Synergistic Interaction in the Analgesic-Like Effects of Maqui Berry and Citrus Is Antagonized by Sweeteners

Although physiologically pain has a protective function, in many diseases, it is one of the most prominent symptoms. Today, new trends are focused on finding more natural alternatives to conventional treatments to alleviate it. Thereby, the purpose of this investigation was to obtain preclinical data of the antinociceptive properties of a lyophilized obtained from a newly designed maqui–citrus beverage alone and added with different sweeteners. To achieve this objective, maqui berry and citrus pharmacological activity were studied separately, as well as the interaction of both ingredients. In addition, due to the controversy generated regarding the intake of sugars, related to different metabolic diseases, the influence of different sweeteners (stevia, sucralose, or sucrose) was studied to determine their possible influence on the bioactive compounds of this product. For the attainment of our goals, a pharmacological evaluation, using the 1% formalin test, a nociceptive pain model in mice, was performed by using a sub-efficacious dosage of Maqui (25 mg/kg, i.p.) alone and combined with citrus, and then compared with the effects obtained in the presence of the different sweeteners. As a result, the antinociceptive response of the maqui was synergized in the presence of citrus in the neurogenic and inflammatory phases of the formalin test. However, this response was partially or totally reduced in the presence of the sweeteners. Our study gives preclinical evidence that a combination of maqui and citrus might exert beneficial actions to relieve pain, whereas the presence of sweeteners could reduce or avoid it.

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Optimisation of microwave-assisted extraction from Phyllanthus amarus for phenolic compounds-enriched extracts and antioxidant capacity

Chemical Papers ◽

10.1515/chempap-2016-0009 ◽

2016 ◽

Vol 70 (6) ◽

Cited By ~ 10

Author(s):

Van T. Nguyen ◽

Michael C. Bowyer ◽

Ian A. van Altena ◽

Christopher J. Scarlett

Keyword(s):

Phenolic Compounds ◽

Antioxidant Capacity ◽

Bioactive Compounds ◽

Pharmacological Activity ◽

Extraction Efficiency ◽

Phyllanthus Amarus ◽

Microwave Assisted Extraction ◽

Microwave Assisted ◽

Assisted Extraction ◽

Extraction Parameters

Abstractis known as a healing herb which has traditionally been used in the treatment of various diseases such as hepatitis, diabetes and cancer. The extraction parameters have great effects on the extraction efficiency of bioactive compounds and pharmacological activity of the extracts. This study sought to optimise the microwave-assisted extraction parameters for phenolic compounds-enriched extracts and antioxidant capacity from

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Instant Insights: Nutraceuticals in fruit and vegetables

10.19103/9781786769251 ◽

2020 ◽

Keyword(s):

Vitamin C ◽

Bioactive Compounds ◽

Crop Production ◽

Metabolic Diseases ◽

Antioxidant Properties ◽

Bioactive Compound ◽

Fruit And Vegetables ◽

Specific Cell ◽

Anthocyanin Content ◽

Genetic Dissection

This specially curated collection features three reviews of current and key research on nutraceuticals in fruit and vegetables. The first chapter provides a brief description of the chemistry of bioactive compounds (BCs) and their presence in temperate fruits, and discusses recent advances in strategies towards improving sustainable crop production for nutraceuticals. It examines polyphenols, carotenoids, vitamin C and production practices that influence bioactive compound synthesis. The second chapter describes the claimed health benefits associated with the antioxidant properties of bioactive compounds found in mangoes, such as vitamin C, phenolics and carotenoids. The chapter also examines specific cell, animal and clinical studies that suggest mango pulp, juice and extract are effective against metabolic diseases and certain forms of cancer. The final chapter considers how developments such as genetic dissection using fruit ripening mutants, new transgenic plants, and molecular breeding have opened a road map for scientists to further unravel the intricacies and regulation of genes governing fruit quality attributes. Improvements in precision in engineering plant genomes have enabled development of novel tomatoes with marketable traits such as higher carotenoid and anthocyanin content, both beneficial for human health.

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Pharmacological evaluation of the anxiolytic-like effects of Lippia graveolens and bioactive compounds

Pharmaceutical Biology ◽

10.1080/13880209.2017.1310908 ◽

2017 ◽

Vol 55 (1) ◽

pp. 1569-1576 ◽

Cited By ~ 8

Author(s):

María Eva González-Trujano ◽

Laura Yunuen Hernández-Sánchez ◽

Verónica Muñoz Ocotero ◽

Alejandro Dorazco-González ◽

Patricia Guevara Fefer ◽

...

