scholarly journals Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1738 ◽  
Author(s):  
Subhadeep Chakrabarti ◽  
Snigdha Guha ◽  
Kaustav Majumder
Keyword(s):  
Bioactive Peptides ◽  
Scientific Evidence ◽  
Bioactive Peptide ◽  
Health Claims ◽  
Commercial Application ◽  
Potential Health ◽  
Physiological Functions ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Production Techniques

Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment.

scholarly journals A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract

2021 ◽  
Vol 14 (5) ◽  
pp. 467
Author(s):  
Ana Henriques Mota ◽  
Inês Prazeres ◽  
Henrique Mestre ◽  
Andreia Bento-Silva ◽  
Maria João Rodrigues ◽  
...  
Keyword(s):  
Biological Activities ◽  
Scientific Evidence ◽  
Release Profile ◽  
Health Claims ◽  
Topical Formulation ◽  
Sambucus Nigra ◽  
Western Asia ◽  
Wide Range ◽  
The Impact ◽  
Over Time

Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time.

scholarly journals Soybean Bioactive Peptides and Their Functional Properties

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1211 ◽  
Author(s):  
Cynthia Chatterjee ◽  
Stephen Gleddie ◽  
Chao-Wu Xiao
Keyword(s):  
Chronic Diseases ◽  
Soy Protein ◽  
Bioactive Peptides ◽  
Soy Proteins ◽  
Health Claim ◽  
Potential Health ◽  
Physiological Functions ◽  
Target Organs ◽  
Soy Peptides ◽  
The Usa

Soy consumption has been associated with many potential health benefits in reducing chronic diseases such as obesity, cardiovascular disease, insulin-resistance/type II diabetes, certain type of cancers, and immune disorders. These physiological functions have been attributed to soy proteins either as intact soy protein or more commonly as functional or bioactive peptides derived from soybean processing. These findings have led to the approval of a health claim in the USA regarding the ability of soy proteins in reducing the risk for coronary heart disease and the acceptance of a health claim in Canada that soy protein can help lower cholesterol levels. Using different approaches, many soy bioactive peptides that have a variety of physiological functions such as hypolipidemic, anti-hypertensive, and anti-cancer properties, and anti-inflammatory, antioxidant, and immunomodulatory effects have been identified. Some soy peptides like lunasin and soymorphins possess more than one of these properties and play a role in the prevention of multiple chronic diseases. Overall, progress has been made in understanding the functional and bioactive components of soy. However, more studies are required to further identify their target organs, and elucidate their biological mechanisms of action in order to be potentially used as functional foods or even therapeutics for the prevention or treatment of chronic diseases.

scholarly journals Beneficial Effects of Soybean-Derived Bioactive Peptides

2021 ◽  
Vol 22 (16) ◽  
pp. 8570
Author(s):  
Il-Sup Kim ◽  
Woong-Suk Yang ◽  
Cheorl-Ho Kim
Keyword(s):  
Blood Pressure ◽  
Amino Acids ◽  
Anticancer Agents ◽  
Bioactive Peptides ◽  
Calcium Absorption ◽  
The Body ◽  
Cognitive Capacity ◽  
Blood Cholesterol ◽  
Physiological Functions ◽  
Wide Range

Peptides present in foods are involved in nutritional functions by supplying amino acids; sensory functions related to taste or solubility, emulsification, etc.; and bioregulatory functions in various physiological activities. In particular, peptides have a wide range of physiological functions, including as anticancer agents and in lowering blood pressure and serum cholesterol levels, enhancing immunity, and promoting calcium absorption. Soy protein can be partially hydrolyzed enzymatically to physiologically active soy (or soybean) peptides (SPs), which not only exert physiological functions but also help amino acid absorption in the body and reduce bitterness by hydrolyzing hydrophobic amino acids from the C- or N-terminus of soy proteins. They also possess significant gel-forming, emulsifying, and foaming abilities. SPs are expected to be able to prevent and treat atherosclerosis by inhibiting the reabsorption of bile acids in the digestive system, thereby reducing blood cholesterol, low-density lipoprotein, and fat levels. In addition, soy contains blood pressure-lowering peptides that inhibit angiotensin-I converting enzyme activity and antithrombotic peptides that inhibit platelet aggregation, as well as anticancer, antioxidative, antimicrobial, immunoregulatory, opiate-like, hypocholesterolemic, and antihypertensive activities. In animal models, neuroprotective and cognitive capacity as well as cardiovascular activity have been reported. SPs also inhibit chronic kidney disease and tumor cell growth by regulating the expression of genes associated with apoptosis, inflammation, cell cycle arrest, invasion, and metastasis. Recently, various functions of soybeans, including their physiologically active functions, have been applied to health-oriented foods, functional foods, pharmaceuticals, and cosmetics. This review introduces some current results on the role of bioactive peptides found in soybeans related to health functions.

