scholarly journals Breastfeeding Status and Duration and Infections, Hospitalizations for Infections, and Antibiotic Use in the First Two Years of Life in the ELFE Cohort

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1607 ◽  
Author(s):  
Davisse-Paturet ◽  
Adel-Patient ◽  
Divaret-Chauveau ◽  
Pierson ◽  
Lioret ◽  
...  
Keyword(s):  
Lower Risk ◽  
Reference Group ◽  
Antibiotic Use ◽  
High Income ◽  
Breastfeeding Duration ◽  
Inverse Association ◽  
Gastrointestinal Infections ◽  
Middle Income ◽  
Breastfed Infants ◽  
Strong Inverse Association

In low- and middle-income countries, the protective effect of breastfeeding against infections is well established, but in high-income countries, the effect could be weakened by higher hygienic conditions. We aimed to examine the association between breastfeeding and infections in the first 2 years of life, in a high-income country with relatively short breastfeeding duration. Among 10,349 young children from the nationwide Etude Longitudinale Française depuis l’Enfance (ELFE) birth cohort, breastfeeding and parent-reported hospitalizations, bronchiolitis and otitis events, and antibiotic use were prospectively collected up to 2 years. Never-breastfed infants were used as reference group. Any breastfeeding for <3 months was associated with higher risks of hospitalizations from gastrointestinal infections or fever. Predominant breastfeeding for <1 month was associated with higher risk of a single hospital admission while predominant breastfeeding for ≥3 months was associated with a lower risk of long duration (≥4 nights) of hospitalization. Ever breastfeeding was associated with lower risk of antibiotic use. This study confirmed the well-known associations between breastfeeding and hospitalizations but also highlighted a strong inverse association between breastfeeding and antibiotic use. Although we cannot infer causality from this observational study, this finding is worth highlighting in a context of rising concern regarding antibiotic resistance.

scholarly journals A Biohistorical Perspective of Typhoid and Antimicrobial Resistance

2019 ◽  
Vol 69 (Supplement_5) ◽  
pp. S388-S394 ◽  
Author(s):  
Claas Kirchhelle ◽  
Zoe Anne Dyson ◽  
Gordon Dougan
Keyword(s):  
Antimicrobial Resistance ◽  
Antibiotic Use ◽  
High Income ◽  
Evolutionary Divergence ◽  
Middle Income ◽  
Middle Income Countries ◽  
International Funding ◽  
History Of ◽  
Cultural Status ◽  
Selection For

AbstractWe combine methodology from history and genetics to reconstruct the biosocial history of antimicrobial resistance (AMR) in the bacterium Salmonella enterica serovar Typhi (S. Typhi). We show how evolutionary divergence in S. Typhi was driven by rising global antibiotic use and by the neglect of typhoid outside of high-income countries. Although high-income countries pioneered 1960s precautionary antibiotic regulations to prevent selection for multidrug resistance, new antibiotic classes, typhoid’s cultural status as a supposedly ancient disease of “undeveloped” countries, limited international funding, and narrow biosecurity agendas helped fragment effective global collective action for typhoid control. Antibiotic-intensive compensation for weak water and healthcare systems subsequently fueled AMR selection in low- and middle-income countries but often remained invisible due to lacking surveillance capabilities. The recent rise of extensively drug-resistant typhoid bears the biosocial footprint of more than half a century of antibiotic-intensive international neglect.

scholarly journals The Association Between Healthcare Resources, Non-communicable Diseases, and Covid-19 Mortality: An Epidemiological Study of 139 Countries

2021 ◽  
Author(s):  
Shahram Arsang-Jang ◽  
Masoud Tokazebani Belasi ◽  
Farid Najafi ◽  
Mitra Darbandi ◽  
Malik Zain Raza ◽  
...  
Keyword(s):  
Communicable Diseases ◽  
High Income ◽  
Inverse Association ◽  
Middle Income ◽  
Non Communicable Diseases ◽  
Life Years ◽  
Out Of Pocket Payments ◽  
Hospital Beds ◽  
Access And Quality ◽  
Disease Study

