scholarly journals Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2070
Author(s):  
Ruey-Shin Juang ◽  
Xing Su ◽  
I-Chi Lee
Keyword(s):  
Parathyroid Hormone ◽  
Multilayer Film ◽  
Blood Compatibility ◽  
Surface Hydrophobicity ◽  
Multilayer Films ◽  
Feasibility Assessment ◽  
Hemolysis Test ◽  
Systemic Disorder ◽  
Good Biocompatibility ◽  
High Level

Chronic kidney disease (CKD) is a systemic disorder that combines complex bone and mineral abnormalities. The high level of parathyroid hormone (PTH) in the blood causes irreversible renal dysfunction and cardiovascular disease. Therefore, it is necessary to reduce level of PTH in the blood of patients with uremic state. In this study, chitosan and heparin were chosen to form polysaccharide-based multilayer films based on their antibacterial ability, good biocompatibility and hemocompatibility. In addition, a previous study has revealed that PTH is a heparin/polyanion binding protein because of the similarity of heparin to the cell surface proteoglycans. Subsequently, the surface properties including thickness, surface hydrophobicity and surface charge of a series of multilayer films were analyzed. The PTH adsorption rate of a series of multilayer films was also assessed. The results revealed that the optimizing condition is (CHI/HEP)2.5 and 60 min in both PBS only and PBS with the addition of bovine serum albumin, which demonstrated the specific adsorption of PTH on the materials. Furthermore, the hemolysis test also revealed that (CHI/HEP)2.5 shows good blood compatibility. It is considered that polysaccharide-based multilayer films may provide an alternative for the surface modification of hemodialysis membranes and equipment.

Advances in Biodegradable Vascular Stent Materials

2020 ◽  
Vol 987 ◽  
pp. 93-98
Author(s):  
Jun Yan Liu ◽  
Jin Guo Wang ◽  
Yun Hai Yu ◽  
Na Wang
Keyword(s):  
Cell Growth ◽  
Blood Vessels ◽  
Human Blood ◽  
Blood Compatibility ◽  
Clinical Treatment ◽  
Vascular Stent ◽  
Cell Compatibility ◽  
Good Biocompatibility ◽  
Materials Used ◽  
Over Time

Biodegradable vascular stent is mainly made of materials that can be naturally decomposed. After implantation into human blood vessels, the vascular stent can be continuously degraded over time and eventually disappear completely after the treated blood vessels are healed and support from the vascular stent is not needed. The vascular stent materials used in clinic should have good biocompatibility, which mainly involves blood compatibility and cell compatibility. In terms of cell compatibility, the influence of materials on cell growth should be observed. The various biological materials should have good anticoagulant character, so as to reduce the tendency of thrombosis and avoid the occurrence of various risk events in clinical treatment.

Strategy of differentiation therapy: effect of dual-frequency ultrasound on the induction of liver cancer stem-like cells on a HA-based multilayer film system

2019 ◽  
Vol 7 (35) ◽  
pp. 5401-5411 ◽  
Author(s):  
I-Chi Lee ◽  
Siaka Fadera ◽  
Hao-Li Liu
Keyword(s):  
Drug Resistance ◽  
Liver Cancer ◽  
Multilayer Film ◽  
Multilayer Films ◽  
Film System ◽  
Dual Frequency ◽  
Differentiation Therapy ◽  
System P ◽  
Therapy Effect ◽  
Frequency Ultrasound

HA-based multilayer films were used to select CSCs, and LIUS induces CSC differentiation and reduces drug resistance and invasion ability.

scholarly journals Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host–guest interactions in polyelectrolyte multilayer films for cancer therapy

RSC Advances ◽  
2020 ◽  
Vol 10 (34) ◽  
pp. 20073-20082 ◽  
Author(s):  
Soobin Wang ◽  
Alessia Battigelli ◽  
Dahlia Alkekhia ◽  
Alexis Fairman ◽  
Valentin Antoci ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
Protein Tyrosine Phosphatase ◽  
Multilayer Film ◽  
Tyrosine Phosphatase ◽  
Multilayer Films ◽  
Controlled Delivery ◽  
Polyelectrolyte Multilayer ◽  
Supramolecular Complexation ◽  
Protein Tyrosine Phosphatase Inhibitor

