scholarly journals Detection of Lung Cancer Cells in Solutions Using a Terahertz Chemical Microscope

Sensors ◽  
2021 ◽  
Vol 21 (22) ◽  
pp. 7631
Author(s):  
Yuichi Yoshida ◽  
Xue Ding ◽  
Kohei Iwatsuki ◽  
Katsuya Taniizumi ◽  
Hirofumi Inoue ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Ph Measurement ◽  
Cell Detection ◽  
Liquid Biopsies ◽  
Precise Analysis ◽  
Excellent Candidate ◽  
Group A ◽  
Personalized Cancer ◽  
Cancer Cell Detection

Cancer genome analysis has recently attracted attention for personalized cancer treatment. In this treatment, evaluation of the ratio of cancer cells in a specimen tissue is essential for the precise analysis of the genome. Conventionally, the evaluation takes at least two days and depends on the skill of the pathologist. In our group, a terahertz chemical microscope (TCM) was developed to easily and quickly measure the number of cancer cells in a solution. In this study, an antibody was immobilized on a sensing plate using an avidin-biotin reaction to immobilize it for high density and to improve antibody alignment. In addition, as the detected terahertz signals vary depending on the sensitivity of the sensing plate, the sensitivity was evaluated using pH measurement. The result of the cancer cell detection was corrected using the result of pH measurement. These results indicate that a TCM is expected to be an excellent candidate for liquid biopsies in cancer diagnosis.

scholarly journals Design of MEMS-based Microfludic Channel to Detect Cancer Cells in Blood

2020 ◽  
Vol 11 (1) ◽  
pp. 561-566
Author(s):  
Syed Shameem ◽  
RamaKrishna T V ◽  
Sahithi M ◽  
Rohitha B ◽  
Keerthana J ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Early Stage ◽  
Microfluidic Channel ◽  
Cell Detection ◽  
Malignant Growth ◽  
Simple Manner ◽  
Abnormal Cells ◽  
Mass Displacement ◽  
Cancer Cell Detection

Cancer refers to any of countless infections characterized by the development of abnormal cells that divide uncontrollably and can invade and destroy normal body tissue. Malignant growth frequently can spread all through your body. Cancer is the second driving reason for death on the planet. In this paper, we propose to found a H-cell to screen carcinogenic cells in a given sample of blood based on the principle of diffusion. This model incorporates the planning of a MEMS-based microfluidic channel to screen and recognize different cells depending on the size and various characteristics of the cells. Some of the methods which are implemented not efficient models for cancer cells detection in blood. The mass, displacement technique has been implemented in this investigation for cancer cell detection, with the help of this achieves the accuracy and better throughput. One cancer cell contains = 1.70371e-24 mass, such that with a weight of this formula, find out the total no of cells in the blood. This is the best method compared to existed methods. Using this count, the weight has been calculate early-stage cancer and treatment with a simple manner, CTCs in the blood is the un potential matter for health, H-cells have been measured with proposed weight and force technique such that in this investigation also calculate the healthy and cancer cells also. Finally, using this methodology achieves 93.58% accuracy, 0.00124 MSE. These are very good results compared to conventional methods.

A label-free activatable aptamer probe for colorimetric detection of cancer cells based on binding-triggered in situ catalysis of split DNAzyme

The Analyst ◽  
2014 ◽  
Vol 139 (17) ◽  
pp. 4181-4184 ◽  
Author(s):  
Hui Shi ◽  
Duo Li ◽  
Fengzhou Xu ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
...  
Keyword(s):  
Cell Surface ◽  
Cancer Cells ◽  
Living Cell ◽  
Colorimetric Detection ◽  
Cell Detection ◽  
Label Free ◽  
Aptamer Probe ◽  
Cancer Cell Detection ◽  
In Situ Catalysis

A label-free activatable aptamer probe was developed for cancer cell detection through recognition-switched split DNAzyme activity on a living cell surface.

Nanoparticle modification of microfluidic cell separation for cancer cell detection and isolation

The Analyst ◽  
2020 ◽  
Vol 145 (1) ◽  
pp. 257-267 ◽  
Author(s):  
Yun Zhou ◽  
Ziye Dong ◽  
Hermella Andarge ◽  
Wei Li ◽  
Dimitri Pappas
Keyword(s):  
Surface Modification ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Separation ◽  
Cell Detection ◽  
Multiple Cancer ◽  
Nanoparticle Surface ◽  
Nanoparticle Surface Modification ◽  
Cancer Cell Detection

We present a nanoparticle surface modification approach to improve the microfluidic performance in detecting cancer cells. Multiple cancer cell lines were included in this work, and the capture ability of the chip with surface modification reached a significant increase.

