Association of Sleep Duration and Insomnia Symptoms with Components of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults with Metabolic Syndrome in Taiwan

The study determined the association of sleep duration and insomnia symptoms with the components of metabolic syndrome and inflammation in middle-aged and older adults with metabolic syndrome in Taiwan. This cross-sectional study used the database compiled in Taiwan between 2004–2013. A total of 26,016 volunteers aged 35 years and above were selected. Metabolic syndrome was defined according to the International Diabetes Federation. Compared with regular sleep duration (6–8 h/day), short (<6 h/day) or long sleep duration (>8 h/day) and insomnia symptoms significantly increased the odds ratios of high waist circumference, high blood pressure, low high-density lipoprotein-cholesterol, high triglycerides, high fasting blood glucose, and high C-reactive protein. Insomnia symptoms did not modify the effects of sleep duration on the components of metabolic syndrome and inflammation. Our study suggests that short or long sleep duration and insomnia symptoms may have an adverse effect on metabolic syndrome and inflammation.

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The association between cardiorespiratory fitness and metabolic syndrome diagnosis: A cross-sectional study in Indonesian middle-aged and older adults

Physical Activity Review ◽

10.16926/par.2021.09.26 ◽

2021 ◽

Vol 9 (2) ◽

pp. 101-110

Author(s):

Novita Intan Arovah ◽

Kristiann C. Heesch

Keyword(s):

Older Adults ◽

Metabolic Syndrome ◽

Cardiorespiratory Fitness ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Sectional Study ◽

Middle Aged ◽

Cvd Risk ◽

Cross Sectional ◽

6 Minute Walk Test

Objectives: The roles of cardiorespiratory fitness (CF) in reducing cardiovascular disease (CVD) and all-cause mortality risks are well established; however, little is known about the role of CF in reducing risk of metabolic syndrome (MetS), a cluster of CVD risk factors, particularly in Asian countries. This research examined associations between CF and MetS diagnosis and its five components in Indonesian middle-aged and older adults. Methods: This cross-sectional study included 161 participants (aged 63±8 years; 70% female). CF was assessed with a 6-minute walk test. MetS diagnosis and its components were assessed with the Adult Treatment Panel III. Logistic regression modelling was conducted to examine the relationships between CF and MetS diagnosis and its components, after adjustment for BMI and other confounders. BMI was categorized using cut-points for Asians. Results: In adjusted models, participants with low CF had a greater likelihood of being diagnosed with MetS than those with high CF (OR=4.79, 95%CI:2.17-10.62). They were also more likely to have low high-density lipoprotein (OR=2.07, 95%CI:1.02-4.18) or hypertriglyceridemia (OR=2.37, 95%CI:1.15-4.86). There was also borderline significant findings that suggested that participants with low CF had greater likelihood of having abdominal obesity (OR=2.34, 95%CI:0.97-5.65, p=0.06) or hyperglycaemia (OR=2.07 95%CI:0.98-4.41, p=0.06). Conclusions: Low CF is associated with increased likelihood of being diagnosed with MetS. The adverse effects of low CF are mainly characterized by dyslipidaemia. Public health messages should emphasise the importance of improving CF for preventing MetS. Assessment of CF could be useful for targeting individuals most likely to benefit from intervention to prevent MetS.

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SLEEP DURATION AND METABOLIC SYNDROME IN OBESE ADOLESCENTS

Media Gizi Indonesia ◽

10.20473/mgi.v16i1.33-37 ◽

2021 ◽

Vol 16 (1) ◽

pp. 33

Author(s):

Nur Aisiyah Widjaja ◽

Rendi Aji Prihaningtyas ◽

Roedi Irawan ◽

Meta Herdiana Hanindita

Keyword(s):

Metabolic Syndrome ◽

Sleep Duration ◽

Fasting Blood Glucose ◽

International Diabetes Federation ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Obese Adolescents ◽

