scholarly journals A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1637
Author(s):  
Safaa Omer ◽  
Romána Zelkó

Currently, ocular inserts and nanoparticles have received much attention due to the limited bioavailability of conventional eye preparations and the toxicity problems of systemic drug administration. The current systematic review aims to present recent studies on the use of electrospun nanofiber-based ocular inserts to improve the bioavailability of drugs used for different ophthalmic diseases. A systematic search was performed in PubMed, Ovid Medline, Web of Science, ScienceDirect, Scopus, Reaxys, Google Scholar, and Google Patents/Espacenet taking “drug-loaded”, “nanofibers”, and “ophthalmic inserts” and their equivalent terms as keywords. The search was limited to original and peer-reviewed studies published in 2011–2021 in English language. Only 13 out of 795 articles and 15 out of 197 patents were included. All results revealed the success of nanofiber-based ocular inserts in targeting and improved bioavailability. Ocular inserts based on nanofibers can be used as safe, efficient carriers for the treatment of anterior and posterior eye diseases.

2021 ◽  

Introduction: Social networks can perform a peculiar role in people's communication in the case of crisis and disaster. These media are interactive, digital, or mobile-based tools. Accordingly, the present study aimed to assess the role of social media in earthquakes. Materials and Methods: In this current systematic review, a query was conducted on such databases as Embase, Web of Science, Scopus, and Cochrane for articles in English language, based on the required criteria from 2000 to 2019 regarding the role of social media in disaster. As a result, 13,924 studies were retrieved, among which 3,963 were deleted due to duplication. Finally, among 244 selected articles, 19 full-text articles were analyzed. Result: In the present research, 19 studies were thoroughly reviewed. The findings were assigned to four main categories (identification, notification, requests, as well as storage and retrieval of information) with 12 sub-topics. Most of the main topics and subsets were as follows: medical and food needs, information about the accident, as well as medical and relief services, efforts to save lives, the amount of damage, problems and limitations, post-crisis measures, such as keeping calm, reducing anxiety, avoiding high-risk areas, asking for financial assistance, as well as using the information to provide relief and map the affected areas and evacuation centers. Conclusion: Considering the behavior of people in different geographical locations in the earthquake crisis, it seems that the case study of how to use social media in disaster management carries profound implications for modeling and localizing the cases in related disaster management institutions of many different countries, such as Iran.


2021 ◽  
Vol 11 (10) ◽  
pp. 1865-1872
Author(s):  
Nawaf Labban

This systematic review aimed to compile information and report the color stability and translucency of polymer-infiltrated ceramic-network (PICN) materials for suitable clinical applications in dentistry. Original peer-reviewed articles in electronic databases including PubMed, MEDLINE, Scopus, and Web of Science were searched to identify relevant papers published between January 2013 and August 2020. The published papers were only in the English language and limited to in vitro studies, and experimental reports were considered. The data from nine studies were considered when reviewing the color stability and translucency of PICN in comparison to other commonly used restorative materials. Among the included studies, color stability assessment was performed in five studies, and the other four studies were involved in the combined assessment of both color stability and translucency. PICN materials are a comparatively newer class of restorative materials and are recommended to overcome the drawbacks of ceramics and resin composites. The outcomes of previous laboratory studies still do not provide convincing results regarding the optical properties of PICN materials. However, with existing sources and evidence, PICN materials exhibit less color stability than ceramics do but better color stability compared to that of resin nanoceramics (RNC) and resin composites. The translucency of PICN materials is low compared to that of ceramics, nanoceramics, and resin composites.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 885-886
Author(s):  
Christy Costanian ◽  
Raymond Farah ◽  
Sola Bahous ◽  
Abla Sibai

Abstract This review presents findings on the role of female reproductive factors on longevity.A comprehensive systematic literature search was conducted using four electronic databases: OVID Medline, Web of Science, PubMed and Google Scholar from inception until May 2020 and restricted to English language articles that tackle the relationship between reproductive factors and longevity in its various definitions. Our search yielded a total of 306 articles. After screening based on the eligibility criteria,37 articles were included for review. The majority of studies were prospective and conducted in Western populations. The most consistent findings were between parity and increased longevity. The role of ages at menarche and menopause, premature menopause, as well as reproductive lifespan on longevity were not conclusive. Whether gender of offspring is related to maternal longevity is yet to be fully elucidated.Variations in findings are in the majority due to differentials in the definition of longevity as an outcome. Further longitudinal studies based in developing countries are needed to examine reproductive factors related to longevity.