Abstract Background: To provide an overview of the worldwide association between hospital beds, the burden of non-communicable diseases (NCDs), and COVID-19 mortality.Methods: Data was extracted regarding COVID-19 deaths and cases from the Our World in Data as of March 23, 2021. The following data was obtained:1) NCDs disability-adjusted life years (DALYs), health-adjusted life expectancy, and the health access and quality index from the Global Burden of Disease study; 2) the number of hospital beds, physicians, nurses and midwives per population, and out-of-pocket payments from the WHO website. Using the multilevel generalized linear model, these variables’ independent associations with COVID-19 mortality rate ratio (MRR) was examined.Results: Hospital beds were associated with reduced COVID-19 mortality (MRR=0.47; 95% CI: 0.44 to 0.5) globally. During COVID-19 peak periods, despite a decreasing trend in COVID-19 MRR with increasing beds in high-income countries, the odds of mortality remained high even within the highest percentile of hospital beds (MRR=1.54 for 20th-40th and 1.06 for >60th bed percentile, respectively). On the contrary, in middle-income countries, an inverse association was observed between the number of hospital beds and COVID-19 mortality in both periods. NCD DALYs were associated with increased COVID-19 deaths, particularly during peak mortality periods in high-income countries. Death-to-case ratio increased by approximately two times during the peak vs non-peak mortality periods.Conclusions: COVID-19 is a syndemic interacting with non-communicable diseases and not only a pandemic. A comprehensive national healthcare plan against COVID-19 spread should include adequate measures to protect vulnerable patients with pre-existing chronic conditions.

Is Brain-Derived Neurotrophic Factor: A Common Link Between Neurodegenerative Disorders and Cancer?

2019 ◽  
Vol 16 (4) ◽  
pp. 344-352
Author(s):  
Radhika Khosla ◽  
Avijit Banik ◽  
Sushant Kaushal ◽  
Priya Battu ◽  
Deepti Gupta ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
Neurotrophic Factor ◽  
Animal Studies ◽  
Neurodegenerative Disorder ◽  
Indirect Evidence ◽  
Brain Derived Neurotrophic Factor ◽  
Common Disease ◽  
Inverse Association ◽  
Bdnf Expression ◽  
Strong Inverse Association

Background: Cancer is a common disease caused by the excessive proliferation of cells, and neurodegenerative diseases are the disorders caused due to the degeneration of neurons. Both can be considered as diseases caused by the dysregulation of cell cycle events. A recent data suggests that there is a strong inverse association between cancer and neurodegenerative disorders. There is indirect evidence to postulate Brain-derived Neurotrophic Factor (BDNF) as a potential molecular link in this association. Discussion: The BDNF levels are found to be downregulated in many neurodegenerative disorders and are found to be upregulated in various kinds of cancers. The lower level of BDNF in Alzheimer’s and Parkinson’s disease has been found to be related to cognitive and other neuropsychological impairments, whereas, its higher levels are associated with the tumour growth and metastasis and poor survival rate in the cancer patients. Conclusion: In this review, we propose that variance in BDNF levels is critical in determining the course of cellular pathophysiology and the development of cancer or neurodegenerative disorder. We further propose that an alternative therapeutic strategy that can modulate BDNF expression, can rescue or prevent above said pathophysiological course. Larger studies that examine this link through animal studies are imperative to understand the putative biochemical and molecular link to wellness and disease.

A Global Perspective on Occupational Health and Safety

2017 ◽  
Author(s):  
Jorma H. Rantanen
Keyword(s):  
Occupational Health ◽  
Occupational Injuries ◽  
Health And Safety ◽  
Psychosocial Problems ◽  
Occupational Health And Safety ◽  
High Income ◽  
Global Perspective ◽  
Occupational Hazards ◽  
Middle Income ◽  
Informal Workers

Occupational hazards as well as occupational injuries and diseases are frequent and serious problems not only in industrialized high-income countries, but also in low- and middle-income countries (LMICs). In high-income countries, the occurrence of occupational injuries and chemically-related disorders has decreased while psychosocial problems and issues for disabled, aging, and other vulnerable workers have increased. In the LMICs, “traditional” occupational hazards and related injuries and diseases are still a major concern. Globalization, while providing some benefits to workers, has presented many negative effects, such as transfer of hazardous technologies and substances to LMICs, widening of income gaps, and worsening of working conditions and worker income, especially for agricultural workers, those with little education, and informal workers. The chapter provides a global overview of work and workers as well occupational health and safety hazards and related challenges.