Mesoporous silica film-assisted amplified electrochemiluminescence for cancer cell detection

2015 ◽  
Vol 51 (74) ◽  
pp. 14072-14075 ◽  
Author(s):  
Mei-Sheng Wu ◽  
Xiao-Tao Sun ◽  
Meng-Jiao Zhu ◽  
Hong-Yuan Chen ◽  
Jing-Juan Xu
Keyword(s):  
Mesoporous Silica ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Silica Film ◽  
Cell Detection ◽  
Amplification Method ◽  
Mesoporous Silica Film ◽  
Cancer Cell Detection

A novel mesoporous silica film-assisted amplification method is reported for the sensitive electrochemiluminescence detection of cancer cells.

MICROFLUIDIC CHIP FOR CANCER CELL DETECTION AND DIAGNOSIS

2018 ◽  
Vol 18 (01) ◽  
pp. 1830001 ◽  
Author(s):  
CHIYU LI ◽  
WANG LI ◽  
CHUNYANG GENG ◽  
HAIJUN REN ◽  
XIAOHUI YU ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Microfluidic Chip ◽  
Cell Biology ◽  
Cell Detection ◽  
Microfluidic Chips ◽  
Cell Capture ◽  
Unique Method ◽  
Detection And Diagnosis ◽  
Cancer Cell Detection

Since cancer becomes the most deadly disease to our health, research on early detection on cancer cells is necessary for clinical treatment. The combination of microfluidic device with cell biology has shown a unique method for cancer cell research. In the present review, recent development on microfluidic chip for cancer cell detection and diagnosis will be addressed. Some typical microfluidic chips focussed on cancer cells and their advantages for different kinds of cancer cell detection and diagnosis will be listed, and the cell capture methods within the microfluidics will be simultaneously mentioned. Then the potential direction of microfluidic chip on cancer cell detection and diagnosis in the future is also discussed.

Specific detection of cancer cells through aggregation-induced emission of a light-up bioprobe

2017 ◽  
Vol 53 (15) ◽  
pp. 2398-2401 ◽  
Author(s):  
Jian Chen ◽  
Hong Jiang ◽  
Huipeng Zhou ◽  
Zhenzhen Hu ◽  
Niu Niu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Detection Method ◽  
Cell Detection ◽  
Specific Detection ◽  
Aggregation Induced Emission ◽  
Specific Cancer ◽  
Cancer Cell Detection

A specific cancer cell detection method through the aggregation-induced emission of a light-up bioprobe is developed.

Rapid bladder cancer cell detection from clinical urine samples using an ultra-thin silicone membrane

The Analyst ◽  
2016 ◽  
Vol 141 (2) ◽  
pp. 652-660 ◽  
Author(s):  
Jennie H. Appel ◽  
Hao Ren ◽  
Mandy L. Y. Sin ◽  
Joseph C. Liao ◽  
Junseok Chae
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
High Throughput ◽  
Urine Samples ◽  
Cell Detection ◽  
Silicone Membrane ◽  
Bladder Cancer Cells ◽  
Cancer Cell Detection ◽  
Cancerous Cells

A high-throughput strategy capable of differentiating bladder cancer cells from non-cancerous cells based on their respective cellular traction forces.

Detection of cancer cells using triplex DNA molecular beacons based on expression of enhanced green fluorescent protein (eGFP)

2014 ◽  
Vol 50 (67) ◽  
pp. 9547-9549 ◽  
Author(s):  
Dongmei Xi ◽  
Xindong Wang ◽  
Shiyun Ai ◽  
Shusheng Zhang
Keyword(s):  
Green Fluorescent Protein ◽  
Cancer Cells ◽  
Enhanced Green Fluorescent Protein ◽  
Fluorescent Protein ◽  
Molecular Beacons ◽  
Triplex Dna ◽  
Cell Detection ◽  
Novel Strategy ◽  
Green Fluorescent ◽  
Cancer Cell Detection

A novel strategy was developed for cancer cell detection using triplex DNA based on expression of enhanced green fluorescent protein.

scholarly journals Biomechanical Properties of Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 887
Author(s):  
Gaël Runel ◽  
Noémie Lopez-Ramirez ◽  
Julien Chlasta ◽  
Ingrid Masse
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Crucial Role ◽  
Biomechanical Properties ◽  
Supplementary Information ◽  
Cancer Cell Growth ◽  
Diagnosis And Prognosis ◽  
Surrounding Environment ◽  
Surrounding Extracellular Matrix

Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for molecular biomarkers to try to classify and stratify cancers, much effort needs to be made to take account of morphological and nanomechanical parameters that could provide supplementary information concerning tissue complexity adaptation during cancer development. The biomechanical properties of cancer cells and their surrounding extracellular matrix have actually been proposed as promising biomarkers for cancer diagnosis and prognosis. The present review first describes the main methods used to study the mechanical properties of cancer cells. Then, we address the nanomechanical description of cultured cancer cells and the crucial role of the cytoskeleton for biomechanics linked with cell morphology. Finally, we depict how studying interaction of tumor cells with their surrounding microenvironment is crucial to integrating biomechanical properties in our understanding of tumor growth and local invasion.

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