scholarly journals Antibacterial Activities of Prenylated Isoflavones from Maclura tricuspidata against Fish Pathogenic Streptococcus: Their Structure-Activity Relationships and Extraction Optimization

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7451
Author(s):  
Jae-Woong Lim ◽  
Yang Hee Jo ◽  
Ji-Seok Choi ◽  
Mi Kyeong Lee ◽  
Ki Yong Lee ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Principal Component ◽  
Antibacterial Activities ◽  
Clinical Effects ◽  
Extraction Temperature ◽  
Box Behnken Design ◽  
High Antibacterial Activity ◽  
Low Cytotoxicity ◽  
Zoonotic Bacteria ◽  
Temperature Time

Streptococcus zoonotic bacteria cause serious problems in aquaculture with clinical effects on humans. A structure-antibacterial activity relationships analysis of 22 isoflavones isolated from M. tricuspidata (leaves, ripe fruits, and unripe fruits) against S. iniae revealed that prenylation of the isoflavone skeleton was an important key for their antibacterial activities (minimum inhibitory concentrations: 1.95–500 μg/mL). Through principal component analysis, characteristic prenylated isoflavones such as 6,8-diprenlygenistein (4) were identified as pivotal compounds that largely determine each part’s antibacterial activities. M. tiricuspidata ripe fruits (MTF), which showed the highest antibacterial activity among the parts tested, were optimized for high antibacterial activity and low cytotoxicity on fathead minnow cells using Box–Behnken design. Optimized extraction conditions were deduced to be 50%/80 °C/7.5 h for ethanol concentration/extraction temperature/time, and OE-MTF showed contents of 6,8-diprenlygenistein (4), 2.09% with a MIC of 40 µg/mL. These results suggest that OE-MTF and its active isoflavones have promising potential as eco-friendly antibacterial agents against streptococcosis in aquaculture.

scholarly journals 5-Bromo-1-(4-chlorobenzyl)-1H-indole-2-carboxamides as new potent antibacterial agents

2018 ◽  
Vol 24 (6) ◽  
pp. 327-332 ◽  
Author(s):  
Yogesh D. Mane ◽  
Smita S. Patil ◽  
Dhanraj O. Biradar ◽  
Bhimrao C. Khade
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Gram Negative Bacteria ◽  
Internal Standards ◽  
Gram Negative ◽  
E Coli ◽  
High Antibacterial Activity

Abstract Ten 5-bromoindole-2-carboxamides were synthesized, characterized and evaluated for antibacterial activity against pathogenic Gram-negative bacteria Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Salmonella Typhi using gentamicin and ciprofloxacin as internal standards. Compounds 7a–c, 7g and 7h exhibit high antibacterial activity with a minimum inhibitory concentration (MIC) of 0.35–1.25 μg/mL. Compounds 7a–c exhibit antibacterial activities that are higher than those of the standards against E. coli and P. aeruginosa.

scholarly journals Synthesis, antibacterial activities, and sustained perfume release properties of optically active5-hydroxy- and 5-acetoxyalkanethioamide analogues

2020 ◽  
Vol 26 (1) ◽  
pp. 84-98
Author(s):  
Yasutaka Shimotori ◽  
Masayuki Hoshi ◽  
Narihito Ogawa ◽  
Tetsuo Miyakoshi ◽  
Taisei Kanamoto
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Sustained Release ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Optically Active ◽  
High Antibacterial Activity ◽  
Subsequent Deacetylation

Abstract5-Acetoxy- and 5-hydroxyalkanethioamide analogues showed high antibacterial activity against Staphylococcus aureus. Antibacterial thioamides were prepared from 5-alkyl-δ-lactones by amidation, thionation, and subsequent deacetylation. Optically active thioamides with 99% diastereomeric excesses were prepared by diastereomeric resolution using Cbz-L-proline as the resolving agent. Antibacterial thioamides were slowly lactonized by a lipase catalyst. Therefore, these thioamides are potential sustained-release perfume compounds having antibacterial properties.

scholarly journals Schiff Base of Metal Complex Derived from Glycine and Benzaldehyde

2020 ◽  
pp. 105-114
Author(s):  
Ishaq Yahaya Lawan ◽  
Mohammed Muftahu Beli ◽  
Mohammed Adamu ◽  
Fatima Baba Isah ◽  
Maryam Abubakar
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complex ◽  
Schiff Base Ligand ◽  
Conductivity Measurement ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
E Coli ◽  
High Antibacterial Activity ◽  
Ir Analysis

Schiff base ligand derived from glycine and benzaldehyde was synthesized together with its metal complexes (zinc and cobalt). The solubility, IR analysis and conductivity measurement were carried out. Antibacterial activities were evaluated using well-diffusion method. The bacterial assay was carried out on two pyogenic bacteria E. coli and Staphylococci and the results showed that the complexes have high antibacterial activity.

