scholarly journals The Role of Counter-Ions in Peptides—An Overview

2020 ◽  
Vol 13 (12) ◽  
pp. 442
Author(s):  
Karol Sikora ◽  
Maciej Jaśkiewicz ◽  
Damian Neubauer ◽  
Dorian Migoń ◽  
Wojciech Kamysz
Keyword(s):  
Mobile Phase ◽  
Analytical Techniques ◽  
Drug Formulation ◽  
Biological Processes ◽  
Multiple Functions ◽  
Mobile Phase Additives ◽  
Counter Ions ◽  
Living Organisms ◽  
The Impact

Peptides and proteins constitute a large group of molecules that play multiple functions in living organisms. In conjunction with their important role in biological processes and advances in chemical approaches of synthesis, the interest in peptide-based drugs is still growing. As the side chains of amino acids can be basic, acidic, or neutral, the peptide drugs often occur in the form of salts with different counter-ions. This review focuses on the role of counter-ions in peptides. To date, over 60 peptide-based drugs have been approved by the FDA. Based on their area of application, biological activity, and results of preliminary tests they are characterized by different counter-ions. Moreover, the impact of counter-ions on structure, physicochemical properties, and drug formulation is analyzed. Additionally, the application of salts as mobile phase additives in chromatographic analyses and analytical techniques is highlighted.

scholarly journals The Origin and Evolution of Language and the Propagation of Organization

1970 ◽  
Vol 5 (2) ◽  
pp. 75-81 ◽  
Author(s):  
Robert K. Logan
Keyword(s):  
Knowledge Management ◽  
New Media ◽  
Evolution Of Language ◽  
Origin And Evolution ◽  
Language And Culture ◽  
Origin Of Language ◽  
Engineering Problems ◽  
Living Organisms ◽  
The Impact

In this presentation we will study propagating organization. We begin by examining the evolution and origin of language by briefly reviewing the impact of the phonetic alphabet (Logan 2004a), the evolution of notated language (Logan 2004b), the origin of language and culture (Logan 2006, 2007), the role of collaboration in knowledge management (Logan and Stokes 2004), the impact of “new media” (Logan in preparation). We will then connect this work to the propagating organization of all living organisms (Kauffman et al. in press) where we will show that information in biotic systems are the constraints that instruct living organisms how to operate. We will demonstrate that instructional or biotic information is quite different than the classical notion of information Shannon developed for addressing engineering problems in telecommunications. We also will show that biosemiosis is in some sense equivalent to propagating organization (Kauffman et al. in press). We then conclude our presentation with the speculation that there exist at least seven levels of biosemiosis.

scholarly journals Mutational Signatures as Sensors of Environmental Exposures: Role of Smoking in COVID-19 Vulnerabilities

2021 ◽  
Author(s):  
Yoo-Ah Kim ◽  
Ermin Hodzic ◽  
Ariella Saslafsky ◽  
Damian Wojtowicz ◽  
Bayarbaatar Amgalan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Environmental Factors ◽  
Disease Progression ◽  
Environmental Exposures ◽  
Biological Processes ◽  
Mutational Signatures ◽  
Mutational Signature ◽  
The Impact ◽  
Pathway Level

