scholarly journals Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review

Vaccines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 82
Author(s):  
Ihsanul Hafiz ◽  
Didi Nurhadi Illian ◽  
Okpri Meila ◽  
Ahmad Rusdan Handoyo Utomo ◽  
Arida Susilowati ◽  
...  
Keyword(s):  
Molecular Biology ◽  
Real World ◽  
Health Problem ◽  
Narrative Review ◽  
Health Science ◽  
Major Health Problem ◽  
Major Health ◽  
Post Vaccination ◽  
The Social ◽  
The World

The ongoing COVID-19 pandemic, as a result of the SARS-CoV-2 virus, since December 2019, is a major health problem and concern worldwide. The pandemic has impacted various fields, from the social to the development of health science and technology. The virus has been mutating and thus producing several new variants, rushing research in the field of molecular biology to develop rapidly to overcome the problems that occur. Vaccine clinical studies are developing promptly with the aim of obtaining vaccines that are effective in suppressing the spread of the virus; however, the development of viral mutations raises concerns about the decreasing effectiveness of the resulting vaccine, which also results in the need for more in-depth studies. There have been 330 vaccines developed, including 136 clinical developments and 194 pre-clinical developments. The SARS-CoV-2 variant continues to evolve today, and it poses a challenge in testing the effectiveness of existing vaccines. This is a narrative review describing the emergence of the COVID-19 pandemic, development of vaccine platforms, identification of concerning mutations and virus variants in various countries of the world, and real-world monitoring of post-vaccination effectiveness and surveillance.

scholarly journals PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Omid Reza Tamtaji ◽  
Mohammad Behnam ◽  
Mohammad Ali Pourattar ◽  
Michael R. Hamblin ◽  
Maryam Mahjoubin-Tehran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Health Problem ◽  
Molecular Mechanisms ◽  
Primary Brain Tumor ◽  
Epigenetic Mechanisms ◽  
Major Health Problem ◽  
Major Health ◽  
The World ◽  
Cellular Pathways

AbstractGlioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma.

scholarly journals Complete Stenosis of the Uretero Vesical Junction in Urogenital Tuberculosis: Management and Evolution

2021 ◽  
Vol 3 (1) ◽  
pp. 21-23
Author(s):  
O. Elidrissi ◽  
M. Rkik ◽  
W. Bai ◽  
Y. Ghannam ◽  
M. Dakir ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Health Problem ◽  
Disease Type ◽  
Ureteral Stenosis ◽  
Major Health Problem ◽  
Major Health ◽  
Urogenital Tuberculosis ◽  
The World

Urogenital tuberculosis continues to be a major health problem around the world due to the epidemic of HIV infection. We report the case of a 40-year-old patient followed for urogenital tuberculosis and who presented during her follow-up a complication of her disease type ureteral stenosis, managed by endoscopic route. We try through our work to focus on the value of surveillance after anti-bacillary treatment in order to watch for complications and act in an innocuous way.

scholarly journals A STUDY ON CLINICAL PATTERN OF ADVERSE DRUG REACTIONS TO THE DRUGS USED FOR HYPERTENSION AND ASSESMENT OF MEDICATION KNOWLEDGE IN SUCH PATIENTS.

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Vandana Sharma ◽  
Hetal Solanki ◽  
Narendra Kumar ◽  
Bhairvi Kumari
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Drug Reactions ◽  
Health Problem ◽  
Drug Reactions ◽  
Medication Knowledge ◽  
Major Health Problem ◽  
Major Health ◽  
Hypertensive Patients ◽  
The World

The aim of the present study was to monitor adverse drug reactions associated with antihypertensive drugs. due to its high prevalence, Hypertension is a major health problem throughout the world and very less studies has been aimed at assessing the patient’s knowledge and awareness about hypertension and adherence to antihypertensive medication among hypertensive patients .Hypertension is a major health problem and risk factor for stroke, coronary heart diseases and antihypertensive treatment is used to reduce renal and cardiovascular diseases by lowering blood pressure. Occurrence of adverse reactions among hypertensive patients could prevent or delay patients from achieving desired therapeutic goals. The study was conducted by one to one patient interview using a questionnaire-based medication knowledge form, Adverse Drug Reaction Monitoring Form drafted according to the World Health Organisation Monitoring Guidelines. A total of 86 adverse drug reactions were observed in 127 hypertensive patients during the 6 month study. In this study the ADRs were found probable (51.16%), possible (32.56%), unclassifiable (11.63%) and unlikely (4.65%) by using WHO causality assessment scale. By using Naranjo algorithm scale it was found that ADRs were possible in 77.91% and probable in 22.09% of cases. This study also found that amlodipine was responsible for most of the ADRs and among the entire ADRs reported headache was the commonest followed by dizziness, pedal oedema, fatigue, abdominal pain, dry cough, breathlessness, bradycardia, muscle cramps, sedation, diarrhoea and irritation all over thebody. After counseling by clinical pharmacist medication knowledge was found to be increased. Keywords: Adverse drug reaction, medication knowledge, hypertension

Prevention and Treatment of Early Childhood Caries (ECC)

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Jeffrey .
Keyword(s):  
Early Childhood ◽  
Health Problem ◽  
Early Childhood Caries ◽  
Health Providers ◽  
Missing Teeth ◽  
Optimal Basis ◽  
Major Health Problem ◽  
Major Health ◽  
Childhood Caries

