scholarly journals Association of Serum 25-Hydroxyvitamin D Concentration with Pulmonary Function in Young Adults

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1728 ◽  
Author(s):  
Vanda Craveiro ◽  
Maria Cabral ◽  
Joana Araújo ◽  
Helena Falcão ◽  
João Guimarães ◽  
...  
Keyword(s):  
Young Adults ◽  
Pulmonary Function ◽  
Statistical Significance ◽  
Population Based ◽  
Institute Of Medicine ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

The role of vitamin D on pulmonary function is unclear and is mostly studied in patients, smokers and elderly people. The aim of this paper was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] concentration and pulmonary function in young adults. Cross-sectional analysis of 499 individuals that were evaluated at 21 years of age as part of the population-based cohort Epidemiological Health Investigation of Teenagers in Porto (EPITeen). Serum 25(OH)D was categorized according to the Institute of Medicine. Pulmonary function was evaluated using spirometry. Linear regression models were used to estimate the regression coefficients (β) and its 95% confidence intervals (95% CI), and were adjusted for confounders. Education, smoking, body mass index, and season of evaluation were determinants of serum 25(OH)D concentration. Prevalence of serum 25(OH)D concentration <50 nmol/L was 48.9%. A decrease in all pulmonary function parameters, with the decrease of serum 25(OH)D, was observed. The higher effect was found for peak expiratory flow (PEF). Having as reference participants with serum 25(OH)D concentration ≥50 nmol/L, PEF was significantly lower for those with a concentration of 30 to <50 nmol/L (β= −0.576; 95% CI: −0.943, −0.210), and for those with a concentration of <30 nmol/L (β= −0.650; 95% CI: −1.155, −0.146). Although only PEF attained statistical significance, the consistent results with the other parameters support the role of serum 25(OH)D to promote better pulmonary function in young adults.

Association between 25-hydroxyvitamin D and inflammatory biomarker levels in a cross-sectional population-based study, São Paulo, Brazil

2016 ◽  
Vol 36 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Wysllenny N. de Souza ◽  
Marina M. Norde ◽  
Érica Oki ◽  
Marcelo M. Rogero ◽  
Dirce M.L. Marchioni ◽  
...  
Keyword(s):  
Population Based ◽  
Sao Paulo ◽  
São Paulo ◽  
Cross Sectional ◽  
Population Based Study ◽  
Inflammatory Biomarker ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study

2014 ◽  
Vol 45 (4) ◽  
pp. 1019-1026 ◽  
Author(s):  
Tricia L. Larose ◽  
Arnulf Langhammer ◽  
Yue Chen ◽  
Carlos A. Camargo ◽  
Pål Romundstad ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Lung Function ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Health Study ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Hunt Study

The association between vitamin D status and lung function in adults with asthma remains unclear.We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19–55 years) with self-reported asthma in the Nord-Trøndelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol·L−1was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (β) and 95% confidence intervals.44% of asthma adults had serum 25(OH)D levels <50 nmol·L−1. Its associations with lung function measures seemed to be modified by sex and allergic rhinitis (p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol·L−1was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol·L−1was significantly associated with lower FEV1/FVC ratio (β=−8.60%; 95% CI: −16.95%– −0.25%).Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis.

scholarly journals No associations between serum concentrations of 25-hydroxyvitamin D and parathyroid hormone and depression among US adults