scholarly journals Need for Accurate and Standardized Determination of Amino Acids and Bioactive Peptides for Evaluating Protein Quality and Potential Health Effects of Foods and Dietary Supplements

2008 ◽  
Vol 91 (4) ◽  
pp. 894-900 ◽  
Author(s):  
G Sarwar Gilani ◽  
Chaowu Xiao ◽  
Nora Lee
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Ion Exchange ◽  
Bioactive Peptides ◽  
Protein Quality ◽  
The United States ◽  
Health Claims ◽  
World Health ◽  
Potential Health

Abstract Accurate standardized methods for the determination of amino acid in foods are required to assess the nutritional safety and compositional adequacy of sole source foods such as infant formulas and enteral nutritionals, and protein and amino acid supplements and their hydrolysates, and to assess protein claims of foods. Protein digestibility-corrected amino acid score (PDCAAS), which requires information on amino acid composition, is the official method for assessing protein claims of foods and supplements sold in the United States. PDCAAS has also been adopted internationally as the most suitable method for routine evaluation of protein quality of foods by the Food and Agriculture Organization/World Health Organization. Standardized methods for analysis of amino acids by ion-exchange chromatography have been developed. However, there is a need to develop validated methods of amino acid analysis in foods using liquid chromatographic techniques, which have replaced ion-exchange methods for quantifying amino acids in most laboratories. Bioactive peptides from animal and plant proteins have been found to potentially impact human health. A wide range of physiological effects, including blood pressure-lowering effects, cholesterol-lowering ability, antithrombotic effects, enhancement of mineral absorption, and immunomodulatory effects have been described for bioactive peptides. There is considerable commercial interest in developing functional foods containing bioactive peptides. There is also a need to develop accurate standardized methods for the characterization (amino acid sequencing) and quantification of bioactive peptides and to carry out dose-response studies in animal models and clinical trials to assess safety, potential allergenicity, potential intolerance, and efficacy of bioactive peptides. Information from these studies is needed for determining the upper safe levels of bioactive peptides and as the basis for developing potential health claims for bioactive peptides. This information is, in turn, needed by regulatory agencies for developing appropriate policy and regulations on adding these substances to foods and for determining if health claims are scientifically substantiated.

scholarly journals Early Balkan Metallurgy: Origins, Evolution and Society, 6200–3700 BC

2021 ◽  
Author(s):  
Miljana Radivojević ◽  
Benjamin W. Roberts
Keyword(s):  
Metal Production ◽  
The Balkans ◽  
Archaeological Data ◽  
Tin Bronze ◽  
Wide Range ◽  
Production Distribution ◽  
Societal Context ◽  
Copper Gold ◽  
Production Techniques ◽  
Early Metallurgy

AbstractThis paper analyses and re-evaluates current explanations and interpretations of the origins, development and societal context of metallurgy in the Balkans (c. 6200–3700 BC). The early metallurgy in this region encompasses the production, distribution and consumption of copper, gold, tin bronze, lead and silver. The paper draws upon a wide range of existing archaeometallurgical and archaeological data, the diversity and depth of which make the Balkans one of the most intensively investigated of all early metallurgical heartlands across the world. We focus specifically on the ongoing debates relating to (1) the independent invention and innovation of different metals and metal production techniques; (2) the analysis and interpretation of early metallurgical production cores and peripheries, and their collapses; and (3) the relationships between metals, metallurgy and society. We argue that metal production in the Balkans throughout this period reflects changes in the organisation of communities and their patterns of cooperation, rather than being the fundamental basis for the emergence of elites in an increasingly hierarchical society.

Wide-Range Many-Core SoC Design in Scaled CMOS: Challenges and Opportunities

2021 ◽  
Vol 29 (5) ◽  
pp. 843-856
Author(s):  
Sriram Vangal ◽  
Somnath Paul ◽  
Steven Hsu ◽  
Amit Agarwal ◽  
Saurabh Kumar ◽  
...  
Keyword(s):  
Wide Range ◽  
Challenges And Opportunities ◽  
Many Core ◽  
Scaled Cmos

scholarly journals New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3888
Author(s):  
Boon-Peng Puah ◽  
Juriyati Jalil ◽  
Ali Attiq ◽  
Yusof Kamisah
Keyword(s):  
Immune Cells ◽  
Scientific Evidence ◽  
Special Role ◽  
Real Potential ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
The Relationship ◽  
Cancer Activity ◽  
Reduced Risk