Controlled delivery of a potent anticancer drug, SHP099, after supramolecular complexation into a versatile multilayer film.

scholarly journals Recycling of multilayer plastic packaging materials by solvent-targeted recovery and precipitation

2020 ◽  
Vol 6 (47) ◽  
pp. eaba7599
Author(s):  
Theodore W. Walker ◽  
Nathan Frelka ◽  
Zhizhang Shen ◽  
Alex K. Chew ◽  
Jesse Banick ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Multilayer Film ◽  
Multilayer Films ◽  
Packaging Materials ◽  
Constant Composition ◽  
Waste Streams ◽  
Ethylene Vinyl Alcohol ◽  
Plastic Packaging ◽  
Material Efficiency ◽  
Polymer Solubility

Many plastic packaging materials manufactured today are composites made of distinct polymer layers (i.e., multilayer films). Billions of pounds of these multilayer films are produced annually, but manufacturing inefficiencies result in large, corresponding postindustrial waste streams. Although relatively clean (as opposed to municipal wastes) and of near-constant composition, no commercially practiced technologies exist to fully deconstruct postindustrial multilayer film wastes into pure, recyclable polymers. Here, we demonstrate a unique strategy we call solvent-targeted recovery and precipitation (STRAP) to deconstruct multilayer films into their constituent resins using a series of solvent washes that are guided by thermodynamic calculations of polymer solubility. We show that the STRAP process is able to separate three representative polymers (polyethylene, ethylene vinyl alcohol, and polyethylene terephthalate) from a commercially available multilayer film with nearly 100% material efficiency, affording recyclable resins that are cost-competitive with the corresponding virgin materials.

Tribological and Corrosive Properties of Tin/AlN Multilayer Film

2012 ◽  
Vol 560-561 ◽  
pp. 837-841
Author(s):  
Pu Hong Tang ◽  
Jie Mao ◽  
Chong You Feng
Keyword(s):  
Corrosion Resistance ◽  
Coefficient Of Friction ◽  
Gas Flow ◽  
Multilayer Film ◽  
Corrosion Current ◽  
Multilayer Films ◽  
Nitrogen Gas ◽  
Corrosion Properties ◽  
Wear Rates ◽  
The Coefficient Of Friction

TiN/AlN nanoscale multilayer films were deposited by pulsed laser ablation on silicon, with different argon and nitrogen gas flow rates. The total thickness of the TiN/AlN multilayer film was approximately 1μm. The friction and corrosion properties were studied by tribological and corrosive tests. In tribological tests, ball-on-disc was used to determine coefficients of friction and wear rates. The coefficient of friction against a Si3N4 ball varied considerably between films, as does the wear rate. The lowest coefficient of friction μ=0.97 was shown at sample 1, whereas the other three multilayer films were ranged from 1.0 to 1.5. In corrosion test, the anodic polarization characteristics were measured in a 3.5% NaCl solution at room temperature to examine the corrosion resistance. The potentiodynamic polarization measurements showed that for all the multilayer films the corrosion potential shift to higher values, and the corrosion current density decreased with increasing of nitrogen gas flow rate, which indicate a higher nitrogen partial pressures lead to a better corrosion resistance.

High-level production of human parathyroid hormone in Bombyx mori larvae and BmN cells using recombinant baculovirus

Gene ◽  
1995 ◽  
Vol 167 (1-2) ◽  
pp. 33-39 ◽  
Author(s):  
Sinnakaruppan Mathavan ◽  
Vigdis T. Gautvik ◽  
Erik Rokkones ◽  
Ole Kristoffer Olstad ◽  
B. Najma Kareem ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bombyx Mori ◽  
Recombinant Baculovirus ◽  
Human Parathyroid Hormone ◽  
High Level ◽  
Level Production ◽  
Bmn Cells

