scholarly journals Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer

2019 ◽  
Vol 12 (2) ◽  
pp. 87 ◽  
Author(s):  
Surinder M. Soond ◽  
Maria V. Kozhevnikova ◽  
Paul A. Townsend ◽  
Andrey A. Zamyatnin
Keyword(s):  
Cancer Therapy ◽  
Cancer Diagnosis ◽  
Therapeutic Potential ◽  
Basic Research ◽  
Protease Inhibition ◽  
Cysteine Cathepsin ◽  
Recent Developments ◽  
Therapeutic Development ◽  
Cathepsin Protease ◽  
Areas Of Interest

In keeping with recent developments in basic research; the importance of the Cathepsins as targets in cancer therapy have taken on increasing importance and given rise to a number of key areas of interest in the clinical setting. In keeping with driving basic research in this area in a translational direction; recent findings have given rise to a number of exciting developments in the areas of cancer diagnosis; prognosis and therapeutic development. As a fast-moving area of research; the focus of this review brings together the latest findings and highlights the translational significance of these developments.

scholarly journals Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Jong-Min Lee ◽  
Tae-Jong Yoon ◽  
Young-Seok Cho
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Potential ◽  
Sirna Delivery ◽  
Molecular Therapy ◽  
Specific Gene ◽  
Regulation Mechanism ◽  
Rna Molecules ◽  
Effective Delivery ◽  
Recent Developments

RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that enables sequence-specific gene silencing by promoting degradation of specific mRNAs. Molecular therapy using small interfering RNA (siRNA) has shown great therapeutic potential for diseases caused by abnormal gene overexpression or mutation. The major challenges to application of siRNA therapeutics include the stability and effective delivery of siRNAin vivo. Important progress in nanotechnology has led to the development of efficient siRNA delivery systems. In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery and the application of siRNA in clinical trials for cancer therapy. This review will also offer perspectives on future applications of siRNA therapeutics.

The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations

2019 ◽  
Vol 26 (13) ◽  
pp. 2330-2355 ◽  
Author(s):  
Anutthaman Parthasarathy ◽  
Sasikala K. Anandamma ◽  
Karunakaran A. Kalesh
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Therapeutic Potential ◽  
The Past ◽  
Recombinant Production ◽  
Tremendous Progress ◽  
Recent Developments ◽  
Therapeutic Peptides ◽  
Development Processes ◽  
Delivery Strategies

Peptide therapeutics has made tremendous progress in the past decade. Many of the inherent weaknesses of peptides which hampered their development as therapeutics are now more or less effectively tackled with recent scientific and technological advancements in integrated drug discovery settings. These include recent developments in synthetic organic chemistry, high-throughput recombinant production strategies, highresolution analytical methods, high-throughput screening options, ingenious drug delivery strategies and novel formulation preparations. Here, we will briefly describe the key methodologies and strategies used in the therapeutic peptide development processes with selected examples of the most recent developments in the field. The aim of this review is to highlight the viable options a medicinal chemist may consider in order to improve a specific pharmacological property of interest in a peptide lead entity and thereby rationally assess the therapeutic potential this class of molecules possesses while they are traditionally (and incorrectly) considered ‘undruggable’.

Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways

2019 ◽  
Vol 14 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Cong Tang ◽  
Guodong Zhu
Keyword(s):  
Cancer Therapy ◽  
Tyrosine Kinase ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Cell Receptor ◽  
Transmembrane Receptors ◽  
Biological Responses ◽  
Different Types

The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a major role in oncogenesis as well as its well-known function in the regulation of immune responses and inflammation. Therefore, we made a review of the diverse molecular mechanisms by which the NF-κB pathway is constitutively activated in different types of human cancers and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. We also discussed various pharmacological approaches employed to target the deregulated NF-κB signaling pathway and their possible therapeutic potential in cancer therapy. Moreover, Syk (Spleen tyrosine kinase), non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immune-receptors like the B-cell receptor (BCR), which can also activate the inflammasome and NF-κB-mediated transcription of chemokines and cytokines in the presence of pathogens would be discussed as well. The highlight of this review article is to summarize the classic and novel signaling pathways involved in NF-κB and Syk signaling and then raise some possibilities for cancer therapy.

