scholarly journals Association between Habitual Dietary Iron Intake and Glucose Metabolism in Individuals after Acute Pancreatitis

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3579
Author(s):  
Wandia Kimita ◽  
Xinye Li ◽  
Juyeon Ko ◽  
Sakina H. Bharmal ◽  
David Cameron-Smith ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Glucose Metabolism ◽  
Confidence Interval ◽  
Total Iron ◽  
Dietary Iron ◽  
Iron Intake ◽  
Habitual Intake ◽  
Adjusted Model ◽  
Prospective Longitudinal ◽  
Haem Iron

Dietary intake of iron is known to be associated with impaired glucose metabolism. However, its involvement in derangements of glucose metabolism after acute pancreatitis (AP) is not completely understood. The aim was to investigate the association between dietary iron intake and markers of glucose metabolism in individuals after an attack of AP. Fasting blood samples were collected to analyse markers of glucose metabolism (fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c)). The EPIC-Norfolk food frequency questionnaire was used to determine the habitual intake of dietary iron (total, haem, and non-haem). Multivariable linear regression analyses were conducted and six statistical models were built to adjust for covariates. A total of 109 individuals after AP were studied in a cross-sectional fashion. Total iron (β (95% confidence interval) = −0.19 (−0.35, −0.05); p = 0.01 in the most adjusted model) and non-haem iron (β (95% confidence interval) = −0.19 (−0.33, −0.04); p = 0.03 in the most adjusted model) were significantly associated with FPG, consistently in all adjusted model. Total iron and non-haem iron did not have consistent significant associations with HbA1c. Dietary haem iron intake was not associated with either FPG or HbA1c. Habitual intake of dietary iron is inversely associated with FPG in individuals after an attack of AP and may be involved in the pathogenesis of new-onset diabetes after pancreatitis. Prospective longitudinal studies are now warranted to unveil the specific mechanism underlying the involvement of dietary iron.

scholarly journals Associations of Habitual Mineral Intake with New-Onset Prediabetes/Diabetes after Acute Pancreatitis

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3978
Author(s):  
Claire F. Norbitt ◽  
Wandia Kimita ◽  
Juyeon Ko ◽  
Sakina H. Bharmal ◽  
Maxim S. Petrov
Keyword(s):  
Acute Pancreatitis ◽  
Glucose Metabolism ◽  
Dietary Intake ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glycated Haemoglobin ◽  
Fasting Plasma ◽  
Habitual Intake ◽  
Prospective Longitudinal ◽  
New Onset

Associations between habitual dietary intake of minerals and glucose metabolism have been extensively studied in relation to metabolic disorders. However, similar research has yet to be conducted in individuals after acute pancreatitis (AP). The main aim was to investigate the associations between habitual intake of 13 minerals and glycaemic status: new-onset prediabetes/diabetes after AP (NODAP), pre-existing prediabetes/type 2 diabetes (T2DM), and normoglycaemia after AP (NAP). Associations between the dietary intake of minerals and markers of glucose metabolism (glycated haemoglobin and fasting plasma glucose) were also studied. The EPIC-Norfolk food frequency questionnaire was used in a cross-sectional fashion to determine the habitual intake of 13 dietary minerals. ANCOVA as well as multiple linear regression analyses were conducted and five statistical models were built to adjust for covariates. The study included 106 individuals after AP. In the NODAP group, intake of 4 minerals was significantly less when compared with the NAP group: iron (B = −0.076, p = 0.013), nitrogen (B = −0.066, p = 0.003), phosphorous (B = −0.046, p = 0.006), and zinc (B = −0.078, p = 0.001). Glycated haemoglobin was significantly associated with iodine intake (B = 17.763, p = 0.032) and manganese intake (B = −17.147, p = 0.003) in the NODAP group. Fasting plasma glucose was significantly associated with manganese intake (B = −2.436, p = 0.027) in the NODAP group. Habitual intake of minerals differs between individuals with NODAP, T2DM, and NAP. Prospective longitudinal studies and randomised controlled trials are now warranted to further investigate the associations between mineral intake and NODAP.

scholarly journals Total and Nonheme Dietary Iron Intake Is Associated with Metabolic Syndrome and Its Components in Chinese Men and Women