Lycopene is a well-known compound found commonly in tomatoes which brings wide range of health benefits against cardiovascular diseases and cancers. From an anti-cancer perspective, lycopene is often associated with reduced risk of prostate cancer and people often look for it as a dietary supplement which may help to prevent cancer. Previous scientific evidence exhibited that the anti-cancer activity of lycopene relies on its ability to suppress oncogene expressions and induce proapoptotic pathways. To further explore the real potential of lycopene in cancer prevention, this review discusses the new insights and perspectives on the anti-cancer activities of lycopene which could help to drive new direction for research. The relationship between inflammation and cancer is being highlighted, whereby lycopene suppresses cancer via resolution of inflammation are also discussed herein. The immune system was found to be a part of the anti-cancer system of lycopene as it modulates immune cells to suppress tumor growth and progression. Lycopene, which is under the family of carotenoids, was found to play special role in suppressing lung cancer.

Layered Manufacturing: Challenges and Opportunities

2002 ◽  
Vol 758 ◽  
Author(s):  
Khershed P. Cooper
Keyword(s):  
Science Research ◽  
Scientific Activity ◽  
Layered Manufacturing ◽  
Full Potential ◽  
Local Composition ◽  
Photosensitive Polymers ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Future Direction

ABSTRACTLayered Manufacturing (LM) refers to computer-aided manufacturing processes in which parts are made in sequential layers relatively quickly. Parts that are produced by LM can be formed from a wide range of materials such as photosensitive polymers, metals and ceramics in sizes from a centimeter to a few meters with sub-millimeter feature resolutions. LM has found use in diverse areas including biomedical engineering, pharmaceuticals, aerospace, defense, electronics and design engineering. The promise of LM is the capability to make customized complex-shaped functional parts without specialized tooling and without assembly. LM is still a few years away from fully realizing its promise but its potential for manufacturing remains high. A few of the fundamental challenges in materials processing confronting the community are improving the quality of the surface finish, eliminating residual stress, controlling local composition and microstructure, achieving fine feature size and dimensional tolerance and accelerating processing speed. Until these challenges are met, the applicability of LM and its commercialization will be restricted. Sustained scientific activity in LM has advanced over the past decade into many different areas of manufacturing and has enabled exploration of novel processes and development of hybrid processes. The research community of today has the opportunity to shape the future direction of science research to realize the full potential of LM.

scholarly journals Genome-Wide Identification of Resveratrol Intrinsic Resistance Determinants in Staphylococcus aureus

Antibiotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 82
Author(s):  
Liping Liu ◽  
Hanne Ingmer ◽  
Martin Vestergaard
Keyword(s):  
Staphylococcus Aureus ◽  
Stress Response ◽  
Inhibitory Activity ◽  
Bacterial Species ◽  
Dna Integrity ◽  
Intrinsic Resistance ◽  
Potential Health ◽  
Cellular Effects ◽  
Development Of Resistance ◽  
Wide Range

Resveratrol has been extensively studied due to its potential health benefits in multiple diseases, for example, cancer, obesity and cardiovascular diseases. Besides these properties, resveratrol displays inhibitory activity against a wide range of bacterial species; however, the cellular effects of resveratrol in bacteria remain incompletely understood, especially in the human pathogen, Staphylococcus aureus. In this study, we aimed to identify intrinsic resistance genes that aid S. aureus in tolerating the activity of resveratrol. We screened the Nebraska Transposon Mutant Library, consisting of 1920 mutants with inactivation of non-essential genes in S. aureus JE2, for increased susceptibly to resveratrol. On agar plates containing 0.5× the minimum inhibitory concentration (MIC), 17 transposon mutants failed to grow. Of these, four mutants showed a two-fold reduction in MIC, being the clpP protease mutant and three mutants with deficiencies in the electron transport chain (menD, hemB, aroC). The remaining 13 mutants did not show a reduction in MIC, but were confirmed by spot-assays to have increased susceptibility to resveratrol. Several genes were associated with DNA damage repair (recJ, xerC and xseA). Treatment of S. aureus JE2 with sub-inhibitory concentrations of resveratrol did not affect the expression of recJ, xerC and xseA, but increased expression of the SOS–stress response genes lexA and recA, suggesting that resveratrol interferes with DNA integrity in S. aureus. Expression of error-prone DNA polymerases are part of the SOS–stress response and we could show that sub-inhibitory concentrations of resveratrol increased overall mutation frequency as measured by formation of rifampicin resistant mutants. Our data show that DNA repair systems are important determinants aiding S. aureus to overcome the inhibitory activity of resveratrol. Activation of the SOS response by resveratrol could potentially facilitate the development of resistance towards conventional antibiotics in S. aureus.

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