scholarly journals Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 395
Author(s):  
Aikaterini Berdiaki ◽  
Monica Neagu ◽  
Eirini-Maria Giatagana ◽  
Andrey Kuskov ◽  
Aristidis M. Tsatsakis ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Academic Research ◽  
Cancer Therapeutics ◽  
Disease Evolution ◽  
Structure Changes ◽  
Recent Developments ◽  
Distribution Composition ◽  
Membrane Components ◽  
Cancer Tissues

The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded by the components of the extracellular matrix (ECM). Glycosaminoglycans (GAGs), natural biomacromolecules, essential ECM, and cell membrane components are extensively altered in cancer tissues. During disease progression, the GAG fine structure changes in a manner associated with disease evolution. Thus, changes in the GAG sulfation pattern are immediately correlated to malignant transformation. Their molecular weight, distribution, composition, and fine modifications, including sulfation, exhibit distinct alterations during cancer development. GAGs and GAG-based molecules, due to their unique properties, are suggested as promising effectors for anticancer therapy. Considering their participation in tumorigenesis, their utilization in drug development has been the focus of both industry and academic research efforts. These efforts have been developing in two main directions; (i) utilizing GAGs as targets of therapeutic strategies and (ii) employing GAGs specificity and excellent physicochemical properties for targeted delivery of cancer therapeutics. This review will comprehensively discuss recent developments and the broad potential of GAG utilization for cancer therapy.

scholarly journals Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

Oncotarget ◽  
2015 ◽  
Vol 6 (42) ◽  
pp. 44179-44190 ◽  
Author(s):  
Xiang-Jun Tang ◽  
Xu-Yong Sun ◽  
Kuan-Ming Huang ◽  
Li Zhang ◽  
Zhuo-Shun Yang ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Therapy ◽  
Therapeutic Potential ◽  
Targeted Cancer Therapy ◽  
Car T Cell ◽  
Car T ◽  
A Cell

scholarly journals Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1713 ◽  
Author(s):  
Timothy A. McKinsey ◽  
Thomas M. Vondriska ◽  
Yibin Wang
Keyword(s):  
Heart Failure ◽  
Therapeutic Potential ◽  
Noncoding Rnas ◽  
Loss Of Function ◽  
Sequencing Technologies ◽  
Recent Developments ◽  
Non Coding Rnas ◽  
Epigenomic Regulation ◽  
Generation Sequencing ◽  
Epigenetic Processes

Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the pathogenesis of cardiac disease in adults. Investigations using genetic and pharmacologic gain- and loss-of-function approaches have interrogated the function of distinct epigenetic regulators, while the increased deployment of the suite of next-generation sequencing technologies have fundamentally altered our understanding of the genomic targets of these chromatin modifiers. Here, we review recent developments in basic and translational research that have provided tantalizing clues that may be used to unlock the therapeutic potential of the epigenome in heart failure. Additionally, we provide a hypothesis to explain how signal-induced crosstalk between histone tail modifications and long non-coding RNAs triggers chromatin architectural remodeling and culminates in cardiac hypertrophy and fibrosis.

Therapeutic potential of algal natural products against metabolic syndrome: A review of recent developments

2020 ◽  
Vol 97 ◽  
pp. 286-299 ◽  
Author(s):  
Ilekuttige Priyan Shanura Fernando ◽  
BoMi Ryu ◽  
Ginnae Ahn ◽  
In-Kyu Yeo ◽  
You-Jin Jeon
Keyword(s):  
Metabolic Syndrome ◽  
Natural Products ◽  
Therapeutic Potential ◽  
Recent Developments

scholarly journals Navigating the Crossroads of Cell Therapy and Natural Heart Regeneration