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1663 ◽  
Author(s):  
Zhenni Zhu ◽  
Fan Wu ◽  
Ye Lu ◽  
Chunfeng Wu ◽  
Zhengyuan Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Ferritin ◽  
Smoking Status ◽  
Heme Iron ◽  
Nonheme Iron ◽  
Total Iron ◽  
Positive Trend ◽  
Dietary Iron ◽  
Iron Intake ◽  
Men And Women

The causal relationship between serum ferritin and metabolic syndrome (MetS) remains inconclusive. Dietary iron intake increases serum ferritin. The objective of this study was to evaluate associations of total, heme, and nonheme dietary iron intake with MetS and its components in men and women in metropolitan China. Data from 3099 participants in the Shanghai Diet and Health Survey (SDHS) obtained during 2012–2013 were included in this analysis. Dietary intake was assessed by 24-h diet records from 3 consecutive days. Multivariate generalized linear mixed models were used to evaluate the associations of dietary iron intake with MetS and its components. After adjustment for potential confounders as age, sex, income, physical exercise, smoking status, alcohol use, and energy intake, a positive trend was observed across quartiles of total iron intake and risk of MetS (p for trend = 0.022). Compared with the lowest quartile of total iron intake (<12.72 mg/day), the highest quartile (≥21.88 mg/day) had an odds ratio (95% confidence interval), OR (95% CI), of 1.59 (1.15,2.20). In addition, the highest quartile of nonheme iron intake (≥20.10 mg/day) had a 1.44-fold higher risk of MetS compared with the lowest quartile (<11.62 mg/day), and higher risks of MetS components were associated with the third quartiles of total and nonheme iron intake. There was no association between heme iron intake and risk of MetS (p for trend = 0.895). Associations for total and nonheme iron intake with MetS risk were found in men but not in women. Total and nonheme dietary iron intake was found to be positively associated with MetS and its components in the adult population in metropolitan China. This research also revealed a gender difference in the association between dietary iron intake and MetS.

scholarly journals Dietary Iron Intake and Incident Type 2 Diabetes in Chinese Middle-Aged and Elderly Population: A Prospective Cohort Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 47-47 ◽  
Author(s):  
Shu-Yi Li ◽  
Rong-Huan Zhong ◽  
Jing-An Long ◽  
Aiping Fang ◽  
Huilian Zhu
Keyword(s):  
Elderly Population ◽  
Red Meat ◽  
Heme Iron ◽  
Total Iron ◽  
Dietary Iron ◽  
Iron Intake ◽  
Middle Aged ◽  
Incident Type ◽  
Incident Type 2 Diabetes

Abstract Objectives Excessive dietary iron intake may lead to iron overload and further induce pancreatic islet damage to increase risk of diabetes, which has a higher prevalence in middle-aged and elderly population. We aimed to explore the association between dietary iron intake and incident type 2 diabetes (T2D) in Chinese middle-aged and elderly population. Methods This study was based on the Guangzhou Nutrition and Health Study (GNHS), an on-going, community-based prospective cohort study that recruited participants aged 40–75 years from 2008. All participants were followed up every three years. 2765 participants free of diabetes were included in data analysis. Dietary iron intake was obtained by a validated food-frequency questionnaire at baseline. T2D was ascertained by self-reported diabetes medications, fasting glucose ≥7.0 mmol/L or glycosylated hemoglobin ≥6.5%. Cox proportional hazards models were used to estimate HRs and 95% CIs. Results We ascertained 209 incident diabetes cases during 13,634 person-years of observation. The mean ± SD intakes of dietary total iron, heme iron and nonheme iron among all participants were 20.40 ± 2.73 mg/d, 1.26 ± 0.62 mg/d and 19.14 ± 2.66 mg/d, respectively. The multivariate-adjusted HR and 95% CI for T2D for the highest quartile of heme iron intake compared with the lowest quartile was 2.11 (95% CI: 1.14–3.89, P-trend = 0.014). However, the association between total iron intake or a nonheme iron intake with T2D risk was no significant difference. The adjusted HR for T2D risk was 1.79 (95% CI:1.05–3.08, P-trend = 0.037) for heme iron intake from red meat, while no association was found for heme iron intake from poultry or fish. Conclusions Greater intake of heme iron, especially heme iron from red meat, was associated with higher risk of incident T2D in Chinese middle-aged and elderly population, while intakes of total iron and nonheme were not related to diabetes. Controlling heme iron intake, especially red meat intake, may be a target to prevent T2D in middle-aged and elderly population. Funding Sources The National Science Foundation of China; the National Science Foundation of Guangdong Province, China.