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

scholarly journals Acute Cholecystitis Caused by Ceftriaxone Stones in an Adult

2009 ◽  
Vol 2009 ◽  
pp. 1-2 ◽  
Author(s):  
Christian D. Becker ◽  
Robert A. Fischer
Keyword(s):  
Adult Patient ◽  
Acute Cholecystitis ◽  
Health Problem ◽  
Medical Literature ◽  
Early Recognition ◽  
Gallstone Formation ◽  
Sludge Formation ◽  
Major Health Problem ◽  
Major Health ◽  
First Case

Acute cholecystitis is a major health problem. There are multiple etiologies to be considered and early recognition of the condition is important to optimize management and outcome. We report the first case in the medical literature of symptomatic acute cholecystitis triggered by ceftriaxone-associated gallbladder sludge formation and, importantly, solid ceftriaxone gallstone formation in an adult patient with underlying mineral and pigment cholecystolithiasis, necessitating cholecystectomy. This case serves as a reminder for physicians to keep this uncommon cause of cholecystolithiasis and cholecystitis in mind in patients who receive prolonged ceftriaxone therapy. These patients should be cautioned to promptly report to their physicians any signs or symptoms of cholecystitis in order to ensure timely and appropriate evaluation.

SOCIOLOGICAL PROBLEMS OF RITUAL: SOME REFLECTIONS

2021 ◽  
Vol 74 (2) ◽  
pp. 67-71
Author(s):  
Zh.K. Madalieva ◽  
Keyword(s):  
Social Action ◽  
Real World ◽  
Symbolic Meaning ◽  
Traditional Society ◽  
Social Functions ◽  
Individual Life ◽  
Human Community ◽  
The Social ◽  
The World ◽  
Definition Of

The article discusses in detail the essence and meaning of ritual as a social action. The study of the nature of this phenomenon involves, first of all, the study of various approaches to the definition of the concept of "ritual" and related phenomena. Analyzing the existing definitions, the author comes to the conclusion that "ritual" is a certain set of actions that have symbolic meaning. The symbolism of the ritual is manifested in its connecting role with the world of the sacred, sacred. The article emphasizes that in the consciousness of a person in a traditional society, the sacred world is present in the real world through ritual. As an archaic form of culture, ritual was also a way of regulating and maintaining collective life. The ritual served as a means of integrating and maintaining the integrity of the human community, giving it stability. Therefore, the article focuses on the social functions of the ritual in both public and individual life.

scholarly journals New Drugs for Acute Heart Failure

2012 ◽  
Vol 7 (1) ◽  
pp. 35-38
Author(s):  
Mohammad Salman ◽  
Syed Allahsan ◽  
Manzoor Mahmood ◽  
Md Khairul Anam ◽  
Shahed Mohammad Anwar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Acute Heart Failure ◽  
Health Problem ◽  
Standard Therapy ◽  
New Drugs ◽  
European Medicines Agency ◽  
Major Health Problem ◽  
Major Health ◽  
Long Time

Acute heart failure is a major health problem responsible for several million hospitalizations worldwide each year. Standard therapy has not changed for long time and includes diuretics and variable use of vasodilators or inotropes. Recently Nesiritide and Levosimendan are two drugs for the treatment of acute heart failure which have been approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMEA), respectively. There was little concern that Nesiritide can worsen the renal failure but recent trials had abolished this concern. DOI: http://dx.doi.org/10.3329/uhj.v7i1.10208 UHJ 2011; 7(1): 35-38

scholarly journals Danske og Internationale tendenser: Idræt og Sundhed

2015 ◽  
Vol 31 ◽  
pp. 99-110
Author(s):  
Thomas Skovgaard
Keyword(s):  
Physical Activity ◽  
Physical Inactivity ◽  
Built Environments ◽  
Environmental Determinants ◽  
Major Health Problem ◽  
Major Health ◽  
Strong Focus ◽  
Environmental Determinants Of Health ◽  
The Social ◽  
Health Enhancing Physical Activity

In the last decades there has been increasing recognition that physical inactivity represents a major health problem. Attention has been directed towards making the population more physical active in everyday life. Strategies have focused on individual, social and environmental determinants of health enhancing physical activity. This article argues that policies on physical activity, on top of addressing individual lifestyle factors, must include a strong focus on and plans for intervention in the social and built environments that influence the ability and interest in being physical active.

scholarly journals A Review on Lepa Kalpana in Dadru W.R.T. to Brihatrayi and Laghutrayi

2021 ◽  
Vol 11 (4) ◽  
pp. 102-105
Author(s):  
Lalita Sharma ◽  
Sudama Singh Yadav
Keyword(s):  
Fungal Infection ◽  
Health Problem ◽  
Skin Diseases ◽  
Modern Science ◽  
Treatment Modalities ◽  
Major Health Problem ◽  
Psychological Burden ◽  
Major Health ◽  
Almost All ◽  
Topical Absorption

Skin is the outermost covering of body and the largest organ of the integumentary system. Skin diseases are major health problem with emotional and psychological burden on patients. In Ayurvedic classics, almost all the skin diseases come under the broad heading of Kushtha. Dadru is a type of Kushtha which can be correlated with Tinea infection (fungal infection) in modern science. Three genera of dermatophytes infect skin i.e. Trichophyton spp, Epidermophyton spp and Microsporum spp. Ayurveda describes a multitude of treatment modalities for skin diseases in relation with various types of kushtha. One of them is the topical use of medicaments over the skin for topical absorption which allows faster absorption and better management of skin diseases. Lepa kalpana is a herbal or herbo-mineral drug for topical use. Although lepa is an important therapy in various diseases but it is highly useful specifically in dermatological diseases. This review describes different lepas which are especially mentioned for Dadru in doctrines of Ayurveda. Key words: Dadru, Kushtha, Lepa kalpana , Skin diseases.

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