Background: Environmental exposures such as smoking are widely recognized risk factors in the emergence of lung diseases such as lung cancer and acute respiratory distress syndrome (ARDS). However, the strength of environmental exposures is difficult to measure, making it challenging to understand their impacts. On the other hand, some COVID-19 patients develop ARDS in an unfavorable disease progression and smoking has been suggested as a potential risk factor among others. Yet initial studies on COVID-19 cases reported contradictory results on the effects of smoking on the disease. Some suggest that smoking might have a protective effect against it while other studies report an increased risk. A better understanding of how the exposure to smoking and other environmental factors affect biological processes relevant to SARS-CoV-2 infection and unfavorable disease progression is needed. Approach: In this study, we utilize mutational signatures associated with environmental factors as sensors of their exposure level. Many environmental factors including smoking are mutagenic and leave characteristic patterns of mutations, called mutational signatures, in affected genomes. We postulated that analyzing mutational signatures, combined with gene expression, can shed light on the impact of the mutagenic environmental factors to the biological processes. In particular, we utilized mutational signatures from lung adenocarcinoma (LUAD) data set collected in TCGA to investigate the role of environmental factors in COVID-19 vulnerabilities. Integrating mutational signatures with gene expression in normal tissues and using a pathway level analysis, we examined how the exposure to smoking and other mutagenic environmental factors affects the infectivity of the virus and disease progression. Results: By delineating changes associated with smoking in pathway-level gene expression and cell type proportions, our study demonstrates that mutational signatures can be utilized to study the impact of exogenous mutagenic factors on them. Consistent with previous findings, our analysis showed that smoking mutational signature (SBS4) is associated with activation of cytokines mediated singling pathways, leading to inflammatory responses. Smoking related changes in cell composition were also observed, including the correlation of SBS4 with the expansion of goblet cells. On the other hand, increased basal cells and decreased ciliated cells in proportion were associated with the strength of a different mutational signature (SBS5), which is present abundantly but not exclusively in smokers. In addition, we found that smoking increases the expression levels of genes that are upregulated in severe COVID-19 cases. Jointly, these results suggest an unfavorable impact of smoking on the disease progression and also provide novel findings on how smoking impacts biological processes in lung.

scholarly journals A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion

2021 ◽  
Vol 8 ◽  
Author(s):  
Soudeh Ghafouri-Fard ◽  
Tayyebeh Khoshbakht ◽  
Bashdar Mahmud Hussen ◽  
Mohammad Taheri ◽  
Mohammad Samadian
Keyword(s):  
Cell Proliferation ◽  
Present Review ◽  
Molecular Pathways ◽  
Biological Processes ◽  
Affect Expression ◽  
Non Coding Rnas ◽  
The Impact

MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from MIR1290 gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of in vitro, animal and human investigations about the impact of miR-1290 in the development of malignancies.

scholarly journals Effect of Surface Roughness on Aggregation of Polypeptide Chains: A Monte Carlo Study

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 596
Author(s):  
Nguyen Truong Co ◽  
Mai Suan Li
Keyword(s):  
Surface Roughness ◽  
Self Assembly ◽  
Molecular Mechanisms ◽  
Monte Carlo Study ◽  
The Self ◽  
Living Organisms ◽  
Polypeptide Chains ◽  
The Impact ◽  
Kinetics Of

The self-assembly of amyloidogenic peptides and proteins into fibrillar structures has been intensively studied for several decades, because it seems to be associated with a number of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. Therefore, understanding the molecular mechanisms of this phenomenon is important for identifying an effective therapy for the corresponding diseases. Protein aggregation in living organisms very often takes place on surfaces like membranes and the impact of a surface on this process depends not only on the surface chemistry but also on its topology. Our goal was to develop a simple lattice model for studying the role of surface roughness in the aggregation kinetics of polypeptide chains and the morphology of aggregates. We showed that, consistent with the experiment, an increase in roughness slows down the fibril formation, and this process becomes inhibited at a very highly level of roughness. We predicted a subtle catalytic effect that a slightly rough surface promotes the self-assembly of polypeptide chains but does not delay it. This effect occurs when the interaction between the surface and polypeptide chains is moderate and can be explained by taking into account the competition between energy and entropy factors.

scholarly journals Impact of temperature and photoperiod on survival and biomarkers of senescence in common woodlouse

2018 ◽  
Author(s):  
Charlotte Depeux ◽  
Ascel Samba-Louaka ◽  
Christine Braquart-Varnier ◽  
Jérôme Moreau ◽  
Jean-François Lemaître ◽  
...  
Keyword(s):  
Experimental Design ◽  
Environmental Factors ◽  
Environmental Conditions ◽  
Opposite Effect ◽  
Experimental Approach ◽  
Galactosidase Activity ◽  
Age Related ◽  
Living Organisms ◽  
The Impact