scholarly journals Measurement of haem and total iron in fish, shrimp and prawn using ICP-MS: Implications for dietary iron intake calculations

2016 ◽  
Vol 201 ◽  
pp. 222-229 ◽  
Author(s):  
Matthew S. Wheal ◽  
Emma DeCourcy-Ireland ◽  
Jessica R. Bogard ◽  
Shakuntala H. Thilsted ◽  
James C.R. Stangoulis
Keyword(s):  
Total Iron ◽  
Dietary Iron ◽  
Iron Intake ◽  
Icp Ms

scholarly journals Dietary Fibre Intake in Type 2 and New-Onset Prediabetes/Diabetes after Acute Pancreatitis: A Nested Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1112
Author(s):  
Xinye Li ◽  
Wandia Kimita ◽  
Jaelim Cho ◽  
Juyeon Ko ◽  
Sakina H. Bharmal ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Glucose Metabolism ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Dietary Fibre ◽  
Glycated Haemoglobin ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Habitual Intake

The association between intake of dietary fibre and glucose metabolism has been extensively investigated in numerous metabolic disorders. However, little is known about this association in individuals after an attack of acute pancreatitis (AP). The aim was to investigate the associations between intake of dietary fibre and markers of glucose metabolism in individuals with new-onset prediabetes or diabetes after acute pancreatitis (NODAP), pre-exiting type 2 prediabetes or diabetes, and normoglycaemia after acute pancreatitis. This cross-sectional study was nested within the parent prospective longitudinal cohort study. The studied markers of glucose metabolism were fasting plasma glucose and glycated haemoglobin. Habitual intake of dietary fibre was determined using the EPIC-Norfolk food frequency questionnaire. Multivariable linear regression analyses were conducted. The study included a total of 108 individuals after AP. In the NODAP group, increased intakes of total fibre (β = −0.154, p = 0.006), insoluble fibre (β = −0.133, p = 0.01), and soluble fibre (β = −0.13, p = 0.02) were significantly associated with a reduction in fasting plasma glucose. Increased intakes of vegetables (β = −0.069, p = 0.004) and nuts (β = −0.039, p = 0.038) were significantly associated with a reduction in fasting plasma glucose. Increased intake of nuts (β = −0.054, p = 0.001) was also significantly associated with a reduction in glycated haemoglobin. None of the above associations were significant in the other study groups. Habitual intake of dietary fibre was inversely associated with fasting plasma glucose in individuals with NODAP. Individuals after an attack of AP may benefit from increasing their intake of dietary fibre (specifically, vegetables and nuts) with a view to preventing NODAP.

scholarly journals Dietary iron intake and risk of non-fatal acute myocardial infarction

2006 ◽  
Vol 9 (4) ◽  
pp. 480-484 ◽  
Author(s):  
Alessandra Tavani ◽  
Silvano Gallus ◽  
Cristina Bosetti ◽  
Maria Parpinel ◽  
Eva Negri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Total Iron ◽  
Alcoholic Beverages ◽  
First Episode ◽  
Italian Population ◽  
Inverse Association ◽  
Dietary Iron ◽  
Iron Intake

AbstractObjectiveThe relation between several measures of body iron and atherosclerotic disease, particularly acute myocardial infarction (AMI), is debated. This is of specific interest since iron is frequently included in supplementation and fortification of foods. We assessed the relation between dietary iron intake and the risk of non-fatal AMI.DesignCase–control study. The information was collected by interviewers using a food-frequency questionnaire tested for validity and reproducibility. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were obtained by multiple unconditional logistic regression models, including terms for energy and alcohol intakea, as well as for sociodemographic factors, tobacco and other major recognised risk factors for AMI.SettingMilan, Italy, between 1995 and 1999.SubjectsCases were 507 patients, below age 79 years, with a first episode of non-fatal AMI, and controls were 478 patients admitted to hospital for a wide spectrum of acute conditions unrelated to known or potential AMI risk factors.ResultsCompared with patients in the lowest tertile of total iron intake, the OR was 0.48 (95% CI 0.29–0.82) for those in the highest tertile. The corresponding value for haem iron was 0.71 (95% CI 0.48–1.06), for non-haem, non-alcohol iron was 0.80 (95% CI 0.51–1.24) and for iron derived from alcoholic beverages was 0.60 (95% CI 0.40–0.90). Sex-specific OR for total iron intake were not heterogeneous.ConclusionsIn this Italian population dietary iron intake was inversely related to AMI risk. This inverse association may depend on other nutrients present in the major sources of iron in the Italian diet.

