scholarly journals 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals

2021 ◽  
Vol 14 (4) ◽  
pp. 362
Author(s):  
Paula Gabriela Manita ◽  
Itxaso Garcia-Orue ◽  
Edorta Santos-Vizcaino ◽  
Rosa Maria Hernandez ◽  
Manoli Igartua
Keyword(s):  
Point Of View ◽  
3D Bioprinting ◽  
Skin Substitutes ◽  
Basic Principles ◽  
Production Methods ◽  
Innovative Strategies ◽  
Physical Support ◽  
Future Goals ◽  
Clinical Point ◽  
3D Printed

The aim of this review is to present 3D bioprinting of skin substitutes as an efficient approach of managing skin injuries. From a clinical point of view, classic treatments only provide physical protection from the environment, and existing engineered scaffolds, albeit acting as a physical support for cells, fail to overcome needs, such as neovascularisation. In the present work, the basic principles of bioprinting, together with the most popular approaches and choices of biomaterials for 3D-printed skin construct production, are explained, as well as the main advantages over other production methods. Moreover, the development of this technology is described in a chronological manner through examples of relevant experimental work in the last two decades: from the pioneers Lee et al. to the latest advances and different innovative strategies carried out lately to overcome the well-known challenges in tissue engineering of skin. In general, this technology has a huge potential to offer, although a multidisciplinary effort is required to optimise designs, biomaterials and production processes.

3D Bioprinting of Functional Skin Substitutes for Chronic Wound Treatment: From Current Achievements to Future Goals

2020 ◽  
Author(s):  
Paula Gabriela Maniţă ◽  
Itxaso García-Orue ◽  
Edorta Santos-Vizcaíno ◽  
Rosa María Hernández ◽  
Manoli Igartua
Keyword(s):  
Chronic Wound ◽  
Wound Treatment ◽  
3D Bioprinting ◽  
Skin Substitutes ◽  
Future Goals

Methods of Network Planning and Management when Implementing Territory Planning Projects

2019 ◽  
pp. 49-54
Keyword(s):  
Large Scale ◽  
Housing Stock ◽  
Network Planning ◽  
Network Models ◽  
Point Of View ◽  
Residential Areas ◽  
Basic Principles ◽  
Planning And Management ◽  
Planning Project ◽  
Complex Process

The success of the Program of housing stock renovation in Moscow depends on the efficiency of resource management. One of the main urban planning documents that determine the nature of the reorganization of residential areas included in the Program of renovation is the territory planning project. The implementation of the planning project is a complex process that has a time point of its beginning and end, and also includes a set of interdependent parallel-sequential activities. From an organizational point of view, it is convenient to use network planning and management methods for project implementation. These methods are based on the construction of network models, including its varieties – a Gantt chart. A special application has been developed to simulate the implementation of planning projects. The article describes the basic principles and elements of modeling. The list of the main implementation parameters of the Program of renovation obtained with the help of the developed software for modeling is presented. The variants of using the results obtained for a comprehensive analysis of the implementation of large-scale urban projects are proposed.

Basic principles of Russian foreign policy under Vladimir Putin

Upravlenie ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 116-122
Author(s):  
Sadeghi Elham Mir Mohammad ◽  
Ahmad Vakhshitekh
Keyword(s):  
Foreign Policy ◽  
International Relations ◽  
World Order ◽  
Policy Decision ◽  
Point Of View ◽  
Russian Foreign Policy ◽  
National Interests ◽  
Basic Principles ◽  
Interstate Relations ◽  
The Moment

The article considers and analyses the basic principles and directions of Russian foreign policy activities during the presidency of V.V. Putin from the moment of his assumption of the post of head of state to the current presidential term. The authors determine the basic principles of Russia's foreign policy in the specified period and make the assessment to them. The study uses materials from publications of both Russian and foreign authors, experts in the field of political science, history and international relations, as well as documents regulating the foreign policy activities of the highest state authorities. The paper considers the process of forming the priorities of Russia's foreign policy both from the point of view of accumulated historical experience and continuity of the internal order, and in parallel with the processes of transformation of the entire system of international relations and the world order. The article notes the multi-vector nature of Russia's foreign policy strategy aimed at developing multilateral interstate relations, achieving peace and security in the interstate arena, actively countering modern challenges and threats to interstate security, as well as the formation of a multipolar world. The authors conclude that at present, Russia's foreign policy activity is aimed at strengthening Russia's prestige, supporting economic growth and competitiveness, ensuring security and implementing national interests. Internal political reforms contribute to strengthening the political power of the President of the Russian Federation and increasing the efficiency of foreign policy decision-making.

