scholarly journals Production of 6-l-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5550
Author(s):  
Viktoriya V. Orlovskaya ◽  
Austin S. Craig ◽  
Olga S. Fedorova ◽  
Olga F. Kuznetsova ◽  
Bernd Neumaier ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Applications ◽  
Automated Synthesis ◽  
Controlled Synthesis ◽  
Widespread Application ◽  
Production Methods ◽  
Valuable Alternative ◽  
Automated Production ◽  
Activity Yield ◽  
The Way

6-l-[18F]Fluoro-m-tyrosine (6-l-[18F]FMT) represents a valuable alternative to 6-l-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease. However, clinical applications of 6-l-[18F]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-l-[18F]FMT using alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0 ± 3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for 11C-labeling. This method enables an uncomplicated switch between 11C- and 18F-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-l-[18F]FMT in the clinic.

Comparative characteristics of provisional crowns made by CAD/CAM milling and 3D printing

2020 ◽  
pp. 45-49
Author(s):  
A.V. Stomatov ◽  
D.V. Stomatov ◽  
P.V. Ivanov ◽  
V.V. Marchenko ◽  
E.V. Piitsky ◽  
...  
Keyword(s):  
3D Printing ◽  
Good Alternative ◽  
Digital Model ◽  
Dental Practice ◽  
Production Methods ◽  
Automated Production ◽  
3D Printing Technology ◽  
Cad Cam ◽  
Milling Method ◽  
Technology Comparison

In this work, the authors studied and compared the two main methods used in dental practice for the automated production of orthopedic structures: the widely used CAD / CAM milling method and the 3D printing technology. As an object of research, temporary crowns were used, which were made on the basis of the same digital model: a) by the method of CAD / CAM milling from polymethylmethacrylate disks; b) by 3D printing from photopolymer resin based on LCD technology. Comparison of production methods and finished designs was carried out according to the following characteristics: strength, durability, aesthetic qualities, accuracy of orthopedic designs, etc. According to the results of the study, it was concluded that 3D printing can be a good alternative to CAD / CAM milling in solving problems of temporary prosthetics.

Structuralism

2018 ◽  
Author(s):  
Michael Lundell ◽  
Vincent P. Pecora
Keyword(s):  
Twentieth Century ◽  
Historical Development ◽  
Literary Studies ◽  
Widespread Application ◽  
Language Functions ◽  
Structural Linguistics ◽  
Universal Truth ◽  
Intellectual Movement ◽  
The Way

Structuralism, generally described, is a twentieth-century intellectual movement associated with linguistic studies in Europe, despite its vast applicability and many adherents. An initial aim of structural linguistics was to investigate – in greater detail than previously – the way language functions as a network of signification. Structuralism’s goal also typically derives from the question of whether universal truth can be revealed in this network in ways that define the constitution of thought. Structuralism focused on the whole of language, the ‘structure’ of the totality, over its individual parts or their historical development. The principles of Structuralism and its later transformations found widespread application outside of linguistics, particularly in anthropology, sociology, literary studies, semiotics, film, musicology, psychology, and philosophy.

Microtubule Destabilization Paves the Way to Parkinson’s Disease

2016 ◽  
Vol 54 (9) ◽  
pp. 6762-6774 ◽  
Author(s):  
D. Cartelli ◽  
G. Cappelletti
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
The Way

Neuroprostheses as an Element of an Eclectic Approach to Intervention in Neurorehabilitation

2014 ◽  
pp. 101-115
Author(s):  
Emilia Mikołajewska
Keyword(s):  
Clinical Practice ◽  
Clinical Applications ◽  
The Novel ◽  
Brain Computer Interfaces ◽  
Specific Approach ◽  
Computer Interfaces ◽  
Eclectic Approach ◽  
Methods And Techniques ◽  
Practice Development ◽  
The Way

Improvements in the effectiveness of contemporary neurorehabilitation emphasize the need for a shift from a specific approach to intervention to an eclectic approach to intervention. The novel strategies of brain-computer interfaces' and neuroprostheses' application in an eclectic approach to intervention may be regarded as leading the way in clinical practice development. There is a limited amount of evidence both in the areas of theoretical principles and clinical applications, but it seems the application of various rehabilitation methods and techniques may effectively support the outcomes of the BCI's and NP's use. The author aims investigates the extent to which the available opportunities are being exploited, including current and potential future applications of neuroprostheses within an eclectic approach to intervention in neurorehabilitation.

