scholarly journals Design of New Polyacrylate Microcapsules to Modify the Water-Soluble Active Substances Release

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 809
Author(s):  
Valentina Sabatini ◽  
Laura Pellicano ◽  
Hermes Farina ◽  
Eleonora Pargoletti ◽  
Luisa Annunziata ◽  
...  
Keyword(s):  
Active Material ◽  
Water Soluble ◽  
Butyl Methacrylate ◽  
Pickering Emulsions ◽  
The Poor ◽  
Combined Use ◽  
Photochemical Stability ◽  
Polymer Wall ◽  
Polymer Shells ◽  
Active Substances

Despite the poor photochemical stability of capsules walls, polyacrylate is one of the most successful polymers for microencapsulation. To improve polyacrylate performance, the combined use of different acrylate-based polymers could be exploited. Herein butyl methacrylate (BUMA)-based lattices were obtained via free radical polymerization in water by adding (i) methacrylic acid (MA)/methyl methacrylate (MMA) and (ii) methacrylamide (MAC) respectively, as an aqueous phase in Pickering emulsions, thanks to both the excellent polymer shells’ stability and the high encapsulation efficiency. A series of BUMA_MA_MMA terpolymers with complex macromolecular structures and BUMA_MAC linear copolymers were synthesized and used as dispersing media of an active material. Rate and yield of encapsulation, active substance adsorption onto the polymer wall, capsule morphology, shelf-life and controlled release were investigated. The effectiveness of the prepared BUMA-based microcapsules was demonstrated: BUMA-based terpolymers together with the modified ones (BUMA_MAC) led to slow (within ca. 60 h) and fast (in around 10 h) releasing microcapsules, respectively.

The content of decenoic acids in drone brood preparations and combined preparations based on it

Biomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 389-393
Author(s):  
D.V. Mitrofanov ◽  
N.V. Budnikova
Keyword(s):  
Royal Jelly ◽  
Storage Conditions ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strict Adherence ◽  
Drone Brood ◽  
Wide Range ◽  
Active Substances ◽  
Melanin Complex

The drone brood contains a large number of substances with antioxidant activity. These substances require stabilization and strict adherence to storage conditions. Among these substances are unique decenoic acids, the content of which is an indicator of the quality of drone brood and products based on it. The ability of drone brood to reduce the manifestations of oxidative stress is shown. There are dietary supplements for food and drugs based on drone brood, which are used for a wide range of diseases. Together with drone brood, chitosan-containing products, propolis, royal jelly can be used. They enrich the composition with their own biologically active substances and affect the preservation of the biologically active substances of the drone brood. Promising are the products containing, in addition to the drone brood, a chitin-chitosan-melanin complex from bees, propolis, royal jelly. The chitin-chitosan-melanin complex in the amount of 5% in the composition of the adsorbent practically does not affect the preservation of decenic acids, while in the amount of 2% and 10% it somewhat worsens. The acid-soluble and water-soluble chitosan of marine crustaceans significantly worsens the preservation of decenoic acids in the product. Drone brood with royal jelly demonstrates a rather high content of decenoic acids. When propolis is introduced into the composition of the product, the content of decenoic acids increases according to the content of propolis.

A cobalt sulfide cluster-based catholyte for aqueous flow battery applications

2018 ◽  
Vol 6 (44) ◽  
pp. 21927-21932 ◽  
Author(s):  
Matthew B. Freeman ◽  
Le Wang ◽  
Daniel S. Jones ◽  
Christopher M. Bejger
Keyword(s):  
Active Material ◽  
Water Soluble ◽  
Molecular Cluster ◽  
Cobalt Sulfide ◽  
Redox Flow Battery ◽  
Flow Battery ◽  
Aqueous Flow ◽  
Sulfide Cluster

A water-soluble Co6S8 molecular cluster was prepared and electrochemically analyzed as a potential active material for redox flow battery applications.