2010 ◽  
Vol 104 (11) ◽  
pp. 1696-1702 ◽  
Author(s):  
Guixiang Zhao ◽  
Earl S. Ford ◽  
Chaoyang Li ◽  
Lina S. Balluz
Keyword(s):  
Parathyroid Hormone ◽  
Major Depression ◽  
Severe Depression ◽  
Diagnostic Algorithm ◽  
Population Based ◽  
Minor Depression ◽  
Serum Concentrations ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Although there is evidence that vitamin D deficiency may play a role in depression, studies done on the associations have yielded mixed results. The present study aimed to examine the associations between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) and the presence of depression among US adults. A cross-sectional, population-based sample (including 3916 participants aged ≥ 20 years) from the 2005–6 National Health and Nutrition Examination Survey was used. Participants' depressive symptoms were assessed using the Patient Health Questionnaire-9 diagnostic algorithm. The associations of 25(OH)D and PTH with depression were explored using multivariate logistic regression models. For all the participants, the age-adjusted prevalence was 5·3  (95 % CI 4·3, 6·5) % for having moderate-to-severe depression, 2·3  (95 % CI 1·7, 3·1) % for having major depression and 3·8  (95 % CI 3·0, 4·6) % for having minor depression. Although the age-adjusted prevalence and the unadjusted OR of having moderate-to-severe depression or major depression decreased linearly with increasing quartiles of 25(OH)D (P < 0·05 for trends), no significant associations remained after adjusting for multiple potential confounders such as demographic variables, lifestyle factors and coexistence of a number of chronic conditions. Neither the age-adjusted prevalence nor the OR (unadjusted or adjusted) of having depression differed significantly by the quartiles of PTH. Thus, in contrast to some of the previous findings, the present results did not show significant associations between serum concentrations of 25(OH)D and PTH and the presence of moderate-to-severe depression, major depression or minor depression among US adults. However, these findings need to be further confirmed in future studies.

scholarly journals Association of Serum 25-Hydroxyvitamin D with Lifestyle Factors and Metabolic and Cardiovascular Disease Markers: Population-Based Cross-Sectional Study (FIN-D2D)

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100235 ◽  
Author(s):  
Maija E. Miettinen ◽  
Leena Kinnunen ◽  
Jaana Leiviskä ◽  
Sirkka Keinänen-Kiukaanniemi ◽  
Eeva Korpi-Hyövälti ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Population Based ◽  
Cross Sectional Study ◽  
Lifestyle Factors ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Disease Markers ◽  
25 Hydroxyvitamin D

scholarly journals Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

2013 ◽  
Vol 17 (4) ◽  
pp. 827-832 ◽  
Author(s):  
Li Chang ◽  
Xiaojuan Liu ◽  
Hua Shi ◽  
Wei Dai ◽  
Hong Wang ◽  
...  
Keyword(s):  
Blood Lead ◽  
Population Based ◽  
University Hospital ◽  
Cross Sectional ◽  
West China ◽  
Hydroxyvitamin D ◽  
South West ◽  
Lead Levels ◽  
Physical Examinations ◽  
25 Hydroxyvitamin D

AbstractObjectiveTo evaluate the prevalence of vitamin D deficiency and insufficiency, as well as their association with Hb and elevated blood lead levels (BLL) in children in China.DesignA cross-sectional and 1-year retrospective study.SettingDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, China.SubjectsChildren aged from 6 months to 14 years living in south-west China who were taken to physical examinations (January–December 2011).ResultsOf 1218 children included in the study, 25-hydroxyvitamin D (25(OH)D) concentration (mean 33·18 (sd 16·48) ng/ml) was deficient in 21·6 % and insufficient in 27·4 %, which were higher than the prevalence of both anaemia at 8·5 % and elevated BLL (Pb ≥ 10 μg/dl) at 1·8 %, but lower than mildly elevated BLL prevalence (5 μg/dl ≤ Pb < 10 μg/dl) at 56·9 %. There was a negative correlation between 25(OH)D concentration and BLL (r = −0·216, P < 0·001) while no significant relationship was found between 25(OH)D concentration and Hb (r = −0·012, P > 0·05). After multivariable adjustment, the significant predictors of 25(OH)D deficiency and insufficiency were increasing child age especially between 8 and 14 years (OR = 18·29; 95 % CI 10·14, 32·99; P < 0·001) and BLL (OR = 1·01; 95 % CI 1·00, 1·02; P = 0·045).ConclusionsThe prevalence of 25(OH)D deficiency and insufficiency was much higher than that of anaemia or elevated BLL in south-west China, and associated with increasing age and BLL.

scholarly journals Prevalence and determinants of vitamin D deficiency and insufficiency among three immigrant groups in Finland: evidence from a population-based study using standardised 25-hydroxyvitamin D data

2020 ◽  
Vol 23 (7) ◽  
pp. 1254-1265
Author(s):  
Folasade A Adebayo ◽  
Suvi T Itkonen ◽  
Eero Lilja ◽  
Tuija Jääskeläinen ◽  
Annamari Lundqvist ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Migrant Health ◽  
Population Based ◽  
Vitamin D Insufficiency ◽  
Dietary Vitamin ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Dairy Consumption ◽  
25 Hydroxyvitamin D

