scholarly journals Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3970
Author(s):  
Anne J. Strikwerda ◽  
Lisanne J. Dommershuijsen ◽  
M. Kamran Ikram ◽  
Trudy Voortman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mediterranean Diet ◽  
Diet Quality ◽  
Dietary Patterns ◽  
Principal Component ◽  
Population Based ◽  
Quality Score ◽  
Rotterdam Study ◽  
The Mediterranean

The Mediterranean diet has been associated with the risk of Parkinson’s disease (PD), but limited research has been performed on other dietary patterns. We studied the relationship between overall diet quality and PD risk in the general population. We included 9414 participants from the Rotterdam Study, a prospective population-based study in the Netherlands. Diet was defined using a Dutch diet quality score, a Mediterranean diet score and data-driven dietary patterns constructed with principal component analysis (PCA). During an average follow-up of 14.1 years, PD was diagnosed in 129 participants. We identified a ‘Prudent’, ‘Unhealthy’ and ‘Traditional Dutch’ pattern from the PCA. We found a possible association between the Mediterranean diet (Hazard ratio (HR) per standard deviation (SD) 0.89 (95% confidence interval (CI) 0.74–1.07)), the ‘Prudent’ pattern (HR per SD 0.81 (95% CI 0.61–1.08)) and the risk of PD. However, no associations with PD risk were found for the Dutch diet quality score (HR per SD 0.93 (95% CI 0.77–1.12)), the ‘Unhealthy’ pattern (HR per SD 1.05 (95% CI 0.85–1.29)) or the ‘Traditional Dutch’ pattern (HR per SD 0.90 (95% CI 0.69–1.17)). In conclusion, our results corroborate previous findings of a possible protective effect of the Mediterranean diet. Further research is warranted to study the effect of other dietary patterns on PD risk.

scholarly journals Urinary sodium-to-potassium ratio: a simple and useful indicator of diet quality in population-based studies

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Parvin Mirmiran ◽  
Zahra Gaeini ◽  
Zahra Bahadoran ◽  
Asghar Ghasemi ◽  
Reza Norouzirad ◽  
...  
Keyword(s):  
Diet Quality ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Principal Component ◽  
Population Based ◽  
Urinary Sodium ◽  
Current Evidence ◽  
Dash Score ◽  
Dietary Intakes ◽  
Spot Urine

Abstract Background Current evidence regarding the prognostic relevance of urinary sodium-to-potassium ratio (Na-to-K ratio), as an indicator of diet quality is limited. This study was conducted to investigate whether urinary Na-to-K ratio could be related to habitual dietary patterns, in a general population. Methods This study was conducted in the framework of the Tehran Lipid and Glucose Study (2014–2017) on 1864 adult men and women. Urinary Na and K concentrations were measured in the morning spot urine samples. Dietary intakes of the participants were assessed using a validated 147-item Food Frequency Questionnaire (FFQ) and major dietary patterns were obtained using principal component analysis. Mediterranean dietary pattern and Dietary Approaches to Stop Hypertension (DASH) score, were also calculated. Multivariable-adjusted linear regression was used to indicate association of dietary patterns and urinary Na-to-K ratio. Results Mean (± SD) age of participants was 43.7 ± 13.9 years and 47% were men. Mean (± SD) urinary Na, K and the ratio was 139 ± 41.0 and 57.9 ± 18.6 mmol/L, 2.40 ± 0.07, respectively. Higher urinary Na-to-K ratio (> 2.37 vs. < 1.49) was related to lower intakes of vegetables (282 vs. 321 g/day), low-fat dairy (228 vs. 260 g/day) and fruits (440 vs. 370 g/day). Western dietary pattern was related to higher urinary Na-to-K ratio (β = 0.06; 95% CI 0.01, 0.16). Traditional dietary pattern, Mediterranean and DASH diet scores were inversely associated with urinary Na-to-K ratio (β = − 0.14; 95% CI − 0.24, − 0.11, β = − 0.07; 95% CI − 0.09, − 0.01, β = − 0.12; 95% CI − 0.05, − 0.02, respectively). Conclusions Spot urinary Na-to-K ratio may be used as a simple and inexpensive method to monitor diet quality in population-based epidemiological studies.

