ADDITIVE MANUFACTURING OF HOLLOW MICRONEEDLES FOR INSULIN DELIVERY

Microneedles (MN) are miniature devices capable of perforating painlessly stratum corneum and delivering active ingredients in the inner epidermal layers. Hollow microneedles (HMNs) are highly detailed objects due to their internal microchannels and thus, their fabrication with Additive Manufacturing (AM) is a challenging task. Vat polymerization techniques provide a sufficient accuracy for such microstructures. Differentiated from other approaches where stereolithography and 2-photon polymerization were adopted, this paper presents the 3D-printing of HMNs purposed for insulin delivery, using the more economic Liquid Crystal Display (LCD) method. First, different geometries (hexagon, square pyramid, beveled) were 3D printed with constant height and varying curing time, printing angle and layer resolution. Quality features in each case were captured with optical and scanning electron microscopy (SEM). The most promising geometry was found to be the beveled one due to the more refined tip area and the feasibility of non-clogged microchannel formation. Among printing parameters, printing angle proved to be the most influential, as it affects resin flow phenomenon during printing process. Lastly, optimized HMN geometry was the beveled configuration, where the average height was measured 900μm, 3D printing angle was set at -45°, the curing time was 10s per layer and the optimal layer height was 30μm.

On the power of lookahead in single-player PuyoPuyo

PuyoPuyo is one of the Tetris-type games, which is dealt with as a single-player game in this paper. The player has a winning strategy if the player can keep playing the game infinitely on a gameboard of a constant height. In this paper, we consider how lookahead of input pieces affects the existence of winning strategies in PuyoPuyo, and show conditions that the player cannot win even with lookahead. First, we show the number of colors sufficient to make the player lose on the gameboard of width w when the number of lookahead pieces is m. Next, we show that ten and twenty-six colors are sufficient to make the player lose on the gameboards of width two and three, respectively, no matter how large the number of lookahead pieces is.

PHYSICO-MATHEMATICAL MODEL OF VENTILATION SYSTEM FORCING OF CLEAN AIR IN LIVESTOCK PREMISES

The microclimate of livestock facilities is determined by a range of factors, including physical parameters: humidity, atmospheric pressure, light, temperature, speed and direction of air movement. Air quality plays an important role - the concentration of harmful gases and microorganisms, dust. The parameters of the microclimate affect not only the productivity of animals, but also their health. In order not to harm the health of the animal and achieve the desired performance, these parameters must be adjusted with special equipment. The purpose of research is to substantiate the design and technological parameters of the ventilation system for the injection of clean air in livestock premises to ensure uniformity of its distribution. The article presents the results of research to substantiate the design and technological parameters of the ventilation system for the injection of clean air in pig farms to ensure uniformity of its distribution. As a result of analytical studies of the parameters of the slit of the nozzle for air injection from the condition of uniform air distribution, an approximate equation for its width δ'y depending on the y-axis location for different effective diameters of the nozzle d'H. For the system of injection of clean air the condition according to which at opening of all discharge valves it is necessary to provide uniformity of distribution of air by system of injection is set. For this purpose the central air duct for air injection should have a wedge-shaped form of length L' with constant height b', with initial width a'N and final a'1. As a result of theoretical researches dependences of a lateral angle of a wedge θ the central air duct of system of injection of pure air and its width on the end a1' on distance between adjacent sections L'0, width of the central air duct on its beginning aN' and quantity of branch pipes for injection N' are established. As a result of analytical studies of pressure losses of the ventilation system of pure air injection of the pigsty, the dependences of changes in pressure losses Δp2 and power NW2 required for pumping air through it on the width of the central air duct aN, air flow through the system qk, length between system pipes L0 and their number N.

The Effects of Geocell Height and Lime Stabilization on Unpaved Road Settlements at Different Water Contents

In this study, lime stabilization and geocell reinforcement methods were investigated for a clayey subgrade of unpaved road at different water contents. This study is especially important in terms of determining the soil improvement method for road construction on wet lands. The effects of the geocell height (50, 100, 150, and 200 mm) and lime content (3, 6, and 12%) on the settlement of the subgrade soil at different water contents (25, 28, 30, 32, and 35%) were analyzed. Accordingly, a large scale plate loading test was designed, and it is utilized to achieve loading-settlement curves. The bearing capacity and modulus of subgrade (k) of soil were determined. It was detected that the geocell height and lime content have different effects at different water contents, and the modulus of subgrade reaction became stable beyond a constant height of the geocell. It was understood that none of these two improvements did not meet the Highways Technical Specifications. It is detected that at least these two improvement techniques are needed to be applied together to meet the specifications for the soil examined in this study.

