scholarly journals New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3888
Author(s):  
Boon-Peng Puah ◽  
Juriyati Jalil ◽  
Ali Attiq ◽  
Yusof Kamisah
Keyword(s):  
Immune Cells ◽  
Scientific Evidence ◽  
Special Role ◽  
Real Potential ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
The Relationship ◽  
Cancer Activity ◽  
Reduced Risk

Lycopene is a well-known compound found commonly in tomatoes which brings wide range of health benefits against cardiovascular diseases and cancers. From an anti-cancer perspective, lycopene is often associated with reduced risk of prostate cancer and people often look for it as a dietary supplement which may help to prevent cancer. Previous scientific evidence exhibited that the anti-cancer activity of lycopene relies on its ability to suppress oncogene expressions and induce proapoptotic pathways. To further explore the real potential of lycopene in cancer prevention, this review discusses the new insights and perspectives on the anti-cancer activities of lycopene which could help to drive new direction for research. The relationship between inflammation and cancer is being highlighted, whereby lycopene suppresses cancer via resolution of inflammation are also discussed herein. The immune system was found to be a part of the anti-cancer system of lycopene as it modulates immune cells to suppress tumor growth and progression. Lycopene, which is under the family of carotenoids, was found to play special role in suppressing lung cancer.

A Review on the Anti-Viral Activity of Houttuynia cordata: A Possible Herb for the Management and Treatment of COVID-19

2021 ◽  
Vol 4 (2) ◽  
pp. 3-10
Author(s):  
Emdormi Rymbai ◽  
Keyword(s):  
Vital Role ◽  
Viral Agent ◽  
Houttuynia Cordata ◽  
Traditional Medicines ◽  
Virulent Newcastle Disease Virus ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
Anti Oxidant

Plants are an important source of natural products and they play a vital role in the field of medicinal chemistry and pharmaceutical science. Traditional medicines have been practiced and used for thousands of years, mostly in Asian countries, where plants are the main sources of medicine. Houttuynia cordata, a herb that belongs to the family Saururaceae, has a wide range of pharmacological activities and is used traditionally in conditions like anisolobis sores, heatstroke, lung carbuncles, malaria, scrotal abscess, tonsillitis, salammoniac poison and has also been widely accepted to possess anti-cancer, anti-oxidant, anti-hypertension, anti-inflammatory, anti-mutagenic, antibacterial, anti-viral and anti-purulent activity. Moreover, it is one of the herbs that was recognized during pandemic outbreaks, such as Severe Acute Respiratory Syndrome Coronavirus (SARS CoV) in China, virulent Newcastle Disease Virus (VNDV) in Java (Indonesia) and Newcastle (England). In this review, we briefly discuss the role of H. cordata as an anti-viral agent and the possibility of developing a dosage form against Coronavirus disease-19 (COVID-19).

scholarly journals ANTI-CANCER ACTIVITY OF CUMINUM CYMINUM: A REVIEW.

2018 ◽  
Vol 6 (04) ◽  
Author(s):  
NIKHIL ARUN CHAUDHARI ◽  
NINAD SATHE
Keyword(s):  
Biologically Active ◽  
Research Papers ◽  
Cuminum Cyminum ◽  
Current Review ◽  
Therapeutic Value ◽  
Wide Range ◽  
Anti Cancer ◽  
Phytochemical Constituents ◽  
Herbal Plant ◽  
Cancer Activity

Jeeraka, commonly known as cumin (Cuminum cyminum Linn.) (Family: Umbelliferae), is a popular herbal plant in traditional ayurvedic medicine, which has since long used as antioxidant, gastric stimulant, anti-flatulence, anti-diarrheal, sprue, anthelmintic, galactagogue, diuretic, astringent, carminative. This plant is pharmacologically and clinically evaluated for various activities like antioxidant, aphrodisiac, antimicrobial, hepato-protective, and anti-inflammatory. It is promulgated to possess a wide range of many phytochemical constituents. The current review is presented to give a comprehensive account of all anti-cancer activities of cumin. It will be helpful to create interest towards cumin and may be useful in developing new and economical anti-cancer formulations with more therapeutic value. The part used of the selected plant is seed. As per retrospective review cumin seed, its essential oil, ethanoic extract and 1­(2­Ethyl, 6­Heptyl) Phenol (EHP), a biologically active compound formerly extracted by benzene are found having anti-cancer activity against 13 different cell lines of various origins and 6 animal models. Also, it can be used as chemopreventive ingredient in the herbal anti-cancer formulation. Total 8 research articles, peer viewed research papers, abstracts and classical texts were reviewed.

