scholarly journals Insights into Mycobacterium leprae Proteomics and Biomarkers—An Overview

Proteomes ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 7
Author(s):  
Sakshi Gautam ◽  
Devesh Sharma ◽  
Anjana Goel ◽  
Shripad A. Patil ◽  
Deepa Bisht
Keyword(s):  
Early Diagnosis ◽  
Causative Agent ◽  
Mycobacterium Leprae ◽  
Pivotal Role ◽  
New Biomarkers ◽  
Shed Light

Although leprosy is curable, the identification of biomarkers for the early diagnosis of leprosy would play a pivotal role in reducing transmission and the overall prevalence of the disease. Leprosy-specific biomarkers for diagnosis, particularly for the paucibacillary disease, are not well defined. Therefore, the identification of new biomarkers for leprosy is one of the prime themes of leprosy research. Studying Mycobacterium leprae, the causative agent of leprosy, at the proteomic level may facilitate the identification, quantification, and characterization of proteins that could be potential diagnostics or targets for drugs and can help in better understanding the pathogenesis. This review aims to shed light on the knowledge gained to understand leprosy or its pathogen employing proteomics and its role in diagnosis.

scholarly journals Ni Oxidation State and Ligand Saturation Impact on the Capability of Octaazamacrocyclic Complexes to Bind and Reduce CO2

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4139
Author(s):  
Barbora Vénosová ◽  
Ingrid Jelemenská ◽  
Jozef Kožíšek ◽  
Peter Rapta ◽  
Michal Zalibera ◽  
...  
Keyword(s):  
Quantum Theory ◽  
Oxidation State ◽  
Central Atom ◽  
Population Analysis ◽  
Mulliken Population Analysis ◽  
Mulliken Population ◽  
Theoretical Methods ◽  
Ni Oxidation ◽  
Shed Light

Two 15-membered octaazamacrocyclic nickel(II) complexes are investigated by theoretical methods to shed light on their affinity forwards binding and reducing CO2. In the first complex 1[NiIIL]0, the octaazamacrocyclic ligand is grossly unsaturated (π-conjugated), while in the second 1[NiIILH]2+ one, the macrocycle is saturated with hydrogens. One and two-electron reductions are described using Mulliken population analysis, quantum theory of atoms in molecules, localized orbitals, and domain averaged fermi holes, including the characterization of the Ni-CCO2 bond and the oxidation state of the central Ni atom. It was found that in the [NiLH] complex, the central atom is reduced to Ni0 and/or NiI and is thus able to bind CO2 via a single σ bond. In addition, the two-electron reduced 3[NiL]2− species also shows an affinity forwards CO2.

scholarly journals Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sami Havukainen ◽  
Jonai Pujol-Giménez ◽  
Mari Valkonen ◽  
Ann Westerholm-Parvinen ◽  
Matthias A. Hediger ◽  
...  
Keyword(s):  
Trichoderma Reesei ◽  
Scientific Literature ◽  
Large Body ◽  
Comprehensive Analysis ◽  
Transport Function ◽  
Sugar Transporters ◽  
New Knowledge ◽  
Electrophysiological Characterization ◽  
Shed Light

AbstractTrichoderma reesei is an ascomycete fungus known for its capability to secrete high amounts of extracellular cellulose- and hemicellulose-degrading enzymes. These enzymes are utilized in the production of second-generation biofuels and T. reesei is a well-established host for their production. Although this species has gained considerable interest in the scientific literature, the sugar transportome of T. reesei remains poorly characterized. Better understanding of the proteins involved in the transport of different sugars could be utilized for engineering better enzyme production strains. In this study we aimed to shed light on this matter by characterizing multiple T. reesei transporters capable of transporting various types of sugars. We used phylogenetics to select transporters for expression in Xenopus laevis oocytes to screen for transport activities. Of the 18 tested transporters, 8 were found to be functional in oocytes. 10 transporters in total were investigated in oocytes and in yeast, and for 3 of them no transport function had been described in literature. This comprehensive analysis provides a large body of new knowledge about T. reesei sugar transporters, and further establishes X. laevis oocytes as a valuable tool for studying fungal sugar transporters.

scholarly journals Nanotechnology in Roman Opaque Red Glass from the 2nd Century AD. Archaeometric Investigation in Red Sectilia from the Decoration of the Lucius Verus Villa in Rome