AbstractMost living organisms display a decline in physiological performances when ageing, a process called senescence that is most often associated with increased mortality risk. Previous researches have shown that both the timing and the intensity of senescence vary a lot within and among species, but the role of environmental factors in this variation is still poorly understood. To fill this knowledge gap, we investigated the impact of environmental conditions on the strength of senescence using an experimental design applied to a population of common woodlouse Armadillidium vulgare intensively monitored in the lab. Cellular senescence biomarkers are available in woodlouse and are age-related. These biomarkers provide relevant biomarkers to test the impact of environmental conditions, through changes in temperature and photoperiod, on individuals of the same age maintained in different environmental conditions. We found different effects of the environmental changing: the increasing of day light modification leaded the same effect as age on our senescence biomarkers while temperature modifications leaded the opposite effect as age on the β-galactosidase activity and cell size. We also demonstrated the existence of sex-specific responses to changes in environmental conditions. By using an experimental approach and biomarkers of senescence in woodlouse, we show that environmental conditions and sex both shape the diversity observed in senescence patterns of woodlouse and underline the importance of identifying senescence biomarkers to understand how environmental conditions influence the evolution of senescence.

scholarly journals The Origin and Evolution of Language and the Propagation of Organization

1970 ◽  
Vol 5 (2) ◽  
pp. 75-81
Author(s):  
Robert K. Logan
Keyword(s):  
Knowledge Management ◽  
New Media ◽  
Evolution Of Language ◽  
Origin And Evolution ◽  
Language And Culture ◽  
Origin Of Language ◽  
Engineering Problems ◽  
Living Organisms ◽  
The Impact

In this presentation we will study propagating organization. We begin by examining the evolution and origin of language by briefly reviewing the impact of the phonetic alphabet (Logan 2004a), the evolution of notated language (Logan 2004b), the origin of language and culture (Logan 2006, 2007), the role of collaboration in knowledge management (Logan and Stokes 2004), the impact of “new media” (Logan in preparation). We will then connect this work to the propagating organization of all living organisms (Kauffman et al. in press) where we will show that information in biotic systems are the constraints that instruct living organisms how to operate. We will demonstrate that instructional or biotic information is quite different than the classical notion of information Shannon developed for addressing engineering problems in telecommunications. We also will show that biosemiosis is in some sense equivalent to propagating organization (Kauffman et al. in press). We then conclude our presentation with the speculation that there exist at least seven levels of biosemiosis.

scholarly journals THE IMPACT OF "WASTENET PROJECT" ON THE ECOLOGY OF TURKEY AND GEORGIA

2015 ◽  
Vol 12 (23) ◽  
pp. 39-46
Author(s):  
Burak KIZILOZ ◽  
Ketevan KUPATADZE
Keyword(s):  
Black Sea ◽  
Waste Water Treatment ◽  
The Black Sea ◽  
Biological Processes ◽  
Black Sea Region ◽  
Natural Treatment Systems ◽  
Natural Treatment ◽  
Regional Authorities ◽  
The Impact

The article describes the project: “A Black Sea network promoting integrated natural Waste water treatment systems – WASTEnet,” which is dedicated to wastewater treatment systems. There is given a discussion of all types of Natural Treatment Systems, their specificity, chemical and biological processes which take place during their functioning. There is shown the impact of this Project and NTS on the example of ecology of Turkey and Georgia. The presented Project helps local and regional authorities and stakeholders to gain insight on the role of innovative and environmentally-friendly technologies, in improving the environment of the Black Sea region.

