
Stability Evaluation ◽  
Stability Studies ◽  
Initial Particle ◽  
Oil In Water ◽  
The Stability

Despite the pharmacological properties of thymoquinone (TQ), its administrationin vivoremains problematic partly due to its poor water solubility, leading to low absorptivity and bioavailability. Hence, the objective of this study is to prepare, characterize, and evaluate the stability of TQ nanoemulsion (TQNE). Conventional emulsion from TQ (TQCE) and empty nano- and conventional emulsions from Triolein (TRNE and TRCE) are also produced for comparison purposes. The oil-in-water nanoemulsions of TQ and Triolein were produced by high-pressure homogenization. Emulsions were characterized physically by droplet size, polydispersity index, zeta potential, and refractive index. The changes of these parameters in TQNE samples stored for 6 months at 4 and 25°C were not statistically significant (P<0.05). In addition, the initial particle sizes of TQNE and TRNE were 119.6 and 119.5 nm, respectively. Stability studies were also performed for the period of 6 months. At the end of the experiment, the percent of remaining TQ in TQNE at 4, 25, and 40°C was 90.6, 89.1, and 87.4 % respectively. Slower degradation of TQ indicated the chemical stability of TQ in TQNE samples. These results indicated that TQNE is stable over a period of 6 months.

Palladium Nanowire Thin Films via Template Growth

2003 ◽  
Vol 775 ◽  
Author(s):  
Donghai Wang ◽  
David T. Johnson ◽  
Byron F. McCaughey ◽  
J. Eric Hampsey ◽  
Jibao He ◽  
...  
Keyword(s):  
Thin Film ◽  
Electron Microscopy ◽  
Thin Films ◽  
X Ray Diffraction ◽  
X Ray ◽  
Transmission Electron ◽  
Conductive Substrate ◽  
Palladium Nanowires ◽  
Efficient Route ◽  
Silica Thin Film

AbstractPalladium nanowires have been electrodeposited into mesoporous silica thin film templates. Palladium continually grows and fills silica mesopores starting from a bottom conductive substrate, providing a ready and efficient route to fabricate a macroscopic palladium nanowire thin films for potentially use in fuel cells, electrodes, sensors, and other applications. X-ray diffraction (XRD) and transmission electron microscopy (TEM) indicate it is possible to create different nanowire morphology such as bundles and swirling mesostructure based on the template pore structure.

In vivo and in vitro application of thin film interferometry to assess contact lens wettability

2018 ◽  
Vol 41 ◽  
pp. S9
Author(s):  
Raied Fagehi ◽  
Ian Pearce ◽  
Katherine Oliver ◽  
Alan Tomlinson
Keyword(s):  
Thin Film ◽  
Contact Lens

scholarly journals Vascularization of tissue engineered cartilage - Sequential in vivo MRI display functional blood circulation

Biomaterials ◽  
2021 ◽  
pp. 121002
Author(s):  
Peter Apelgren ◽  
Matteo Amoroso ◽  
Karin Säljö ◽  
Mikael Montelius ◽  
Anders Lindahl ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Engineered Cartilage

scholarly journals The Potential Roles of Blood–Brain Barrier and Blood–Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1833
Author(s):  
Shannon Morgan McCabe ◽  
Ningning Zhao
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Brain Barrier ◽  
Blood Circulation ◽  
Critical Role ◽  
Systemic Circulation ◽  
Brain Parenchyma ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Brain

Manganese (Mn) is a trace nutrient necessary for life but becomes neurotoxic at high concentrations in the brain. The brain is a “privileged” organ that is separated from systemic blood circulation mainly by two barriers. Endothelial cells within the brain form tight junctions and act as the blood–brain barrier (BBB), which physically separates circulating blood from the brain parenchyma. Between the blood and the cerebrospinal fluid (CSF) is the choroid plexus (CP), which is a tissue that acts as the blood–CSF barrier (BCB). Pharmaceuticals, proteins, and metals in the systemic circulation are unable to reach the brain and spinal cord unless transported through either of the two brain barriers. The BBB and the BCB consist of tightly connected cells that fulfill the critical role of neuroprotection and control the exchange of materials between the brain environment and blood circulation. Many recent publications provide insights into Mn transport in vivo or in cell models. In this review, we will focus on the current research regarding Mn metabolism in the brain and discuss the potential roles of the BBB and BCB in maintaining brain Mn homeostasis.

STUDY OF THE PREVALENCE OF DENTOALVEOLAR ANOMALIES, INCLUDING DISTAL BITE IN CHILDREN AND ADOLESCENTS

Vestnik ◽  
2021 ◽  
pp. 133-137
Author(s):  
Г.Т. Ермуханова ◽  
А.О. Етекбаева
Keyword(s):  
Children And Adolescents ◽  
Blood Circulation ◽  
Circulation System ◽  
Dental Anomalies ◽  
Functional Changes ◽  
Facial Region ◽  
Blood Circulation System ◽  
Lateral Segment ◽  
Distal Occlusion ◽  
Maxillary Region

В данной статье описывается изучение распространенности зубочелюстных аномалий, в том числе и дистального прикуса среди детей и подростков школьного возраста. В настоящее время широко распространены зубочелюстные аномалии, в том числе дистальный прикус среди детей и подростков. Зубочелюстные аномалии приводят к функциональной патологии морфологических нарушений челюстной области. Изменения возрастно увеличиваются и сопровождаются деформацией лицевой области черепа наряду с эстетическими отклонениями.У больных часто наблюдаются нарушения положения позвоночника,функциональные изменения в системе малого кровообращения и задержка психосомтического развития.Это говорит о ранних нарушениях профилактики и несвоевременном оказании ортодонтической,зубопротезной и комплексной медицинской помощи.В связи с этим важную роль играет эпидемиологическая ситуация по зубной аномалии. исполняют информацию. Диагноз дистальной окклюзии называется боковым сегментом верхнего зубного ряда, расположенным перед боковым сегментом нижнего зубного ряда и появлением между ними дистальной стадии. Лечение и прогноз дистальной окклюзии зубного ряда зависит от возраста больного и характера аномалии [1] The article is devoted to the study of the prevalence of dentition anomalies, including distal occlusion among children and adolescents of school age. Currently, dental anomalies, including distal bite, are widespread among children and adolescents. Dental anomalies lead to functional pathology of morphological disorders of the maxillary region. The changes increase with age and are accompanied by deformation of the facial region of the skull along with aesthetic deviations. Patients often have disorders of the spine position, functional changes in the small blood circulation system and delayed psychosomal development.It tells about the early breaches of the prevention of and untimely provision of orthodontic, prosthodontic and comprehensive medical care.In this regard, an important role is played by the epidemiological situation of dental anomalies. execute information. The diagnosis of distal occlusion is called the lateral segment of the upper dentition, located in front of the lateral segment of the lower dentition and the appearance of the distal stage between them. Treatment and prognosis of distal occlusion of the dentition depends on the patient's age and the nature of the anomalies [1].

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