scholarly journals Applications of Additively Manufactured Tools in Abrasive Machining—A Literature Review

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1318
Author(s):  
Mariusz Deja ◽  
Dawid Zieliński ◽  
Aini Zuhra Abdul Kadir ◽  
Siti Nur Humaira
Keyword(s):  
Rapid Tooling ◽  
Rapid Manufacturing ◽  
Abrasive Machining ◽  
Production Methods ◽  
Industrial Environment ◽  
Hard And Brittle Materials ◽  
3D Printed ◽  
Abrasive Tools ◽  
Machine Parts ◽  
Further Development

High requirements imposed by the competitive industrial environment determine the development directions of applied manufacturing methods. 3D printing technology, also known as additive manufacturing (AM), currently being one of the most dynamically developing production methods, is increasingly used in many different areas of industry. Nowadays, apart from the possibility of making prototypes of future products, AM is also used to produce fully functional machine parts, which is known as Rapid Manufacturing and also Rapid Tooling. Rapid Manufacturing refers to the ability of the software automation to rapidly accelerate the manufacturing process, while Rapid Tooling means that a tool is involved in order to accelerate the process. Abrasive processes are widely used in many industries, especially for machining hard and brittle materials such as advanced ceramics. This paper presents a review on advances and trends in contemporary abrasive machining related to the application of innovative 3D printed abrasive tools. Examples of abrasive tools made with the use of currently leading AM methods and their impact on the obtained machining results were indicated. The analyzed research works indicate the great potential and usefulness of the new constructions of the abrasive tools made by incremental technologies. Furthermore, the potential and limitations of currently used 3D printed abrasive tools, as well as the directions of their further development are indicated.

scholarly journals Evaluation of the Ability to Accurately Produce Angular Details by 3D Printing of Plastic Parts

Machines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 150
Author(s):  
Andrei Marius Mihalache ◽  
Gheorghe Nagîț ◽  
Laurențiu Slătineanu ◽  
Adelina Hrițuc ◽  
Angelos Markopoulos ◽  
...  
Keyword(s):  
3D Printing ◽  
Point Of View ◽  
Vertex Angle ◽  
Function Type ◽  
Constant Height ◽  
3D Printers ◽  
3D Printed ◽  
Mathematical Processing ◽  
Plastic Parts

3D printing is a process that has become widely used in recent years, allowing the production of parts with relatively complicated shapes from metallic and non-metallic materials. In some cases, it is challenging to evaluate the ability of 3D printers to make fine details of parts. For such an assessment, the printing of samples showing intersections of surfaces with low angle values was considered. An experimental plan was designed and materialized to highlight the influence of different factors, such as the thickness of the deposited material layer, the printing speed, the cooling and filling conditions of the 3D-printed part, and the thickness of the sample. Samples using areas in the form of isosceles triangles with constant height or bases with the same length, respectively, were used. The mathematical processing of the experimental results allowed the determination of empirical mathematical models of the power-function type. It allowed the detection of both the direction of actions and the intensity of the influence exerted by the input factors. It is concluded that the strongest influence on the printer’s ability to produce fine detail, from the point of view addressed in the paper, is exerted by the vertex angle, whose reduction leads to a decrease in printing accuracy.

scholarly journals Neonatal Birthmarks at the 4 Central Hospitals in Vientiane Capital, Lao PDR

2021 ◽  
Vol 8 ◽  
pp. 2333794X2199090
Author(s):  
Vilounna Sanaphay ◽  
Sourideth Sengchanh ◽  
Alongkone Phengsavanh ◽  
Anousavanh Sanaphay ◽  
Leelawadee Techasatian
Keyword(s):  
Sebaceous Gland ◽  
Neonatal Period ◽  
Lao Pdr ◽  
Skin Lesions ◽  
Medical Advice ◽  
Point Of View ◽  
Parental Anxiety ◽  
Skin Disorders ◽  
Clinical Point ◽  
Therapeutic Procedures

Newborn skin disorders are quite common and happen to occur during the neonatal period. Most of the birthmarks are transient; however, worried parents often seek medical advice from their child’s physician regarding skin lesions. Thus, it is important to differentiate the skin lesions from pathologic ones to avoid unnecessary diagnostic or therapeutic procedures. This is the first published study in Lao neonates that carried out the data from 4 central hospitals in Vientiane Capital, Lao PDR from September 2019 to February 2020. Among 500 neonates, Sebaceous gland hyperplasia (53%), Mongolian patches (46.6%), and Erythema toxicum neonatorum (30%) were the 3 most common cutaneous conditions found in the Lao newborns. From a clinical point of view, these findings are often a source of parental anxiety and medical concern for inexperienced clinicians.