THE INFLUENCE OF SORPTION-DETOXIFYING MEANS ON CUMULATION OF 90SR IN BONE TISSUE OF WHITE RATES WITH COMBINED INTAKE OF 137CS, CD AND PB

2018 ◽  
Vol 1 (3) ◽  
pp. 129-133
Author(s):  
L. L. Zakharova ◽  
◽  
G. A. Zhorov ◽  
V. N. Obryvin ◽  
◽  
...  
Keyword(s):  
Bone Tissue ◽  
Chemical Nature ◽  
Mechanisms Of Action ◽  
The Body ◽  
Biologically Active ◽  
Laboratory Studies ◽  
Animal Body ◽  
White Rats ◽  
Combined Use ◽  
Active Substances

The article presents the results of laboratory studies of the effect of sorption-detoxifying means on the accumulation of 90Sr in the body of white rats. The efficiency of a number of selective and polyfunctional sorbents, detoxicants and other biologically active substances and the developed on their basis sorption-detoxifying complexes as means of efferent therapy and detoxification of the animal body at the combined intake of xenobiotics of radiation and chemical nature was evaluated. It was found that 90Sr cumulation in bones (at the level of 53,3–60,8%) was reduced to the greatest extent with the combined use of substances of different mechanisms of action and origin. The effectiveness of separate use of detoxifying drugs did not exceed 29,1%.

Bioinspired and Multifunctional Phospholipid Polymer Nanoparticles

2016 ◽  
Vol 102 ◽  
pp. 3-11
Author(s):  
Kazuhiko Ishihara ◽  
Wei Xin Chen ◽  
Yuuki Inoue
Keyword(s):  
Acid Group ◽  
Covalent Bonding ◽  
Water Soluble ◽  
Polymer Nanoparticles ◽  
Butyl Methacrylate ◽  
Carboxylic Acid Group ◽  
Cleavage Reaction ◽  
Phospholipid Polymer ◽  
Biodegradable Poly ◽  
Immobilized Proteins

Photoreactive and cytocompatible polymer nanoparticles for immobilizing and photoinduced releasing proteins were prepared. A water-soluble and amphiphilic phospholipid polymer, poly (2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)-co-4-(4-(1-methacryloyloxyethyl)-2-methoxy-5-nitrophenoxy) butyric acid (PL)) (PMB-PL) was synthesized. The PMB-PL underwent a cleavage reaction at the PL unit by photoirradiation at a wavelength of 365 nm. Additionally, the PMB-PL took polymer aggregate in aqueous medium and was used to modify the surface of biodegradable poly (L-lactic acid) (PLA) nanoparticle as an emulsifier. The morphology of the PMB-PL/PLA nanoparticle was spherical and approximately 130 nm in diameter. The carboxylic acid group in the PL unit could be used for immobilization of proteins by covalent bonding. The bound proteins were released by a photoinduced cleavage reaction. Within 60 sec, up to 90% of the immobilized proteins were released by photoirradiation and activity of the protein released in the medium was maintained as well as that the original proteins before immobilization. Octa-arginine (R8) could promote internalization of the protein/PLA/PMB-PL nanoparticles into cells when the R8 was co-immobilized on the nanoparticles. After that, photoirradiation induced protein release from the nanoparticles and proteins distributed more evenly inside cells. From these results, we concluded that PMB-PL/PLA nanoparticles have the potential to be used as smart carriers to deliver proteins to biological systems, such as the inside of living cells.

scholarly journals Improvement of the cucumber protection system in the greenhouse for production environmentally safe products

2020 ◽  
pp. 15-20
Author(s):  
Svetlana Aleksandrovna Dudnikova ◽  
Valentina Vasilievna Lapina ◽  
Nikolay Vasilievich Smolin ◽  
Dmitry Vladimirovich Bochkarev
Keyword(s):  
Biologically Active ◽  
Net Income ◽  
Biological Products ◽  
Yield And Quality ◽  
Combined Use ◽  
Environmentally Safe ◽  
Beginning Of Flowering ◽  
Growth Development ◽  
Active Substances

Production of environmentally friendly cucumber products is one of the important problems of modern vegetable growing. In the current situation, many issues of cucumber technology using the low-volume technology method require adjustment and further improvement. The purpose of the research was to study and assess the effect of combinations of zircon with biofertilizers against the background of the use of biological products on the growth, development, yield and quality of cucumber. The complex treatment of cucumber plants of the F1 Atlet hybrid with biologically active substances (BAS) contributed to an increase in biometric indicators in comparison with the control throughout the entire crop rotation. The period from germination to the beginning of flowering and fruiting decreased, the plant height increased by 7.2–13.2% and the stem diameter by 12.5–17.5%. The yield was significantly influenced by the growth of the leaf area of cucumber plants, which increased in variants with experimental technologies by 5.9–34%. Under the influence of the studied factors, the yield of standard cucumber production increased by 8.0–27.6%. The mass fraction of fruits that do not meet the requirements of the standard was 6.6–8.1%. On the control variant, the output of non-standard products increased to 10%. The highest net income and level of profitability were obtained with the combined use of Zircon with Ecofus, both against the background of the use of biological products (659.3 rubles / m2 or 38.4%) and without them (685.13 rubles / m2 or 40.1%).