scholarly journals Unveiling the Mechanism of Action of 7α-acetoxy-6β-hydroxyroyleanone on an MRSA/VISA Strain: Membrane and Cell Wall Interactions

Biomolecules ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 983
Author(s):  
Filipe Pereira ◽  
Teresa Figueiredo ◽  
Rodrigo F. M. de Almeida ◽  
Catarina A. C. Antunes ◽  
Catarina Garcia ◽  
...  
Keyword(s):  
Cell Wall ◽  
Antibacterial Activity ◽  
Lipid Bilayers ◽  
Mechanism Of Action ◽  
Resistant Bacteria ◽  
High Antibacterial Activity ◽  
Cell Wall Disruption ◽  
Low Cytotoxicity ◽  
Mrsa Strains ◽  
Interesting Alternative

The number of cases of failure in the treatment of infections associated with resistant bacteria is on the rise, due to the decreasing efficacy of current antibiotics. Notably, 7α-Acetoxy-6β-hydroxyroyleanone (AHR), a diterpene isolated from different Plectranthus species, showed antibacterial activity, namely against Methicillin-resistant Staphylococcus aureus (MRSA) strains. The high antibacterial activity and low cytotoxicity render this natural compound an interesting alternative against resistant bacteria. The aim of this study is to understand the mechanism of action of AHR on MRSA, using the MRSA/Vancomycin-intermediate S. aureus (VISA) strain CIP 106760, and to study the AHR effect on lipid bilayers and on the cell wall. Although AHR interacted with lipid bilayers, it did not have a significant effect on membrane passive permeability. Alternatively, bacteria treated with this royleanone displayed cell wall disruption, without revealing cell lysis. In conclusion, the results gathered so far point to a yet undescribed mode of action that needs further investigation.

scholarly journals Correlation between Chemical Composition of Greek Essential Oils and their Antibacterial Activity against Food-borne Pathogens

2007 ◽  
Vol 2 (4) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Nikos G. Chorianopoulos ◽  
Epameinontas T. Evergetis ◽  
Nektarios Aligiannis ◽  
Sofia Mitakou ◽  
George-John E. Nychas ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Antibacterial Activity ◽  
Chemical Composition ◽  
Essential Oils ◽  
Salmonella Enteritidis ◽  
Principal Component ◽  
Antibacterial Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Food Borne

The compositions of forty-nine essential oils obtained from plants growing in areas of biodiversity in Greece were determined by means of gas chromatography and gas chromatography–mass spectrometry. The in vitro antibacterial activities of the oils were evaluated against a panel of five common food-borne bacteria ( Escherichia coli 0157:H7 NCTC 12900, Salmonella Enteritidis PT4, Staphylococcus aureus ATCC 6538, Listeria monocytogenes Scott A and Bacillus cereus FSS 134). Monoterpene hydrocarbons, phenolic monoterpenes and alcohols were the major constituents of the oils, but their concentrations varied greatly between the samples examined. The essential oils obtained from the species endemic to Greece ( Satureja and Origanum) had the most potent bactericidal properties. The chemical composition data were statistically processed through Principal Component Analysis (PCA) and correlated with the antibacterial activities, allowing a rough estimation of the potential of the essential oils antibacterial activity.

scholarly journals Synthesis and characterization of Au nanoparticles for nanomedicine application

2018 ◽  
Vol 15 (35) ◽  
pp. 109-116
Author(s):  
Falah A-H. Mytlak
Keyword(s):  
Gold Nanoparticles ◽  
Antibacterial Activity ◽  
Au Nanoparticles ◽  
Xrd Analysis ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Growth Media ◽  
High Antibacterial Activity ◽  
Laser Ablation Method ◽  
Average Size

Gold nanoparticles AuNPs have proven to be powerful tools in various nanomedicine applications, because of their photo-optical distinctiveness and biocompatibility. Noble metal gold nanoparticles was prepared by pulsed laser ablation method (1064-Nd: YAG with various Laser power from 200 to 800 mJ and 1 Hz frequency) in distil water. The process was characterized using UV-VIS absorption spectroscopy. Morphology and average size of nanoparticles were estimated using AFM and X-ray diffraction (XRD) analysis which show the nature of gold nanoparticles (AuNPs). Antibacterial activity of gold nanoparticles as a function of particles concentration against gram negative bacterium Escherichia coli and gram positive bacterial Staphylococcus aureus was carried out in solid growth media. Gold nanoparticles show high antibacterial activity with zone of inhibition. Antibacterial activities of the synthesized Au nanoparticles were assessed by agar well diffusion method. The stabilized AuNPs exhibited excellent antibacterial sensitivity (12-27 mm) to E. coli and (26-38mm) to Staph aureus.

scholarly journals Facile Synthesis of Silver Nanoparticles with High Antibacterial Activity