Heritage ◽  
2019 ◽  
Vol 2 (3) ◽  
pp. 2597-2611 ◽  
Author(s):  
Mario Bandiera ◽  
Patrice Lehuédé ◽  
Marco Verità ◽  
Luis Alves ◽  
Isabelle Biron ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Chemical Characterization ◽  
Second Step ◽  
Colorimetric Analysis ◽  
Historical Sources ◽  
Pixe Analysis ◽  
X Ray ◽  
Colorimetric Measurements ◽  
Shed Light

This work aims to characterise the chemical composition of Roman opaque red glass sectilia dated to the 2nd century A.D and to shed light on Roman glassmaking production of different shades of red, from red to reddish-brown. Due to the lack of technical historical sources for this period many questions about technological aspects still remain. In this project a multi-disciplinary approach is in progress to investigate the red glass sectilia with several red hues from the Imperial Villa of Lucius Verus (161–169 A.D.) in Rome. First, colorimetric measurements were taken to identify the various red hues. The second step was chemical characterization of the samples and the identification of crystalline colouring phases. Particle Induced X-Ray Emission (PIXE) analysis was used to investigate the chemical composition of these glass samples, while the crystalline phases were identified by Raman Spectroscopy and Scanning Electrons Microscope with Energy Dispersive X-ray Spectrometry (SEM-EDS). Using SEM-EDS nanoparticles were detected as a colouring agent, the chemical composition and the morphology of which has been studied in depth. This information has been compared with the colorimetric analysis to establish any correlation with the different colour hues.

The Legal Characterization of Crypto-Exchange Platforms

Global Jurist ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Andrea Minto
Keyword(s):  
Regulatory Framework ◽  
Pivotal Role ◽  
Demand And Supply ◽  
Trading Systems

Abstract In a thriving crypto-assets market, crypto exchange platforms play a pivotal role. Indeed, such trading systems are instrumental to the matching of demand and supply (trading) as well as the transfer of tokens (settlement and post-trading). Yet, there is currently no bespoke regulatory framework applicable to crypto exchange, raising pressing questions on whether and how those platforms are regulated. This article examines the Italian regulatory framework applicable to crypto-exchange platforms. It shows that the present regulatory engagement with crypto exchanges relates to the qualification of the crypto assets traded. Depending on such qualification, different financial regimes could be triggered.

scholarly journals Characterization of the common bean host and Pseudocercospora griseola, the causative agent of angular leaf spot disease in Tanzania

2016 ◽  
Vol 10 (11) ◽  
pp. 238-245 ◽  
Author(s):  
Amos Chilagane Luseko ◽  
Nchimbi-Msolla Susan ◽  
Mbogo Kusolwa Paul ◽  
Gabriel Porch Timothy ◽  
Miryam Serrato Diaz Luz ◽  
...  
Keyword(s):  
Common Bean ◽  
Causative Agent ◽  
Leaf Spot ◽  
Angular Leaf Spot ◽  
Leaf Spot Disease ◽  
Spot Disease ◽  
The Common ◽  
Pseudocercospora Griseola

scholarly journals Immunological and functional characterization of Mycobacterium leprae protein antigens: an overview

1995 ◽  
Vol 18 (5) ◽  
pp. 791-800 ◽  
Author(s):  
Jelle E.R. Thole ◽  
Brigitte Wieles ◽  
Josephine E. Clark-Curtiss ◽  
Tom H.M. Ottenhoff ◽  
Tobias F. Rinke de Wit
Keyword(s):  
Functional Characterization ◽  
Mycobacterium Leprae ◽  
Protein Antigens

scholarly journals Improving Pediatric Adverse Drug Event Reporting through Clinical Pharmacy Services

2011 ◽  
Vol 16 (4) ◽  
pp. 285-290
Author(s):  
David M. Crowther ◽  
Marcia L. Buck ◽  
Michelle W. McCarthy ◽  
Virginia W. Barton
Keyword(s):  
Causative Agent ◽  
Adverse Drug Event ◽  
Pediatric Patients ◽  
Drug Event ◽  
University Of Virginia ◽  
Children's Hospital ◽  
Therapeutic Class ◽  
Children’S Hospital ◽  
The University