Innovative Strategies for Lipid-Based Drug Delivery

2018 ◽  
pp. 60-84 ◽  
Author(s):  
Navneet Sharma ◽  
Sabna Kotta ◽  
Mohd Aleem ◽  
Shubham Singh ◽  
Rakesh Kumar Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Absorption ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Water Soluble ◽  
Absorption Process ◽  
Innovative Strategies ◽  
The Poor ◽  
Water Soluble Drugs ◽  
Selection Of

In the last decade, there has been a mounting concern in lipid-based formulations to deliver water-soluble drugs. Lipid-based drug delivery systems are one of the budding and promising technologies designed to tackle the poor bioavailability problems. This chapter stresses the different mechanisms of lipophilic drug absorption along with its advantages and limitations. It points out the different mechanisms of how lipid-based excipients and the different formulations interact with the absorption process. This review provides a comprehensive summary about the lipid formulation classification scheme (LFCS), a guide for the selection of appropriate formulation and commonly used excipients for lipid-based formulations, along with the important factors to be considered in formulation design and excipient selection. This review also focuses on the formulation of solid lipid-based formulations, important evaluation aspects, and commercial formulations available for the purpose.

Novel strategy for encapsulation and targeted delivery of poorly water‐soluble active substances

2020 ◽  
Vol 60 (8) ◽  
pp. 2008-2022
Author(s):  
Maja D. Markovic ◽  
Vesna V. Panic ◽  
Sanja I. Seslija ◽  
Ana D. Milivojevic ◽  
Pavle M. Spasojevic ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Water Soluble ◽  
Poorly Water Soluble ◽  
Novel Strategy ◽  
Active Substances

scholarly journals Selective Inhibition on Growth and Photosynthesis of Harmful Cyanobacteria (Microcystis aeruginosa) by Water Soluble Substances of Dendranthema indicum Flowers

Water ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2014
Author(s):  
Yunni Gao ◽  
Fang Zhang ◽  
Jing Wu ◽  
Hui Yang ◽  
Jing Dong ◽  
...  
Keyword(s):  
Microcystis Aeruginosa ◽  
Green Algae ◽  
Solid Phase ◽  
Haematococcus Pluvialis ◽  
Growth Promotion ◽  
Selective Inhibition ◽  
Water Soluble ◽  
Cyanobacterial Blooms ◽  
Aqueous Extracts ◽  
Active Substances

Harmful cyanobacterial blooms become serious environmental issues in various waterbodies, including aquaculture ponds, which inherently need a high biomass and healthy composition of phytoplankton to sustain their high productivity. Indoor bioassays were conducted to investigate the effects of an aqueous extract of Dendranthema indicum flowers on cyanobacteria and green algae species. The thermal stability and polarity of the water-soluble active substances of D. indicum flowers were also assessed based on the growth and photosynthesis responses of Microcystis aeruginosa. There was obvious growth promotion of green algae, including Chlorella vulgaris, Kirchneriella sp. and Haematococcus pluvialis and strong growth inhibition of toxigenic and non-toxigenic M. aeruginosa by aqueous extracts of D. indicum flowers at concentrations ranging from 0.5 to 2.0 g·DW·L−1. The cell concentrations of M. aeruginosa and C. vulgaris were 46.5% and 242.2% of those in the corresponding controls after a 10-day exposure to aqueous extracts of D. indicum flowers at 1.0 g·DW·L−1. There must be some water-soluble active allelochemicals released from D. indicum flowers that are responsible for the selective inhibition of M. aeruginosa rather than green algae. The inhibition ratio of the growth and photosynthesis of M. aeruginosa by aqueous extracts of D. indicum flowers at 2.0 g·DW·L−1 prepared with water at 25 °C and 100 °C were above 90% and 80% compared to the cell density and performance index on absorption basis (PIABS) value of M. aeruginosa in the control on day 6, without significant differences. It indicates that the active substances of D. indicum flowers were thermally stable. The methanol fraction eluted from solid phase extraction (SPE)-enriched aqueous extracts of D. indicum flowers showed the strongest inhibition of the growth and photosynthesis of M. aeruginosa compared to the other four fractions. It indicates that the most polar substances of D. indicum flowers were responsible for the selective inhibition of M. aeruginosa. More experiments are required to identify the responsible active substances and reveal the underlying mechanisms of aqueous extracts of D. indicum flowers that selectively inhibit cyanobacteria and regulate the phytoplankton community structure.

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