scholarly journals Association Between Dietary Pattern and Perceived Stress

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 430-430
Author(s):  
Casey McKenna ◽  
Gerard Dempsey ◽  
Michael Colabelli ◽  
Tharsana Kumarasivam ◽  
Rachel Molzon ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
Stress Response ◽  
Mediterranean Diet ◽  
Perceived Stress ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Healthy Lifestyle ◽  
Principal Component ◽  
Component Analysis ◽  
The Mediterranean

Abstract Objectives Recent evidence is pointing toward the effect of nutrients on neurotransmission. Therefore, dietary patterns may impact the stress response as well as mental wellbeing. This study aims to investigate the relationship between dietary patterns and perceived stress as a way to shed light on the impact of diet quality on psychological stress. Methods An anonymous questionnaire combining three validated scales was distributed through several social media platforms. The questionnaire included the Food-Mood Questionnaire, the Perceived Stress Scale, and the Kessler-6 scale as well as questions assessing frequency of consumption of various tyrosine-rich foods. Inclusion criteria included adults 18 years old or older. Results were analyzed using Spearman's Rho correlation and principal component analysis using SPSS Version 24.0. Results Our results indicated that several components of the Mediterranean diet such as whole grains (P &lt; 0.05), dark green leafy vegetables (P &lt; 0.01), fish (P &lt; 0.01), beans (P &lt; 0.05), and red lean meat (P &lt; 0.01) were negatively correlated with perceived stress total score. Fast food was positively correlated with perceived stress total score (P &lt; 0.01). The principal component analysis identified 3 components: a healthy dietary pattern, a healthy lifestyle, and an unhealthy dietary pattern. Interestingly, a healthy lifestyle, which shared multiple components with the Mediterranean diet, was inversely related to perceived stress total score and mental distress total score. Conclusions Our findings suggest that a dietary pattern similar to the Mediterranean diet may be associated with a lower perceived stress response. Funding Sources None.

scholarly journals Effect of a Mediterranean diet intervention on gastrointestinal function in Parkinson’s disease (the MEDI-PD study): study protocol for a randomised controlled trial

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e053336
Author(s):  
Carley Rusch ◽  
Matthew Beke ◽  
Lily Tucciarone ◽  
Katherine Dixon ◽  
Carmelo Nieves Jr. ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mediterranean Diet ◽  
Rating Scale ◽  
Standard Of Care ◽  
Stool Frequency ◽  
Diet Intervention ◽  
Quality Life ◽  
The Mediterranean ◽  
Randomised Controlled

IntroductionConstipation is a common and sometimes debilitating non-motor symptom of Parkinson’s disease (PD) that can result in intestinal inflammation and microbial dysbiosis. The Mediterranean diet, rich in fermentable fibres and anti-inflammatory phenolic compounds, is associated with reduced risk of developing PD and slower progression of parkinsonism. The Mediterranean diet is often recommended for people with PD; however, no studies to date examine this diet as a therapeutic intervention to modulate gastrointestinal (GI) dysfunction.Methods and analysisThis is a randomised, controlled, parallel study. During a 2-week run-in, participants with PD and constipation symptoms (n=52) will undergo baseline nutritional and neurological assessments and provide a stool sample. Participants will be stratified by sex and Hoehn and Yahr stage and randomised to follow standard of care for constipation (control) or standard of care plus a Mediterranean diet (intervention) for 8 weeks. A study dietitian will provide dietary instruction and weekly follow-up via telephone to both groups to support adherence and monitor adverse events. Questionnaires will assess dietary intake and GI function including stool frequency, form, symptoms and laxative usage. Measurements completed at baseline will be repeated at 4 and 8 weeks of the intervention. The primary outcome is to evaluate the difference between mean change (final–baseline) in Gastrointestinal Symptom Rating Scale (GSRS) constipation syndrome scores for the control versus intervention groups. Secondary outcomes will assess stool frequency and form, weekly GSRS syndrome scores, digestive quality of life, laxative usage, faecal microbial communities and inflammatory markers, anxiety, depression, quality life, body weight and composition, dietary fibre intake and Mediterranean diet adherence.Ethics and disseminationThe study has received University of Florida Institutional Review Board-01 approval (IRB202001333). Findings will be disseminated via conference presentations, lectures and peer-reviewed publications.Trial registration numberNCT04683900.