2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Ali M. Alodat ◽  
Hanan I. Alshagran ◽  
Al-Muatasem M. Al-Bakkar

AbstractThis study systematically reviewed and thematically analyzed studies that investigated psychosocial support services provided to Syrian refugees with disabilities between 2011 and 2020. Nine studies published in the English language were identified from database searches (Google Scholar, PsychInfo, EBSCOhost, Web of Science, and Scopus). Results showed that the forms of psychosocial support services provided to Syrian refugees with disabilities were varied based on the nature of the study and the disability type. The results also provided detailed information about methods, participants, and findings of the identified studies. The thematic analysis results identified six themes that represent the factors related to the psychosocial support services, which were assessment, mental health, psychological well-being, rehabilitation, social participation, and vulnerability. This study provided a set of recommendations that may improve the quality of mental health and psychosocial support services provided to Syrian refugees with disabilities and their families, which are professional development, researches, and policy reforming.


2021 ◽  
Vol 12 ◽  
Author(s):  
Sulmaz Ghahramani ◽  
Kamran Bagheri Lankarani ◽  
Mohammad Yousefi ◽  
Keyvan Heydari ◽  
Saeed Shahabi ◽  
...  

Burnout among healthcare personnel has been exacerbated by the COVID-19 pandemic's unique features. During the COVID-19 pandemic, this systematic review and meta-analysis aims to provide a complete assessment of the prevalence of burnout across various healthcare personnel. Until January 2021, systematic searches for English language papers were conducted using PubMed, Scopus, EMBASE, Web of Science, Cochrane Library, and ProQuest. Thirty observational studies were found after conducting systematic searches. The pooled overall prevalence of burnout was 52% [95% confidence interval (CI) 40–63%]. Pooled emotional exhaustion (EE), depersonalization (DP), and lack of personal accomplishment (PA) were 51% (95% CI 42–61%), 52% (95% CI 39–65%), and 28% (95% CI 25–31%), respectively. This study demonstrated that nearly half of the healthcare workers experienced burnout during the COVID-19 pandemic. In the studies that were included, non-frontline COVID-19 exposed healthcare personnel also experienced burnout. From high to lower middle-income countries, there was a gradient in the prevalence of total burnout, EE, and lack of PA. Further studies on burnout in low and lower-middle-income countries are suggested. A uniform diagnostic tool for the assessment of burnout is warranted.


2019 ◽  
Vol 3 (4) ◽  
pp. 186
Author(s):  
Enes Özkan ◽  
Tuğba Haliloğlu Özkan

This review intends to provide researchers with a brief summary of extracorporeal Shock Wave Therapy (ESWT), and to bring new perspectives by systematic reviewing of the available data on the results of the various effects of ESWT regarding dentistry and the maxillofacial area. Literature search was conducted on December 2017 using the PubmedMedline, Google Scholar, Scopus and Web of Science databases.Articles between 1989 and 2018 were included.Search was performed using the keywords ‘alveolar, dentoalveolar, maxilla, mandibular, oral and sialolthiasis’ words in combination with ‘shock wave or shockwave’. The studies that were decided to include to this systematic review (n: 35) mostly consist of experimental and clinical studies. The current systematic review stated that ESWT has a success rate of up to 50% in the treatment of sialolithiasis. Shock wave therapy has also different dose-dependent effects on each tissue in the intraoral region. Shock wave parameters that will bring optimal biological effect to any treatment indication are yet to be clarified.International Journal of Human and Health Sciences Vol. 03 No. 04 October’19 Page : 186-195


