Bisphenol A Analogues in Food and Their Hormonal and Obesogenic Effects: A Review

Bisphenol A (BPA) is the most well-known compound from the bisphenol family. As BPA has recently come under pressure, it is being replaced by compounds very similar in structure, but data on the occurrence of these BPA analogues in food and human matrices are limited. The main objective of this work was to investigate human exposure to BPA and analogues and the associated health effects. We performed a literature review of the available research made in humans, in in vivo and in vitro tests. The findings support the idea that exposure to BPA analogues may have an impact on human health, especially in terms of obesity and other adverse health effects in children.

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Bisphenol A Analogues: A Brief Review of their Occurrence in Food, Biological Samples and Endocrine Effects

Archives of Ecotoxicology ◽

10.36547/ae.2020.2.4.89-94 ◽

2020 ◽

Vol 2 (4) ◽

pp. 89-94

Author(s):

Nikola Knizatova ◽

Katarína Tokárová ◽

Hana Greifová ◽

Tomáš Jambor ◽

Peter Massányi ◽

...

Keyword(s):

Bisphenol A ◽

Human Health ◽

Human Exposure ◽

Food Packaging ◽

In Vitro Tests ◽

Endocrine Disrupting Chemical ◽

Endocrine Disrupting ◽

Made In

Bisphenol A (BPA) is the most well-known compound from the bisphenol family. There is increasing evidence that bisphenol BPA used in plastics, receipts, food packaging, and other products might be harmful to human health due to its actions as an endocrine-disrupting chemical, therefore BPA is being replaced by compounds very similar in structure, but data on the occurrence and effects of these BPA analogs are limited. Therefore, there is increasing concern regarding human exposure to bisphenol analogs (BPs) due to their widespread use and potential adverse effects. The main objective of this work was to investigate human exposure to BPs and the associated endocrine activities. We performed a literature review of the available research made in humans, in in vivo and in vitro tests. The findings support the idea that exposure to BPs may have an impact on human health, especially in terms of endocrine disruption.

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Nutraceuticals with anti-inflammatory and anti-oxidant properties as intervention for reducing the health effects of fine particulate matter: Potential and Prospects

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207324666210412121226 ◽

2021 ◽

Vol 24 ◽

Author(s):

Tanwi Trushna ◽

Amit K. Tripathi ◽

Sindhuprava Rana ◽

Rajnarayan R. Tiwari

Keyword(s):

Air Pollution ◽

Particulate Matter ◽

Human Health ◽

Health Effects ◽

In Vivo Studies ◽

Future Research ◽

Individual Level ◽

Anti Inflammatory

: Air pollution, especially particulate matter pollution adversely affects human health. A growing pool of evidence has emerged which underscores the potential of individual-level nutritional interventions in attenuating the adverse health impact of exposure to PM2.5. Although controlling emission and reducing the overall levels of air pollution remains the ultimate objective globally, the sustainable achievement of such a target and thus consequent protection of human health will require a substantial amount of time and concerted efforts worldwide. In the meantime, smaller-scale individual-level interventions that can counter the inflammatory or oxidative stress effects triggered by exposure to particulate matter may be utilized to ameliorate the health effects of PM2.5 pollution. One such intervention is incorporation of nutraceuticals in the diet. Here, we present a review of the evidence generated from various in vitro, in vivo and human studies regarding the effects of different anti-inflammatory and antioxidant nutraceuticals in ameliorating the health effects of particulate matter air pollution. The studies discussed in this review suggest that these nutraceuticals when consumed as a part of the diet, or as additional supplementation, can potentially negate the cellular level adverse effects of exposure to particulate pollution. The potential benefits of adopting a non-pharmacological diet-based approach to air pollution-induced disease management have also been discussed. We argue that before a nutraceuticals-based approach can be used for widespread public adoption, further research, especially human clinical trials, is essential to confirm the beneficial action of relevant nutraceuticals and to explore the safe limits of human supplementation and the risk of side effects. Future research should focus on systematically translating bench-based knowledge regarding nutraceuticals gained from in-vitro and in-vivo studies into clinically usable nutritional guidelines.