Development of Hydrologic Concepts in the Northeastern United States

1983 ◽  
Vol 2 (2) ◽  
pp. 165-168
Author(s):  
Martina Johnson
Keyword(s):  
United States ◽  
Analytical Techniques ◽  
The United States ◽  
Northeastern United States ◽  
Mineral Springs ◽  
Erie Canal ◽  
Therapeutic Benefits ◽  
The Impact ◽  
The Relationship

Significant contributions to hydrogeology from the Northeastern United States have resulted from studies of natural phenomena, the occurrence of mineral springs, and two man-made events - the drilling in 1824 of the first fresh water well in the U.S., and the building of the Erie Canal. Development of chemical analytical techniques was prompted by interest in the therapeutic benefits of Saratoga and similar mineral springs, which were used as spas and sources of bottled water. The fundamental concept that the chemical character of ground water is controlled by lithology and by source and movement of water evolved from efforts to explain the origin and chemical differences of springs that were believed to have different medicinal benefits. The first drilled well, at the mouth of the Raritan River, led to the study of saltwater encroachment in the United States. The concept that explains the relationship between freshwater head and the position of the saltwater interface was developed to explain the ebbing and flowing of the well. Although the early hydrologic work was undertaken primarily by chemists and engineers, it was largely the challenge of understanding the position and movement of the saltwater interface that required the talents of geologists from whose studies evolved fundamental hydrogeologic concepts. Even now, evaluation of the role of the zone of dispersion in diagenesis, ore deposition, and geomorphic processes is at the forefront of hydrogeologic research. The building of the Erie Canal demonstrated the delicate ecologic balance of water systems and the need to anticipate the impact of man-made structures on this balance. Hydrologic engineering was advanced during its construction owing to the challenge of controlling the volume of water as well as its depth and velocity.

scholarly journals Impact of D2O on peptidization of l-proline

2019 ◽  
Vol 128 (2) ◽  
pp. 599-610 ◽  
Author(s):  
Agnieszka Fulczyk ◽  
Eliza Łata ◽  
Ewa Talik ◽  
Teresa Kowalska ◽  
Mieczysław Sajewicz
Keyword(s):  
Heavy Water ◽  
High Performance ◽  
Quantitative Result ◽  
Analytical Techniques ◽  
Water Solvent ◽  
Light Scattering Detection ◽  
Aqueous Solvent ◽  
Evaporative Light Scattering ◽  
The Impact

Abstract This is our follow-up study carried out in an order to collect experimental evidence regarding the impact of heavy water (D2O) on the spontaneous oscillatory peptidization of l-proline (l-Pro). Our earlier studies have been focused on the two sulfur-containing proteinogenic α-amino acids, i.e., l-cysteine (l-Cys) and l-methionine (l-Met), and it seemed interesting to assess the effect induced by D2O on one more proteinogenic α-amino acid, i.e., l-Pro. It needs to be added that unlike l-Met, but similar to l-Cys, the oscillatory peptidization of l-Pro dissolved in the organic-aqueous solvent characterizes with the circadian rhythm. As analytical techniques, we used high-performance liquid chromatography with the evaporative light-scattering detection (HPLC-ELSD), mass spectrometry (MS), scanning electron microscopy (SEM), and turbidimetry. The obtained results can in certain sense be viewed as analogous to those earlier reported for l-Cys and l-Met by demonstrating that heavy water considerably hampers the oscillatory peptidization of l-Pro. However, an unexpected observation was also made than unlike the cases with l-Cys and l-Met, the observed hampering effect of D2O on the oscillatory peptidization of l-Pro is not monotonously dependent on the concentration of D2O in the system, but it is the strongest pronounced for 10% (v/v) D2O in the employed binary methanol–water solvent (with the investigated proportions of D2O in this solvent changing from 0 to 30%). Although we have no rational explanation for this striking effect, we believe that it should not pass unnoticed and therefore it is emphasized in this study. Maybe this firm quantitative result will prove an inspiration for future researchers interested in getting a deeper insight into the role of D2O in life processes, and more specifically in the kinetic and the mechanistic aspects thereof.

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