Author(s):  
Lakshman SAMARANAYAKE ◽  
Kausar Fakhruddin ◽  
Chamila Panduwawala

Early detection, isolation, and management of COVID-19 patients are crucial to contain the current pandemic. The CDC in USA recently included "sudden loss of taste (dysgeusia/ageusia) and smell (anosmia/hyposmia)” as symptoms of COVID-19. If these symptoms are reliable forerunner symptoms of COVID-19, then it may facilitate early detection and containment of the disease. Hence, we systematically evaluated the contemporary evidence on dysgeusia and anosmia as trigger symptoms in COVID-19. Ovid MEDLINE, EBSCO host, and Web of Science databases were searched between December 25, 2019-May 30, 2020.Of the 13 identified records, eight (totaling 11,054 COVID-19 patients), were included, as per the selection criteria. The studies emanated mostly from the European community, as well as China, the USA, and Iran. In total, anosmia and dysgeusia symptoms were present in 74.9 % and 81.3% ambulatory as well as hospitalized, mild-to-severe cases of COVID-19 patients, respectively. The European, US, and Iran data indicate that olfactory, and gustatory symptoms appear prior to general COVID-19 symptoms in a majority of the patients. To our knowledge, this is the first systematic review analyzing the prevalence of chemosensory dysfunction in COVID-19. Further, studies are essential to evaluate their utility as harbingers of COVID-19 onset, and to establish clinical practice guidelines.


2019 ◽  
Vol 9 (1) ◽  
pp. 90
Author(s):  
Cyruz P Tuppal ◽  
Paolo D Vega ◽  
Marina Magnolia G. Ninobla ◽  
Mark Donald Reñosa ◽  
Abdullah Al-Battashi ◽  
...  

Background: Nursing profession continues to evolve, expand, and link its practice that requires evidence to strengthen its body of knowledge, and research utilization (RU) is pivotal towards this realization.Purpose: This systematic review aimed to critically identify, select, appraise, and synthesize research evidence about the barriers to and facilitators of research utilization.Methods: There were 17,961 papers during the initial database search and 85 papers from other sources from the electronic databases including Web of Science, CINAHL, Complete, Scopus, OVID, Medline, PsychInfo, SocIndex, Internurse, British Nursing Index, ERIC, and PubMed. After further analysis, thirty-six articles were included in the analysis that explicitly identified and described the barriers to and facilitators of research utilization in nursing.Results: Based on the findings, the lack of awareness about research, lack of authority to change their practice, overwhelming publications, and lack of compiled literature were the topmost identified barriers to RU. On the other hand, organizational and colleague support, and continuing education as both personal and professional commitment can further facilitate research utilization.Conclusion: Despite extensive studies conducted addressing the barriers to research utilization, the findings suggest a consistent reproach on the capability of nurses to maximize and utilize research. The same elements that may serve as barriers to, can likewise become the impetus in gaining sufficient research utilization among nurses.


2020 ◽  
pp. 135481662093890
Author(s):  
Tomáš Krajňák

A vast literature has focused on the effects of terrorism on tourism demand. This article aims to contribute to this strand of literature by systematically reviewing existing studies and subsequently synthesising their findings. Based on a systematic search of the Web of Science and Scopus databases, a total of 45 peer-reviewed English-language articles were included. The review was conducted and reported under Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The general conclusion is that, with some exceptions, terrorism negatively affects tourism demand. To decompose the effects of terrorism on tourism demand, several main themes were identified within the studies. However, effects varied widely depending on context, for example, terrorism and tourism demand variables used or locations and time periods studied. Consequently, the review identifies gaps in existing research and provides important suggestions for future studies.


Author(s):  
Zulma M. Medeiros ◽  
Amanda V. B. Vieira ◽  
Amanda T. Xavier ◽  
Gilberto S. N. Bezerra ◽  
Maria de Fátima C. Lopes ◽  
...  

The Global Program to Eliminate Lymphatic Filariasis (GPELF) is a program that aims to eliminate lymphatic filariasis by 2030. The GPELF strategy is based on interrupting transmission using mass drug administration (MDA) and, in parallel, managing morbidity cases. However, it has been seen that there is a shortage of research in the literature and public policies regarding this last pillar. In this study, we reviewed the literature and available information regarding the burden of filarial morbidity. In addition, we identified that in the Americas, the implementation of structured services with regard to morbidity assistance in the Americas was scarce. We formed a review that aimed to assess the pathogenesis, epidemiology, repercussions, and treatment of filarial morbidity in countries in the Americas where lymphatic filariasis is endemic. Structured searches were carried out on PubMed, LILACS, Scopus, and Web of Science databases without time and language restrictions. Three reviewers evaluated the 2150 studies and performed data extraction, and quality assessment by assigning scores to the studies found. The current literature and available information on the burden of filarial morbidity, as well as the implementation of structured services with regard to morbidity assistance in the Americas, were all found to be scarce. Now that this knowledge gap has been identified, both health services and researchers need to seek the implementation and enhancement of the maintenance of GPELF strategies that relate to the morbidity pillar.


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