AbstractObjective:We investigated the determinants of serum 25-hydroxyvitamin D [S-25(OH)D] and dietary vitamin D sources among three immigrant groups in Finland and compared their S-25(OH)D to the general Finnish population.Design:Cross-sectional population-based Migrant Health and Wellbeing Study and the nationally representative Finnish Health 2011 Survey. S-25(OH)D was standardised according to the Vitamin D Standardisation Program. Vitamin D sources were assessed by interview.Setting:Six different municipalities in Finland (60°–63°N).Participants:Immigrants aged 18–64 years (446 Russians, 346 Somalis, 500 Kurds), 798 Finns aged 30–64 years.Results:The mean of S-25(OH)D was 64 (95 % CI 62, 66), 44 (95 % CI 41, 46), 35 (95 % CI 34, 37) and 64 (95 % CI 62, 66) nmol/l for Russians, Somalis, Kurds and Finns, respectively. S-25(OH)D among Somalis and Kurds was lower compared with Finns (P < 0·001). The prevalence of vitamin D deficiency (S-25(OH)D <30 nmol/l) and insufficiency (S-25(OH)D <50 nmol/l) was higher among immigrants than Finns (P < 0·001). Vitamin D-rich foods differed between the groups; vitamin D-fortified fat spread consumption was higher among Somalis (91 %) than among Russians (73 %) and Kurds (60 %); fish was less consumed among Kurds (17 %) than among Russians (43 %) and Somalis (38 %); and 57 % Russians, 56 % Kurds and 36 % Somalis consumed vitamin D-fortified dairy daily (P < 0·001 for all). Daily smoking, alcohol consumption and winter blood sampling were determinants of vitamin D insufficiency (P ≤ 0·03). Older age, physical activity, fish and vitamin D-fortified dairy consumption were associated with lower odds of insufficiency (P ≤ 0·04).Conclusions:Vitamin D status differed among immigrant groups and the determinants are, to some degree, associated with learned or existing cultural behaviours.

scholarly journals Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed

2010 ◽  
Vol 163 (2) ◽  
pp. 339-348 ◽  
Author(s):  
Guri Grimnes ◽  
Bjørg Almaas ◽  
Anne Elise Eggen ◽  
Nina Emaus ◽  
Yngve Figenschau ◽  
...  
Keyword(s):  
Validation Study ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Linear Models ◽  
Serum Levels ◽  
Population Based ◽  
Cross Sectional ◽  
Population Based Study ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

ObjectiveBecause we found higher serum 25-hydroxyvitamin D (25(OH)D) levels among smokers than among non-smokers with analyses using an electrochemiluminescence immunoassay (ECLIA) from Roche, the purpose of the present study was to examine whether this difference between smokers and non-smokers was maintained using other serum 25(OH)D assays.DesignA cross-sectional population-based study on 6932 participants from the Tromsø study, 1994–1995, and one validation study comparing six different serum 25(OH)D assays in 53 non-smokers and 54 smokers were performed.MethodsThe association between smoking, season and serum 25(OH)D as measured by ECLIA (Roche) was assessed in the population-based study using general linear models with multivariate adjustments. In the validation study, serum levels of 25(OH)D were analysed with liquid chromatography coupled with mass spectrometry assay from two different laboratories, RIA (DiaSorin), HPLC, RIA (IDS) and ECLIA (Roche). T-tests and linear mixed model analyses were performed to compare the serum 25(OH)D levels in smokers and non-smokers within and between the methods.ResultsIn the population-based study, the serum levels of 25(OH)D using the ECLIA method were 51.9, 53.2 and 72.0 nmol/l in never, former and current smokers (P<0.01). In the validation study, the serum concentration of 25(OH)D was 10.3 nmol/l higher in smokers than in non-smokers (P<0.01) using the ECLIA (Roche), while non-significantly lower serum levels of 25(OH)D were found in smokers using the other five methods.ConclusionsThese two studies indicate that the ECLIA (Roche) overestimates serum 25(OH)D levels in smokers by unknown mechanisms. If confirmed, this might have clinical consequences, and the issue needs further exploration.

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