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Recent Advances in Particulate Matter and Nanoparticle Toxicology: A Review of theIn VivoandIn VitroStudies

BioMed Research International ◽

10.1155/2013/279371 ◽

2013 ◽

Vol 2013 ◽

pp. 1-22 ◽

Cited By ~ 127

Author(s):

Abderrahim Nemmar ◽

Jørn A. Holme ◽

Irma Rosas ◽

Per E. Schwarze ◽

Ernesto Alfaro-Moreno

Keyword(s):

Particulate Matter ◽

Health Effects ◽

Molecular Mechanisms ◽

Experimental Models ◽

Cellular Mechanisms ◽

Mortality And Morbidity ◽

Mechanisms Of Toxicity ◽

Adverse Health Effects

Epidemiological and clinical studies have linked exposure to particulate matter (PM) to adverse health effects, which may be registered as increased mortality and morbidity from various cardiopulmonary diseases. Despite the evidence relating PM to health effects, the physiological, cellular, and molecular mechanisms causing such effects are still not fully characterized. Two main approaches are used to elucidate the mechanisms of toxicity. One is the use ofin vivoexperimental models, where various effects of PM on respiratory, cardiovascular, and nervous systems can be evaluated. To more closely examine the molecular and cellular mechanisms behind the different physiological effects, the use of variousin vitromodels has proven to be valuable. In the present review, we discuss the current advances on the toxicology of particulate matter and nanoparticles based on these techniques.

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Endocrine Disruptors: A Critical Review of In Vitro and In Vivo Testing Strategies for Assessing Their Toxic Hazard to Humans

Alternatives to Laboratory Animals ◽

10.1177/026119290002800101 ◽

2000 ◽

Vol 28 (1) ◽

pp. 81-118 ◽

Cited By ~ 12

Author(s):

Robert D. Combes

Keyword(s):

Endocrine Disruptors ◽

Human Exposure ◽

Mechanisms Of Action ◽

Environmental Chemicals ◽

Toxicity Tests ◽

In Vitro Tests ◽

Wide Range ◽

The Us

Currently, there is much concern that a wide range of both synthetic and naturally occurring environmental chemicals can act as endocrine disruptors (EDs), and can adversely affect humans and wildlife. Many in vivo and in vitro tests have been proposed for screening EDs, and several regulatory agencies, including the US Environmental Protection Agency (EPA), have recommended tier-testing schemes. Unfortunately, most of the proposed toxicity tests have substantial problems, including non-specificity and lack of reproducibility. There is also uncertainty concerning their relevance for generating useful hazard data for risk assessment purposes, in view of the diversity of the possible ED mechanisms of action (for example, receptor binding, steroidogenesis and modulation of the homeostatic processes which regulate endogenous responses to hormones). Moreover, most of the suggested test methods have yet to be validated according to internationally accepted criteria, although the OECD and the US EPA have defined tests for validation, and an interlaboratory “prevalidation” exercise has been initiated by the OECD. All this is compounded by the lack of information regarding human exposure levels to EDs, and a lack of direct evidence for a causal link between exposure and the development of adverse human health effects. In addition, the regulatory testing of EDs has important negative implications for animal welfare, as some of the proposed in vivo tests require large group sizes of animals and stressful procedures. From a detailed analysis of the available published literature, it is concluded that it is impossible to assess the relative values of currently available in vitro and in vivo toxicity tests for EDs, or to recommend any test or test battery. Any plans for the widespread testing of EDs are therefore premature and might be unnecessary, at least for detecting possible human effects. Several recommendations are made for rectifying this unsatisfactory situation, including the postponement of screening programmes pending: a) more information on human exposure; b) further details of the mechanisms of action of EDs; and c) the development of improved tests, followed by their proper scientific validation.