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2498 ◽  
Author(s):  
Anni Feng ◽  
Jiankang Cao ◽  
Junying Wei ◽  
Feng Chang ◽  
Yang Yang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Antibacterial Activities ◽  
Molar Ratio ◽  
Facile Synthesis ◽  
Gram Negative ◽  
Morphology Transition ◽  
Gram Positive Bacteria ◽  
High Antibacterial Activity ◽  
Reverse Microemulsion Method

We report on a reverse microemulsion method for the synthesis of silver nanocrystals and examine their antibacterial activities. As the molar ratio of water to sodium bis(2-ethylhexyl) sulfosuccinate (AOT) increases to 25, a morphology transition from a sphere-like nanocrystal to a wire-like one was observed. For both the gram-negative and gram-positive bacteria, the wire-like silver nanocrystal showed higher antibacterial activities. We conclude that the morphology of silver nanocrystals dominates their antibacterial activity.

scholarly journals Antibacterial Properties of Titanate Nanofiber Thin Films Formed on a Titanium Plate

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Mitsunori Yada ◽  
Yuko Inoue ◽  
Iwao Noda ◽  
Tomohiro Morita ◽  
Toshio Torikai ◽  
...  
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Antibacterial Activity ◽  
Silver Nanoparticle ◽  
Antibacterial Properties ◽  
Sodium Titanate ◽  
Antibacterial Activities ◽  
Ultraviolet Rays ◽  
Titanium Plate ◽  
High Antibacterial Activity

A sodium titanate nanofiber thin film and a silver nanoparticle/silver titanate nanofiber thin film formed on the surface of a titanium plate exhibited strong antibacterial activities against methicillin-resistantStaphylococcus aureus, which is one of the major bacteria causing in-hospital infections. Exposure of the sodium titanate nanofiber thin film to ultraviolet rays generated a high antibacterial activity due to photocatalysis and the sodium titanate nanofiber thin film immediately after its synthesis possessed a high antibacterial activity even without exposure to ultraviolet rays. Elution of silver from the silver nanoparticle/silver titanate nanofiber thin film caused by the silver ion exchange reaction was considered to contribute substantially to the strong antibacterial activity. The titanate nanofiber thin films adhered firmly to titanium. Therefore, these titanate nanofiber thin film/titanium composites will be extremely useful as implant materials that have excellent antibacterial activities.

scholarly journals Optimization of Selected Process Parameters Affecting Yield of Green Synthesized Silver Nanoparticles and Their Antibacterial Activity

2021 ◽  
pp. 25-36
Author(s):  
F. A. Ekaji ◽  
C. O. Akujobi ◽  
S. I. Umeh
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Process Parameters ◽  
Antibacterial Activities ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Box Behnken Design ◽  
E Coli ◽  
Optimized Conditions ◽  
Green Synthesized Silver Nanoparticles

Aims: To optimize effects of selected process parameters affecting yield of green synthesized silver nanoparticles and their antibacterial activity. Study Design: Study was designed with 3 factors Box Behnken Design (Minitab 17) and Response optimizer (Minitab 17) was used to determine optimum values of the factors. Place and Duration of Study: Department of Microbiology, Federal University of Technology, Owerri, Nigeria, from March to November, 2020. Methodology: After extraction by boiling, qualitative phytochemical analysis of leaves’ extracts of Ipeoma batatas, Commelina africana and Manihot esculenta was carried out. Following synthesis of silver nanoparticles as prescribed by Box Behnken design, yield of AgNPs was optimized with Response optimizer (Minitab 17). Then antibacterial activity of resulting AgNPs was tested against isolates of P. aeruginosa and E. coli. Results: Extracts contained alkaloids, tannins, proteins and amino acids, flavonoids and phenolic compounds, but no sterols and cardiac glycosides. Optimum pH, temperature and time obtained with Response Optimizer resulted in 62.6%, 55.8% and 54.9% increase in yield of AgNPs, with leaf extracts of C. africana, M. esculenta and I. batatas respectively, compared to un-optimized conditions. Absorbance for resulting AgNPs peaked between 380 to 400 nm. Zones of inhibition (mm) of P. aeruginosa with AgNPs synthesized using extracts of C. africana, I. batatas and M. esculenta were 10, 10 and 9 respectively, under un-optimized condition, and 12, 10 and 8 respectively, for optimized conditions. Against E. coli, they were 11, 11 and 12 for AgNPs synthesized with extracts of C. africana, I. batatas and M. esculenta respectively, under un-optimized condition, and 13, 9 and 11 respectively, for optimized conditions. Conclusion: Leaf extracts of C. africana, I. batatas and M. esculenta can be used in synthesizing AgNPs, with marked antibacterial activities. Box Behnken design is useful for optimization of effects of process parameters.

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