Glucose Levels

Shorter sleep duration is a risk factor for obesity and metabolic syndrome. Previous studies conducted on diff erent races showed inconsistent results. The purpose of this study was to analyze the diff erences in sleep duration in obese adolescents who suff er from metabolic syndrome compared with obese adolescents who do not suff er from metabolic syndrome. A cross sectional study was carried out on 59 obese adolescents who visited the Pediatric Nutrition and Metabolic Disease Clinic in Dr. Soetomo General Academic Hospital, Surabaya. Subjects were selected using total sampling techniques who met the inclusion and exclusion criteria in August-November 2018. Anthropometry (weight, height and waist circumference), blood pressure, and blood tests (HDL cholesterol levels, triglycerides, and fasting blood glucose levels) were held to determine obesity according to CDC 2000 and metabolic syndrome according to International Diabetes Federation. The diff erence in sleep duration in obese adolescents suff ering from metabolic syndrome and without metabolic syndrome analyzed using Chi square test. A total of 27 subjects (45.8%) suff ered from metabolic syndrome. Most obese adolescents (57,6%) have suffi cient sleep duration (≥ 8 hours/day). There was no sleep duration diff erences in obese adolescents suff ering and not suff ering from metabolic syndrome (p> 0.05).

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Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study

Acta Endocrinologica ◽

10.1530/eje-09-1078 ◽

2010 ◽

Vol 162 (5) ◽

pp. 919-923 ◽

Cited By ~ 28

Author(s):

Anna C Phillips ◽

Douglas Carroll ◽

Catharine R Gale ◽

Janet M Lord ◽

Wiebke Arlt ◽

...

Keyword(s):

Metabolic Syndrome ◽

Military Service ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Cross Sectional ◽

Us Army ◽

Telephone Interviews ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Vietnam Era

ObjectivesThe aim of these analyses was to examine the association of cortisol, DHEAS and the cortisol:DHEAS ratio with the metabolic syndrome (MetS) and its components.DesignThe analyses were cross-sectional.MethodsParticipants were 4255 Vietnam era US army veterans. From military service files, telephone interviews and a medical examination, occupational, socio-demographic and health data were collected. MetS was ascertained from data on body mass index; fasting blood glucose or a diagnosis of diabetes; blood pressure or a diagnosis of hypertension; high-density lipoprotein cholesterol; and triglyceride levels. Contemporary morning fasted cortisol and DHEAS concentrations were determined. The outcomes were MetS and its components. Analysis was by logistic regression, first adjusting for age and then additionally for an array of candidate confounders.ResultsCortisol, although not in the fully adjusted analysis, and DHEAS were both related to MetS. Whereas high cortisol concentrations were associated with an increased risk of MetS, high DHEAS concentrations appeared protective. By far, the strongest associations with MetS were observed for the cortisol:DHEAS ratio; the higher the ratio, the greater the risk of having MetS. The ratio was also significantly related to four of the five MetS components.ConclusionsThe cortisol:DHEAS ratio is positively associated with MetS. Prospective analyses are needed to help untangle direction of causality, but this study suggests that the cortisol:DHEAS ratio is worthy of further study in this and other health contexts.

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Comparing the validity of continuous metabolic syndrome risk scores for predicting pediatric metabolic syndrome: the CASPIAN-V study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2018-0384 ◽

2019 ◽

Vol 32 (4) ◽

pp. 383-389 ◽

Cited By ~ 1

Author(s):

Mehri Khoshhali ◽

Ramin Heshmat ◽

Mohammad Esmaeil Motlagh ◽

Hasan Ziaodini ◽

Mahdi Hadian ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Principal Component ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Risk Scores ◽

Cross Sectional ◽

Z Scores ◽

Iranian Children

Abstract Background The aim of this study was to compare the validity of various approaches to pediatric continuous metabolic syndrome (cMetS) scores including siMS scores (2 waist/height + fasting blood glucose [FBG]/5.6 + triglycerides [TG]/1.7 + systolic blood pressure [BP]/130 + high-density lipoprotein [HDL]/1.02), Z-scores, principal component analysis (PCA) and confirmatory factor analysis (CFA) for predicting metabolic syndrome (MetS). Methods This nationwide cross-sectional study was conducted on 4200 Iranian children and adolescents aged 7–18 years. The cMetS was computed using data on HDL, cholesterol, TGs, FBG, mean arterial pressure (MAP) and waist circumference (WC). The areas under the receiver operating characteristic curves (AUCs) were used to compare the performances of different cMetS scores. Results Data of 3843 participants (52.4% boys) were available for the current study. The mean (standard deviation [SD]) age was 12.6 (3) and 12.3 (3.1) years for boys and girls, respectively. The differences in AUC values of cMetS scores were significant based on the Delong method. The AUCs (95% confidence interval [CI]) were for Z-scores, 0.94 (0.93, 0.95); first PCA, 0.91 (0.89, 0.93); sum PCA, 0.90 (0.88, 0.92), CFA, 0.79 (0.76, 0.3) and also for siMS scores 1 to 3 as 0.93 (0.91, 0.94), 0.92 (0.90, 0.93), and 0.91 (0.90, 0.93), respectively. Conclusions The results of our study indicated that the validity of all approaches for cMetS scores for predicting MetS was high. Given that the siMS scores are simple and practical, it might be used in clinical and research practice.