scholarly journals Plasma Hepcidin Increases with Prolonged Running in Male, but Not Female, Collegiate Distance Runners with Low Iron Stores

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1777-1777
Author(s):  
David Barney ◽  
James Ippolito ◽  
Claire Berryman ◽  
Stephen Hennigar
Keyword(s):  
Serum Ferritin ◽  
Iron Status ◽  
Total Iron ◽  
Negative Regulator ◽  
Dietary Iron ◽  
Iron Intake ◽  
Distance Runners ◽  
Vo2 Max ◽  
Iron Stores ◽  
Males And Females

Abstract Objectives Hepcidin is a negative regulator of extracellular iron availability and dietary iron absorption. Previous studies have shown that hepcidin increases with prolonged endurance exercise, but not in those with low iron stores (serum ferritin &lt;30 ng/mL). The objective of this study was to determine the plasma hepcidin response to exercise, compared to rest, in highly trained male and female collegiate distance runners. Methods In a cross-over design, healthy male (n = 14; age 20.2 ± 1.4 y; BMI 20.4 ± 1.6 kg/m2; VO2 max 69.8 ± 5.6 mL/kg/min) and female (n = 14; age 20.1 ± 1.4 y, P = 0.79; BMI 18.1 ± 1.6 kg/m2, P &lt; 0.001; VO2 max 62.5 ± 4.2 mL/kg/min, P &lt; 0.001) collegiate distance runners performed a bout of running (males: 109.8 ± 8.7 min, 15.0 ± 1.3 miles; females: 87.7 ± 10.4 min, P &lt; 0.0001, 11.3 ± 1.5 miles, P &lt; 0.0001) or no activity (rest) separated by 2 weeks. Indicators of iron status and plasma hepcidin were determined at baseline and three hours after exercise or rest. Dietary iron and total iron intake (dietary iron + iron from supplements) were determined by Food Frequency Questionnaires. Results Serum ferritin (males: 24.0 ± 15.9 ng/mL, females: 19.4 ± 9.5 ng/mL, P = 0.39) and plasma hepcidin (males: 22.3 ± 20.6 ng/mL, females: 24.6 ± 19.6 ng/mL, P = 0.77) did not differ between males and females at baseline. Baseline hemoglobin (males: 14.5 ± 0.8 g/dL, females: 13.4 ± 1.0 g/dL, P &lt; 0.01) and hematocrit (males: 45.3 ± 2.2%, females: 42.1 ± 2.6%, P &lt; 0.01) were greater in males compared to females. Dietary iron intake (males: 18.6 ± 6.3 mg/d, females: 17.1 ± 6.4 mg/d, P = 0.55) and total iron intake (males: 48.7 ± 32.9 mg/d, females: 64.6 ± 32.3 mg/d, P = 0.22) did not differ between males and females. Plasma hepcidin increased with exercise compared to rest in males (change from rest: 30.3 ± 42.0 ng/mL, P = 0.02) but not in females (change from rest: 0.8 ± 32.0 ng/mL, P = 0.93). Change in plasma hepcidin with exercise was correlated with sex (R = 0.380, P = 0.05) and BMI (R = 0.383, P = 0.04), but not baseline ferritin, run time, run distance, hemoglobin, hematocrit, dietary iron, or total iron intake (P &gt; 0.05 for all). Conclusions The post-exercise hepcidin response occurs in male, but not female, collegiate distance runners with low iron stores. These findings indicate that declines in iron status in female distance runners are independent of exercise-induced hepcidin. Funding Sources Intramural funds to S.R.H.

scholarly journals Risk of anaemia among women engaged in biomass-based fish smoking as their primary livelihood in the central region of Ghana: a comparative cross-sectional study

BMC Nutrition ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Daniel Armo-Annor ◽  
Esi K. Colecraft ◽  
Seth Adu-Afarwuah ◽  
Aaron Kobina Christian ◽  
Andrew D. Jones
Keyword(s):  
Central Region ◽  
Cross Sectional Study ◽  
Total Iron ◽  
Biomass Fuel ◽  
Dietary Iron ◽  
Iron Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Past ◽  
Increased Risk