scholarly journals Antibacterial, Antiviral, Antioxidant, and Anticancer Activities of Postbiotics: A review of Mechanisms and Therapeutic Perspectives

2021 ◽  
Vol 12 (2) ◽  
pp. 2629-2645
Keyword(s):  
Human Health ◽  
Fermentation Process ◽  
Biological Activities ◽  
Scientific Evidence ◽  
Food Allergies ◽  
Live Cells ◽  
Anticancer Activities ◽  
Wide Range ◽  
Anti Cancer ◽  
Improve Health

Several scientific evidence has shown the advantageous effects of probiotic-derived metabolites on human health. Postbiotics are a wide range of bioactive compounds derived from probiotics through a fermentation process and/or produced in pure forms in laboratory scales. These compounds have native biological activities that have been extensively studied in recent years. Immunomodulation, antimicrobial, anti-cancer, antioxidant, anti-diabetic, and reduction of food allergies compose the most important biological roles of postbiotics. In terms of safety, it has been confirmed that postbiotics, as potential substitute elements, might be superior to their parent live cells. Also, due to their appropriate economic, technological, and clinical features, they could be employed as favorable apparatuses in the food and drug industry to improve health benefits. This review comprehensively discusses the concept of postbiotics and their characteristics, emphasizing their potential antibacterial, antiviral, antioxidant, and anticancer activities.

scholarly journals Malpighiaceae de Colombia: Patrones de distribución, riqueza, endemismo y diversidad filogenética

2021 ◽  
Vol 9 (1) ◽  
pp. 39-54
Author(s):  
Diego Giraldo-Cañas
Keyword(s):  
Species Richness ◽  
Phylogenetic Diversity ◽  
American Continent ◽  
Altitudinal Gradients ◽  
The Andes ◽  
Plant Group ◽  
Wide Range ◽  
The Family ◽  
Relationship Of ◽  
The Relationship

Malpighiaceae constitutes a family of 77 genera and ca. 1300 species, distributed in tropical and subtropical regions of both hemispheres. They are mainly diversified in the American continent and distributed in a wide range of habitats and altitudinal gradients. For this reason, this family can be a model plant group to ecological and biogeographical analyses, as well as evolutive studies. In this context, an analysis of distribution, richness, endemism and phylogenetic diversity of Malpighiaceae in natural regions and their altitudinal gradients was undertaken. Malpighiaceae are represented in Colombia by 34 genera and 246 species (19.1% of endemism). Thus, Colombia and Brazil (44 genera, 584 species, 61% of endemism) are the two richest countries on species of this family. The highest species richness and endemism in Colombia is found in the lowlands (0-500 m a.s.l.: 212 species, 28 endemics); only ten species are distributed on highlands (2500-3200 m a.s.l.). Of the Malpighiaceae species in Colombia, Heteropterys leona and Stigmaphyllon bannisterioides have a disjunct amphi-Atlantic distribution, and six other species show intra-American disjunctions. Both richness and endemism decrease with altitude (y = -0.061x + 173.57; R2 = 0.82; y = -0.009x + 27.76; R2 = 0.95, respectively). Amazonia (116 species, 4 endemics) and the Andes (89 species, 23 endemics) exhibit the highest richness among the family. In Colombia, 15 of the 19 clades among the family are represented, where the most diversified are the Stigmaphyllon clade (5 genera, 48 species, 10 endemics), the Byrsonima clade (3/39/5) and the Hiraea clade (3/31/9). The relationship of phylogenetic diversity with altitude is similar to the pattern of specific richness by altitudinal interval. Amazonia, Orinoquia, and Magdalena Valley show highest phylogenetic diversity. These results, combined with those of other highly diversified biological groups in the country, could be important to define and delimitate new priority areas for conservation in Colombia.