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Prevalence of Metabolic Syndrome and Its Components in Bamboutos Division’s Adults, West Region of Cameroon

BioMed Research International ◽

10.1155/2019/9676984 ◽

2019 ◽

Vol 2019 ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Wiliane J. T. Marbou ◽

Victor Kuete

Keyword(s):

Metabolic Syndrome ◽

Abdominal Obesity ◽

Task Force ◽

Fasting Blood Glucose ◽

International Diabetes Federation ◽

Cross Sectional Study ◽

Cross Sectional ◽

Mets Component ◽

West Region ◽

Hs Crp

The prevalence of metabolic syndrome (MetS) and its associated risks remain unappreciated in Bamboutos Division, west region of Cameroon. This study aimed to evaluate the prevalence of MetS, its individual components, and associated risk factors among Bamboutos Division’s adults population using a Joint Interim Statement of the International Diabetes Federation (IDF) Task Force on Epidemiology and Prevention definitions parameters. A cross-sectional study was conducted from May 2016 to May 2018 in Mbouda ADLUCEM Hospital and Mbouda District Hospital, two reference hospitals in Bamboutos Division, west region of Cameroon. Interview, physical and clinical examinations, and lipid and fasting blood glucose measurements were conducted for 604 adults. The definition of MetS proposed by IDF was used. The prevalence of MetS was 32.45% with highly significant female predominance (46.11% for females and 14.01 % for males). In the entire participants, the most common abnormalities were low-HDL (82.78%) and hypertriglyceridemia (53.97%) [p<0.001]. Participants with obesity (OR: 16.34; 95% CI: 9.21-28.96), overweight (OR: 7.45; 95% CI: 4.17-13.30), and highest hs-CRP (hs-CRP >11 mg/l) had a higher risk of developing MetS. The most common MetS component was abdominal obesity (OR: 353.13; 95% CI: 136.16-915.81). MetS is prevalent among Bamboutos Division’s adults in west region of Cameroon and abdominal obesity is the most common MetS component. This study highlights the need for evidence-based prevention, diagnosis, and management of MetS and its associated factors among Bamboutos Division’s adults in Cameroon.

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THE ASSOCIATION BETWEEN PHYSICAL ACTIVITY AND METABOLIC SYNDROME IN OLDER ADULTS WITH OBESITY

Journal of Frailty & Aging ◽

10.14283/jfa.2018.34 ◽

2018 ◽

pp. 1-6

Author(s):

F. Xu ◽

S.A. Cohen ◽

I.E. Lofgren ◽

G.W. Greene ◽

M.J. Delmonico ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Metabolic Syndrome ◽

Lower Risk ◽

Density Lipoprotein ◽

Activity Levels ◽

Cross Sectional ◽

Physical Activity Levels ◽

Physical Activity Recommendations ◽

Activity Recommendations

Background: Physical activity reduces the likelihood of developing metabolic syndrome (MetS). However, the association between different physical activity levels and MetS remains unclear in older adults with obesity. Methods: This cross-sectional study used four waves of data (2007-2008, 2009-2010, 2011-2012, 2013-2014) from two datasets: The National Health and Nutrition Examination Survey and United Sates Department of Agriculture’s Food Patterns Equivalents Database. The sample included adults 60+ years of age (n= 613) with obesity who had physical activity and MetS data. Physical activity was assessed using the Global Physical Activity Questionnaire and categorized into three physical activity levels (low, medium, and high); and medium or high physical activity levels are aligned with or exceed current physical activity recommendations. Participants were classified as having MetS using a commonly agreed upon definition. Multiple logistic regression models examined the association between the three physical activity levels and MetS risk factors and MetS. All analyses adjusted for potential confounding variables and accounted for complex sampling. Results: Of 613 respondents, 72.1% (n=431) were classified as having MetS, and 44.3% (n = 263) had not met physical activity recommendations. Participants with high levels of physical activity had a lower risk of MetS (OR = 0.31, 95%CI: 0.13, 0.72) and more healthful levels of high-density lipoprotein cholesterol (OR = 0.39, 95%CI: 0.18, 0.84), blood pressure (OR = 0.39, 95%CI: 0.20, 0.77), fasting glucose (OR = 0.34, 95%CI: 0.15, 0.78) than participants categorized as having low physical activity. Conclusions: Physical activity is associated with lower risk of MetS only for participants with the highest level of physical activity, which suggests that physical activity dosage is important to reduce MetS risk in older adults with obesity.