Keyword(s):

Bioactive Compounds ◽

Pharmacological Evaluation

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Antioxidant and Signal-Modulating Effects of Brown Seaweed-Derived Compounds against Oxidative Stress-Associated Pathology

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/9974890 ◽

2021 ◽

Vol 2021 ◽

pp. 1-22

Author(s):

Rahima Begum ◽

Saurav Howlader ◽

A. N. M. Mamun-Or-Rashid ◽

S. M. Rafiquzzaman ◽

Ghulam Md Ashraf ◽

...

Keyword(s):

Oxidative Stress ◽

Bioactive Compounds ◽

Molecular Mechanisms ◽

Metabolic Diseases ◽

Antioxidant Properties ◽

Brown Seaweed ◽

Sulfated Polysaccharide ◽

Bioactive Substances ◽

Brown Seaweeds ◽

Therapeutic Properties

The biological and therapeutic properties of seaweeds have already been well known. Several studies showed that among the various natural marine sources of antioxidants, seaweeds have become a potential source of antioxidants because of their bioactive compounds. Most of the metabolic diseases are caused by oxidative stress. It is very well known that antioxidants have a pivotal role in the treatment of those diseases. Recent researches have revealed the potential activity of seaweeds as complementary medicine, which have therapeutic properties for health and disease management. Among the seaweeds, brown seaweeds (Phaeophyta) and their derived bioactive substances showed excellent antioxidant properties than other seaweeds. This review focuses on brown seaweeds and their derived major bioactive compounds such as sulfated polysaccharide, polyphenol, carotenoid, and sterol antioxidant effects and molecular mechanisms in the case of the oxidative stress-originated disease. Antioxidants have a potential role in the modification of stress-induced signaling pathways along with the activation of the oxidative defensive pathways. This review would help to provide the basis for further studies to researchers on the potential antioxidant role in the field of medical health care and future drug development.

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Inflammatory pathways involved in adipose tissue hypertrophy and the effect of Acai (Euterpe oleracea Martius) on the modulation of this process: a review

Research Society and Development ◽

10.33448/rsd-v9i9.6813 ◽

2020 ◽

Vol 9 (9) ◽

pp. e62996813

Author(s):

Tamires Cássia de Melo Souza ◽

Gabriel Vitor de Melo Souza ◽

Ana Carolina Pinheiro Volp

Keyword(s):

Adipose Tissue ◽

Chronic Inflammation ◽

Bioactive Compounds ◽

Metabolic Diseases ◽

Sample Size Calculation ◽

Control Group ◽

Euterpe Oleracea ◽

Treatment And Prevention

Adipose tissue plays an important role in chronic inflammation and the presence of bioactive compounds in food has been widely discussed as a means of prevention and treatment of various pathological conditions. The aim of this review is to promote an overview and elucidate pathways involved in the chronic inflammatory process triggered by adipose tissue hypertrophy and to discuss data related to the use of Acai in the modulation of inflammation. Initially, a narrative review was carried out on metabolic and molecular pathways involved in the process of subclinical chronic inflammation (NF-κB, AP-1, cross-talk between macrophages and adipocytes, increased LPS and Nrf2 pathway). Then, an integrative review was carried out on the effect of Acai in processes of chronic subclinical inflammation in humans. The database consulted was PubMed, in which the name of the fruit was crossed with the descriptors "inflammation" and "chronic diseases", prioritizing in vivo and in vitro studies related to the human species, carried out in the last ten years. It was observed that the immunomodulatory effects of Acai are increasingly clear, however, are not enough to classify the fruit as a tool in the treatment and prevention of metabolic diseases. To make possible more comprehensive inferences, it is necessary that future studies include assessment of the bioavailability of the bioactive compounds present, in addition to being performed using more suitable methods, with humans, containing sample size calculation, control group and placebo.

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Physicochemical properties and bioactive compounds content in encapsulated freeze-dried powders obtained from blueberry, elderberry, blackcurrant and maqui berry

Journal of Berry Research ◽

10.3233/jbr-190409 ◽

2019 ◽

Vol 9 (3) ◽

pp. 431-447 ◽

Cited By ~ 5

Author(s):

Carolina Busso Casati ◽

Rosa Baeza ◽

Virginia Sánchez

Keyword(s):

Physicochemical Properties ◽

Bioactive Compounds ◽

Freeze Dried ◽

Maqui Berry

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The formalin test: A tonic pain model in the primate

Pain ◽

10.1016/0304-3959(84)90815-7 ◽

1984 ◽

Vol 20 (1) ◽

pp. 97-105 ◽

Cited By ~ 71

Author(s):

Meenakshi Alreja ◽

Pradeep Mutalik ◽

Usha Nayar ◽

S. K. Manchanda

Keyword(s):

Formalin Test ◽

Pain Model ◽

Tonic Pain

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Equivalent intraperitoneal doses of ibuprofen supplemented in drinking water or in diet: a behavioral and biochemical assay using antinociceptive and thromboxane inhibitory dose–response curves in mice