Abstract Background Fish smoking using biomass fuel is an important livelihood for women living in the coastal regions of Ghana and may contribute to anaemia risk. We assessed whether women who smoke fish as their primary livelihood are at increased risk of anaemia compared to women in other livelihoods in the Central Region of Ghana. Methods We conducted a comparative cross-sectional study of 330 randomly selected adult women (18–49 years) whose primary livelihood was either fish smoking (FSL) involving the burning of biomass fuel (n = 175) or other livelihoods (OL) not involving burning of firewood (n = 155). Data on participants’ recent diet were collected from a single, quantitative 24-h dietary recall and qualitative 7-day food frequency questionnaire of animal-source food (ASF) consumption. We further assessed participants’ haemoglobin concentration using the Urit 12 Hemocue system. We compared total iron intakes, the proportion of dietary iron from animal and plant sources, mean haemoglobin concentrations, and anaemia prevalence between FSL and OL women. Results Fish was the most frequently consumed ASF by both groups of women. Although OL women consumed more diverse ASFs in the past week compared with the FSL women (3.4 ± 1.2 vs. 2.7 ± 1.3; p < 0.001), the contribution of ASFs to total iron intake in the past day was greater for the FSL women (49.5% vs. 44.0%; p = 0.030). Estimated total dietary iron intake in the past day was generally low (5.2 ± 4.7 mg) and did not differ by group. The unadjusted prevalence of anaemia was 32 and 27.1% among the FSL and OL women, respectively (p = 0.33). After covariates adjustment, the FSL women had statistically higher anaemia prevalence (36.4% vs. 20.5%; p = 0.032) and 80% greater risk of being anemic (RR: 1.8; 95% CI: 1.1, 3.0) than the OL women. Conclusion Women who use biomass fuel to smoke fish as their primary livelihood had an increased risk of anaemia. Furthermore, the average 24-h dietary iron intake among both the FSL and OL women was below their daily iron requirement. Interventions to enhance women’s dietary iron intake and reduce their livelihood related biomass smoke exposure may be warranted in this population.

Dietary iron intake and the risk of type 2 diabetes mellitus in middle-aged and older adults in urban China: A Prospective Cohort Study

2020 ◽  
pp. 1-22
Author(s):  
Shu-Yi Li ◽  
Fan Wang ◽  
Xiao-Ting Lu ◽  
Rong-Huan Zhong ◽  
Jing-An Long ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Older Adults ◽  
Heme Iron ◽  
Nonheme Iron ◽  
Total Iron ◽  
Urban China ◽  
Dietary Iron ◽  
Iron Intake ◽  
Middle Aged

Abstract The association between dietary iron intake and diabetes risk remains inconsistent. We aimed to explore the association of dietary iron intake and type 2 diabetes mellitus (T2DM) risk in middle-aged and older adults in urban China. This study used data from the Guangzhou Nutrition and Health Study (GNHS), an on-going community-based prospective cohort study. Participants were recruited from 2008 to 2013 in Guangzhou community. 2,696 participants aged 40-75 years without T2DM at baseline were included in data analyses, with a median of 5.6 (IQR: 4.1-5.9) years of follow-up. T2DM was identified by self-reported diagnosis, fasting glucose ≥7.0 mmol/L, or glycosylated hemoglobin ≥6.5%. Cox proportional hazard models were used to estimate HRs and 95%CIs. We ascertained 205 incident T2DM cases during 13,476 person-years. The adjusted HR for T2DM risk in the fourth quartile of heme iron intake was 1.92 (95%CI: 1.07, 3.46; P-trend=0.010), compared with the first quartile intake. These significant associations were found in heme iron intake from total meat (HR:2.74; 95%CI: 1.22, 6.15; P-trend=0.011) and heme iron intake from red meat (HR:1.86; 95%CI: 1.01, 3.44; P-trend=0.034), but not heme iron intake from processed meat, poultry or fish/shellfish. The association between dietary intake of total iron or nonheme iron with T2DM risk had no significance. Our findings suggested that higher dietary intake of heme iron (especially from red meat), but not total iron or nonheme iron, was associated with greater T2DM risk in middle-aged and older adults.

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