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Association of Triglyceride Glucose (TyG) Index With Leukoaraiosis in Middle-aged and Older Adults: A Cross-sectional Study

10.21203/rs.3.rs-124306/v1 ◽

2020 ◽

Author(s):

Dong-Hyuk Jung ◽

Byoung Jin Park ◽

Yong-Jae Lee

Keyword(s):

Older Adults ◽

Brain Mri ◽

Multiple Logistic Regression Analysis ◽

Fasting Blood Glucose ◽

Cross Sectional Study ◽

Health Examination ◽

Sectional Study ◽

Middle Aged ◽

Cross Sectional ◽

Tyg Index

Abstract Background: Leukoaraiosis refers to lesions of high signal intensity in the periventricular and subcortical white matter that result from chronic microvascular ischemic damage to the brain. Increasing evidence suggests that the triglyceride glucose (TyG) index is associated with arterial stiffness and cardiovascular disease, which are both closely related to ischemic arterial damage. We hypothesized that the serum TyG index could be associated with cerebrovascular microangiopathy as measured by leukoaraiosis among middle-aged and older adults.Methods: This cross-sectional study included 2,162 Korean adults aged ≥45 years who participated in a health examination program between 2010 and 2011. TyG index was calculated as Ln (fasting triglycerides (mg/dl) × fasting blood glucose (mg/dl)/2). TyG index quartiles were categorized as follows: Q1, ≤8.12; Q2, 8.13-8.50 Q2, 8.51-8.89; and Q4, ≥8.90. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for leukoaraiosis based on brain MRI scans were calculated across TyG index quartiles using multiple logistic regression analysis.Results: The overall prevalence of leukoaraiosis was 5.4% and increased with serum TyG index quartiles. Compared to the lowest quartile, the ORs (95% CIs) of the highest TyG index quartile for leukoaraiosis was 2.37 (1.17-4.79) after adjusting for age, sex, body mass index, smoking status, alcohol intake, regular exercise, mean arterial pressure, total cholesterol, HDL cholesterol levels, hypertension, and type 2 diabetes.Conclusions: The serum TyG index was positively and independently associated with leukoaraiosis. Our findings indicate that the TyG index might be a useful additional measure for assessing cerebrovascular microangiopathy in clinical settings.

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Study of renal functions in metabolic syndrome and its correlation with various parameters

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200763 ◽

2020 ◽

Vol 8 (3) ◽

pp. 960

Author(s):

Anand N. ◽

Vidya T. A.

Keyword(s):

Metabolic Syndrome ◽

Renal Function ◽

Diastolic Pressure ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

University Hospital ◽

Cross Sectional ◽

Renal Functions ◽

Cholesterol Levels

Background: Metabolic syndrome includes a constellation of various metabolic abnormalities that have been associated with cardiovascular disease, stroke and all-cause mortality in the general population. It has now been established that it is also associated with renal dysfunction. This study was done to assess renal function in metabolic syndrome in Indian population as well as its correlation with different parameters of the metabolic syndrome.Methods: A cross-sectional study was conducted in a university hospital from 2014 - 2015. Renal functions were studied in 100 obese individuals, 50 with and 50 without metabolic syndrome after informed consent and the results were analysed.Results: 100 obese individuals, 50 with and 50 without metabolic syndrome were compared. All underwent a physical examination and relevant investigations. All parameters of renal function showed significant derangement in cases as compared to controls. 38 patients (76%) among the cases (N=50) of metabolic syndrome had altered renal functions versus 9 patients (18%) among controls (n=50). Individually, there was a significant correlation of altered renal function (reduced estimated glomerular filtration rate eGFR and presence of microalbuminuria) with fasting blood glucose and systolic blood pressure (p=0.001), diastolic pressure (p=0.003) and triglyceride levels (p=0.036). High density lipoprotein-cholesterol levels did not show a significant correlation.Conclusions: Obese individuals with metabolic syndrome have significant derangement of renal functions as compared to those without metabolic syndrome. Most parameters of the syndrome are also independently associated with alteration of renal functions.