Research News

2002 ◽  
Vol 06 (10) ◽  
pp. 361-366
Keyword(s):  
Prostate Cancer ◽  
Parkinson’S Disease ◽  
Stem Cells ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Conclusive Evidence ◽  
Genetically Engineered ◽  
New Gene ◽  
Organic Produce ◽  
The Way

"Brain Hole" Finding Brings New Insight to Parkinson's Disease. Gene Therapy for Prostate Cancer. Robotic Pediatric Cardiac Surgeries Successful in China. Chinese Scientists Found New Gene Remedy for Cancer. Genetically Engineered Potato on the Way. Device Offers Bloodless Checks for Diabetics. Researchers Draws Stem Cells from Mouse Pancreases. Top NZ Scientist Works on Designer Trees. Gene Research at Canterbury University Earns International Praise. No Conclusive Evidence that Organic Produce is More Nutritious. Singapore to Use Mosquito as Weapon against Dengue. Scientist Warns of New Eye Correction Treatment.

Medical Decisions

1980 ◽  
Vol 25 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Douglas Black
Keyword(s):  
Renal Failure ◽  
Decision Theory ◽  
Bayes Theorem ◽  
Clinical Applications ◽  
Mathematical Methods ◽  
Medical Problems ◽  
Medical Decisions ◽  
Additional Information ◽  
Terminal Renal Failure ◽  
The Way

In relation to the application of decision theory to medical problems, a description is given of the terms ‘probability’, ‘utility’ and ‘coherence’. The use of utilities is illustrated by comparing the outcomes of various methods of palliating terminal renal failure. The use of Bayes' theorem in incorporating additional information is described. Reference is made to specific clinical applications of mathematical methods. Some general comments are made on the way in which clinical and other medical decisions are reached.

Operation of Controls on Everyday Products

1992 ◽  
Vol 36 (5) ◽  
pp. 509-513 ◽  
Author(s):  
W. Schoorlemmer ◽  
H. Kanis
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Visual Impairments ◽  
The Self ◽  
Self Reliance ◽  
Impaired People ◽  
The Way

Previous research shows that the self-reliance of physically impaired people can be seriously jeopardized by their inability to operate controls on everyday products. In the research reported in this paper a study is made into the operational difficulties faced by people suffering from Parkinson's disease, from spasticism, from visual impairments, and by physically non-impaired subjects. This paper reports the forces that can be exerted by these subjects, the way they actually manipulate controls, and the operational difficulties the subjects experience including both the force exertion and other operational difficulties. Finally, design implications are briefly looked into.

Characterisation of Local Bone Ash for Bone China Production

2013 ◽  
Vol 66 (1) ◽  
Author(s):  
Zainal Zakaria ◽  
Hamdzun Haron
Keyword(s):  
Raw Materials ◽  
Porcelain Body ◽  
Porcelain Factory ◽  
Production Methods ◽  
Bone China ◽  
Local Bone ◽  
Bone Ash ◽  
Clay Body ◽  
Materials Used ◽  
The Way

Clay body can be defined as a mixture of clay or other minerals to achieve a specific purpose in the production of ceramics. Among the types of clay that can produce white translucent ceramic products is porcelain. 'Porcelain' is derived from Italian word porselino which means 'piglet'. It is said that the name was given based on a cowry shell which is small and plump like a piglet or porselino and the shell also has shiny transparent finish like porcelain. Porcelain was produced in the 10th century during the reign of Emperor Hou Zhou Shi Zong, China. In 1748 a modification was carried out to the porcelain body by a British ceramic manufacturer Thomas Frye in Bow porcelain factory, London. The new body was known as 'fine porcelain'. He has formulated 45 % cattle bone ash in his porcelain mix to produce finer porcelain body, stronger, lower level of maturity during firing and its translucent effect was even greater. The term 'Bone China' was introduced by Josiah Spode in 1789 from Stoke after he successfully improved the formulation created by Frye. The beauty of bone china product in various forms is interesting enough for people to collect this exclusive product. However, bone china product has becoming an issue for Muslims who questions the materials used such as the permissible status of the bone used in its production. To solve this problem, a research has been carried out to identify the raw materials, the production methods and the way of detecting what type of bone used in the production of bone china. 

Neural Transplantation: Prospects for Clinical use

1993 ◽  
Vol 2 (1) ◽  
pp. 13-31 ◽  
Author(s):  
William J. Freed
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Cell Biology ◽  
Demyelinating Diseases ◽  
Neural Transplantation ◽  
Term Outcome ◽  
Widespread Application ◽  
Long Term Outcome ◽  
Cord Injury

Neural transplantation has been extensively applied in Parkinson's disease, including numerous clinical studies, studies in animal models, and related basic research on cell biology. There is evidence that the clinical trials of both adrenal medulla transplantation and fetal substantia nigra transplantation have produced a detectable clinical effect, although it is not yet clear whether the clinical benefit is sufficient to justify a more widespread application of these procedures. Studies of long-term outcome and quantitative tests are important in assaying the degree of benefit produced by transplantation procedures in Parkinson's disease and for developing improved and refined procedures. Other disease-related applications of neural transplantation are beginning to be developed. These include Huntington's disease, chronic pain, epilepsy, spinal cord injury, and perhaps even demyelinating diseases and cortical ischemic injury. Although most of these applications lie in the future, it is not too soon to begin to consider the scientific justification that should be required for initiation of human clinical trials.

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