Influence of Chamber Geometrical Parameters on Suppressing Explosion Propagation

In this article, the effect of a chamber’s geometrical parameters on suppressing gas explosion propagation was studied. Three rectangular chambers were used in the study, with a constant length of 0.5 m, a constant height of 0.2 m, and a variable width of 0.3 m, 0.5 m, and 0.8 m; each chamber was installed in a pipeline system for experimental research. The experimental results showed that when the chamber length and height were fixed at 0.5 m and 0.2 m, respectively, the suppression effect of the chamber on the explosion shockwave improves with the increase in the chamber width; when the chamber width increases to 0.8 m, the chamber has suppressive effect on explosion shockwave propagation. It was also found that the suppression effect of the chambers on the explosion flame improves with the increase in the chamber width; when the width of the chamber is 0.5 m, the chamber effectively suppresses explosion flames. Based on the experimental results, a numerical model was established to simulate the suppression effect of five types of chambers with a length, width, and height of 0.5 m × 0.3 m × 0.2 m, 0.3 m × 0.5 m × 0.2 m, 0.5 m × 0.5 m × 0.2 m, 0.5 m × 0.8 m × 0.2 m, and 0.8 m × 0.5 m × 0.2 m, respectively. The numerical simulation results indicated that when the chamber length and height are constant at 0.5 m and 0.2 m, respectively, the suppressive effect of the chamber on the shockwave improves as the chamber width increases; when the chamber width increases to 0.8 m, the shockwave overpressure at the chamber outlet is attenuated by 10.61%, indicating that the chamber suppresses the propagation of explosion shockwave, which is consistent with the experimental results obtained in the study. It was also found that when the chamber width and height were constant at 0.5 m and 0.2 m, respectively, as the chamber length increases, the overpressure increases first and then weakens. When the chamber length increases to 0.8 m, the overpressure at the chamber outlet is attenuated by −14.16%, indicating that the chamber is not able to suppress the propagation of explosion shockwave. Finally, a numerical simulation of the propagation process of a methane-air mixture and explosion flames in different chambers was performed to analyse the effect of chamber geometrical parameters on explosion suppression effect.

Evaluation of the Ability to Accurately Produce Angular Details by 3D Printing of Plastic Parts

3D printing is a process that has become widely used in recent years, allowing the production of parts with relatively complicated shapes from metallic and non-metallic materials. In some cases, it is challenging to evaluate the ability of 3D printers to make fine details of parts. For such an assessment, the printing of samples showing intersections of surfaces with low angle values was considered. An experimental plan was designed and materialized to highlight the influence of different factors, such as the thickness of the deposited material layer, the printing speed, the cooling and filling conditions of the 3D-printed part, and the thickness of the sample. Samples using areas in the form of isosceles triangles with constant height or bases with the same length, respectively, were used. The mathematical processing of the experimental results allowed the determination of empirical mathematical models of the power-function type. It allowed the detection of both the direction of actions and the intensity of the influence exerted by the input factors. It is concluded that the strongest influence on the printer’s ability to produce fine detail, from the point of view addressed in the paper, is exerted by the vertex angle, whose reduction leads to a decrease in printing accuracy.

The descriptional power of queue automata of constant length

We consider the notion of a constant length queue automaton—i.e., a traditional queue automaton with a built-in constant limit on the length of its queue—as a formalism for representing regular languages. We show that the descriptional power of constant length queue automata greatly outperforms that of traditional finite state automata, of constant height pushdown automata, and of straight line programs for regular expressions, by providing optimal exponential and double-exponential size gaps. Moreover, we prove that constant height pushdown automata can be simulated by constant length queue automata paying only by a linear size increase, and that removing nondeterminism in constant length queue automata requires an optimal exponential size blow-up, against the optimal double-exponential cost for determinizing constant height pushdown automata. Finally, we investigate the size cost of implementing Boolean language operations on deterministic and nondeterministic constant length queue automata.

On Monotonic Pattern in Periodic Boundary Solutions of Cylindrical and Spherical Kortweg–De Vries–Burgers Equations

We studied, for the Kortweg–de Vries–Burgers equations on cylindrical and spherical waves, the development of a regular profile starting from an equilibrium under a periodic perturbation at the boundary. The regular profile at the vicinity of perturbation looks like a periodical chain of shock fronts with decreasing amplitudes. Further on, shock fronts become decaying smooth quasi-periodic oscillations. After the oscillations cease, the wave develops as a monotonic convex wave, terminated by a head shock of a constant height and equal velocity. This velocity depends on integral characteristics of a boundary condition and on spatial dimensions. In this paper the explicit asymptotic formulas for the monotonic part, the head shock and a median of the oscillating part are found.

Real-Time Terrain-Following of an Autonomous Quadrotor by Multi-Sensor Fusion and Control

For the application of the autonomous guidance of a quadrotor from confined undulant ground, terrain-following is the major issue for flying at a low altitude. This study has modified the open-source autopilot based on the integration of a multi-sensor receiver (a Global Navigation Satellite System (GNSS)), a Lidar-lite (a laser-range-finder device), a barometer and a low-cost inertial navigation system (INS)). These automatically control the position, attitude and height (a constant clearance above the ground) to allow terrain-following and avoid obstacles based on multi-sensors that maintain a constant height above flat ground or with obstacles. The INS/Lidar-lite integration is applied for the attitude and the height stabilization, respectively. The height control is made by the combination of an extended Kalman filter (EKF) estimator and a cascade proportional-integral-derivative (PID) controller that is designed appropriately for the noise characteristics of low accuracy sensors. The proposed terrain-following is tested by both simulations and real-world experiments. The results indicate that the quadrotor can continuously navigate and avoid obstacles at a real-time response of reliable height control with the adjustment time of the cascade PID controller improving over 50% than that of the PID controller.