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Signalling-Dependent Adverse Health Effects of Carbon Nanoparticles Are Prevented by the Compatible Solute Mannosylglycerate (Firoin) In Vitro and In Vivo

PLoS ONE ◽

10.1371/journal.pone.0111485 ◽

2014 ◽

Vol 9 (11) ◽

pp. e111485 ◽

Cited By ~ 7

Author(s):

Andrea Autengruber ◽

Ulrich Sydlik ◽

Matthias Kroker ◽

Tamara Hornstein ◽

Niloofar Ale-Agha ◽

...

Keyword(s):

Health Effects ◽

Carbon Nanoparticles ◽

Compatible Solute ◽

Adverse Health Effects ◽

Adverse Health

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Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Ciência & Saúde Coletiva ◽

10.1590/s1413-81232012000200015 ◽

2012 ◽

Vol 17 (2) ◽

pp. 407-434 ◽

Cited By ~ 113

Author(s):

Laura N. Vandenberg ◽

Ibrahim Chahoud ◽

Jerrold J Heindel ◽

Vasantha Padmanabhan ◽

Francisco J.R Paumgartten ◽

...

Keyword(s):

Risk Assessment ◽

General Population ◽

Bisphenol A ◽

Health Effects ◽

Human Exposure ◽

Human Biomonitoring ◽

Urine Samples ◽

Internal Exposure ◽

Human Tissues ◽

Adverse Health Effects

Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.

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Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020

Toxics ◽

10.3390/toxics8030068 ◽

2020 ◽

Vol 8 (3) ◽

pp. 68

Author(s):

Mahesh Padukudru Anand ◽

Kjell Larsson ◽

Gunnar Johanson ◽

Harish C. Phuleria ◽

P. Veeranna Ravindra ◽

...

Keyword(s):

Health Effects ◽

Dietary Exposure ◽

Screening Methods ◽

In Vivo Models ◽

Important Indicator ◽

Biomass Smoke ◽

Adverse Health Effects ◽

Adverse Health

This report summarizes the outcome of a workshop held in Mysuru, India in January 2020 addressing the adverse health effects of exposure to biomass smoke (BMS). The aim of the workshop was to identify uncertainties and gaps in knowledge and possible methods to address them in the Mysuru study on Determinants of Health in Rural Adults (MUDHRA) cohort. Specific aims were to discuss the possibility to improve and introduce new screening methods for exposure and effect, logistic limitations and other potential obstacles, and plausible strategies to overcome these in future studies. Field visits were included in the workshop prior to discussing these issues. The workshop concluded that multi-disciplinary approaches to perform: (a) indoor and personalized exposure assessment; (b) clinical and epidemiological field studies among children, adolescents, and adults; (c) controlled exposure experiments using physiologically relevant in vitro and in vivo models to understand molecular patho-mechanisms are warranted to dissect BMS-induced adverse health effects. It was perceived that assessment of dietary exposure (like phytochemical index) may serve as an important indicator for understanding potential protective mechanisms. Well trained field teams and close collaboration with the participating hospital were identified as the key requirements to successfully carry out the study objectives.

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The influence of lipid droplet size on the oral bioavailability of vitamin D2encapsulated in emulsions: an in vitro and in vivo study

Food & Function ◽

10.1039/c6fo01565d ◽

2017 ◽

Vol 8 (2) ◽

pp. 767-777 ◽

Cited By ~ 29

Author(s):

L. Salvia-Trujillo ◽

B. Fumiaki ◽

Y. Park ◽

D. J. McClements

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Health Effects ◽

Droplet Size ◽

Oral Bioavailability ◽

Functional Foods ◽

Adverse Health Effects ◽

Lipid Droplet Size

Vitamin D deficiency is prevalent in some populations leading to adverse health effects, and therefore there is a need to supplement functional foods and beverages with this important micronutrient.

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