scholarly journals Anticancer effects of Melissa officinalis: A traditional medicine

2021 ◽  
Author(s):  
Parviz Faraji ◽  
Mostafa Araj-Khodaei ◽  
Maryam Ghaffari ◽  
Jafar Ezzati Nazhad Dolatabadi
Keyword(s):  
Cancer Cells ◽  
Potential Effect ◽  
Biological Processes ◽  
Melissa Officinalis ◽  
Anticancer Effects ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
Medical Plant ◽  
Cancer Agent

Melissa officinalis (M. officinalis) is an herbal-based plant from the family of Lamiaceae and native to Europe and the Mediterranean region, widely used to cure various cancers. Phytochemical investigations proved different compounds such as polyphenolic compounds, flavonoids, and essential oil in the stem and leaves of M. officinalis as main ingredients contributing to different antitumor activity, including antiproliferation and antioxidant antiangiogenetic, antimigratory, antiapoptotic, and change in cell cycle profile of cancer cells. Herbal formulations with colorful ingredients use several types of these mentioned biological processes to display synergistic cancer treatment activities. M. officinalis extracts a wide range from water to ethanol using varied mechanisms to reduce the viability of cancer cells. Hence, scientists are currently interested in evaluating these extracts based on the medical plant to minimize the adverse effects of conventional anti-cancer drugs and discover these mechanisms to pave the way for future studies. This review aimed to discuss the recent studies that M. officinalis have used as an anti-cancer agent to investigate its potential effect on several types of cancer. Therefore, after a short introduction of M. officinalis, we will explain the several biological processes by which M. officinalis exert an anti-cancer effect.

scholarly journals Effect of Sodium Fluoride (NaF) Exposure on Heart: Protective Effect of Eugenol with Reference to the Lipid Metabolic Profiles

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Srinivas K ◽  
Shanmugam K. R. ◽  
Shanmugam B. ◽  
Venkatasubbaiah G. ◽  
Ravi S. ◽  
...  
Keyword(s):  
Protective Effect ◽  
Effective Treatment ◽  
Sodium Fluoride ◽  
Review Article ◽  
Metabolic Profiles ◽  
Wide Range ◽  
Anti Cancer ◽  
Phytochemical Compounds ◽  
Anti Oxidant ◽  
Cancer Activity

Flavonoids are phytochemical compounds found in a variety of plants, fruits, vegetables, leaves, and barks, it offers a wide range of health benefits. Quercetin is a polyphenolic flavonoid that is found in onions, apples, berries, broccoli, grapes, nuts, cherries and many other food products. Pharmacologically, quercetin has been examined for various disorders and is reported to possess the ability to prevent as well as treat them. It possesses anti-oxidant, anti-allergic, anti-inflammatory, anti-viral and anti-cancer activity as well. Developing suitable formulation for the delivery of quercetin to specific site leads to better compliance and effective treatment of the disease. This review article highlights the beneficiary activities exhibited by quercetin along with the mechanism behind its activity, followed by reporting the different quercetin formulations developed in last few years.

scholarly journals Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach

2021 ◽  
pp. 64-69
Author(s):  
Pavan Kumar Tummala ◽  
Sreeja Nannapaneni ◽  
Sumana Pratyusha Durvasula ◽  
Supriya Chadalavada ◽  
Sunandini Venigandla ◽  
...  
Keyword(s):  
Conventional Medicine ◽  
Hemidesmus Indicus ◽  
Alternative Medicines ◽  
Medicinal Plant Extracts ◽  
Wide Range ◽  
Anti Cancer ◽  
Ethanolic Extracts ◽  
Cyclohexane Carboxylate ◽  
Cancer Studies ◽  
Cancer Activity

Background: Phytocompounds in medicinal plants have a wide range of properties and are alternative medicines for those who cannot be helped by conventional medicine. Objective: In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts. Methods: Gas chromatography and Mass spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area. Results: The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Conclusion: Out of twenty selected compounds, docking results showedMethyl-1-Cyclohexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.