2021 ◽  
Vol 9 ◽  
Author(s):  
Stefan Elde ◽  
Hanjay Wang ◽  
Y. Joseph Woo
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Trials ◽  
Cell Therapy ◽  
Cause Of Death ◽  
Natural Regeneration ◽  
Therapeutic Potential ◽  
Myocardial Regeneration ◽  
Heart Regeneration ◽  
Recent Developments

Cardiovascular disease remains the leading cause of death worldwide despite significant advances in our understanding of the disease and its treatment. Consequently, the therapeutic potential of cell therapy and induction of natural myocardial regeneration have stimulated a recent surge of research and clinical trials aimed at addressing this challenge. Recent developments in the field have shed new light on the intricate relationship between inflammation and natural regeneration, an intersection that warrants further investigation.

scholarly journals From Translation Studies and audiovisual translation to media accessibility

Target ◽  
2016 ◽  
Vol 28 (2) ◽  
pp. 248-260 ◽  
Author(s):  
Aline Remael ◽  
Nina Reviers ◽  
Reinhild Vandekerckhove
Keyword(s):  
Speech Recognition ◽  
Basic Research ◽  
Translation Studies ◽  
Hybrid Form ◽  
Audio Description ◽  
Translation Practice ◽  
Recent Developments ◽  
Key Issues ◽  
The One

Abstract Recent developments in Translation Studies and translation practice have not only led to a profusion of approaches, but also to the development of new text forms and translation modes. Media Accessibility, particularly audio description (AD) and subtitling for the deaf and hard-of-hearing (SDH), is an example of such a ‘new’ mode. SDH has been evolving quickly in recent decades and new developments such as interlingual SDH and live subtitling with speech recognition bring it closer to established forms of translation and interpreting. On the one hand, interlingual SDH reintroduces Jakobson’s (1959) ‘translation proper’ while the use of speech recognition has led to the creation of a hybrid form that has affinities with both subtitling and interpreting. Audio description, for its part, cannot even be fitted into Jakobson’s ‘intersemiotic translation’ model since it involves translation from images into words. Research into AD is especially interesting since it rallies methods from adjacent disciplines, much in the same way that Holmes ([1972] 1988) described TS when it was a fledgling discipline. In 2008, Braun set out a research agenda for AD and the wealth of topics and research approaches dealt with in her article illustrate the immense complexity of this field and the work still to be done. Although AD and SDH research have developed at different paces and are concerned with different topics, converging trends do appear. Particularly the role of technology and the concept of multimodality seem to be key issues. This article aims to give an overview of current research trends in both these areas. It illustrates the possibilities of technology-driven research – particularly popular in SDH and live-subtitling research – while at the same time underlining the value of individual, human-driven approaches, which are still the main ‘modus operandi’ in the younger discipline of AD where much basic research is still required.

Sustainability in Higher Education through Basic Science Research

2012 ◽  
pp. 56-66
Author(s):  
P. Yogeeswari ◽  
D. Sriram
Keyword(s):  
Higher Education ◽  
Basic Science ◽  
Basic Research ◽  
Science Research ◽  
Medical Sciences ◽  
Industrial Growth ◽  
Non Profit ◽  
Social Sciences And Humanities ◽  
Basic Science Research ◽  
Recent Developments

Basic research in Universities is essential for a sustainable development. Recent developments in higher education have seen the inclusion of curiculum redesigned to serve the concept of developming young minds in the intrepretation, execution, and use of basic science research. The challenge for educators is to “demystify” research and teach in ways that are professionally meaningful as well as intellectually acceptable. The objective of this chapter is to bring in various case studies to prove the essentiality of basic research in higher education with specific concern over pharmaceutical industrial growth plans. Data on R&D in higher education can be broken down by field of science (natural sciences, engineering, medical sciences, agricultural sciences, social sciences, and humanities), by type of costs (current expenditures, capital expenditures), and by source of funds (business enterprise, government, higher education, private non-profit, and funds from abroad). Measures of R&D performance in the higher education sector are often estimated by national authorities, and evaluation methods are periodically revised. It is necessary to review the design and conduct of higher education R&D surveys to improve the comparability of these indicators.

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