scholarly journals Socioeconomic Disparities in Foods/Beverages and Nutrients Consumed by U.S. Adolescents When Snacking: National Health and Nutrition Examination Survey 2005–2018

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2530
Author(s):  
Navika Gangrade ◽  
Janet Figueroa ◽  
Tashara M. Leak
Keyword(s):  
National Health ◽  
Low Socioeconomic Status ◽  
Low Income ◽  
High Income ◽  
Future Research ◽  
Nutrition Examination Survey ◽  
Middle Income ◽  
Low Socioeconomic ◽  
Health And Nutrition ◽  
Income Ratio

Snacking contributes a significant portion of adolescents’ daily energy intake and is associated with poor overall diet and increased body mass index. Adolescents from low socioeconomic status (SES) households have poorer snacking behaviors than their higher-SES counterparts. However, it is unclear if the types of food/beverages and nutrients consumed during snacking differ by SES among adolescents. Therefore, this study examines SES disparities in the aforementioned snacking characteristics by analyzing the data of 7132 adolescents (12–19 years) from the National Health and Nutrition Examination Survey 2005–2018. Results reveal that adolescents from low-income households (poverty-to-income ratio (PIR) ≤ 1.3) have lower odds of consuming the food/beverage categories “Milk and Dairy” (aOR: 0.74; 95% CI: 0.58-0.95; p = 0.007) and “Fruits” (aOR: 0.62, 95% CI: 0.50–0.78; p = 0.001) as snacks and higher odds of consuming “Beverages” (aOR: 1.45; 95% CI: 1.19-1.76; p = 0.001) compared to those from high-income households (PIR > 3.5). Additionally, adolescents from low- and middle-income (PIR > 1.3–3.5) households consume more added sugar (7.98 and 7.78 g vs. 6.66 g; p = 0.012, p = 0.026) and less fiber (0.78 and 0.77 g vs. 0.84 g; p = 0.044, p = 0.019) from snacks compared to their high-income counterparts. Future research is necessary to understand factors that influence snacking among adolescents, and interventions are needed, especially for adolescents from low-SES communities.

scholarly journals Influenza vaccination and risk for cardiovascular events: a nationwide self-controlled case series study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Abhijit Sen ◽  
Inger Johanne Bakken ◽  
Ragna Elise Støre Govatsmark ◽  
Torunn Varmdal ◽  
Kaare Harald Bønaa ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Influenza Vaccination ◽  
Lower Risk ◽  
Cardiovascular Events ◽  
Case Series ◽  
Baseline Risk ◽  
Inverse Association ◽  
Relative Risks ◽  
Case Series Study ◽  
Cardiovascular Medications

Abstract Background US and European guidelines diverge on whether to vaccinate adults who are not at high risk for cardiovascular events against influenza. Here, we investigated the associations between influenza vaccination and risk for acute myocardial infarction, stroke and pulmonary embolism during the 2009 pandemic in Norway, when vaccination was recommended to all adults. Methods Using national registers, we studied all vaccinated Norwegian individuals who suffered AMI, stroke, or pulmonary embolism from May 1, 2009 through September 30, 2010. We defined higher-risk individuals as those using anti-diabetic, anti-obesity, anti-thrombotic, pulmonary or cardiovascular medications (i.e. individuals to whom vaccination was routinely recommended); all other individuals were regarded as having lower-risk. We estimated incidence rate ratios with 95% CI using conditional Poisson regression in the pre-defined risk periods up to 180 days following vaccination compared to an unexposed time-period, with adjustment for season or daily temperature. Results Overall, we observed lower risk for cardiovascular events following influenza vaccination. When stratified by baseline risk, we observed lower risk across all three outcomes in association with vaccination among higher-risk individuals. In this subgroup, relative risks were 0.72 (0.59–0.88) for AMI, 0.77 (0.59–0.99) for stroke, and 0.73 (0.45–1.19) for pulmonary embolism in the period 1–14 days following vaccination when compared to the background period. These associations remained essentially the same up to 180 days after vaccination. In contrast, the corresponding relative risks among subjects not using medications were 4.19 (2.69–6.52), 1.73 (0.91–3.31) and 2.35 (0.78–7.06). Conclusion In this nationwide study, influenza vaccination was associated with overall cardiovascular benefit. This benefit was concentrated among those at higher cardiovascular risk as defined by medication use. In contrast, our results demonstrate no comparable inverse association with thrombosis-related cardiovascular events following vaccination among those free of cardiovascular medications at baseline. These results may inform the risk–benefit balance for universal influenza vaccination.