A Dutchman in London: reflections of a hospital chief executive from the Netherlands in the NHS

BMJ Leader ◽  
2021 ◽  
pp. leader-2021-000509
Author(s):  
Marcel Levi
Keyword(s):  
Health Care ◽  
The Netherlands ◽  
Health Care Professionals ◽  
Chief Executive ◽  
Point Of View ◽  
British Society ◽  
The Public ◽  
Interesting Insight ◽  
Clinical Point ◽  
High Level

BackgroundThe NHS is a fascinating health care system and is enjoying a lot of support from all layers of British society. However, it is clear that the system has excellent features but also areas that can be improved.Story of selfA number of years as a chief executive in one of London’s largest hospital has brought me a wealth of impressions, experiences, and understanding about working in the NHS. Contrasting those to my previous experience as chief executive in Amsterdam (The Netherlands) provides an interesting insight.ObservationsVery strong features of the NHS are the high level of health care professionals, the focus on quality and safety, and involvement of patients and the public. However, the NHS can significantly improve by addressing the lack of clinical professionals in the lead, curtailing ever increasing bureaucracy, and reducing its peculiar preference for outsourcing even the most crucial activities to private parties. The frequent inability to swiftly and successfully complete goal-directed negotiations as well as the large but from a clinical point of view irrelevant private sector are areas of sustained bewilderment. Lastly, the drive for innovation and transformation as well as the level of biomedical research in the NHS and supported by the British universities is fascinating and outstanding.

scholarly journals 3D Printed Polymeric Hydrogels for Nerve Regeneration

Polymers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1041 ◽  
Author(s):  
Binoy Maiti ◽  
David Díaz Díaz
Keyword(s):  
Nerve Regeneration ◽  
Nerve Cell ◽  
Clinical Applications ◽  
Cell Regeneration ◽  
3D Bioprinting ◽  
Ability To Regenerate ◽  
3D Printed ◽  
Polymeric Hydrogels ◽  
Human Nervous System

The human nervous system lacks an inherent ability to regenerate its components upon damage or diseased conditions. During the last decade, this has motivated the development of a number of strategies for nerve regeneration. However, most of those approaches have not been used in clinical applications till today. For instance, although biomaterial-based scaffolds have been extensively used for nerve reparation, the lack of more customized structures have hampered their use in vivo. This highlight focuses mainly on how 3D bioprinting technology, using polymeric hydrogels as bio-inks, can be used for the development of new nerve guidance channels or devices for peripheral nerve cell regeneration. In this concise contribution, some of the most recent and representative examples are highlighted to discuss the challenges involved in various aspects of 3D bioprinting for nerve cell regeneration, specifically when using polymeric hydrogels.

scholarly journals Alterações dimensionais em pastas de óxido de zinco/eugenol: um novo método para sua mensuração

2021 ◽  
pp. 39-55
Author(s):  
Léo Werner Süffert ◽  
Ennio Pessôa
Keyword(s):  
Standard Deviation ◽  
Personal Information ◽  
High Variability ◽  
Point Of View ◽  
New Method ◽  
Extensive Review ◽  
Review Of The Literature ◽  
Dimensional Changes ◽  
Impression Materials ◽  
Clinical Point

After an extensive review of the literature, regarding zinc.oxide/eugenol impression pastes, we selected 20 of the most representatives as our references. Trough personal information of several of the investigators it was discovered that dimensional changes of theese materials is one of the most difficult properties to be measured. A new method was developed to measure dimensional changes ot 4 (four) of the most widely used zinc.oxide/eugenol impression materials in Brazil. The results, presented through several graphs and tables showed that dimensional changes varied from 0,003%, values which may probably be considered negligible from a clinical point of view. We noticed, however, high values for standard deviation and variance which indicate the high variability within the experiments. Those values were not found when we used the same method with mercaptan and silicone impression materials, in which the measurement of dimensional changes was highly reproducible. One hypothesis (which we intend to investigate in a later research) is that, during storage, a sedimentation could occur, of the components of greater density! Consequently ther might result a change in composition, independent of the method used to establishe the proportion of the two pastes, be it by wheight or measurement of lenght, which could be the cause of variability of the composition of each mixture!

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