Homocysteine Levels Show Significant Differences among Mediterranean Dietary Quality Index Variables Compared to Folate and Vitamin B12 Status in Women

2015 ◽  
Vol 85 (3-4) ◽  
pp. 202-210 ◽  
Author(s):  
Ivona Višekruna ◽  
Ivana Rumbak ◽  
Ivana Rumora Samarin ◽  
Irena Keser ◽  
Jasmina Ranilović
Keyword(s):  
Mediterranean Diet ◽  
Diet Quality ◽  
Quality Index ◽  
Fruits And Vegetables ◽  
Reproductive Age ◽  
Dietary Quality ◽  
Vitamin B ◽  
Cross Sectional ◽  
Poor Diet ◽  
The Mediterranean

Abstract. Results of epidemiologic studies and clinical trials have shown that subjects following the Mediterranean diet had lower inflammatory markers such as homocysteine (Hcy). Therefore, the aim of this cross-sectional study was to assess female diet quality with the Mediterranean diet quality index (MDQI) and to determine the correlation between MDQI, homocysteine, folate and vitamin B12 levels in the blood. The study participants were 237 apparently healthy women (96 of reproductive age and 141 postmenopausal) between 25 and 93 years. For each participant, 24-hour dietary recalls for 3 days were collected, MDQI was calculated, and plasma Hcy, serum and erythrocyte folate and vitamin B12 levels were analysed. Total MDQI ranged from 8 to 10 points, which represented a medium-poor diet for the subjects. The strength of correlation using biomarkers, regardless of group type, age, gender and other measured parameters, was ranked from best (0.11) to worst (0.52) for olive oil, fish, fruits and vegetables, grains, and meat, in this order. Hcy levels showed the best response among all markers across all groups and food types. Our study shows significant differences between variables of the MDQI and Hcy levels compared to levels of folate and vitamin B12 in participants with medium-poor diet quality, as evaluated according to MDQI scores.

Migraine is related to an increased risk of Parkinson’s disease: A population-based, propensity score-matched, longitudinal follow-up study

Cephalalgia ◽  
2016 ◽  
Vol 36 (14) ◽  
pp. 1316-1323 ◽  
Author(s):  
Hsin-I Wang ◽  
Yu-Chun Ho ◽  
Ya-Ping Huang ◽  
Shin-Liang Pan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Survival Rate ◽  
Propensity Score ◽  
Population Based ◽  
Free Survival ◽  
Follow Up Study ◽  
Increased Risk ◽  
Migraine Group

Background The association between migraine and Parkinson’s disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD. Methods A total of 41,019 subjects aged between 40 and 90 years with at least two ambulatory visits with a diagnosis of migraine in 2001 were enrolled in the migraine group. A logistic regression model that included age, sex, pre-existing comorbidities and socioeconomic status as covariates was used to compute the propensity score. The non-migraine group consisted of 41,019 propensity score-matched, randomly sampled subjects without migraine. The PD-free survival rate were estimated using the Kaplan–Meier method. Stratified Cox proportional hazard regression was used to estimate the effect of migraine on the risk of developing PD. Results During follow-up, 148 subjects in the migraine group and 101 in the non-migraine group developed PD. Compared to the non-migraine group, the hazard ratio of PD for the migraine group was 1.64 (95% confidence interval: 1.25–2.14, p = 0.0004). The PD-free survival rate for the migraine group was significantly lower than that for the non-migraine group ( p = 0.0041). Conclusions This study showed an increased risk of developing PD in patients with migraine.

scholarly journals Trend of recognizing depression symptoms and antidepressants use in newly diagnosed Parkinson's disease: Population‐based study

2021 ◽  
Author(s):  
Khalid Orayj ◽  
Tahani Almeleebia ◽  
Easwaran Vigneshwaran ◽  
Sultan Alshahrani ◽  
Sirajudeen. S. Alavudeen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Population Based ◽  
Depression Symptoms ◽  
Newly Diagnosed ◽  
Population Based Study

scholarly journals Special Issue “Mediterranean Diet and Metabolic Diseases”

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2680
Author(s):  
Emmanuella Magriplis ◽  
Michail Chourdakis
Keyword(s):  
Mediterranean Diet ◽  
Dietary Patterns ◽  
Metabolic Diseases ◽  
Special Issue ◽  
Beneficial Effects ◽  
The Mediterranean

The Mediterranean diet (MD) has been considered among the healthiest dietary patterns since a little over 50 years ago, Ancel Keys—as the key figure—provided evidence for the beneficial effects of the MD [...]

Sign in / Sign up

Export Citation Format

Share Document