scholarly journals Breastfeeding Duration and Development of Dysglycemia in Women Who Had Gestational Diabetes Mellitus: Evidence from the GUSTO Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 408
Author(s):  
Sumali S. Hewage ◽  
Xin Yu Hazel Koh ◽  
Shu E. Soh ◽  
Wei Wei Pang ◽  
Doris Fok ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Tolerance Test ◽  
Diabetes Risk ◽  
Breastfeeding Duration ◽  
Oral Glucose ◽  
Inverse Association ◽  
Index Pregnancy

(1) Background: Breastfeeding has been shown to support glucose homeostasis in women after a pregnancy complicated by gestational diabetes mellitus (GDM) and is potentially effective at reducing long-term diabetes risk. (2) Methods: Data from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study were analyzed to understand the influence of breastfeeding duration on long-term dysglycemia (prediabetes and diabetes) risk in women who had GDM in the index pregnancy. GDM and dysglycemia four to seven years postpartum were determined by the oral glucose tolerance test (OGTT). A Poisson regression model with a robust error variance was used to estimate incidence rate ratios (IRRs) for dysglycemia four to seven years post-delivery according to groupings of the duration of any breastfeeding (<1, ≥1 to <6, and ≥6 months). (3) Results: Women who had GDM during the index pregnancy and complete breastfeeding information and OGTT four to seven years postpartum were included in this study (n = 116). Fifty-one women (44%) had postpartum dysglycemia. Unadjusted IRRs showed an inverse association between dysglycemia risk and ≥1 month to <6 months (IRR 0.91; 95% confidence interval [CI] 0.57, 1.43; p = 0.68) and ≥6 months (IRR 0.50; 95% CI 0.27, 0.91; p = 0.02) breastfeeding compared to <1 month of any breastfeeding. After adjusting for key confounders, the IRR for the ≥6 months group remained significant (IRR 0.42; 95% CI 0.22, 0.80; p = 0.008). (4) Conclusions: Our results suggest that any breastfeeding of six months or longer may reduce long-term dysglycemia risk in women with a history of GDM in an Asian setting. Breastfeeding has benefits for mothers beyond weight loss, particularly for those with GDM.

scholarly journals An Analysis of Environmental Efficiency and Environmental Pollution Treatment Efficiency in China’s Industrial Sector

2021 ◽  
Vol 13 (5) ◽  
pp. 2579 ◽  
Author(s):  
Xiao-Ning Li ◽  
Ying Feng ◽  
Pei-Ying Wu ◽  
Yung-Ho Chiu
Keyword(s):  
Environmental Pollution ◽  
Environmental Governance ◽  
Income Group ◽  
Industrial Sector ◽  
High Income ◽  
Environmental Efficiency ◽  
Technical Level ◽  
High Income Group ◽  
Middle Income ◽  
Income Groups

This research adopts the meta Dynamic Directional Distance Functions (DDF) model in order to calculate the environmental efficiency and environmental governance efficiency of China’s industrial sector from 2010 to 2017 from the overall, sub-regional, and sub-provincial perspectives and discusses the technical gaps in regional environmental pollution control and the reasons for ineffective environmental governance. The research results show that the overall level of environmental governance efficiency in China’s industrial sector is relatively high over this time period, and the group frontier calculation results have improved compared to the meta frontier. The actual technical level of the high-income group is closest to the potential technical level, and the upper-middle income group is still far from the potential technical level. The main reason for the ineffective environmental governance of the provinces in the high-income group is ineffective management, while the main reason for ineffective environmental governance of the provinces in the upper-middle-income groups is technical inefficiency. Regardless of high-income groups or upper-middle-income groups, each province’s inefficiency of environmental governance is caused by inefficiency of the input factors.

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