PeerJ ◽

10.7717/peerj.2239 ◽

2016 ◽

Vol 4 ◽

pp. e2239 ◽

Cited By ~ 13

Author(s):

Raghda A.M. Salama ◽

Nesreen H. El Gayar ◽

Sonia S. Georgy ◽

May Hamza

Keyword(s):

Drinking Water ◽

Dose Response ◽

Formalin Test ◽

Response Curves ◽

Time Curve ◽

Pain Model ◽

Threshold Time ◽

Dose Response Curves ◽

Inhibitory Agents ◽

Incisional Pain

Background.Ibuprofen is used chronically in different animal models of inflammation by administration in drinking water or in diet due to its short half-life. Though this practice has been used for years, ibuprofen doses were never assayed against parenteral dose–response curves. This study aims at identifying the equivalent intraperitoneal (i.p.) doses of ibuprofen, when it is administered in drinking water or in diet.Methods.Bioassays were performed using formalin test and incisional pain model for antinociceptive efficacy and serum TXB2for eicosanoid inhibitory activity. The dose–response curve of i.p. administered ibuprofen was constructed for each test using 50, 75, 100 and 200 mg/kg body weight (b.w.). The dose–response curves were constructed of phase 2a of the formalin test (the most sensitive phase to COX inhibitory agents), the area under the ‘change in mechanical threshold’-time curve in the incisional pain model and serum TXB2levels. The assayed ibuprofen concentrations administered in drinking water were 0.2, 0.35, 0.6 mg/ml and those administered in diet were 82, 263, 375 mg/kg diet.Results.The 3 concentrations applied in drinking water lay between 73.6 and 85.5 mg/kg b.w., i.p., in case of the formalin test; between 58.9 and 77.8 mg/kg b.w., i.p., in case of the incisional pain model; and between 71.8 and 125.8 mg/kg b.w., i.p., in case of serum TXB2levels. The 3 concentrations administered in diet lay between 67.6 and 83.8 mg/kg b.w., i.p., in case of the formalin test; between 52.7 and 68.6 mg/kg b.w., i.p., in case of the incisional pain model; and between 63.6 and 92.5 mg/kg b.w., i.p., in case of serum TXB2levels.Discussion.The increment in pharmacological effects of different doses of continuously administered ibuprofen in drinking water or diet do not parallel those of i.p. administered ibuprofen. It is therefore difficult to assume the equivalent parenteral daily doses based on mathematical calculations.

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Beverages Based on Second Quality Citrus Fruits and Maqui Berry, a Source of Bioactive (Poly)phenols: Sorting Out Urine Metabolites upon a Longitudinal Study

Nutrients ◽

10.3390/nu13020312 ◽

2021 ◽

Vol 13 (2) ◽

pp. 312

Author(s):

Vicente Agulló ◽

Cristina García-Viguera ◽

Raúl Domínguez-Perles

Keyword(s):

Longitudinal Study ◽

High Performance ◽

Metabolic Diseases ◽

Citrus Fruits ◽

Urine Metabolites ◽

Sweetened Beverages ◽

Lower Extent ◽

Isoferulic Acid ◽

Hydroxyphenylacetic Acid ◽

Maqui Berry

The intake of sugar-sweetened beverages has been associated with an augmented prevalence of metabolic diseases, namely, obesity, type II diabetes, and metabolic syndrome. On the other hand, nowadays, it is broadly accepted that foods and beverages rich in (poly)phenols could contribute to reducing the incidence of these pathologies. In this sense, the objective of the work was to revalue second quality citrus fruits for the development of new beverages, rich in anthocyanins and flavanones (maqui berry and second qualities citrus-based), and evaluate the influence of alternative sweeteners (sucralose, sucrose, or stevia), regarding the bioaccessibility and bioavailability of these bioactive compounds in the frame of a chronic (longitudinal) intervention. To fulfill this objective, a longitudinal study of the urinary excretion of anthocyanins and flavanones, after 2-months of ingestion of the developed maqui-citrus beverage, by 138 volunteers (n = 46 per beverage) and the analysis of the resulting phenolic metabolites by ultra-high performance liquid chromatography coupled to mass spectrometry (UHPLC-ESI-QqQ-MS/MS) was carried out. As major results, the bioavailable metabolites of caffeic acid (CA), catechol (CAT), 3,4-di-hydroxyphenylacetic acid (DHPAA), eriodictyol (E), homoeriodictyol (HE), hippuric acid (HA), naringenin (N), trans-ferulic acid (TFA), 2,4,6-tri-hydroxybenzaldehyde (THBA), trans-isoferulic acid (TIFA), and vanillic acid (VA) were detected. Accordingly, significantly different bioavailability was dependent on the sweetener used, allowing proposing stevia and, to a lower extent, sucralose, as valuable alternatives to sucrose.

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