Childlessness and Health Among Older Adults: Variation Across Five Outcomes and 20 Countries

2019 ◽  
Author(s):  
Nekehia T Quashie ◽  
Bruno Arpino ◽  
Radoslaw Antczak ◽  
Christine A Mair
Keyword(s):  
Health Outcomes ◽  
The United States ◽  
Future Research ◽  
Cross Sectional ◽  
Aging Policy ◽  
Logistic Regression Models ◽  
Wide Range ◽  
The Family ◽  
National Economic ◽  
The Relationship

Abstract Objectives No previous study to the best of our knowledge has examined the association between childlessness and health using a wide range of countries and health outcomes. This study improves previous literature by examining the relationship between “childlessness” (1 = childless for any reason, 0 = parent of biological, step, or adopted child) and health across 20 countries and five health outcomes. Methods Drawing on cross-sectional harmonized data from the family of Health and Retirement Surveys across the United States (HRS, Wave 11), Europe (SHARE, Waves 4 and 5), Mexico (MHAS, Wave 3), and China (CHARLS, Wave 2), we use logistic regression models to estimate the association between childlessness and poor health (poor self-rated health, 1 or more ADL limitations, 1 or more IADL limitations, 1 or more chronic conditions, and depression) in a sample of adults aged 50 and older across 20 countries (N = 109,648). Results Our results point to an absence of associations between childlessness and health, and suggest that childlessness may be associated with better (e.g., Mexico, Hungary) or worse health (e.g., Austria, Estonia, Netherlands, Poland) in certain contexts and for certain measures. Discussion We discuss these findings in light of the meaning of childlessness, as well as cross-national economic, social, and cultural contexts to provide suggestions for aging policy and future research.

scholarly journals Role of Interleukin-34 in Cancer

Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 252 ◽  
Author(s):  
Eleonora Franzè ◽  
Carmine Stolfi ◽  
Edoardo Troncone ◽  
Patrizio Scarozza ◽  
Giovanni Monteleone
Keyword(s):  
Cancer Cells ◽  
Immune Cells ◽  
Multiple Roles ◽  
Cancer Cell Proliferation ◽  
Potential Therapeutic Target ◽  
Wide Range ◽  
Tumor Growth And Metastasis ◽  
The Relationship ◽  
And Diffusion

Cross-talk between cancer cells and the immune cells occurring in the tumor microenvironment is crucial in promoting signals that foster tumor growth and metastasis. Both cancer cells and immune cells secrete various interleukins (IL), which, either directly or indirectly, stimulate cancer-cell proliferation, survival, and diffusion, as well as contribute to sculpt the immune microenvironment, thereby amplifying tumorigenic stimuli. IL-34, a cytokine produced by a wide range of cells, has been initially involved in the control of differentiation, proliferation, and survival of myeloid cells. More recent studies documented the overexpression of IL-34 in several cancers, such as hepatocarcinoma, osteosarcoma, multiple myeloma, colon cancer, and lung cancer, and showed that tumor cells can produce and functionally respond to this cytokine. In this review, we summarize the multiple roles of IL-34 in various cancers, with the aim to better understand the relationship between the expression of this cytokine and cancer behavior and to provide new insights for exploring a new potential therapeutic target.

Design, Synthesis and Biological Activity Evaluation of Novel N-Acylation Substituted Isatin Derivatives

2013 ◽  
Vol 683 ◽  
pp. 34-37
Author(s):  
Bin Zeng ◽  
Xiao Hua Zhu
Keyword(s):  
Human Cancer ◽  
Biological Activities ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Design And Synthesis ◽  
Wide Range ◽  
Anti Cancer ◽  
Endogenous Compound ◽  
Isatin Derivatives ◽  
Cancer Activity

Isatin, an endogenous compound existent in many organisms, shows a wide range of biological activities. In this paper, we like to report the design and synthesis of several isatin derivatives through the acetalization and N-Acylation. Six newly synthesized compounds were characterized on the basis of 1H NMR, and those compounds were determined using two different human cancer cell . Anti-cancer activity showed those compounds IC50＜50 μm.

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