Optimization of Optical Properties of SiO2/TiO2/SiO2 Multilayer Films

2012 ◽  
Vol 509 ◽  
pp. 294-302 ◽  
Author(s):  
Jia Miao Ni ◽  
Qi Bin Gu
Keyword(s):  
Optical Properties ◽  
Visible Light ◽  
Wavelength Range ◽  
Multilayer Film ◽  
Multilayer Films ◽  
Design Parameters ◽  
Light Wavelength ◽  
Transparent Films ◽  
Optical Films ◽  
Optimizing Design

The computer aid simulation of optical properties of thin films has been used to optimize SiO2/TiO2/SiO2 multilayer films to obtain high transparent films in this paper. The maximum transmittance at the visible light wavelength range is proper criteria for optical films optimizing design. The effect of design parameters (film thickness and refractive index) on optical properties of SiO2/TiO2/SiO2 multilayer films were also discussed in detail. According to the result of optimization, high quality SiO2/TiO2/SiO2 multilayer film with a maximum of > 99% at visible light wavelength range can be achieved on the glass.

Saline-enabled self-healing of polyelectrolyte multilayer films

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 8877-8881 ◽  
Author(s):  
Xiaoxia Hu ◽  
Shimei Xu ◽  
Shun Feng ◽  
Jide Wang ◽  
Jie Xu
Keyword(s):  
Normal Saline ◽  
Multilayer Film ◽  
Multilayer Films ◽  
Self Healing ◽  
Polyelectrolyte Multilayer ◽  
Rapid Healing ◽  
Polyelectrolyte Multilayer Film

After introducing a third polyelectrolyte, the healing ability of polyelectrolyte multilayer film fabricated by LbL technique is largely enhanced, and can undergo rapid healing of several tens of micrometer-sized cuts when exposed to normal saline.

scholarly journals Using Crossmatch tests for serological compatibility assessment intra- and interspecific at dogs and cats

2016 ◽  
Vol 73 (2) ◽  
pp. 394
Author(s):  
Sergiu Adrian Muntean ◽  
Cristina Laura Ștefănuț ◽  
Rareș Drăgan ◽  
Laurent Ognean ◽  
Ildiko Barabasi
Keyword(s):  
Blood Cells ◽  
Blood Donors ◽  
Blood Compatibility ◽  
Blood Products ◽  
Transfusion Therapy ◽  
Veterinary Clinic ◽  
Blood Samples ◽  
Clinical Interest ◽  
Compatible Blood ◽  
High Level

Introduction: Selecting compatible blood is essential for the safety and efficiency of transfusion therapy both in cats, which can show preformed alloantibodies, and in canines, which usually do not have such antibodies. Correct performing and repeating Crossmatch tests can prevent both immediate and delayed immune reactions caused by sensitization of patients. In the cats’ case, it is called into question solving low availability of sources of compatible blood donors by using canines, if it would be possible dog-cat xenocompatibility. Aims: The aim of this study is to comparatively analyze serological intraspecific and interspecific compatibility on samples of dogs and cats in order to evaluate the possibility of implementing transfusion therapy with canine blood to feline patients. Materials andMethods: There were conducted Crossmatch tests on blood samples (n=42) collected (on EDTA) from dogs (n=36) and from cats (n=6) from the FMV Cluj-Napoca clinics and from a private veterinary clinic. There were performed 156 Crossmatch tests, predominantly through quick technique on smears (Ognean and Cernea, 2011) and in some cases (15%) the method based on separating the plasma and preparing hematies suspension (5%) from the previously washed red blood cells concentrate.Results: Intraspecific compatibility on dogs was predominantly negative. Remarkable is the case of a canine patient on which we registered all 24 Crossmatch major tests high positive intensity (3+), corresponding to a patient with preformed alloantibodies, without a historical therapy with blood products. Regarding the intraspecific compatibility tests, as we had expected, all 30 xenocompatibility dog-cat tests showed high positive reactions, both for major and minor Crossmatch. (3+/4+).Conclusions: The intraspecific evaluations revealed a high level of blood compatibility in the case of dogs unsensitivized through previous blood transfusions, yet without excluding the possibility of some atypical sensitivization for clinical interest. Having all the interspecific tests exclusively highly positive, we can not sustain a probable xenotransfusion.

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