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Metabolic syndrome in middle-aged and older women: A cross-sectional study

Women s Health ◽

10.1177/17455065211070673 ◽

2022 ◽

Vol 18 ◽

pp. 174550652110706

Author(s):

Mayle Andrade Moreira ◽

Saionara Maria Aires da Câmara ◽

Sabrina Gabrielle Gomes Fernandes ◽

Ingrid Guerra Azevedo ◽

Álvaro Campos Cavalcanti Maciel

Keyword(s):

Metabolic Syndrome ◽

Older Women ◽

Abdominal Obesity ◽

Menopausal Status ◽

Age Groups ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Age At Menarche ◽

Middle Aged ◽

Cross Sectional

Objective: This study aims to compare the prevalence of metabolic syndrome between different age groups of middle-aged and older women and to assess whether these differences are independent of potential covariates. Methods: Study conducted with 510 women divided into three age groups: 45–54, 55–64 and 65–74 years. Socioeconomic, reproductive and lifestyle variables were self-reported. We defined metabolic syndrome using the National Cholesterol Education Program Adult Treatment Panel III criteria (abdominal obesity, diabetes, reduced high-density lipoprotein, elevated triglycerides, and hypertension). Logistic regression assessed the association between age groups, and metabolic syndrome was adjusted for covariates (socioeconomic variables, age at menarche and at first childbirth, parity, menopausal status, physical activity variables and smoking). Results: Women aged 55–64 years presented higher prevalence of all metabolic syndrome criteria than the other groups, except for abdominal obesity, which was higher in the oldest group. In the fully adjusted analysis, the 55–64 years age group continues to exhibit significantly higher odds of presenting metabolic syndrome when compared to the youngest group (45–54 years) (OR = 2.257; 95% CI = 1.20:4.24). There was no statistical difference in the odds of presenting metabolic syndrome when comparing the oldest and the youngest groups (OR = 1.500; 95% CI = 0.85:2.65). Conclusion: The higher prevalence of metabolic syndrome among those aged 55–64 years may indicate that middle-aged women become unhealthy earlier in the life course and that many of them may die prematurely. This result highlights the importance of screening metabolic syndrome earlier in the midlife and the need for public health policies aimed at reducing adverse effects in later years.

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Prevalence of metabolic syndrome in 25—45-year-old Novosibirsk dwellers

Terapevticheskii arkhiv ◽

10.17116/terarkh2016881051-56 ◽

2016 ◽

Vol 88 (10) ◽

pp. 51-56 ◽

Cited By ~ 6

Author(s):

M I Voevoda ◽

N A Kovalkova ◽

Yu I Ragino ◽

N Yu Travnikova ◽

D V Denisova

Keyword(s):

Metabolic Syndrome ◽

International Diabetes Federation ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Research Society ◽

Population Based ◽

Blood Cholesterol ◽

Cross Sectional ◽

Detection Evaluation ◽

Population Based Survey

Aim. To study the prevalence of metabolic syndrome (MS) and its components in a 25—45-year-old Novosibirsk population. Subjects and methods. The Novosibirsk Research Institute of Internal and Preventive Medicine conducted a cross-sectional population-based survey in one of the typical districts of Novosibirsk in 2013—2015. The survey covered 346 men and 408 women. The criteria of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATP III, 2001), the International Diabetes Federation (IDF, 2005), the Joint Interim Statement (JIS, 2009), and the All-Russian Research Society of Cardiologists (ARRSC, 2009) were used to detect MS. According to the ARRSC criteria, MS was recorded if a waist circumference (WC) was >80 cm for women and >94 cm for men in conjunction with 2 of the following criteria: a blood pressure ≥130/85 mm Hg, triglycerides (TG) ≥1.7 mmol/l, high-density lipoprotein (HDL) cholesterol

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