OBJECTIVES The purpose of this study was to summarize adverse drug event (ADE) reporting and to characterize the type of healthcare practitioners involved in reporting over a 10-year period at a 120-bed university-affiliated children's hospital. METHODS The University of Virginia Children's Hospital ADE database was analyzed for records involving pediatric patients. Data from patients <18 years of age who were admitted to the University of Virginia Children's Hospital between January 1, 2000, and December 31, 2009, were analyzed. Data collected included drug name and therapeutic class of the suspected causative agent, description of the event, severity, causality, outcome, and the type of healthcare practitioner reporting the event. RESULTS A total of 863 ADEs were reported over the 10-year period. The 5 most common types reported were extravasation injury (10%), rash (8%), hypotension (5%), pruritus (5%), and renal failure (3%). A total of 196 (21%) cases were categorized as mild, 436 (47%) cases as moderate, and 296 (32%) cases as severe. Further characterization of extravasations was performed to identify trends relating to potential causes. In 45 (57%) reports, parenteral nutrition was identified as the causative agent. Full recovery was documented in 21 (47%) extravasations. Of the total events reported, 83% were reported by pharmacists, 16% by nurses, and <1% by other healthcare practitioners. CONCLUSIONS Results of this study are consistent with those of previous studies involving ADE reporting in children's hospitals. This consistency is due in part to system design and use of unit-based pharmacists as the primary reporters.

scholarly journals Identification and characterization of new biomarkers that can predict the development of heart failure in hypertrophic cardiomyopathy

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Raffaele Altara ◽  
Marleen H.M. Hessel ◽  
Rob J.J. Hermans ◽  
Ben J.A. Janssen ◽  
Matthijs W. Blankesteijn
Keyword(s):  
Heart Failure ◽  
Hypertrophic Cardiomyopathy ◽  
New Biomarkers ◽  
Identification And Characterization

Religious Identity: Reflections on Revelation and Rationality

2009 ◽  
Vol 3 (4) ◽  
pp. 443-459
Author(s):  
Majid Amini
Keyword(s):  
Religious Identity ◽  
Religious Diversity ◽  
Pivotal Role ◽  
Public Theology ◽  
Individual Identity ◽  
The Public ◽  
Political Implications ◽  
Ethnic Origins

AbstractThere is a widespread assumption that ethnic origins substantially contribute, if not constitute, the identity of individuals. In particular, among the ethnic elements, it is claimed that religion takes precedence and people could be individuated in terms of their religious affiliations. Indeed, public theology as an attempt to expand on the public consequences of religious doctrines and beliefs is predicated on the legitimacy of the idea of religious identity. However, the purpose of this article is to show that strictly speaking identity cannot be constituted by religion. More precisely, it is argued that a phenomenological characterization of individual identity fails to do justice to the philosophical requirements of identity. The argument is obviously philosophical by nature and is developed through an analysis of the concept of revelation. The phenomenon of revelation plays a pivotal role in the Jewish, Christian and Islamic traditions, yet by its very nature owes its authenticity to something prior to itself; namely, reason. This entails the priority of reason over revelation and as such undermines claims that purport to define identity in terms of revelation/religion. This detachment of identity from religion would clearly have far reaching socio-political implications for issues such as religious diversity, pluralism and multiculturalism in particular and public theology in general.

Concise Review of Classical Guitar Modelling Technologies

2021 ◽  
Vol 11 (1) ◽  
pp. 25
Author(s):  
Alexandre M. Löw ◽  
Herbert M. Gomes ◽  
César M. A. Vasques
Keyword(s):  
Degrees Of Freedom ◽  
Research Area ◽  
Coupled Systems ◽  
Mode Shapes ◽  
Classical Guitar ◽  
Concise Review ◽  
Lumped Parameter ◽  
Basic Approaches ◽  
Shed Light

Analytical modeling and numerical simulation of multiphysics coupled systems is an exciting research area, even when it comes to intrinsically linear or linearized formulations, as is usually the case with coupled vibroacoustic problems. The combined effect of many localized geometrical miss-modeling with significant uncertainty in mechanical characterization of some organic materials yields large discrepancies in the natural frequencies and mode shapes obtained. The main goal of this work is to compare two basic approaches for the modeling of stringed musical instruments in the frequency domain: simplified lumped-parameter analytic modeling, considering only the most influential degrees of freedom, and discretized finite element modal analysis. Thus, the emphasis is on a review of some key references in this field, including previous work by the authors, which may shed light on some of the most relevant issues surrounding this problem.

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